Volume 13 | Issue 9

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Chitta-Pras?dana, Yoga Sutras, Conflict Resolution, Polarization, Emotional Regulation, Mindfulness

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The multi-target effects of bioactive compounds and their therapeutic potential are well explained by a network pharmacology framework. Computational network pharmacology methods were applied in this research to evaluate Scaevola taccada leaf extract's wound-healing activity. The GC-MS analysis identified a total of 20 active phytoconstituents, and Lipinski's rule was applied to filter for drug-likeness. 192 target-identified relevant genes were contrasted with 5,482 wound healing-related genes retrieved from the GeneCards database. 86 overlapping targets were determined through Venn analysis and are considered to be candidate therapeutic targets for wound healing. Essential hub genes were obtained through protein-protein interaction (PPI) analysis and included PPARG, ESR1, HIF1A, and MAPK1 as being essential regulators. GO enrichment analysis identified their involvement in inflammation, proliferation, and tissue remodelling through significant roles in nuclear receptor activation, transcription factor binding, and cell migration. Participation of putative targets in significant pathways like estrogen signaling, HIF-1 signaling, MAPK signaling, and regulation of lipid/atherosclerosis was again confirmed by KEGG pathway enrichment. The complex interaction between phytochemicals and molecular targets was demonstrated by the compound-target-pathway network constructed with Cytoscape. All of these findings indicate the prospective use of Scaevola taccada as a natural medicinal compound by showing it to modulate multi-gene and multi-pathway interactions to achieve wound-healing effects. This article emphasizes the employment of network pharmacology in validating traditional medicinal herbs for modern drug discovery, aside from providing molecular evidence for the pharmacological basis of Scaevola taccada

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network pharmacology, Scaevola taccada, wound healing, genes, molecular targets.

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This study investigates the intersection of hermeneutics with the ethical frameworks of Jainism and Hinduism, with a focus on their relevance to contemporary environmental sustainability discourse. Employing a hermeneutic methodology, the study interprets verses from foundational texts of these two Indian religious traditions to extract principles conducive to ecological sustainability. Central concepts such as non-violence, religious duties and sacredness of nature have been examined through interpretive lenses to uncover their ecological significance. Through an examination of religious verses, this paper highlights the contributions of these religions to modern sustainability practices. This paper explores how the ancient Indian traditions of Jainism and Hinduism provide ethical, and practical frameworks that align with the principles of sustainable development. By examining these traditions not merely as repositories of spiritual belief, but as dynamic systems of ecological ethics, the study seeks to contribute to the growing interdisciplinary dialogue between religion, philosophy, and environmental studies. The study proposes that religious literacy should be enhanced in terms of its significance for environmental conservation thereby proposing a pathway of environmental sustainability grounded in ethical worldviews, demonstrating how ancient religious philosophies can inform and enrich contemporary sustainability paradigms.

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Jainism, Hinduism, Environment, Sustainability, Interdependence

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Nasal drug delivery system having a numerous benefits, including quick immersion, avoiding first-pass metabolism, and non-invasive administration, hence drawn a lot of attention. A introduction to nasal deconstruction and physiology is given in this review, along with a discussion of the variables affecting medicine immersion and bioavailability. The convenience of administration and bettered patient compliance are impoetant in the design of the nasal medicine delivery system, which remains the favoured route of medicine delivery in malignancy of colorful disadvantages. Remedy through intranasal administration has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. Nasal medicine delivery has been around for centuries and employed both rest and recreation, and also for the treatment of colorful conditions such as migraine, decongestion, and in exigency. The route is accessible and popular. It has multitudinous advantages similar to direct delivery to the (Central Nervous System) CNS, high bioavailability, needles aren't used , and no special chops are needed to delivery the medicine.

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Nasopulmonary,Physiology,Absorption,Deconstruction,CNS,Bioavailability.

