Volume 12 | Issue 9

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Safety pharmacology is a fast-growing field that generates data to support risk/benefit analysis using the fundamentals of pharmacology in a regulatory-driven manner. The identification of an adverse effect liability, data projection for the safety margin computation, and clinical safety monitoring are the three main concerns for safety pharmacology. Man's breathing is impacted by many medicines. After they are administered, the respiratory system is either directly affected, or a central, metabolic, or vascular action results in alterations in respiratory function. These guidelines suggest that the first investigations be conducted on conscious, unrestrained animals, with a single dose of the medication being given in most cases. Plethysmography in guinea pigs or rats is the most effective method for studying the impact on respiratory function. It is possible to distinguish between medications that change lung mechanical properties and those that impact respiratory control by measuring the ventilatory parameters of resistance, inspiratory time, expiratory time, peak inspiratory flow, and peak exploratory flow. Studying how these medications affect pathogenic animals' respiratory systems is therefore highly beneficial.

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Safety pharmacology, Drug safety, Respiratory functions

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Abstract: White collar crimes in the corporate sector have emerged as a significant concern worldwide, including in India. This research paper aims to provide a comprehensive analysis of white collar crimes specifically in the corporate sector, with a focus on banking laws in India. The study explores the nature, causes, and consequences of such crimes, while also examining the regulatory framework in place to prevent and address them. The research adopts a multidisciplinary approach, combining legal, economic, and criminological perspectives to investigate the various aspects of white collar crimes in the corporate sector. It draws upon existing literature, case studies, and relevant legal provisions to develop a holistic understanding of the subject matter. The paper begins by defining white collar crimes and outlining their distinctive characteristics, including their non-violent nature and their perpetration by individuals in positions of power within organizations. It then delves into the specific context of the corporate sector, highlighting the vulnerability of the banking industry to such crimes due to its complex and interconnected nature. The study further examines the existing legal framework in India pertaining to white collar crimes in the banking sector, with a particular emphasis on the legislative enactments, regulations, and guidelines governing the prevention, detection, and prosecution of these offenses. The research critically evaluates the effectiveness of these legal provisions and identifies potential gaps and challenges in their implementation. Moreover, the paper analyzes several prominent cases of white collar crimes in the Indian corporate sector, particularly within the banking industry, to illustrate the modus operandi, motives, and consequences of such offenses. It also discusses the impact of white collar crimes on the economy, investors, and public trust in the banking system. Lastly, the research provides recommendations to strengthen the legal framework and enhance regulatory mechanisms to effectively combat white collar crimes in the corporate sector, specifically within the banking industry. These recommendations include measures to improve corporate governance, enhance transparency and accountability, strengthen enforcement agencies, and promote ethical practices in the banking sector. In conclusion, this research aims to contribute to the existing body of knowledge on white collar crimes in the corporate sector, specifically focusing on the banking industry in India. By identifying the challenges and proposing relevant solutions, this study endeavors to assist policymakers, legal practitioners, and regulators in formulating and implementing more effective measures to prevent and address white collar crimes in the corporate sector.

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Money Laundering - Stages And Methods Anti-Money Laundering Mechanism in India: PMLA 2002. Judicial Precedents Regarding Money Laundering in India

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Bharatiy Pradhanamantri Shree Narendr Modi Ke Padosi Pratham Niti Ke Tahat Bhutan Ke Sath Bharat Ka Sambandh : Ek Vyakhya

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Bharatiy Pradhanamantri Shree Narendr Modi Ke Padosi Pratham Niti Ke Tahat Bhutan Ke Sath Bharat Ka Sambandh : Ek Vyakhya

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With the use of computer-aided design (CAD) software, 3D printing is also known as additive manufacturing. There are various 3D printing technologies available, including Selective Laser Sintering (SLS), Stereolithography (SL), and Fused Deposition Model (FDM). Many biomedical materials, including metals, polymers, bioink, ceramics, and bioactive glasses, are used in it. Recent technological advancements in 3D printing have revolutionised the use of organ models, such as the intricate heart structure that is vital to human health maintenance. Hearts are frequently printed in three dimensions using FDM and polyjet technologies. Using 3D bioprinting, we are now in the early stages of creating artificial organs such as pancreas composed of pancreatic islets. The uses of 3D printing are outlined in this review. Because of its sustainable properties, which include low cost, minimal post-processing, and minimal material waste even when making complicated organs like hearts 3D printing is a technology of the future.

