Volume 9 | Issue 8

 Abstract

Introduction. Breast cancer is a problem that is still faced throughout the world. The incidence of cancer in Indonesia is at number 8 in Southeast Asia. The incidence of breast cancer in women is 42.1 per 100,000 population. Aromatase inhibitors are hormonal therapy used in postmenopausal breast cancer with positive ER and/or positive PR. The third generation aromatase inhibitors are divided into 2 categories, namely non-steroidal agents that are reversible and steroid agents that are irreversible. Based on existing studies, there are no consistent research results regarding the incidence of recurrence after aromatase inhibitor therapy, both steroids and non-steroidal. Methods. This study is an analytical observational study with a retrospective cross- sectional design using secondary data from medical records. The research was carried out at the Surgical Clinic of RSUD dr. Soetomo Surabaya on October 1, 2020 until the end with the subject of LABC patients at POSA Surgery RSUD Dr. Soetomo who has undergone mastectomy and radiotherapy and has received adjuvant hormonal aromatase inhibitor therapy for 2 years from January 2018 to January 2020. Results. In the nonsteroidal aromatase inhibitor group, 18 subjects (60%) experienced recurrence and 16 subjects in the steroid aromatase inhibitor group (32%) with an OR of 0.314 (0.12-0.81; p=0.014. Based on the results of multivariate analysis, it was found that the increased risk of recurrence was significantly affected only by the administration of aromatase inhibitor p= 0.052 Conclusion. Women with locally advanced breast cancer after mastectomy who received aromatase inhibitor steroid therapy had a 0.314 times lower risk of recurrence than those who received non-steroidal aromatase inhibitor therapy.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Breast cancer, aromatase inhibitor steroid, recurrence

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This new species has been found in the Intestine of fish Barilius Barana (Ham.) collected from River Ganga in district Kanpur. Out of these only two specimens were found infected with six trematode worms. The experiment was carried out from the laboratory from August to October.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Barilius Barana (Ham.), Intestine, Allocreadiun Kanpurensis.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The Sieved biomass of Ailanthus excelsa was chemically treated with Sulfuric acid (H2SO4) to produce acid- factionalized biosorbent used for O-Nitro Phenol removal from aqueous environment. Various analytical techniques were utilized to investigate the surface area, surface morphology, crystallinity, elemental composition of the sulfuric acid-treated biomass for removal of O-Nitro Phenol. Batch experiments were carried out as functions of different process parameters such as pH, initial dye concentration, biosorbent dose and temperature. The optimum conditions for removal of ONP were found to be pH (2.0), biosorbent dose (50 mg), and initial dye concentration (100 mg L-1).The temperature (288K) had a strong influence on the biosorption process. The Langmuir, Freundlich and Temkin isotherms model, sorption of ONP onto SBAE were studied. The rate of sorption was found to obey pseudo-second order kinetics and intraparticle diffusion model with correlation coefficient value R2 is 0.9981. Thermodynamic studies showed that the biosorption process was spontaneous and exothermic. The sieved SBAE is a promising biosorbent for ONP removal from aqueous solutions.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Sulphonated Biomass of Ailanthus excelsa (SBAE), O-Nitro Phenol (ONP), Isotherm study

