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Volume 9 | Issue 8

Volume 9 | Issue 8 | Month  
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  Paper Title: CONSTRUCTION OF SIMPLIFIED MICROBIAL CONSORTIUM FROM GOLD ORNAMENTS AND THEIR SENSITIVY AGAINST DISINFECTANTS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108162

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108162

  Register Paper ID - 210905

  Title: CONSTRUCTION OF SIMPLIFIED MICROBIAL CONSORTIUM FROM GOLD ORNAMENTS AND THEIR SENSITIVY AGAINST DISINFECTANTS

  Author Name(s): Priyadharshni.R, Renugadevi.S, Saranya.T, Dr.A.M.Ramachandran

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b425-b434

 Year: August 2021

 Downloads: 837

 Abstract

Jewelry is the common accessories worn by healthcare workers in hospitals. High level of microorganisms is seen on the jewels and other accessories. A total of 60 pieces of gold jewelleries like 20 chains, 20 rings, 10 bangles and 10 anklets were collected from health care workers at KMCH, Coimbatore and some volunteers from non healthcare workers (other professional workers living in Tirupur) and used for study. The samples were examined microscopically, morphologically, culturally and biochemically using standard procedures. The identified microorganisms were Staphylococcus aureus, Streptococcus sp, Methicillin- resistant Staphylococcus aureus, Bacillus sp, Escherichia coli, Shigella sp, Serratia sp, Pseudomonas sp, Citrobacter sp, Klebsiella sp. The fungal isolates include Aspergillus niger, Aspergillus flavus, Penicillium sp. The mean population counts of bacteria and fungi isolated from the pieces of human jewelleries ranged from 1.09 x 105 to 1.41 x 105 Cfu/ml and 1.32 x 105 to 4.32 x 105 Cfu/ml respectively. Staphylococcus aureus was the most common encountered bacterial isolates in all the four types of jewelleries. Different kinds of microbes identified from jewels of health care workers when compared with other professional workers. The sensitivity of this identified microbes against disinfectant was identified using Alum, sodium bicarbonate, vinegar, hydrogen peroxide, and Dettol. Dettol shows high amount of sensitivity against microbes when compare with others. Staphylococcus aureus, Streptococcus sp, E.coli, Klebsiella sp, Bacillus sp, Pseudomonas sp are sensitive to all type of disinfectant. This study revealed that it is very important to sanitize the jewellery with disinfectant at every interval of time regularly.


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Jewels, Healthcare workers, Bacteria, Fungi, Alum, Hydrogen peroxide, Vinegar, Sodium bicarbonate, Dettol, Antimicrobial sensitivity test.

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  Paper Title: Quest for Perfection Amid imperfection in Girish Karnad`s Hayavadana

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108161

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108161

  Register Paper ID - 210942

  Title: QUEST FOR PERFECTION AMID IMPERFECTION IN GIRISH KARNAD`S HAYAVADANA

  Author Name(s): Dr. Pinki Negi Bora

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b420-b424

 Year: August 2021

 Downloads: 951

 Abstract


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desire, perfection, conflicts, relationship, struggles, fate, pleasures, imperfection, incompleteness

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  Paper Title: DEVELOPING A MODEL TO REDUCE THE COST OF CONSTRUCTION OF RESIDENTIAL BUILDING THROUGH VALUE ENGINEERING

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108160

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108160

  Register Paper ID - 210921

  Title: DEVELOPING A MODEL TO REDUCE THE COST OF CONSTRUCTION OF RESIDENTIAL BUILDING THROUGH VALUE ENGINEERING

  Author Name(s): Pooja Patil, Dr. S K Patil, Mr. Satyajeet Patil

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b410-b419

 Year: August 2021

 Downloads: 853

 Abstract


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Value Engineering, 6 Phase methodology, Cost reduction, Precise. Productivity

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  Paper Title: STUDY OF BUCKLING ANALYSIS OF COMPOSITE PLATE

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108159

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108159

  Register Paper ID - 210931

  Title: STUDY OF BUCKLING ANALYSIS OF COMPOSITE PLATE

  Author Name(s): Shubham Ankolikar, Nikita Nagmoti, Maruti Khot

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b404-b409

 Year: August 2021

 Downloads: 906

 Abstract

In this paper buckling analysis of carbon fiber laminated composite plate is performed by using classical laminated plate theory (CLPT) for simply supported plate. The critical buckling load of the composite laminated plate is evaluated by finite element method with help of ABAQUS software. The critical buckling load of plate is affected by the fiber orientation, aspect ratio, plate thickness, mesh size and boundary condition of the stacking sequence and FEA element. The composite laminated plate made of carbon fiber gives maximum critical buckling load at any boundary condition. Some results have been obtained for different parameter and are discussed in detail.