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The issue of climate contamination it is indeed a pressing global concern with the emissions form gas powered vehicles being a significant contributor. This may transition towards alternative models of transportation with electric vehicles emerging as leading solution in India. The adoption of electric vehicles is gaining momentum and various aspects of this shift are being closely examined. Form the past decade there has been escalating interest enthusiasm for the electronic vehicles is very important of transportation in the coming years. This paper gives the awareness and satisfaction level of Electronic vehicle in India.

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Key words: Electric Vehicle , types of Electric Vehicles, consumer perception.

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This study has been undertaken to inspect the impacts of rhymes channels in fostering educational values in early childhood. It also explores the crucial role of these channels in the cognitive development of young audiences in addition to enhanced second language acquisition. As rhymes, songs and rhythms play a major role in the early stages of childhood its impact is much stronger and faster in early childhood developments such as language learning, phonological and Psychological awareness, reading and spelling, social interactions, vocabulary expansion, syntax and sentence structuring and more. The purpose of this study was to investigate the direct and indirect impacts of YouTube children's songs on preschool children's language development and second language acquisition. The article examines the impact of direct exposure to YouTube children's music on the preschool child. Furthermore, a research of the effects of these nursery channels on preschoolers revealed that exposure to YouTube music can help children learn by increasing engagement, creating a desired environment, improving concentration and memory, and keeping children on track. On the contrary, these channels might be far more misleading to children because passive consumption causes behavioural changes and greater screen time limits their imagination and inventiveness. Thus, nursery rhyme channels can be employed as an effective learning aid. Keywords: Rhymes channels, second language acquisition, language development, educational values, YouTube, phonological awareness, vocabulary, rhymes, and songs.

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Rhymes channels, second language acquisition, language development, educational values, YouTube, phonological awareness, vocabulary, rhymes, and songs.

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This research examines the credit evaluation methodologies and financial tactics implemented by Shriram Finance Limited, a leading non-banking financial company (NBFC) in India. The study investigates the company's strategies for managing loans and advances, evaluating its risk management protocols, and analyzing its financial stability and growth trajectory. Through a detailed analysis that includes ratio analysis and a review of loan growth patterns, the study identifies key strengths, weaknesses, and potential opportunities for expansion within the company. The findings underscore the importance of Shriram Finance's customer-centric services and its strategic focus on financial inclusion in driving its success. Nonetheless, the company faces ongoing challenges such as the management of non-performing assets (NPAs) and the need for adherence to regulatory requirements. The study concludes by offering recommendations aimed at enhancing credit risk assessment processes and improving operational efficiency to support sustainable growth in the competitive NBFC landscape.

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Non-Banking Financial Companies ,Credit Evaluation, Financial Growth ,Shriram Finance Ltd, Financial Inclusion, NBFCs

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This article aims at understanding the loyalty of customers who travel across borders for medical treatments by exploring various factors of customer relationship management. Medical tourism has become an influential industry in last few years and contributes heavily in any corporate hospital's revenues, however it is not short of any challenges though, thus through this article, relationship between CRM, and customer loyalty was identified. The study is based on Mixed Methods (qualitative and quantitative) wherein the quantitative study was done via cross-sectional analytic study design, wherein primary data was collected through a structured questionnaire on a 5-point Likert scale from 419 respondents and processed through descriptive statistics and multiple regression technique using SPSS. The qualitative study involved a focus group discussion between the employees working across several divisions of International Patients Services of the hospitals under the sampling frame chosen for a quantitative study. 'Trust' as a driver of CRM was found to be the most significant contributors of loyalty, thus strategies around this element shall guide the corporate hospitals in establishing India for its competitive advantage and a hub for medical tourism. Since there have been very limited studies of this kind that have been undertaken concerning the Indian hospitals, this study is one of its kind which shall highlight the important factors as perceived by international patients and employees of the hospitals and thus can further be utilized by the corporate hospitals to strategies their business processes to make the most out of this emerging area of medical tourism.

