Volume 10 | Issue 9

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In recent years, ultra-high-pressure liquid chromatography (UHPLC) become the modern standard HPLC platform. UHPLC, with its shorter analysis time and quicker column equilibration, is ideally suited to rapid method development. This article provides a critical review of the current status, the benefits and the limitations of UHPLC in method development. We use case studies to describe best practices and recent advances.

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HPLC, UHPLC, UPLC, Method Development, Pharmaceutical analysis, Column/mobile-phase screening.

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Antimicrobial activity, Caralluma adscendens var. fimbriata, Protein-Ligands interaction.

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Ten Virtues, Pure Ethics of Human, Terma, Taking refuge, Triple Gems

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Insurance is a wide concept that simply means mode of savings. It is an activity or a process through which the savings of the people are mobilized, invested and made available back to them with some returns over their invested amount. Almost every person tends to save their money so that they may get some sort of protection from the uncertain future, losses and risks. Choosing insurance as a means of covering losses, protection from uncertain future is a modern technique. Though, India is said to be the highest in Asia-pacific region in term of growth in savings but still, India is a country which is under-insured. At present, private life insurance companies are taking active part in mobilizing the savings and people are also strengthening their trust in private players. The performance of the life insurance company is not confined to only selling the insurance products, marketing and advertisement but it necessarily includes customer satisfaction. This paper discusses about the insurance policies offered by the HDFC Life, the returns available on these policies and measuring the ultimate customer satisfaction. For this purpose, the HDFC Life from Lucknow and Kanpur have been chosen for the study. A structured questionnaire have been used for the collection of data from 200 customers. Multiple regression analysis have been used for measuring the customer satisfaction.

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Insurance, Life Insurance, HDFC Life, Customer Satisfaction, Insurance Policies

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Almost every organisation now strives to raise awareness of their interest in cloud computing for Internet of Things (IoT) applications. The large volume of data produced by diverse devices may be stored and managed effectively by integrating IoT devices with cloud computing technologies. The IoT-cloud architecture is complicated by these firms' large data security, though. We suggest a cloud-enabled IoT ecosystem backed by multifactor authentication and lightweight cryptography encryption approaches to safeguard large data systems in order to address security concerns. The suggested Hybrid Cloud Environment aims to provide data protection for enterprises. The Hybrid Cloud Environment combines public and private clouds. Here, we attempt data encryption using AES and after which data security will be provided by the cloud. And those who request the file need decryption key from Trusted Authority (TA). As a result, the performance of the suggested architecture using metrics like computational time, security strength, encryption time, and decryption time can only be evaluated for those who obtain keys from TA.

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Trusted Authority, Encryption, Decryption, Data Security, Multifactor Authentication.

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Cloud computing is a convoluted framework that empowers wanted administrations by joining an assortment of arranged gadgets. Cloud computing is comprised of a few kinds of configurable dispersed frameworks with different degrees of network for use. Associations are quickly taking on cloud networks because of benefits like expense viability, versatility, unwavering quality, and adaptability. The possibility clients expect to take on the cloud, however, its security issues impact clients' trust in its administration. As of now, there are numerous information security frameworks, standards, and guides to defend associations from security threats, but these are not specific to cloud organizations. The Cloud Security Alliance (CSA) has delivered Cloud Controls Matrix Version 4 (CCM v4.0), distributed in the last year of 2021 to give security controls, especially to cloud organizations. The Cloud control matrix (CCM) and it provide the various controls that need to be implemented by the service provider to avoid/reduce/mitigate the risks related to the service provided. This research paper provides an overview of the implementation of the cloud security alliance model. We have identified a total of 26 cloud security risks, threats, attacks, and vulnerabilities. We mapped it into a CCM to test its effectiveness measurement and find out if the CCM identified solution is the best security control or not.