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Abstract: Background: India has successfully brought down maternal mortality ratio (MMR) by 9 points in one year, as per data released by the Registrar General of India. Rajasthan and Uttar Pradesh are among the states that have shown most decline. Labour and birth are an amazing integration of powerful physiological and psychological forces that bring a new human life into the world. The woman may be apprehensive about entering an unknown, and perhaps threatening, hospital environment and concerned about relinquishing her personal autonomy and identity. Especially the first stage of labour is the longest in duration as compare to the other two stages. Early identification of complications and prevention helps a long way in reducing maternal fetal morbidity and mortality since the labouring and birthing process is a life-changing event for many women. Nurses need to be respectful, available, encouraging, supportive, and professional in dealing with all women. The nursing management for labor and birth should include comfort measures, emotional support, information and instruction, advocacy, and support for the partner. Objectives: To assess the knowledge of final year GNM students regarding nursing management of first stage of labour by using structured knowledge questionnaire, to find the association between knowledge score and selected demographic variables. Material and methods: Data were collected from 50 samples from selected school of nursing Data were collected by using structured knowledge questionnaire. The demographic variables analyzed in the study were age, sex, religion and source of information. The study sample was selected by a non- probability convenience sampling technique. Data obtained were tabulated and analyzed in terms of objectives of the study using descriptive and inferential statistics. Results: The study revealed that 50 % had adequate knowledge, 18 % had inadequate knowledge and 32 % had moderate knowledge. There was significant association between age and source of information. There was no association between the sex and religion of the Final year GNM students. Conclusion: The findings of the study revealed that educating the students would be effective in updating the knowledge and skills regarding management of first stage of labour.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords: Knowledge, Selected demographic variables, First stage of labour.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Mixed solvency, Poorly water soluble drugs, Titrimetry, UV Spectrophotometry, TLC, harmful organic solvents, green chemistry

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

: Generating a fraudulent communication that appears to come from a reputable source is known as phishing. The most widely used mode of communication is e-mail. The purpose is to steal personal information like credit card numbers and login credentials, or to infect the victim's machine with malicious software. Phishing is a common type of cyberattack that everyone should be aware of. Phishing starts with a phone call, e-mail, or other form of communication designed to entice a victim. The communication looks to come from a reliable source in this form of attack. If the attacker is deceiving the victim, it is usually advised to give crucial information to a fraudulent website. Malware can be downloaded on occasion downloaded to the machine that could be used as a target Attackers profit financially by collecting their victims' credit card information or other personal information. Phishing e-mails are occasionally sent to employees in order to get login information or other personal information in order to conduct a complex attack on a company. Phishing is a popular entry vector for cyber-attacks like Advanced Permanent Threats (APT) and ransomware. During a phishing assault, attackers can collect background information about the victim's personal and professional history, hobbies, and activities by using social engineering and other public information resources, such as social networks like LinkedIn, Facebook, and Twitter.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Phishing, Forensic analysis, NLP Algorithm, Random Forest, Cybersecurity.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Multilevel inverters have been widely accepted for high-power high-voltage applications though the multilevel inverters hold attractive features, usage of more switches in the conventional configuration poses a limitation to its wide range application. Therefore, 7-level inverter topology is introduced using less number of switches and gate trigger circuitry, thereby ensuring the minimum switching losses, reducing size and installation cost. Multilevel inverter (MLI) plays a vital role in the field of power electronics and being widely used in many industrial and commercial applications. The multilevel inverter topology is the proper option from the point of view of modularity and simplicity of control.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Multilevel DC to AC inverter, PIC Microcontroller, SPWM.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

pulsating, culminating, pertinent, bhagavatism, emergence, genesis

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Population, Health, Development, Coronavirus, Economy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Background: One of the most aeroallergen causing allergy disease is house dust mite (HDM). Skin prick test (SPT) has high specificity and sensitivity for diagnosing allergy due to inhaled substances. Immunotherapy should be initiated whenever there is positivity of house dust mite skin prick test result. Objective: This study aimed to investigate the efficacy of immunotherapy based on induration diameter of skin prick test result to house dust mite allergen. Methods: This retrospective study was conducted in Pediatric allergy and immunology outpatient clinic of Dr. Soetomo General Hospital Surabaya. Medical record was taken from January 1st until December 31st 2020 period. House dust mite allergy was diagnosed based on positivity of skin prick test to HDM. Immunotherapy efficacy was evaluated with daily symptom score (dSS), daily medication score (dMS), and Combined Symptom and Medication Score (CSMS) at least 3 months after immunotherapy. Age, gender, duration of illness, nutritional status, family history of atopic allergic disease, and other allergic comorbidities were stipulated as confounding variable. Statistical analysis were normality distribution test, wilcoxon rank test, spearman test, and regression analysis. Results: Sixty patient of HDM allergy (33 boys and 27 girls), were included in this study. Significant alteration of dSS, dMS, and CSMS before and after immunotherapy evaluated with wilcoxon rank test result (p=0.000 respectively). There was no correlation of each confounding variables to induration diameter of SPT. Positive correlation between induration diameter and CSMS score was tested with Spearman test (p=0.003, r= 0.373). Conclusions: Smaller induration diameter of HDM SPT result could be predictive for immunotherapy efficacy.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