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CRM - Customer relationship management, CL - Customer Loyalty, EFA - Exploratory Factor Analysis, MT - Medical tourism, FGD - Focus group discussion

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Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a critical global health issue, with an estimated 1.7 billion people infected and 10 million new cases in 2020. TB is a leading cause of death worldwide, outpacing HIV/AIDS, and is increasingly complicated by drug resistance. Current treatment for drug-sensitive TB involves a combination of isoniazid, rifampicin, ethambutol, and pyrazinamide. However, multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) require more complex regimens, incorporating newer agents such as bedaquiline, delamanid, and pretomanid. Despite historical advancements, including the discovery of the TB pathogen by Dr. Robert Koch in 1882, TB continues to challenge global health systems. In India, a high-burden country, TB remains a significant issue with a high mortality rate. The Revised National TB Control Program (RNTCP) and the WHO's END TB strategy aim to drastically reduce TB deaths by 2035. Addressing TB effectively requires ongoing research, innovative treatment approaches, and improved diagnostic and treatment strategies to overcome the persistent challenges of this disease.

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Tuberculosis (TB), Mycobacterium tuberculosis, Multidrug-Resistant TB (MDR-TB), Extensively Drug-Resistant TB (XDR-TB).

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In the rapidly evolving Indian business landscape, the application of advanced financial strategies is crucial for business professionals aiming to drive growth, manage risks, and optimize performance. This article explores key financial strategies within the Indian context, focusing on capital budgeting, risk management, financial planning, and the use of financial derivatives. It highlights the unique challenges and opportunities faced by Indian businesses, including regulatory considerations, market volatility, and economic diversity. The article concludes with a discussion on the importance of continuous learning and adaptability in the Indian financial sector, along with recommendations for further exploration.

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Financial Strategies, Business Professionals, Capital Budgeting

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In this regard, the increasing volume of online transactions has made the effective securities of the payment gateway a prime concern. This innovative research paper looks into the strategic and technological emerging concerning the improvement in security in the payment gateway. It researched a number of advanced techniques for the effectiveness of the security risks associated with electronic payment, which include tokenization, multi-factor authentication, machine learning, and blockchain technology. The in-depth review of these technologies and description of best practices for their implementation will allow an estimation of the technologies' positive impacts on overall security related to payment gateways. Other important findings include the effectiveness that these technologies promise against modern challenges in security and make useful recommendations for organizations to further strengthen their payment systems. This paper is a good overview for including high-level security and thus sets ground for further research in the area.

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Payment Gateway Security, Tokenization, Multi-Factor Authentication, Machine Learning, Blockchain Technology, Fraud Detection, Electronic Payments, Security Measures, Advanced Technologies, Cyber Threats

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Recent years have seen an increase in the number of people doing theoretical chemistry. This increase has been facilitated by the development of computer software which is increasingly easy to use. Computational chemistry is used when a mathematical method is sufficiently well developed that it can be automated for implementation on a computer. Very few aspect of chemistry can be computed exactly, but almost every aspect of chemistry has been described in qualitative or approximate quantitative computational scheme. Often a qualitative or approximate computation can give useful insight into chemistry if we understand what it tells us and what it doesn't. In this study, Geometric optimization of some Schiff bases were done using computational methods - Molecular mechanics (MM+) and semi empirical methods (PM3). The software used is HYPERCHEM. The geometric parameters were calculated and the results thus obtained were compared with x-ray crystallographic results. The parameters were comparable.

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Computational Chemistry, Molecular Mechanics, Semiempirical methods, Schiff Bases

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ABSTRACT Background: Piriformis muscle has a predominance type-I fibers which has a tendency to develop shortness or tightness when the muscle is abnormally stressed. Tightness leads to reduction in ROM, affects flexibility and causes discomfort and pain. A shortened piriformis can further produce compression of sciatic nerve. A treatment program addressing hip abductors and extensors strengthening is needed in treatment of piriformis tightness.In the previous studies it was found that there is correlation between gluteus medius weakness and piriformis tightness. Methodology: Sedentary individuals with piriformis tightness{n=26}were included in this study. Gluteus medius strengthening exercises were given for 3 weeks. Pre and post range of motion and values were noted. Result: There was improvement in range of motion i.e abduction and external rotation ranges and reduction in pain was also observed. Conclusion : It is concluded that gluteus medius strengthening exercises helps in improving range of motion and decreasing pain in subjects with piriformis tightness in healthy sedentary individuals.