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Buckling, Carbon fiber laminated composite, Critical buckling load, ABAQUS

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  Paper Title: AN OVERVIEW OF AUTOMOBILE INDUSTRY IN INDIA

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108158

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108158

  Register Paper ID - 210907

  Title: AN OVERVIEW OF AUTOMOBILE INDUSTRY IN INDIA

  Author Name(s): Dr.T.Vijayaragavan

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b398-b403

 Year: August 2021

 Downloads: 1196

 Abstract

The Automobile industry is very important driver of economic growth of India. India is expected to be the world's third-largest automotive market in terms of volume by 2026. The automobiles produced in the country uniquely cater to the demands of low- and middle-income groups of population which makes this sector stand out among the other automobile-producing countries. The Government has come out with Automotive Mission Plan (AMP) 2016-26 which will help the automotive industry to grow and will benefit Indian economy. The rapidly globalising world is opening newer opportunities for the transportation industry, especially while it makes a shift towards electric, electronic and hybrid cars, which are deemed more efficient, safe, and reliable mode of transportation. With this background, this paper explains the overview of Automobile industry in India in terms of production, sales and export trend in different years.


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Automobile industry, Economic growth, Government, Globalisation, Performance, Opportunity.

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  Paper Title: DUPONT ANALYSIS OF POWER GRID CORPORATION OF INDIA LTD.'S FINANCIAL PERFORMANCE

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108157

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108157

  Register Paper ID - 210877

  Title: DUPONT ANALYSIS OF POWER GRID CORPORATION OF INDIA LTD.'S FINANCIAL PERFORMANCE

  Author Name(s): RAHUL PAL

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b389-b397

 Year: August 2021

 Downloads: 923

 Abstract


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DuPont, Return on Equity, Net Profit Margin, Asset Turnover Ratio

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  Paper Title: BIOTECHNOLOGY AND INTELLECTUAL PROPERTY RIGHTS: CHALLENGES AND PROBLEMS FACING BY THE DEVELOPING NATIONS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108156

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108156

  Register Paper ID - 210879

  Title: BIOTECHNOLOGY AND INTELLECTUAL PROPERTY RIGHTS: CHALLENGES AND PROBLEMS FACING BY THE DEVELOPING NATIONS

  Author Name(s): RISHI SINGH SOLANKI, Dr. Aarti Rathi

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b376-b388

 Year: August 2021

 Downloads: 903

 Abstract

Modern Biotechnology is a biological based technology. In which living organisms (or parts of organisms) are use for making or modifying products, for improving plant or animals or for developing microorganisms for specific industrial purposes. Modern biotechnology is considered as a new global technology because of the growth and development in modern biotechnology has been so rapid. These rapid advancements in modern biotechnology create lot of confusion and challenges or issues before patent offices of the developing contraries as well as developed nations to granting IP protection for this naval technological based inventions. The main purpose of this research article is to find out and in depth analysis of these challenges and problems facing by the developing nations as well as devolved nations.


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Biotechnology, Recombinant DNA Technology, Patent, TRIPS etc.

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  Paper Title: DEVELOPMENT OF EDIBLE WATER BUBBLES BY SPHERIFICATION

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108155

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108155

  Register Paper ID - 210900

  Title: DEVELOPMENT OF EDIBLE WATER BUBBLES BY SPHERIFICATION

  Author Name(s): Elakhya S, Arya Aravind, Jaya Surekha A, Charumathi G, Dr Hema Prabha P

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b367-b375

 Year: August 2021

 Downloads: 1023

 Abstract


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Calcium chloride, Calcium lactate, encapsulation, gel membrane, Sodium alginate, spherification

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  Paper Title: A STUDY ON STUDY HABITS OF DEGREE COLLEGE HISTORY STUDENTS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108154

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108154

  Register Paper ID - 210884

  Title: A STUDY ON STUDY HABITS OF DEGREE COLLEGE HISTORY STUDENTS

  Author Name(s): Dr. Venkatarao Palati

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b361-b366

 Year: August 2021

 Downloads: 869

 Abstract

Abstract: The key to becoming an effective student is learning how to study smarter, not harder. This becomes more and more true as you advance in your education. An hour or two of studying a day is usually sufficient to make it through high school with satisfactory grades, but when college arrives, there aren't enough hours in the day to get all your studying in if you don't know how to study smarter. This study attempts to find out the study habits of undergraduate students and analyze relationship between study habits and academic performance and various other factors that affects study habits. It is generally believed that a student learns effective study habits in school. So college students are generally assumed to have effective study habits, but, the environment of school and college are very different and need of effective study habits is even more at college level as compared to school. So, this paper consists of details about why effective study habits are needed at college level and effective study habits that a college student must have in order to learn and eventually score better.