House dust mite; skin prick test; induration diameter; immunotherapy; symptom score; medication score

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

carbon nanotubes, cancer, therapy, carrier, mediators

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The COVID-19 pandemic will undeniably transform the way we live and work for the predictable future, and new trends will emerge that will become part of our new normal. In the Indian circumstance, the impact of COVID-19 outburst appears devastating. With the national GDP falling into negative numbers, the country seems like facing one of its horrible economic recessions. The real estate sector touched the lowest of lows during the nearly three-month-long national lockdown. The real estate industry in India has experienced a slowdown in the advancement of projects under construction and delayed consumer decisions to purchase the properties. Some of the challenges faced by the industry are the liquidity crisis, migration of workers and interruptions in the supply chain for building materials. Furthermore, the sentiment in the market has become worse in recent times. This paper outlines the major real impact of Covid-19 on Indian real estate industry. And also present some Indian government initiatives which would benefit the sector and take it to its glorious past.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Key words: Real Estate, Covid 19, liquidity crisis, Government initiatives

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

With the progression in the field of Chronobiology, modern drug delivery approaches have been raised to another idea of chronopharmacology. however, the major limited access in the improvement of drug delivery system that coordinate the circadian rhythm chronopharmaceutical drug delivery system (ChrDDS) might be the accessibility of proper innovation. The most recent decade has seen the rise of ChrDDS against a few illnesses. This review presents the idea of chronopharmaceutics, addresses hypothetical/formal ways to deal with this sub-discipline, underscores potential disease targets, returns to existing advances and instances of ChrDDS. Future improvement in chronopharmaceutics might be made at the interface of other developing techniques, for example, system biology and nanomedicine. The expanding research in ChrDDS may lead to the formation of another sub-discipline in pharmaceutics known as chronopharmaceutics.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Chronopharmaceutics, Chronotherapeutics, Circadian rhythm, Chronopharmaceutical technology, Chronopharmacology.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Background and purpose: Adhesive capsulitis is a syndrome defined in its purest sense as idiopathic painful restriction of shoulder movement that results in global restriction of the glenohumeral joint.Loss of ROM, especially that of external rotation and pain in subjects with adhesive capsulitis results in severe functional impairments, especially overhead activities. Mobilizations are means of increasing joint mobility and decreasing pain by passively gliding the joint surfaces to stretch the capsule that has been shown to be effective by various researches throughout the globe. Muscle energy techniques are a newer technique that focuses on contractile elements to reduce pain, increase ROM and improve function. Methodology: 32 samples of adhesive capsulitis were selected by convenient sampling technique. Total study duration was of 2 months. Samples were randomly divided in to 2 groups. Conventional exercises were given in both the groups. In 1st group MET was given in addition to conventional exercise and in 2nd group Maitland mobilization was given. Total protocol was of 1 month,5 days a week ,twice a day. Two outcome measures were used.NPRS for Pain and Active External Rotation and abduction ROM (Using Universal Goniometer). Data analysis and Result: The data has been analysed using SPSS version 16. The significance level had been kept at 95%. The data has been screened for normality before applying any statistical tests. Changes in the outcome measures have been analysed within groups as well as between groups. NPRS in both the groups ROM in both the groups Conclusion: The present study found significant improvements in pain and ROM in both groups. Yet, greater improvement is found in MET group for pain and ROM as compared to Maitland group.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Key-words: Adhesive capsulitis, MET, Maitland

