Volume 10 | Issue 9

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Designed, Deterioration, Environmental-Friendly, Hazard, Industrialization, Sustainable etc.

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? Abstract The adhesion between two materials, at least one of which is a mucosal surface, is generally referred to as mucoadhesion. Mucosal medication delivery has drawn a lot of interest during the past few decades. Mucoadhesive dosage forms may be created to provide a regulated rate of drug release for a better therapeutic result by enabling prolonged retention at the site of application. Drug molecules that are not suitable for oral administration, such as those that undergo acid degradation or substantial first-pass metabolism, may benefit from the application of dosage forms to mucosal surfaces. The nature of the mucosal tissue and the physicochemical characteristics of the polymeric formulation are just two examples of the many variables that affect a dosage form's capacity to adhere to mucous membranes. This review article seeks to give a general overview of the numerous mucoadhesion issues, Mucoadhesive materials, factors affecting mucoadhesion, evaluation techniques, and ultimately various Mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal). In the past 20 years, mucoadhesion has attracted fresh interest in drug delivery applications that involve extending the residence time of Mucoadhesive dose forms through various mucosal channels. Topical and local systems based on Mucoadhesive have demonstrated improved absorption. Since Mucoadhesive drug administration has a large surface area and a strong blood flow, it provides quick absorption and good bioavailability. Drug distribution over the mucosa avoids first-pass hepatic metabolism and gastrointestinal enzyme degradation. In order to distribute a rising number of high-molecular-weight sensitive compounds, such as peptide and oligonucleotides, mucosal drug delivery systems may be useful. The goal of this review is to provide a thorough explanation of mucoadhesion, most popular routes of administration for mucoadhesives along with oral and parenteral routes for minimisation of the nasal delivery by thermoreversible mucoadhesive.

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? Keywords Mucoadhesion, mucoadhesive drug delivery systems, nasal and parenteral routes, Thermoreversible Mucoadhesive

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The economy of the North East suffers from many issues since independence due to its geographical isolation and corrupt government bodies. The main reason for the downgrade of the economy of that area is the lack of proper administration of the central bodies. The introduction of the New Economic Reforms though considered bliss for the economy of the North East Region however the answer to this question is quite controversial and complex.

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Globalisation, North East India, agriculture, economy, problem and prospects.

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In the last decade, a lot of research has been done on wireless communications. The existing research focus on designing and developing technology driven, efficient and multiple applications-oriented antenna. The metamaterial antennas have proved their potential in research domain for its high efficiency, moderate gain and multiband applications. A triple layered, multiband, metamaterial inspired antenna is designed, developed, analyzed and presented in this paper. The proposed antenna design exhibits resonance at 3.34 GHz, and 5.35 GHz frequencies with moderate gain. The FR4 substrate has been utilized as a substrate. The claimed antenna is applicable for various wireless applications.

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Wireless communication, Metamaterial antenna, Split Ring Resonator

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Ambedkar, Buddhism, Dalit women, Buddhist women

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With the antibiotic resistance growth, there is rise of interest in discovering novel antimicrobial agents. The antibiotics restored with metal nanoparticles because of its enduring antibacterial properties. This investigation aimed for gold nanoparticles biosynthesis and determines the antibacterial efficacy against some human bacterial species.The gold nanoparticles was characterized by UV, FT-IR and DLS. The impacts of synthesized gold nanoparticles were tested against E.coli (Gram-negative), S. aureus (Gram positive), S.pneumoniae (Gram positive) and K. pneumonia (Gram-negative) by disc diffusion method (Kirby Bauer test).The gold nanoparticles were synthesized from the plant Coleus amboinicus leaves extract. The spectrum of UV-Vis revealed a higher peak at 546 nm; the FTIR showed the phenolic compounds in the plant extract that were responsible for the formation of gold nanoparticles and the DLS revealed the size to be 104.5 nm. The gold nanoparticles indicate the minimum and maximum activity for antibacterial pathogens towards E.coli, K. pneumonia, S.pneumoniae and S. aureus. Thus, the synthesized gold nanoparticles might be a better option to develop an antibacterial agent against selected bacterial human pathogens.

