Volume 11 | Issue 9

 Abstract

Preformulation refers to a collection of research that concentrate on a novel drug candidate's physicochemical characteristics that might influence the drug's performance and the creation of a dosage form. This can support the necessity for molecular change or offer crucial information for formulation design. Before developing a pharmaceutical formulation, consideration was given to each drug's inherent chemical and physical qualities. This characteristic offers a framework for combining medications with pharmaceutical components to create dosage forms. The goal of the preformulation study is to create a dosage form that is beautiful, stable, safe, and effective by determining the kinetic rate profile, compatibility with other ingredients, and physico-chemical parameters of new therapeutic compounds. Drug solubility, partition coefficient, dissolving rate, polymorphic forms, and stability are among these qualities, and they all play significant roles in preformulation studies. The drug molecule's polymorphism, which includes crystal and amorphous forms, reveals many chemical, physical, and medicinal descriptions. This article describes a few characteristics and methods for medication preformulation evaluation parameters.

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Preformulation , Physiochemical Properties ,Compatibility , Methods.

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Thermal stress analysis of laminates under plane stress conditions of elasticity have been performed with mixed semi-analytical model. The displacements and transverse stresses that occur naturally at an interface of laminae are considered as fundamental dependent variables and thus continuity of transverse stresses and displacements are implicitly maintained at the laminae interfaces. The mathematical model consists of defining a two-point boundary value problem (BVP) governed by a set of coupled first-order ordinary differential equations (ODEs). The accuracy and the effectiveness of the proposed model are assessed by comparing numerical results from the present investigation with the available elasticity solutions under plane stress conditions.

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semi-analytical method; laminate; plane stress; thermal load

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ABSTRACT This article delves into the timeless literary theme that "For every action, there is an opposite reaction" through an examination of three iconic works: Shakespeare's Macbeth, Mary Shelley's Frankenstein, and Samuel Taylor Coleridge's The Rime of the Ancient Mariner. Each of these literary masterpieces serves as a vivid canvas upon which the intricate web of cause and effect is masterfully woven. In Macbeth, it is witnessed that the ambitious ascent of the titular character, whose actions driven by vaulting ambition set in motion a chain of events marked by guilt, paranoia, and the disintegration of relationships. Frankenstein explores the consequences of Victor Frankenstein's impulsive ambition to create life, leading to the creation of a monster and a relentless pursuit of revenge. In The Rime of the Ancient Mariner, the haunting encounter between a mariner and a supernatural ghostly ship and a serpentine creature, showcasing the opposing reactions triggered by the mariner's actions of reverence and regret. This article illuminates how these literary examples emphasize the profound principle of actions and their consequences, inviting readers to contemplate the intricate interplay of choices, motivations, and outcomes within the vast tapestry of human experience. Through the analysis of these works, readers gain a deeper understanding of the complexities of human nature and the moral fabric of our world, reaffirming the enduring power of this fundamental theme in literature.

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Index Terms: Action, Consequences, Disintegration, Reaction

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Botulinum toxins have made their way into dentistry specially in Prosthodontics for both dental esthetic and therapeutic uses. Botox is a neurotoxin derived from bacterium clostridium botulinum. Botulinum toxin inhibits the release of Acetylcholine, a neurotransmitter responsible for the activation of muscle contraction and glandular secretion, and its administration results in reduction of tone in the injected muscle. They provide most significant, minimally invasive procedure at low cost with limited recovery time. This review article explains the basics of botulinum toxin and its extensive and detailed uses in prosthodontics.