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The nurturing of a child in a woman's womb occurs in a space untouched by bias or hierarchy. Yet, once gender is ascertained, discrimination and subordination begin to unfold, giving rise to socially constructed notions of masculinity and femininity. Violence against women and the systematic denial of their freedom under patriarchal dominance transcend barriers of class, caste, and religion, demonstrating that gender inequality is a deeply ingrained social reality. Central to women's liberation is the assertion of individuality and the insistence on acknowledgment. Within this context, Meghna Pant, an acclaimed voice in contemporary Indian feminist literature, through her novel One and a Half Wife, portrays the manifold hardships experienced by her protagonist within the domains of family and society. The protagonist's awakening of an inner consciousness and her defiance of imposed restrictions not only reveal the intricacies of women's lived realities but also provide a powerful model of inspiration for those bound within suffocating marital frameworks. This study, therefore, aims to acquaint the pangs and difficulties through which the protagonist resists repression rooted in patriarchal traditions and rigid belief systems, with specific emphasis on the narrative techniques employed by the author, Meghna Pant.

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Patriarchal, Suppression, Feminism, Self-recognition, Subjugation

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Background: Felodipine, a calcium channel blocker, suffers from poor aqueous solubility and limited oral bioavailability, which restricts its therapeutic efficacy. To overcome these limitations, nanoparticle-based delivery systems provide a promising approach for enhancing solubility, stability, and sustained release. Methods: Felodipine-loaded polymeric nanoparticles were prepared using the nanoprecipitation method with PLGA as the polymer and PVA as the stabilizer. Preformulation studies, including organoleptic evaluation, FTIR, ?max determination, melting point, solubility, partition coefficient, and drug excipient compatibility, were carried out. The formulations (F1-F5) were characterized for physical appearance, particle size, zeta potential, SEM morphology, pH, drug content, entrapment efficiency, in vitro drug release, and stability studies under ICH conditions. Results: Preformulation confirmed drug identity, purity, and lipophilic character (log P = 4.1). The prepared nanoparticles exhibited uniform, milky dispersions with particle sizes in the range of 234-254 nm. Formulation F4 showed optimal stability with a zeta potential of -13.7 mV, spherical morphology, and high entrapment efficiency (86.4%). In vitro release studies revealed sustained drug release, with F4 showing maximum release (92.9% over 8 hours) following zero-order kinetics. Stability testing confirmed no significant changes in drug content, pH, or release profile after three months at accelerated conditions. Conclusion: Felodipine-loaded PLGA nanoparticles, particularly formulation F4, demonstrated favorable physicochemical characteristics, enhanced entrapment, controlled release, and stability. This delivery system offers a promising strategy to improve the solubility, bioavailability, and therapeutic efficacy of Felodipine compared to conventional formulations.

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Felodipine, Polymeric Nanoparticles, PLGA, Nanoprecipitation, Controlled Release, Oral Bioavailability

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A total of 108 samples of working physiotherapist were taken , ipaq-sf questionnaires and oldenburg burnout inventory scale were distributed and data was analysed by spss software There was no significant correlation between physical activity level and occupational burnout in physiotherapists

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Occupational Burnout, ipaq-sf, hepa (health enhanced physical activity

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Pharmaceuticals can acquire impurities during different phases of their development, transportation, and storage, rendering them potentially hazardous for administration. Therefore, it is essential to identify and quantify these impurities. In this context, analytical instrumentation and methodologies are crucial. It has been demonstrated that sophisticated analytical methods for ensuring pharmaceutical quality have significantly transformed public health and contributed to the ongoing enhancement of healthcare delivery. This review emphasizes the most recent analytical techniques, such as mass spectrometry (MS), spectroscopy and chromatography method aimed at enhancing drug quality. These methods are used in quality control laboratories to ensure the identity, purity, safety, efficacy and performance of drug products

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Drug quality control, Pharmaceutical analysis, Analytical techniques, Quality Assurance