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Coleus amboinicus, gold nanoparticles, Antibacterial activity, nanotechnology

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Cognitive impairment of dementia is memory loss problems in the elderly. Primary care providers are the first point of contact for most patients with these disorders and should be familiar with their diagnosis, prognosis and management. Both mild cognitive impairment and mild dementia are characterized by objective evidence of cognitive impairment. The main distinctions between mild cognitive impairment and mild dementia are that in the, more than one cognitive domain is involved and substantial interference with daily life is evident. The diagnosis of mild cognitive impairment and mild dementia is based mainly on the history and cognitive examination. The prognosis for mild cognitive impairment and mild dementia is an important motivation for diagnosis, as in both, there is a heightened risk for further cognitive.

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Dementia, Alzheimer's disease, Mild cognitive impairment, Epidemiology, Diagnosis,

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Manipulation, Dark psychology, Predator, Stream of consciousness, Psychoanalysis, Oscar Wilde, Virginia Woolf.

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INTRODUCTION- Episiotomy can be delineated as the procedure in which vaginal orifice is enlarged through an incision of the perineum. This procedure is commonly done for almost all women to help for a safe and easy labour particularly during their first de-livery. This incision befalls either through the second phase of labour or rights earlier the labour. Episiotomy comprises some types such as: medio-lateral, median, lateral and J-shaped episiotomy. Of these, a medio-latera l episiotomy is the most repeated. A study to assess the knowledge regarding infrared lamp therapy on healing of episiotomy wound. The data was collected through structured knowledge questioner to assess the knowledge on infrared lamp therapy through episiotomy wound healing among GNM III year students. The study was conducted in nursing colleges at Amroha. OBJECTIVE - the objective of the study was to assess the knowledge regarding infrared lamp therapy on healing of episiotomy wound among GNM III year students. METHODS - non probability convenience sampling methods was used for sampling. Total sample size was 60. Pre designed questionnaire was used in the study. Questions were related to knowledge about infrared lamp therapy and episiotomy. Participants were directed to complete the test on offline mode. The data was statistically analysed. RESULT- 60 GNM III year students participated. Result revealed that 6 students have poor level of knowledge, 5 students have average knowledge and majority of 49 students have good knowledge of infrared lamp therapy and episiotomy. CONCLUSION - The test revealed that there was a no significant association of knowledge with selected demographic variables. The present study proved that the assessment was significantly effective in improving the knowledge of G.N.M III year students regarding infrared lamp therapy on healing of episiotomy wound.

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Infrared lamp therapy, Episiotomy wound, Wound healing

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Despite all improvements in rheumatoid arthritis, we are still not able to prevent or cure the disease. Diagnostic delays due to lack of access to a specialist and costly therapies are still a major obstacle for many patients. Even in first-world countries, the treat-to-target principle and the goal of disease remission are often missed. Thus, rheumatoid arthritis (RA) is still the reason for disability and reduced quality of life for many patients. So, is it time to move the goalpost even further? Where are we heading next? And will we finally be able to cure the disease? These questions are addressed in our review article.

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P4 medicine, personalized medicine, digital health, Rheumatoid arthritis

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Occupational stress, health risk, working environment.

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Worldwide, cervical cancer is the fourth most frequent cancer in women with an estimated 604 000 new cases in 2020. Of the estimated 342,000 deaths from cervical cancer in 2020, about 90% of these occur in low- and middle-income countries. Women living with HIV are 6 times more likely to develop cervical cancer compared to women without HIV, and an estimated 5% of all cervical cancer cases are attributable to HIV. Moreover, in all world regions the contribution of HIV to cervical cancer falls disproportionately on younger women.In high-income countries, programmes are in place which enables girls to be vaccinated against HPV and women to get screened regularly and treated adequately. Screening allows pre-cancerous lesions to be identified at stages when they can easily be treated. In low-and middle-income countries, there is limited access to these preventative measures and cervical cancer is often not identified until it has further advanced and symptoms develop. In addition, access to treatment of cancerous lesions (for example, cancer surgery, radiotherapy and chemotherapy) may be limited, resulting in a higher rate of death from cervical cancer in these countries.The high mortality rate from cervical cancer globally (age standardized rate among women: 13.3/100 000 in 2020) could be reduced by effective interventions at different stages of life.