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Key words: study habits, Degree college, teachers,

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  Paper Title: RELATIONSHIP OF TEACHING EFFECTIVENESS AND PROFESSIONAL ATTITUDE OF P.U. COLLEGE HISTORY TEACHERS OF P.U. COLLEGE OF KALABURAGI EDUCATIONAL DISTRICT

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108153

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108153

  Register Paper ID - 210886

  Title: RELATIONSHIP OF TEACHING EFFECTIVENESS AND PROFESSIONAL ATTITUDE OF P.U. COLLEGE HISTORY TEACHERS OF P.U. COLLEGE OF KALABURAGI EDUCATIONAL DISTRICT

  Author Name(s): Dr. Venkatarao Palati

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b353-b360

 Year: August 2021

 Downloads: 846

 Abstract


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P.U. College History teachers, Teaching effectiveness, professional attitude, relationship

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  Paper Title: MURDER OR JUSTICE- A PARADOXICAL VIEW ON ENCOUNTER KILLINGS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108152

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108152

  Register Paper ID - 210891

  Title: MURDER OR JUSTICE- A PARADOXICAL VIEW ON ENCOUNTER KILLINGS

  Author Name(s): Vanshika Mittal

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b343-b352

 Year: August 2021

 Downloads: 894

 Abstract

India being one of the largest democracies in the world has been witnessing an unprecedented failure when it comes to the justice delivery system. The unnecessary delay, harassment of witnesses, lack of protection given to both victim and the witness, politically and socially influenced public officials, custodial violence, unlawful detention, excessive remedies available, more protection and leniency towards the accused and false encounters by police are few factors which prove to be prejudicial to the criminal justice delivery system. The present article will deal mainly about the excessive powers given to the policemen on arrest and extra-judicial killings against which appropriate actions are not taken and which is now becoming a latest trend giving it a label of immediate justice. I will also bring into consideration the loopholes in the judicial system and the media trials which are having the major influential force in jeopardizing actual justice. In a leading case, Justice Markandey Katju described such encounter killings as cold-blooded murders, rather than just calling it as an extra- judicial killing. It is however, very important to consider the opinion as to why such acts are being given attempts to and why is there no procedure to curb such extra- judicial killings, yet. Why is there a blind trust on the functioning of police officer? Why such violations of fundamental rights are not brought under the purview constitution and rather given it a name of the judicial act? Even though there are a number of judicial pronouncements regarding the extra- judicial killings, these questions are still unanswered. Therefore, the object of writing this paper is to give importance to this issue which is being largely ignored. The object is to bring into light the injustice caused by even one false encounter leading to death of an accused whose guilt has not even been proved yet. Every person on this earth has a right to be tried and executed lawfully and this is why the trust on judiciary subsists.


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Encounters, Murder, Justice, Proportionality, Sovereign Immunity, Necessity, Media Trials

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  Paper Title: ???? ??????? ??? ??????? ??????? ??? ???? ????? ??????????? ?? ????? ????? ?? ??????

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108151

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108151

  Register Paper ID - 210545

  Title: ???? ??????? ??? ??????? ??????? ??? ???? ????? ??????????? ?? ????? ????? ?? ??????

  Author Name(s): ?? ??????? ?????

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b337-b342

 Year: August 2021

 Downloads: 924

 Abstract


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???? ??????? ??? ??????? ??????? ??? ???? ????? ??????????? ?? ????? ????? ?? ??????

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  Paper Title: PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF MUSA ACUMINATA AND CARICA PAPAYA PEELS AGAINST FOOD POISONING BACTERIA

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108150

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108150

  Register Paper ID - 210615

  Title: PHYTOCHEMICAL ANALYSIS AND ANTIBACTERIAL ACTIVITY OF MUSA ACUMINATA AND CARICA PAPAYA PEELS AGAINST FOOD POISONING BACTERIA

  Author Name(s): Saeed Ur Rab, Jyoti Biswas, Vinod Kumar Gupta

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b327-b336

 Year: August 2021

 Downloads: 900

 Abstract


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Food poisoning, antibacterial, phytochemicals, Ethanol extraction, Carica papaya, Musa acuminata, Campylobacter jejuni, Bacillus cereus, Antibacterial screening, Zone of Inhibition.