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This case study examines the management and clinical outcomes of a 59-year-old male diagnosed with multiple myeloma, a rapidly progressing hematologic malignancy. After completing several cycles of chemotherapy, the patient achieved remission and was recommended for an autologous bone marrow transplant (BMT). The pre-transplant conditioning regimen included stem cell collection, high-dose chemotherapy, and subsequent stem cell infusion. The patient was closely monitored for common post-transplant complications, including infection, graft-versus-host disease (GVHD), and mucositis. Following a successful engraftment phase and appropriate supportive care, the patient demonstrated positive outcomes, with improved blood counts and a stable recovery. Nursing care played a central role throughout the transplant process. Key responsibilities included infection prevention, pain management, nutritional support, and monitoring for complications such as GVHD and mucositis. Nurses implemented strict infection control protocols, provided education on self-care and symptom recognition, and offered emotional support. During the post-transplant phase, blood counts were monitored, infection precautions were enforced, and chemotherapy-related side effects were managed. The successful outcome of this case highlights the importance of comprehensive nursing interventions in enhancing patient recovery, reducing complications, and supporting a smoother post-BMT recovery.

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Bone marrow transplantation, multiple myeloma, nursing care.

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The Shiva Purana, a gem among the eighteen principal Puranas in Hinduism, brims with a tapestry of spiritual, philosophical, and cultural tales woven around the enigmatic figure of Lord Shiva. Beyond mere theological and devotional significance, the text unveils a tapestry of profound insights into environmental consciousness, echoing the intricate ecological ethos woven into the very fabric of ancient Indian thought. This research article delves into the intricate environmental themes woven throughout the Shiva Purana, meticulously examining its shlokas, narratives, and symbolic representations to unveil the profound ecological wisdom embedded within. Employing a qualitative content analysis, this study delves into pivotal research inquiries regarding the text's depiction of nature, its significance in the context of contemporary environmental dilemmas, and the tangible ramifications of its insights. The article delves into the intricate limitations and formidable challenges that arise when attempting to interpret and implement these ancient insights within modern contexts, offering a rich and nuanced understanding of the Shiva Purana's significant contribution to environmental consciousness.

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Shiva Purana, environmentalism, sacred ecology, Hindu philosophy, sustainability, forest symbolism, Shaivism, Shiva, nature worship

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The pesticide market size in India is estimated to be INR229.4 billion in 2022, and it is expected to reach INR342.3 billion by 2028, with a projected Compounded Annual Growth Rate (CAGR) of 4.6% to 4.08%. Therefore, pesticides have become essential for farming (FAO, 2020). There are 293 pesticides registered in India, of which 104 are produced in the country itself. India is the fourth largest pesticide producer in the world. To promote sustainable agriculture in India and ensure food security for India's growing population, it is essential to protect crops from pests. Pesticides play a vital role in modern agriculture, but lack of awareness and misuse pose serious threats to both the environment and human health. India, with the world's largest population, is a high producer and consumer of pesticides. Overuse, lack of awareness, and unsafe handling practices are prevalent among both educated and uneducated farmers in India. This study, conducted in Bilaspur district of Chhattisgarh, examines pesticide use patterns and farmers' perceptions, focusing on health and environmental concerns. Primary data were collected from 100 farmers in three villages of Bilaspur (Birkona, Lokhandi, and Turkadih) using a structured and pre-tested questionnaire. By combining insights from the literature with field-based observations that collected information on farmers' demographic characteristics, awareness of pesticide laws and regulations, handling and storage practices, and knowledge of potential hazards, the study aims to contribute to a better understanding of pesticide practices in developing regions and underline the importance of awareness, training, and policy interventions to promote safe and sustainable pesticide use.