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risk, threat, attack, vulnerabilities, cloud, matrix, measurement

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The most significant objective of this paper is to determine an outstanding model for forecasting the price of a bitcoin for the future days. All along the way accepting various factors and methods in finding a price can be utilized with different techniques like Long-Short Term Memory (LSTM) and Support Vector Regression (SVR). This paper deals with analyzing and reviewing the great practicable methods used to accurately predict bitcoin prices. The most significant aspect that should be taken into account is that the bitcoin prices from earlier years should be taken from the database to perform prediction. For analysis, the dataset should be pre-processed and adjusted for the actual review process. The most significant feature of this paper is to pre-process the dataset which is found to be uncooked. Besides, pre-processing the dataset, on the other side, the utilization of various models like Support Vector Regression, Linear Regression, and Long-Short Term Memory, and the generation of accurate results will also be explained in this paper. Additionally, the proposed work will show the applications of predicting frameworks in real life, and issues related to accuracy are also added. The paper further presents Machine Learning models with the best accuracy, the impact of training and testing ratios, and the removal of outliers to predict the price of bitcoin. The efficiency of bitcoin price prediction will be the greatest solution to the financial markets.

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Support Vector Regression, LSTM, Financial market, Bitcoin, Machine Learning.

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Beginning in early 2020, the COVID-19 epidemic has caused tremendous social, economic, political, and public health disruption throughout the planet. We organised the COVID-19 Coping Research, a national longitudinal cohort study, to explore the impact of pandemic-related stresses and changes in life circumstances on mental health and well-being. The first two waves demonstrated that the Coronavirus-created reality resulted in lower incomes and impoverishment for a significant number of households: compared to the pre-Coronavirus period, household income decreased for approximately one-fourth of households (23%), while 65% of households maintained their income level. More than 90% of respondents in the Second Wave reported a willingness to continue observing the preventative measures even after they were gradually lifted/eased.

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1 st wave , 2nd wave covid-19 situation analysis Covid-19 Symptoms, Poor Health infrastructure, Covid-19 deaths, symptoms covid-19 policies

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French writings on the downfall of the Mughal Empire: the writings of Law de Lauriston and Comte de Modave

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A group of abnormalities known as Potter syndrome and Potter phenotype are connected to an unborn child's lack of amniotic fluid and renal failure. Oligohydramnios, or having insufficient amniotic fluid during pregnancy, is different from anhydramnios, which has no amniotic fluid. A developing foetus is supported, padded, and safeguarded by amniotic fluid. It is possible for the foetus to develop physical characteristics like unusual facial traits or skeletal defects when there is insufficient amniotic fluid. The lungs are also underdeveloped (pulmonary hypoplasia) when oligo-anhydramnios is prevalent early in pregnancy, which can cause serious breathing problems. This illness is typically brought on by the loss of both kidneys (bilateral renal agenesis). This is referred to as the "classic Potter syndrome" at times. Polycystic kidney disease, dysplastic or hypoplastic kidneys, and obstructive uropathy, which prevents urine from leaving the bladder and accumulates in the kidneys, can also lead to Potter syndrome. There could occasionally be amniotic fluid leaks later in the pregnancy, but this won't cause Potter syndrome. Due mostly to pulmonary hypoplasia, Potter syndrome is an extremely dangerous disorder that frequently results in infant death at or soon after birth.

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Potter syndrome; oligohydramnios; anhydramnios; uropathy

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: In this paper the present study reveals Sangli district literacy rate in Maharashtra state for the duration of 2011-2021.Maharashtra is the third largest state regarding the geographical region and 2nd largest state in respect of population in India. It has studied on the basis census of 2011 -2021. Literacy plays a vital function to develop any society. Literacy is defined because the capability to read and write with understanding if any language as per the census of India. According to the 2011 census the common literacy in Maharashtra state is 82.34 per cent the stages of literacy vary from district to district. to the 2011 census the common literacy in Sangli District is 79.84 % in 2011. in this paper mentioned the literacy rate show the diagrams, graphs, maps and tables had been interpreted inside the mild of literacy rate in Maharashtra. Literacy has been taken into consideration as one of the high elements and an indicator for socio-economic development of the people of area.

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Literacy Rate, Literate Population, Sangli District.