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Botulinum Toxin, Botox, Prosthodontics

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?????? ?????? ???????, 1872 ?? ??????? ?? ?? ???? ??? ???????? ?? ???? ??? ??? ????? ??? ?? ?????? ???? ?? ???????? ???? ???? ????? ??????? ??? ???? ?????? ???? ???? ????? ?????? ?? ?????? ??? ???? ??? ???????? ?? ???????????? ?? ???? ?-?????? ?? ??????? ?????? ?? ??? ?-?????? ???? ?? ??? ?????? ?? ????? ????? ???? ?? ?????? ???? ??? ?????? ???? ??? ??????? ??? ???????? ?? ???? ??? ???? ???????? ???, ??????? ?????? ?????? ?? ???? ???? ?? ??? ????????????? ????? ???? ?????? ???? ???????? ?-????????? ?? ???? ????????? ???????? ?? ????? ???? ?? ??????????? ???? ??? ????? ?? ?????? ???? ??? ????? ???????? ?? ?????? ?? ?????????? ?? ????????? ????? ?? ?????? ???????? ?? ?????? ?? ??????? ?? ??? ???? ?????? ????? ???? ????? ???????????? ???????, 2000 ???? ??? ?-???????? ?? ????? ????? ?? ??????? ??????? ?? ??????? ??? ?? ?????? ???? ???? ????????? ?????? ?? ???????? ???? ??? ????? ???????????? ??????? ?? ???? 10 ? ?-???????? ?? ????? ?? ??????? ??, ?? ???? ?? ?????? ??, ???????? ?? ???????? ?-???????? ?? ??????, ?- ???????? ?? ????? ?? ???? ??? ?- ???????? ?? ?????? ?? ?????? ???? ??? ??? ?? ??? ????? ?? ???? ???? ?????? ?????????? ???? ???

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?-??????, ?-???????? ?? ??????, ????? ????????????, ????????, ?????

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Buttermilk's (Takra) importance has been mentioned in many of the Ayurvedic classical texts It is included in diet and taken as medicine worldwide. Ayurveda says our Ahara (diet) itself is medicine. Takra (buttermilk) is used in the form of diet, various recipes are prepared from it. Takra (buttermilk) has been used as a medicine internally and externally. It's also given in the form of after drink with various medicines according to disease condition It is also called Granny's probiotics. This article discusses the various uses of buttermilk in various conditions externally and internally. Ayurvedic utility of buttermilk and precautions while consuming it, as well as those who should not take it and how it should be taken. The supremacy of buttermilk over curd has also been discussed along with its nutritive value. All these points are discussed in a nutshell in this article.

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Takra, buttermilk, Ayurveda, Granny's probiotics, diseases

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India has a big agriculture industry. It is essential for the survival and growth of the Indian economy. India is a major producer of numerous agricultural products. Soil is important for the cultivation of crops. Soil is a dynamic, non-renewable natural resource that is necessary for life. Young Indian farmers frequently struggle with choosing the proper crop depending on the requirements of the soil. As a result, they see a huge drop in productivity. Farmers with practical experience used to cultivate crops in the past. Farmers can no longer choose the best crop based on the characteristics and attributes of the soil. In order to suggest the crop that can be harvested in that particular soil, a recommendation system that makes use of a machine learning algorithm has been created. The user-supplied image of the soil is processed in the proposed system and divided into one of four soil types: clay, alluvial, red, and black. This is achieved using a MobileNetV2 Architecture model. When the soil type is predicted, a number of crops that can be produced there are advised. Our proposed approach maps the soil and crop data to predict the list of crops that will grow well in a given soil. The farmers will therefore find our suggested approach helpful in guiding them to select the best crops for their soil and in educating Our proposed system achieved Training accuracy of 97.34% and validation accuracy of 99.21%.