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  Paper Title: IMPACT OF COVID-19 ON INDIAN SOCIETY

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108149

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108149

  Register Paper ID - 210885

  Title: IMPACT OF COVID-19 ON INDIAN SOCIETY

  Author Name(s): Dr. P. V. Pawar, Dr. Swati V. Patil

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b323-b326

 Year: August 2021

 Downloads: 1037

 Abstract

The COVID-19 pandemic has led to a dramatic loss of human life worldwide and presents an unprecedented challenge to public health, food systems and the world of work. The economic and social disruption caused by the pandemic is devastating: tens of millions of people are at risk of falling into extreme poverty, while the number of undernourished people, currently estimated at nearly 690 million, could increase by up to 132 million by the end of the year. Millions of enterprises face an existential threat. Nearly half of the world's 3.3 billion global workforce are at risk of losing their livelihoods. Informal economy workers are particularly vulnerable because the majorities lack social protection and access to quality health care and have lost access to productive assets. Without the means to earn an income during lockdowns, many are unable to feed themselves and their families For most, no income means no food, or, at best, less food and less nutritious food. The pandemic has been affecting the entire food system and has laid bare its fragility. Border closures, trade restrictions and confinement measures have been preventing farmers from accessing markets, including for buying inputs and selling their produce, and agricultural workers from harvesting crops, thus disrupting domestic and international food supply chains and reducing access to healthy, safe and diverse diets. The pandemic has decimated jobs and placed millions of livelihoods at risk. As breadwinners lose jobs, fall ill and die, the rood security and nutrition of millions of women and men are under threat, with those in low-income countries, particularly the most marginalized populations, which include small-scale farmers and indigenous peoples, being hardest hit. This paper describes the impact of COVID-19 on Indian society


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Dramatic,vulnerable,confinement, Decimated controlled etc

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  Paper Title: VALUE OF LITERATURE FOR PROFESSIONALS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108148

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108148

  Register Paper ID - 210833

  Title: VALUE OF LITERATURE FOR PROFESSIONALS

  Author Name(s): Dr. Rajesh Kumar Pandey

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b320-b322

 Year: August 2021

 Downloads: 881

 Abstract

Literature is a term used to describe written and sometimes spoken material works of literature, provide a kind of blueprint of human society. It refers to the realm of letters and the writings of a particular period, mostly those whose value lies in the beauty of form or emotional effect. Technology is the science of the industrial arts. Scientists have played an important role in promoting human welfare, but the benefits of science may not have reached the masses, at any rate in ample measure, without technological devices and practical applications.


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Litrature is the Mother of all branches of learning.

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  Paper Title: IMPROVING MATERIAL PRODUCTIVITY THROUGH IMPLEMENTATION OF 5 METHODOLOGY ON CONSTRUCTION PROJECT

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108147

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108147

  Register Paper ID - 210871

  Title: IMPROVING MATERIAL PRODUCTIVITY THROUGH IMPLEMENTATION OF 5 METHODOLOGY ON CONSTRUCTION PROJECT

  Author Name(s): Pallavi Dilip Sagare, Satyajeet B. Patil

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b315-b319

 Year: August 2021

 Downloads: 847

 Abstract

The Productivity is the key factor for any growth of the construction firm because it play dual role such as performance of the industry and economic growth of the industry .The productivity rate of the construction firm can be raised by proper planning, scheduling and controlling the resources. This correct management system will reduces the time, price and conjointly will increase the standard of the product. In any construction firm the resources are namely man, machine& material& finance are utilized to get a better quality of product. Out of this material productivity is play importance role for the performance . This study determines varied issue moving on material productivity on construction site. Study the lean construction concept and their tools. Choose the better tool for implementation on actual site. Then implement the tool of lean construction on actual site and observe the changes. Compare this site with other regular site and analyse the practical conclusions.


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  Paper Title: BALLAD TRADITION OF ODISHA : A BIRD EYE VIEW

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108146

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108146

  Register Paper ID - 210872

  Title: BALLAD TRADITION OF ODISHA : A BIRD EYE VIEW

  Author Name(s): Dr. Sashibhusan Mishra

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b308-b314

 Year: August 2021

 Downloads: 904

 Abstract

Singing of Ballads is a rich and living tradition of a multi-cultural country like India. Ballads are sung in varied forms. Each culture has its indigenous form of ballad singing. In Odisha, the singing of ballads is an essential part of some of the rituals and is closely associated with the cultural life of the Odia people. It just counted as the part and parcel of their cultural itinerary. In this paper, we will discuss the Ballad tradition of Odisha.