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RANGE OF MOTION(ROM),PIRIFORMIS MUSCLE TIGHTNESS(PMT),NUMERIC PAIN RATING SCALE(NPRS)FLEXION ABDUCTION INTERNAL ROTATION (NPRS)

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In this study, the effect of waste glass powder on the properties of different grade concrete was examined by conducting a series of compressive strength, splitting tensile strength and flexural strength tests. According to this aim, waste glass powder (WGP) was first used as a partial replacement for cement and six different ratios of WGP were utilized in concrete production: 0%, 10%,15%, 20%, 25% & 30%.To examine the combined effect of different ratios of WGP on concrete performance, mixed samples were then prepared by replacing cement. For the hardened concrete, 150 mm ? 150 mm ? 150 mm cubic specimens and cylindrical specimens with a diameter of 100 mm and a height of 300 mm were tested to identify the compressive strength and splitting tensile strength of the concrete produced with waste glass powder. Next, a three-point bending test was carried out on samples with dimensions of 150 ? 150 ? 700 mm to obtain the flexure behavior of different mixtures. According to the test results, it is observed that the compressive strength of M30 grade concrete increases up to 25% replacement of waste glass powder after that strength is reduces. Flexural strength and Split tensile strength of M30 grade concrete gradually increases up to 20% replacement of waste glass powder and for 25% and 30% replacements the strength values are reduces .The compressive strength of M40 grade concrete increases up to 30% replacement of waste glass powder. Flexural strength and Split tensile strength of M40 grade concrete gradually increase up to 25% replacement of waste glass powder and for 30% replacements the strength values are reduced.

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WGP, Beam specimen, Split tensile strength, Flexural strength, Compressive strength, M40 grade concrete, M30 grade concrete, Hardened Concrete.

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Om Shri Ganeshaya Namaha!!! Om Namaha Shivaya!!! The laws of Hinduism include dharma and karma. Dharma refers to righteous living and karma refers to a person's words, thoughts and deeds creating their destiny. Dharma comes in four different forms with the first being the universal law. This refers to the laws of physics regulating the forces of nature. Social dharma means that everyone has occupations, duties and responsibilities they must fill. This is an element of moral and religious law. Human law looks at the stages of life and the evolution and natural expression of the mind, feelings, body and soul throughout the stages. Self-dharma is the path a person takes and everything that represents this path. While the book may be placed in the hands of the boys for their own study, it is intended to be simplified by the oral explanations of Everyone, and each chapter serves as an outline on which one or more lessons may be based. They will thus acquire a useful store of sacred authorities on their religion. It has become somewhat of a sectarian name in some parts of Nepal and India, but it is here taken only as meaning the eternal religion. That this book may prove useful in laying a firm foundation of right thinking in the minds of Hindu youths, and may help in shaping them in to pious, moral, loyal and useful citizens of their mother-land and of the empire. Apart from that, Due to unavailability of knowledge about hindu Dharma our Hindu youth become misguided by other religious people like Christian Missionaries etc. When all the Gurukuls were destroyed by Britishers. Britishers ruled over India 200 years and In India Thomas Babington Macaulay is fully credited with the official introduction of. English education all over the India and Britishers banned over Hindi education and he shut down all Gurukuls. Hindu was in Majority therefore Britishers closed gurukuls in order to break down the unity of hindus and then divided all hindus in casteism for divide and rule policy. Eventhough Mugals empire ruled 800 years over India but they did not destroyed Gurukul only Mugals demolished the temples and conversion from Hindus to adopt Islam by hook and crook was their policy...When Macaulay studies came in to existence and all Gurukul was officially banned and destroyed in India, as a result Hindus did not know about the reality of Sanatan Hindu Dharma because Hindus cut off from their roots of Sanatan Hindu Dharma or we can say Macaulay studies kept Hindus far away from their roots of Sanatana Hindu Dharma.

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WISDOM, SCIENCE AND ETHICS IN SANATAN HINDU DHARMA

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The world is witnessing rapid technological growth, with the internet becoming a ubiquitous presence that transcends geographical boundaries, facilitating the flow of information. Data has become an integral part of our daily lives, connecting almost every aspect of modern life to some form of data. Whether it's social media, banking, or retail, our daily routines are intricately linked to data. This increased interconnectedness brings forth new and complex challenges in terms of privacy and data protection, making it crucial to ensure individuals have control over their personal data. India, as one of the fastest-growing economies, is at the forefront of this digital transformation, with various sectors being digitized and the launch of the Digital India program. In response to the growing concern over the protection of personal data and individual privacy rights, the Indian government has introduced several pieces of legislation. The bill's preamble aims to provide a legislative framework for protecting personal data and individual rights in India's rapidly evolving digital landscape. This research aims to analyze the efficiency of the law and the challenges associated with data protection in India. It will also compare the Indian data protection legislative framework with those of the European Union and the USA to identify areas for improvement. The comparison will focus on data protection principles, enforcement mechanisms, individual rights, accountability measures for data processors, cross-border data transfer provisions, and remedies available to individuals in the event of a data protection breach. The research will provide insights into the grey areas where the Indian legislative framework may face complex issues and propose improvements. In the digital age, it is imperative for countries to take significant steps to address the challenges arising from data protection and privacy concerns.