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soil condtions,cultivation,image processing,CNN, MobileNetV2

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Herbal medicine also known as herbalism or phytotherapy is a type of alternative medicine that uses plant extract, herbal, and other natural substances to prevent and treat various health conditions. It is one of the oldest forms of medicine and has been used by different cultures around the word for thousands of year. The ultimate aim of this study is to formulate and evaluate the herbal lotion using herbal extracts of plants having ethnic and dermatological importance in Ayurveda, namely, Leucas aspera, and Ocimum tenifloram. In the current scenario in cosmetics, the use of herbal antifungal lotion containing natural ingredient are more acceptable in public belief. In the formulation we utilizes Tulsi leaves extract, Aloe Vera gel, Rose water, and Leucas aspera leaves extract which are not yet used by any other research work. The plant leaves contain active ingredients that have pharmacological effect on the body and can be used for different purposes. It have possess the various pharmacological activities like antifungal, antioxidant, antitoxic, and antimicrobial activity.

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Leucas aspera, Antifungal Activity, Antimicrobial Activity, Antifungal Herbal Lotion, Phytochemical Screening, Staphylococcus Aureus, Escherichia Coli.

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The project titled "A Study on Consumer Spending via Credit Cards" aims to comprehensively analyze the patterns and trends of consumer expenditure through credit card transactions. In an increasingly digitized economy, credit cards have become a pivotal tool for modern-day transactions. This research endeavors to shed light on the dynamics of consumer behavior by investigating their spending habits, preferences, and the factors influencing their choices when using credit cards. The study will encompass a multi-dimensional approach, combining both quantitative and qualitative methods to gather and interpret data. Quantitative analysis will involve the collection and examination of transaction data from various credit card companies and financial institutions. This data will be subjected to statistical techniques to identify spending trends across different demographics, geographic locations, and product categories. Additionally, the research will delve into qualitative aspects by conducting surveys, interviews, and focus group discussions to gain insights into consumer perceptions, attitudes, and motivations related to credit card usage. Furthermore, the project intends to explore the impact of socio-economic factors, such as income levels, age groups, and cultural backgrounds, on consumer spending behavior. By deciphering these influences, the study aims to provide valuable insights to both financial institutions and policymakers, enabling them to make informed decisions regarding credit card regulations, marketing strategies, and financial literacy initiatives.

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Consumer, Credit Card, Digital Transactions, Digitized economy.

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A major global public health issue linked to increased morbidity and mortality is Chronic Kidney Disease (CKD), a continuum of kidney disease ranging from minor kidney impairment to End-Stage Renal Disease (ESRD). For ESRD patients, longevity and quality of life have improved thanks to advancements in dialysis treatments and the availability of kidney transplantation. In survival analysis, survival data might include patient characteristics that are connected to response, survival, and the development of a disease, as well as survival time and response to a particular treatment. Comparing the survival distributions of experimental animals or human patients, predicting the likelihood of response, survival, or mean lifespan, and identifying risk and/or prognostic factors related to response, survival, and the onset of a disease have been the main goals of the study of survival data. In the modelling of survival data under various types of diseases, parametric regression models are frequently utilised. This study uses the CKD data to examine the effectiveness of the four most used parametric regression modelling techniques: Exponential, Weibull, Gamma, and Lognormal. Based on the results and the minimum values of AIC and BIC, it is concluded that the Gamma model performs better than other models.

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Non-communicable disease, Akaike's Information Criterion (AIC), Bayesian information criterion (BIC), Chronic Kidney Disease, Survival analysis, Parametric regression model.

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?? ???? ?? ???????? ????? ???? ?? ??????? ??? ??? ???????? ?? ???? ?????? ?? ?????? ???? ??? ????? ???? ?? ??????? ??????? ?? ???? ????? ???? ??? ??? ?? ???? ??? ???? ???????? ???? ???????? ?? ?????? ??? ??? ???? ?? ???????? ???? ?? ??? ?? ????????? ?????? ??? ??? ?? ?? ???? ?????? ?? ???????? ??? ????? ?? ??? ?? ??????? ??? ?? ??????? ?? ?????? ?? ???????? ??? ?? ???????? ???? ?? ?????? ??? ???????? (????? ?? ??????) ?? ????????? ???? ???? ??? ??? ??, ???? ??????? ?? ????? ???????? ?????? ???? ?? ??? ????? ??? ??? ?????????? ?? ??????? ?? ?? ????

