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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Authors
Prasanna Kumar Panda,Gitanjali Mishra,Ruchi Bhattacharya,Ritika Singh,Ashish Kumar Netam3
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Keywords
Keyword: Protein 53, invasive tumors, small cell cancer, anticancer activity, Cancer therapy.
Abstract
ABSTRACT:
Tumor Protein 53 or Protein 53 (P53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumors. However, in some of the most difficult-to-treat cancers such as high-grade serous ovarian cancers, triple-negative breast cancers, esophageal cancers, Small cell lungs cancers and squamous cell lung cancers, p53 is mutated in at least 80% of samples. Clearly, therefore, mutant p53 protein is an important candidate target against which new anticancer treatments could be developed. Although traditionally regarded as undruggable, several compounds such as p53 reactivation and induction of massive apoptosis-1 (PRIMA-1), a methylated derivative and structural analogue of PRIMA-1, i.e. APR-246, 2-sulfonylpyrimidines (PK11007), pyrazoles such as PK7088, zinc metallochaperone-1 (ZMC1), a third generation thiosemicarbazone developed by Critical Outcome Technologies Inc. (COTI-2) as well as specific peptides have recently been reported to reactive mutant p53 protein by converting it to a form exhibiting wild-type properties. Consistent with the reactivation of mutant p53, these compounds have been shown to exhibit anticancer activity in preclinical models expressing mutant p53.
IJCRT's Publication Details
Unique Identification Number - IJCRT1812050
Paper ID - 184229
Author type - Indian Author
Page Number(s) - 390-400
Pubished in - Volume 6 | Issue 2 | April 2018
DOI (Digital Object Identifier) -
No Of Downloads - 1194
Author Country - 493111, India, Raipur, Raipur, India, Pharmacy
Publisher Name - IJPUBLICATION | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Published Paper PDF : - http://www.ijcrt.org/papers/IJCRT1812050
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Prasanna Kumar Panda,Gitanjali Mishra,Ruchi Bhattacharya,Ritika Singh,Ashish Kumar Netam3, "REACTIVIVATION OF P53: TARGET TO TREAT BREAST CANCER.", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.6, Issue 2, pp.390-400, April 2018, Available at :http://www.ijcrt.org/papers/IJCRT1812050.pdf
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The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies.
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International Journal of Creative Research Thoughts (IJCRT)
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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