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Usne Kaha tha, a short story by Chandradhar Sharma Guleri, is one of the finest drawn spaces which have immense contributions in arts and aesthetics as a source of knowledge contestation and proliferation of information. The utmost astounding quality of this work is the capacity to entertain and engender many spaces despite being extremely short in its design. The profundity of the work lies in the facilitation of the complexity and complexity of facilitation in a manner which is intrinsically woven with threads of tender and subtle human shades and expressions. The subtle human emotions attain a complex shade and the complex human expressions are expressed in a very lucid manner which gives this work a sense of sublime interjection. The structural grid, historical grid, relationship grids, characters as grids and other grids have a fine interplay with each other. The communication and the communication channels within these grids prosper to present a space for studying tragic as a space of harmonization of random information. The paper intends to study Usne Kaha Tha as an illustration and manifestation of tragic as a confluence of contradictory forces co-existing together in a random orientation.

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Tragedy, Information, randomness, contradictions, harmony

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Microsponge can be effectively incorporated into topical drug delivery systems for dosage form retention on skin, as well as use for oral drug delivery using bioerodible polymers. Entrapment of ingredients in microsponge drug delivery systems is thought to contribute to reduced side effects, improved stability, reduced systemic exposure and minimise local cutaneous reactions, increased elegance, and enhanced formulation flexibility. The Microsponge Delivery System is a novel technology for the controlled release of topical agents that consists of macroporous beads loaded with active agent that are typically 10-25 microns in diameter. When applied to the skin, the microsponge releases its active ingredient in response to time and other stimuli (rubbing, temperature, pH, etc). Numerous studies have shown that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microsponges delivery technology is currently used in cosmetics, OTC skin care, sunscreens, and prescription products. This review focuses on microsponge preparation, characterization, and application.

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Control relaease, Target release, topical formulation, oral administration, Solvent Diffusion Method, Quasi-Emulsion.

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Immunological, Clinical

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EFFECT OF GLOBAL WARMING ON ENVIRONMENT

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The recommendation system plays a crucial part in the current day and employed by many famous apps. The recommendation system has created the gathering of applications, producing a global community, and growing for plentiful knowledge. The recommendation system developed into sCollaborative Filtering, Content-based, and hybrid-based techniques. It is essential to provide the user with movie recommendations so that the user does not have to spend a significant amount of time searching for content that they would like. As a result, the function of the movie recommendation system is quite important in order to acquire user-specific movie choices. After doing considerable research on the internet and consulting a large number of scholarly articles, we came to the conclusion that the suggestions generated by Collaborative Filtering only use a single method for converting text to vectors and only use a single method for determining the degree to which vectors are similar to one another. Our project's goal is to create a recommendation engine that responds to the user in order to obtain ideas for a movie.

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Recommendation Services, Collaborative Filtering, AHP, Comparative analysis

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sentiment, emotions, prediction, mining

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Dual Role, Women, Health, Stress

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Street vending, which provides gainful employment to millions of migrant workers and the poor in cities, suffers from negative perceptions, lack of regulations and subsequent contestations over the use of urban spaces. The street vendors' positive contributions to the public spaces and government receipts go unnoticed due to the failure of urban governance to create adequate infrastructure and the persisting informal economy. Consequently, the substance of the spatial-temporal claim of street vendors to urban public spaces becomes obscure and in conflict with the narratives of the development of urban spaces. In India, the street vendors' right to livelihood is protected and their social protection is guaranteed by the national policy for street vendors. The policy was expected to provide street vendors with legitimacy, dignity, and social inclusion. Nearly two decades later, the policy has evidently brought about various positive impacts in the well-being of street vendors. Little information is published by governments and city authorities to understand and evaluate the effectiveness of the policy. But how far have we accomplished? This is a question that needs careful observation. "Crisis reveals the character," so goes an old saying. The COVID-19 pandemic and subsequent lockdowns of cities exposed the vulnerability of street vendors and the limitations of the policy. Lockdown forced all industrial and commercial activities to be suspended and the streets of the country to be left deserted and empty for months. The crisis left the street vendors with no option for a livelihood but to stare at insecurity and uncertainty. This provided the context for a critical evaluation of the policy for street vendors.

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Street Vendors, Social Protection, Right to Livelihood, Lock-down and Policy for Street Vendors

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