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Digital, Privacy, Data, Protection

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Background & Purpose: Spastic diplegic cerebral palsy (CP) significantly affects lower limb function in children, leading to challenges in muscle control and coordination. This comparative study aims to evaluate the effectiveness of two therapeutic interventions--muscle stimulation combined with exercise versus proprioceptive neuromuscular facilitation (PNF) with stretching--in improving lower limb function among children diagnosed with spastic diplegic CP.

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THE EFFECTIVENESS OF MUSCLE STIMULATION AND CONSERVATIVE THERAPY VERSUS PROPIOCEPTIVE NEUROMUSCULAR FACILITATION (PNF) AMONG WITH STRETCHING IN LOWER LIMB IN SPASTIC DIAPLEGIC CEREBRAL PASLY- A COMPARATIVE STUDY

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The healthcare environment in India has evolved into a World-Class, Cost Effective Healthcare destination for Medical Tourism influenced by ancient traditions and modern advancements; India is rich in alternative therapies that are the traditions of India and time tested in Centuries still have their force to reckon in Healthcare in which the West has no answer in certain diseases/ailments. In this regard, the ancient healthcare traditions namely in Ayurveda, Yoga, Naturopathy, Siddha that have treatments and procedures of their own for certain ailments where the West has no answer in allopathy is gaining importance with establishment of Ayush. To give high standards that are equivalent to JCI India has introduced NABH to give and recognize in healthcare, the National Board of Accreditation of hospitals and healthcare services (NABH) established by the Government of India has designed guidelines for accreditation of wellness centres in collaboration with Ayush. This transformation is underscored by the commitment of the Indian Government to enhance healthcare accessibility and quality, particularly in Post Covid-19 Pandemic.

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HEALTHCARE ENVIRONMENT MADE INDIA AS WORLD CLASS COST EFFECTIVE HEALTHCARE GLOBAL DESTINATION

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ABSTRACT Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels. This study aimed to investigate the potential antidiabetic effects of Momordica charantia (bitter melon) and Spondias mombin (yellow mombin) on streptozotocin (STZ)-induced diabetic rats. The experiment involved six groups of rats: a normal control group, a diabetic control group, a group treated with Metformin as standard drug,a group treated with Momordica charantia, and a group treated with Spondias mombin and a group treated with combination of both herbal drug Spondias mombin and Momordica charantia . Diabetes was induced in the rats using a single intraperitoneal injection of STZ. The treatment groups received oral doses of the respective plant extracts for a duration of four weeks. The results demonstrated that both Momordica charantia and Spondias mombin exhibited significant antidiabetic effects in the diabetic rats. Treatment with these plant extracts resulted in a reduction in fasting blood glucose levels, compared to the diabetic control group. Furthermore, the plant extract-treated groups showed improved glucose tolerance and increased insulin sensitivity compared to the diabetic control group. Biochemical analysis revealed that the plant extracts effectively restored altered lipid profile parameters, including total cholesterol, triglycerides, and low-density lipoprotein cholesterol, towards normal levels. Moreover, treatment with Momordica charantia and Spondias mombin significantly attenuated oxidative stress by increasing antioxidant enzyme activity and reducing malondialdehyde levels. Histopathological examination of pancreatic tissues showed that both plant extracts preserved pancreatic architecture and reduced STZ-induced damage, such as beta-cell degeneration and inflammatory cell infiltration. In conclusion, the findings of this study indicate that Momordica charantia and Spondias mombin have potential antidiabetic properties and may provide beneficial effects in managing diabetes. These plant extracts exhibited hypoglycemic, hypolipidemic, antioxidant, and pancreatic protective effects in STZ-induced diabetic rats. Further research is warranted to explore the underlying mechanisms and identify active compounds responsible for these effects, which could lead to the development of novel therapeutic interventions for diabetes management.

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Keywords: Momordica charantia, Spondias mombin, Streptozotocin, Diabetic Mellitus, T1DM, T2DM.

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