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??? ????????, ????? ??? ????????, ?????? ????????, ??? ????????? ??? ??????

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This research paper conducts a global comparative analysis of LGBT (Lesbian, Gay, Bisexual, and Transgender) rights, examining legal frameworks, societal attitudes, and the impact of LGBT rights movements. Historical evolution is explored, highlighting the influence of culture and colonial legacies. Notable case studies from the U.S., South Africa, and Japan reveal variations in recognition and acceptance. LGBT rights movements play a pivotal role in challenging discrimination and shaping legal landscapes. Despite progress, disparities persist, requiring ongoing advocacy. Policy recommendations include legal recognition, anti-discrimination laws, inclusive healthcare, education, and workplace initiatives. Future areas of focus encompass intersectionality, mental health, and global advocacy. Ultimately, the aim is an inclusive world where all individuals' rights and dignity are upheld, regardless of sexual orientation or gender identity.

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LGBT Rights Worldwide, LGBT Rights India, LGBT Rights

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Since ancient times, gold has been valued as a significant investment item and has been essential to financial markets and portfolios. This research investigates how investors view gold as an investment, focusing on the variables that affect their choices to incorporate gold into their investment plans. Utilising both quantitative and qualitative methodologies, the study uses a mixed-methods research design to collect its data. A thorough analysis of the literature is done to determine the historical importance of gold as a store of value and its function in diversifying investment portfolios. Additionally, the main ideas and empirical research on investor behaviour and the reasons people invest in gold are highlighted in this overview. A survey of a variety of investors, including individual investors, institutional investors, and financial specialists, is part of the research's quantitative phase. The poll tries to pinpoint the variables, such as risk tolerance, market sentiment, inflation expectations, geopolitical events, and global economic conditions, which affect investors' perceptions of gold. It also looks into the most popular gold exposure investments, including physical gold, gold-backed securities, gold exchange-traded funds (ETFs), and mining stocks.

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Awareness, Perception, Gold investment, Portfolio diversification.

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Dance is rhythmical form of exercise, where you dance a set pattern of steps in time with the music. It involves slow to intense kinetic footwork, swaying hand gestures and subtle eye - facial expressions (1). This article explores the complex impacts of dance on people's physical bodies (Sharir) and mental states (Manas). The study investigates how dancing affects cardiovascular health, muscular strength, biomolecules and cognitive abilities, among other physiological and psychological benefits. The article also looks into duration and timming, which gives better effect on stress reduction, emotional well-being, and cognitive improvement. This article contributes to a better understanding of the overall impacts of dancing by combining information from several research and investigating the mechanisms underlying the changes caused by dance in Sharir and manas and its potential use in boosting both mental and physical wellness.

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: Sharir, Manas, Gandharva veda, Upaveda, Samaveda, nrityabhyasa, Dushta Meda, Dhamani prathichaya (Atherosclerosis).

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Medicinal plants are used as a source of drugs since prehistoric times. Nowadays, in developing countries, assurance of protection, quality, and usefulness of medicinal plants and herbal plants has now become a key issue. Medicinal plants such as Ricinus communis are the "backbone" of traditional medicine as they are the rich resources of ingredients which will be utilised in the event and synthesis of medicine. A specific feature of Ricinus communis is its leaves yields a highly toxic substance "ricine" for which no specific anti-dote is available today. This was used as a poison by military/army of various countries during World War II.

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Ricinus communis, Ricine, Ayurveda Cassical uses, Castor oil.