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Pesticide Practice Health Environment

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Indian Digital Economy has emerged as the world's 3rd largest economy after China and the United States, according to the State of India's Digital Economy (SIDE) 2025 reports. The digital economy raises issues like digital piracy that can shake any country's digital economy abruptly. Semiconductor integrated circuits (ICs) or chips are the backbone of every electronic device, whether it is a mobile phone or a TV set. The unauthorised copying of the ICs design and the piracy of chip layouts discourage further innovation in this sector, as its Research and Development requires heavy investment. Considering this as a Global concern, the TRIPS Agreement in 1994 provided guidelines to all the WTO member countries related to the protection of semiconductor integrated circuit layout designs. Based on the guidelines, India enacted a law related to the protection of semiconductor integrated circuit layout designs, i.e. Semiconductor Integrated Circuit Layout Design Act (SICLDA), 2000. This act has emerged as a milestone for the Indian Digital Economy. Awareness of such specialised laws remains limited within the legal education system. The main purpose of this paper is to transcend the disciplinary boundaries and think beyond our own disciplines to innovate, research and explore.

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Legal Education, IPR Awareness, SICLDA 2000, Chip Piracy, Interdisciplinary Learning, Higher Education

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Explainable Artificial Intelligence (XAI) is rapidly increasing in importance as AI systems are deployed in multiple sectors such as healthcare, finance, autonomous systems, educational research, and policymaking. Previous AI models, even though they are accurate, often work as "black boxes." They offer minimal insight into how decisions are made. XAI aims to address this opacity by ensuring AI models are interpretable, fully transparent, and accountable. This increases trust, ensures ethical compliance, and improves collaboration between human and AI systems. This paper has brief discussion of the future of explainable AI (XAI), its uses, technical and ethical challenges, and create ways to design strong and reliable AI frameworks that meet human and legal expectations.

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Explainable AI, XAI, Machine Learning, Transparency in AI, Trust in AI, Challenges

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Administrative Changes in any area are quite common in the current time. This administrative change significantly affect people's lifestyles. During the Mughal period, most of the areas of this subdivision were included in Tajpur Sarkar and Surjapur Pargana of Subah of Bengal. Administrative changes can bring about various transformations at the societal level, compelling people to think about life in new ways. In 1770 AD, the British took over the administration of the undivided Purnea district. Lord Cornwallis introduced the permanent settlement in 1793 AD and many small zamindari system developed in the area. Sued Fakhruddin Hossain was the Nawab of Khagra Estate. At this time, according to the permanent settlement, the revenue of this Pargana was Rs.2,46,226. Through multiple administrative changes, the characteristics of the current Islampur Subdivision have evolved. The current form of Islampur Subdivision has been shaped through various administrative changes. Before 1956 AD, Islampur Subdivision was part of the undivided purnea district, which is an important part of history. This area was ruled under many kings during the epic era, which allowed various cultures and traditions to flourish here. Many Hindu rulers , Muslims rulers and the British have ruled this area, which has influenced the history of the area. On November 1, 1956 , the Islampur Subdivision joined West Bengal from the undivided purnea district of Bihar, marking an important moment between the two area.

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Purnea , Surjapur, Kishanganj, Islampur, British, Administration etc.

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The banking industry is one of the key institutions in the economy of India, but there is always a challenge of workplace conflict affecting organizational productivity and employee welfare. This paper reviews the factors and the impacts of conflicts in the private and public sector banks of Madhya Pradesh with special emphasis on the implications of these conflicts on employee performance. Regression analysis and paired samples t-test were applied to provide data analysis using 100 respondents via stratified random sampling. The results show that the causes of conflicts vary significantly in the two sectors: in the case of the public banks, the bureaucratic hierarchies, the lack of resources and career advancement cause conflicts, whereas in the case of the private banks, performance pressures and customer expectations introduce conflicts. The regression findings support this fact as levels of conflict are significant determinants of employee performance, with more than 40 percent variance being attributed. The paper has highlighted the significance of organised grievance redressal, transparent communication and employee education to convert conflicts to chances of better productivity and organization cohesion.