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Ballads, Odisha, Folk Ballads

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  Paper Title: AN EFFICIENT ALGORITHM FOR OPTIMIZATION OF POWER LOSS IN ECONOMIC LOAD DISPATCH

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108145

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108145

  Register Paper ID - 210811

  Title: AN EFFICIENT ALGORITHM FOR OPTIMIZATION OF POWER LOSS IN ECONOMIC LOAD DISPATCH

  Author Name(s): Anita Sahni, Krishna Teerth Chaturvedi

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b303-b307

 Year: August 2021

 Downloads: 863

 Abstract

This reactive power management in economic load dispatches plays a vital role in improving power quality of the system. The power compensation is the one of the problem in distribution network. The power is maintain the state of the UPQC (Uni?ed power quality conditioner). The UPAC controlled by the STATCOM or DSTATCOM. Different approaches use to maintain the power at needed level in the power distribution network the process done by MOPSO optimization method the MOPSO is the best for this process because we consider the lot of objective function to optimize the place of the UPQC. dissertation use the IEEE 30 bus system for analysis the demand response using the MATLAB environment. In this work proposed modify PSO based power flow is find the demand response in the IEEE bus system. And finally calculated the DG place buses and it is power to optimize the power system. Result shows that proposed work gives good result for choose the busses for balanced the power flow in IEEE system through reactive power optimization in economic load dispatch.


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UPQC, PSO, MOPSO, STATCOM, DSTATCOM Power, Reactive, Optimization, compensation.

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  Paper Title: AN OVERVIEW ON IMPURITY PROFILING OF DRUG AND PHARMACEUTICAL FORMULATIONS

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108144

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108144

  Register Paper ID - 210874

  Title: AN OVERVIEW ON IMPURITY PROFILING OF DRUG AND PHARMACEUTICAL FORMULATIONS

  Author Name(s): Sayali bhagwat arote, Kiran b dhamak, Dr c j bhangale

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b294-b302

 Year: August 2021

 Downloads: 881

 Abstract

In the pharmaceutical world, an impurity is considered to be any other inorganic or organic substance. Today, not only purity profiles are mandatory, but also impurity profiles are also mandatory. Among impurities in the pharmaceutical world, there are any other inorganic or organic material, or residual solvents other than the drug ingredients or substances that arise after synthesis or unwanted substances that remain after the API processing. An impurity is an inorganic or organic substance other than the drug substances, or ingredients, that a result of synthesis or an undesirable chemical that remains in the drug product.


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 Keywords

Key-words: Impurity, Drug, API, ICH, Guidelines

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  Paper Title: DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF PROCESS RELATED IMPURITIES FROM LACIDIPINE BULK AND FORMULATION

  Publisher Journal Name: IJCRT

  DOI Member: 10.6084/m9.doi.one.IJCRT2108143

  Your Paper Publication Details:

  Published Paper ID: - IJCRT2108143

  Register Paper ID - 210875

  Title: DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF PROCESS RELATED IMPURITIES FROM LACIDIPINE BULK AND FORMULATION

  Author Name(s): Sayali bhagwat arote, Kiran b dhamak, Dr c j bhangale

 Publisher Journal name: IJCRT

 Volume: 9

 Issue: 8

 Pages: b281-b293

 Year: August 2021

 Downloads: 867

 Abstract

The process related impurity of Lacidipine 3-{2-[3, 5-bis(ethoxycarbonyl)-1,4-dihydropyridin-4-yl]phenyl}prop-2-enoic acid in bulk and formulations was synthesized, characterized and the RP-HPLC method was developed according to ICH Q2B guidelines for quantitation of impurity in bulk and formulations. The synthesis of intermediate was carried out by Hantzsch pyridine process using substituted aldehyde, EAA and Urea and methanol as catalyst. The percentage yield was found to be 69.89 %. The impurity was recrystallized and purified. The preliminary evaluation was done on lab scale viz. melting point, TLC and elemental analysis. The melting point of impurity was found to be 1560C. The TLC of impurity was carried by using Benzene and Methanol (6:1) and the Rf was found to be 0.80.


Licence: creative commons attribution 4.0

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 Keywords

Key-words: Impurity, Lacidipine, Process, HPLC, Validation

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Creative Commons Attribution 4.0 and The Open Definition



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About IJCRT

The International Journal of Creative Research Thoughts (IJCRT) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world.


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International Journal of Creative Research Thoughts (IJCRT)
ISSN: 2320-2882 | Impact Factor: 7.97 | 7.97 impact factor and ISSN Approved.
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ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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ISSN and 7.97 Impact Factor Details


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ISSN: 2320-2882
Impact Factor: 7.97 and ISSN APPROVED
Journal Starting Year (ESTD) : 2013
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