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This study delves into the longstanding relationship between humans and plants, where the utilization of plants as remedies for human ailments dates back to the dawn of civilization. This research aims to bridge the gap between traditional wisdom and modern science by obtaining experimental data on the medicinal plant C.wallichii. The study's objectives encompass the identification of phytochemical and antioxidant activities, membrane stabilizing properties, antimicrobial potential, thrombolytic activity, and antioxidant capacity of C.wallichii. This study conducted a comprehensive analysis of the methanol extract of C.wallichii leaves, aiming to uncover its phytochemical composition and therapeutic potential. Notably, the extract exhibited significant antioxidant capacity, with a flavonoid content of 66.67 mg of quercetin equivalents per gram of dried extract, and demonstrated reducing power comparable to ascorbic acid. However, antimicrobial assays showed limited inhibitory effects against various pathogens, urging further investigation to enhance its antimicrobial properties. The findings underscore the need for in-depth chemical and pharmacological investigations to isolate bioactive compounds and assess safety and efficacy, offering promising avenues for the development of immunomodulatory therapies, antioxidant supplements, antimicrobial agents, thrombolytic treatments, and membrane protective strategies.

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C.wallichii, Thrombolytic, Vitro Antioxidant, Flavonoid, Actephila, Antimicrobial

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Kushmandavaleha is a traditional Ayurvedic medicine used for respiratory, digestive disorders and one of the Medya Rasayana. As per Charaka samhita, Kalpa sthana "SWABUDHAIVA SAHASRANI KOTIRVAAPI PRAKALPAYET" here Acharya has given liberty to prepare different varieties of formulations with intellect of Vaidya. By keeping this view,pharmaceutical modification of Kushamandavaleha into candy was planned here. The Kushmandavaleha candy can be a convenient alternative for patients who have difficulty swallowing traditional medicine forms and can improve patient compliance. It can also be a more appealing form of the medicine for children and older adults. Idea behind this particular study was to give Ayurvedic medicines in the form of candy especially for children. As we know children are very much found of candies and Ayurvedic medicines are not palatable, so this type of modification will helps to administer medicines easily to children. The study demonstrates the potential of modifying traditional Ayurvedic medicines into candy form to improve patient care especially paediatric age group.

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Kushmandavaleha, Candy, Pharmaceutical Modification

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This paper focuses on analyzing the LockBit Black ransomware, a recent and potent threat that has particularly targeted the healthcare sector. As ransomware continues to evolve and combine various malicious functionalities, it becomes crucial to detect its patterns of infection and persistence methods to prevent data, system, and network contamination. By identifying these infections early, containment can be achieved, and further spread can be avoided. The paper discusses reports and data leaks highlighting LockBit Black's significant contributions to attacks. The method chapter explores different approaches to detecting ransomware, such as static, dynamic, and network-based methods. The paper then describes the specific approach taken in this study, including the tools utilized. The results and discussion section presents the creation of two sandbox environments for manual analysis and the corresponding findings. Additionally, the paper introduces five free online malware analysis platforms, whose reports were compared with the manual results. The IoCs (Indicators of Compromise) identified during the analysis are provided, enabling other researchers to create signatures for early detection, prevention, and the recording of forensic evidence. This study aims to analyze LockBit Black ransomware comprehensively and identify its footprints to serve as a valuable resource.

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LockBit Black; Ransomware; Malware; Attack Signatures; Analysis

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Child sexual abuse includes any activity that uses a child to create sexual gratification either in them or in others. The intent to use children in any way to create sexual arousal is illegal. This criminal behavior that is aggressively prosecuted and severely punished by the legal system of India IPC Section 12 with 3 years imprisonment and fine for child sexual abusers.

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Evaluate, effectiveness, child sexual abuse, school

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Synthesis of exceed quality yoghurt soymilk with cow milk of protein, unsaturated fatty acid, increases value of sensory evaluation, low sugar level, low cholesterol yoghurt application of lactobacillus bulgaricus culture in soymilk in cow milk effect of chemical composition studied. it was found more helpful creation to health. Particular diabetes patient. Mixing soymilk in cow milk improve sensory assessment score and progress the nutritious quality of yoghurt

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: protein, cowmilk, soymilk, unsaturated fatty acid

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