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Employee performance, banking industry, public and private sector banks, workplace conflict, and conflict management, Madhya Pradesh

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Conventional chemotherapy is frequently hampered by a lack of tumor selectivity, resulting in systemic toxicity and a narrow therapeutic window. To address these limitations, this study reports the design, synthesis, and evaluation of actively targeted solid lipid nanoparticles (SLNs) for the enhanced delivery of paclitaxel (PTX). A series of PTX-loaded SLNs were developed and surface-functionalized with folic acid (FA) as a targeting ligand. The formulations included SLNs with FA conjugated directly to the surface (SLNFA) and SLNs with FA attached via polyethylene glycol (PEG) spacers of two different molecular weights, 1000 Da (SLNP1FA) and 4000 Da (SLNP4FA). Physicochemical characterization revealed that surface modification progressively increased particle size while maintaining a narrow distribution, and significantly enhanced drug entrapment. The SLNP4FA formulation demonstrated the highest drug entrapment efficiency at 58.22% and exhibited the most sustained in vitro drug release profile over 48 hours. The therapeutic efficacy of the nanocarriers was assessed against folate receptor (FR)-positive MCF-7 human breast cancer cells. All folate-targeted formulations showed superior cytotoxicity compared to free PTX and non-targeted SLNs. Crucially, the efficacy was dependent on the PEG spacer length, with SLNP4FA exhibiting the highest potency. This formulation achieved an IC50 value of 331.29 nM, representing a 48.39% reduction in the IC50 compared to free PTX. These findings demonstrate that optimizing the PEG spacer length is a critical strategy for overcoming steric hindrance and maximizing receptor-mediated endocytosis. The FA-PEG (4000)-SLN architecture represents a highly effective and promising platform for the targeted delivery of chemotherapeutic agents to solid tumors.

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solid lipid nanoparticles; paclitaxel; nanocarriers; breast cancer

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ABSTRACT : This paper examines the portrayal of women in contemporary arts and culture, focusing on how modernism and evolving societal norms have influenced this depiction. By exploring literature, visual arts, cinema, and digital media, the study identifies patterns and challenges traditional stereotypes, emphasizing the transition from objectification to empowerment. The paper also highlights the role of feminist movements and globalization in shaping contemporary representations of women.

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Key words: Feminism, Empowerment, Intersectionality, Gender Norms, Representation

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E-commerce is a profession in a business that will determine in the future that E-commerce brings world pattern shifts for trading. E-commerce shows uninterrupted business growth in Gujarat. Sponsored by online user support and mobile phone presentation, e-commerce has seen impressive growth in Gujarat over the past few years. This area is scheduled to measure the higher altitude, allowing Gujarat's demographic dividend and increasing internet facilities. However, the overall retailing opportunity is widespread; this region is surrounded by some serious challenges in Gujarat. The current study is to describe the current situation of the e-commerce in Gujarat and the future development. Analyze the current trends of e-commerce in Gujarat and examine e-commerce competitions and events in Gujarat.

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E-Commerce, CAGR, Online Retail, Increasing Internet Users, Electronic Fund Transfer, Economic Growth

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Kaali Zeeri (Centratherum anthelminticum (L.) Kuntze), also known bitter cumin, is a medicinal plant with a long history of use in traditional medicine systems, particularly in Unani practices. This comprehensive review synthesizes data from classical Unani text and modern scientific literature, electronic database such as PubMed, Science direct and google scholar. This review examines the botanical characteristics, phytochemical composition, traditional applications and modern scientific validation of Kaali Zeeri's therapeutic properties. Kaali Zeeri demonstrates significant pharmacological potential in managing various conditions including diabetes, skin disorders, parasitic infections and inflammatory conditions. Recent research has provided scientific validation for many of its traditional uses, particularly its antioxidant, anti-inflammatory, and antidiabetic properties. This review also addresses safety considerations, dosage forms and future research directions for this important medicinal plant.

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Centratherum anthelminticum, Kaali Zeeri, Unani medicine

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Diabetes Mellitus, Lifestyle Modification, Structured Teaching Programme, Client Education, Knowledge

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