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Cervical cancer,HIV,HPV Screening, radiotherapy, Chemotherapy, Pre cancerous lesions , vaccination

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Asthi Marma, Regional anatomy, Surface anatomy

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The in vitro cultivation of mature plant shoot tip explants was used to construct an in vitro micropropagation strategy for the annual medicinally Gloriosa superba L. Shoot tips from 30-35-day-old field-grown plants were employed for in vitro micropropagation shoot tip explants culture. Surface sterilizing of shoot tips was found to be most effective after three minutes in 0.1% HgCl2 solution. For the main establishment of isolated shoot tips on MS medium supplemented with (BAP/Kn/TDZ) (0.5-3.0mg/L), IAA (0.5 mg/L) + (BAP /Kn/ TDZ) (0.5-3.0 mg/L), and (BAP/Kn/TDZ) (0.5-3.0 mg/L) for multiple shoot induction. Within four weeks of culture, multiple shoot bud proliferation was seen at IAA (0.5 mg/L) + (2.0 mg/L) TDZ from shoot explants. The number of shoots per explant varied between 2 and 6. Several shoots were under aseptic conditions removed and subcultures in the same medium to extend the shoot. For root induction, the possibly resulting were transplanted to IAA/IBA (0.0mg/L-2.0mg/L). Within two weeks of culture, rooting was seen. Rooted plantlets were successfully toughened under culture conditions before being planted in the field. The recorded plant survival percentage was 86%. The plants appeared to be in good condition, with no visible phenotypic differences. With an 87% survival rate, the plantlets (12-16 weeks old) were successfully acclimatized to soil.

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In Vitro Micropropagation, Gloriosa superba L, shoot tip, multiple shoot buds, sub captured, and acclimatization

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Pectin is a complex polysaccharide which is found abundantly in green plants. It is extracted mainly from fruits and vegetables, notably citrus fruits. Typically citrus skin has frequently been ideal substance for pectin production owing to its high pectin substance and superior coloring property. Mostly orange, lemon and lime peel are the sources preferred of citrus pectin. It is utilized in food and pharmaceutical industries. Pectin is employed as a gelling agent in jams and jellies. This review article is about, extraction of pectin from orange peels. There are several extraction methods like microwave assisted extraction method, ultrasound assisted extraction method and enzyme assisted method. In this work acid based extraction is discussed, as it gives high yield compared to other methods. The extractions were carried out in various time and temperature combination. The extracted pectin was dried and analyzed for its composition.

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pectin, orange peel, acid based extraction, alcohol precipitation

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Load forecasting, LSTM, Random forest, ANN, Renewable Energy, Classification

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The paper reports an study on ethnomedicinal plants that mainly focused on the traditional herbal medicinal plants used by local communities to cure various human ailments. A survey was carried out from 2017-2019 in Nagaur district of Rajasthan. The data were collected using interviews, group discussion, casual walking, field trips and observations with local communities. A total of medicinal plants distributed in 17-genera and 12-families. The plant species were collected and identified. The main aim to create wareness and save the plant species.

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Ethnomedicinal, Ailments, herbal

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this reserach paper is concerning the maximum critical worldwide documents inside the subject ofprivateness, information safety, records safety and employment, and information safety and social network sites.

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privacy

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Various studies on tribals give rich ethnographic details about their cultural practices, perception and behavioural aspects. Despite all these studies, very few studies are conducted on the health of tribal women especially their reproductive and Nutritional health. This paper will help policy makers to develop realistic health plans based on the felt needs of tribal women. The present paper is an attempt to examine the health and customary practices among tribals with special reference to women. Health is a function, not only of medical care but also of the overall integrated development of society i.e., cultural, economic, educational, social and political situation. Each of these aspects has deep influence on health, which in turn influences all these aspects. In order to understand the customary practices & dimensions of health, it is necessary to examine briefly the basic social, economic, cultural, religious and educational concerns and aspirations of the tribal women. This paper explores the role of tribal women in the socio-economic development of their families and how it effects their health in reciprocation.

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Health, Tribal, Women, customary practices, educational concerns, development

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COVID-19 is impacting provision of renal transplantation in the UK with a reduction in clinical activity. Publicly available Renal Registry and NHS Blood and Transplant reports were analysed to model the number of missed transplant opportunities, waiting list size and change in dialysis population over a six-month period starting 5 March 2020. An estimated 1,670 kidney transplant opportunities may be lost, which will lead to 6,317 active patients on the kidney-alone waiting list, compared to 4,649 based on usual activity estimates. This will result in 1,324 additional patients on dialysis who would otherwise have been transplanted. COVID19 will lead to a marked loss of transplant opportunities and a significantly larger national waiting list. The existing strain on dialysis capacity will be exacerbated as patients remain on dialysis as the only available form of renal replacement therapy. These findings will help inform policy and service specific strategy.

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Kidney transplantation, Covid19, managing COVID-19,Kidney transplant recipients, a challenging situation.

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