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Targeting tumor-driven angiogenesis is a successful method for treating metastatic colorectal cancer (mCRC); however, the availability of multiple medicines, the incidence of resistance, and the paucity of data make selecting a second-line therapy difficult. Numerous prognostic and predictive biomarkers that have been verified The use of in this review is looked at. Second-line management with angiogenesis-targeted medicines Angiogenesis, or the formation of new blood vessels, has been targeted for the treatment of colorectal and other cancers through a variety of pathways and molecules. Angiogenesis is thought to be mediated by the binding of vascular endothelial growth fact Therapy for metastatic colorectal cancer (m CRC) has evolved significantly since the late 1990s, and now includes a combination of doublet or triplet chemotherapy and a targeted agent. Angiogenesis, or the formation of new blood vessels, can be targeted a crucial component of the overall treatment plan Since the first anti-angiogenesis drug was approved in 2004,multiple drugs or (VEGF)-A to VEGF receptor (VEGFR)-2. VEGF pathways in other animals VEGF-A, VEGF-B, and placental GR all play a role in angiogenesis.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Angiogenesis, Vascular endothelial growth factor, Colorectal cancer

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

When cancer starts in a woman's reproductive organs, it is called gynecologic cancer. The five main types of gynecologic cancer are cervical, ovarian, uterine, vaginal, and vulvar. (A sixth type of gynecologic cancer is the very rare fallopian tube cancer.) ?-Peltatin (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. ?-Peltatin is also expressed in endothelial cells and participates in the Estrogen Receptor ? (ER?) signaling to promote cell migration. In this study, we found overexpression of ?-Peltatin in human ovarian cancer. Given that we show that high expression of ?-Peltatin in ovarian cancer patients is associated with shorter recurrence- free survival, we investigated the relationship between ER? and ?-Peltatin at the molecular level. We found that the ?-Peltatin Nuclear Receptor box (NR box) drives a direct interaction with the C domain of ER?. Furthermore, ?-Peltatin participates in gene transcription activation of ER? target genes upon estrogen treatment. Besides, ?-Peltatin expression favors tumorigenicity (is the tendency for cultured cells to give rise to either benign or malignant growing tumors when infected to immunologically nonresponsive animals) and migration and is necessary for tumor growth in vivo in hen xenografted model of an ovarian cancer cell line. These findings suggest that ?-Peltatin is a new cofactor of ER? that functionally participates in the tumorigenic phenotype of ovarian cancer cells. In ER? ovarian cancer patients, ?-Peltatin overexpression is associated with poor survival and may be used as a predictive marker of ovarian cancer recurrence-free survival.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

?-Peltatin, Estrogen-receptor (ER), Ovarian cancer, In vitro, In vivo, Apoptosis, Genotoxic, Tumorigenicity, DNA, Cell Signaling.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

DETECTION OF TEMPERATURE AND CO CONTENT IN SERVER ROOM

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

WSN TEMPERATURE DETECTION SENSORS

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

E-learning Readiness, Item analysis, Reliability, Validity, Norms

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

-life balance, job satisfaction, paramedical professionals, work load, performance

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

A majority of youth in developing countries are in the low- income families where development constraints pose additional challenges to youth due to their limited access to resources, education and training, health care, employment and broader socio-economic development opportunities. The parents have few resources to invest in them and, as a consequence, their homes have the fewest cognitively stimulating materials, and their parents invest less in their education. The stress of living in poverty and struggling to meet daily needs can also impair parenting. The present study explores the elements of the intergenerational mobility among the lower-income families of scheduled caste communities predominant in Puducherry. A quantitative and qualitative approach is used to analyse the intergenerational mobility process. The educational status, occupational experience, family background, socioeconomic status, income variation, school, and college experience, and impact on caste and the government policy, political activities and geographical locations related to research are critically examined and consolidated in the study. They are still performing the traditional occupation and the occupation has even transformed to the next generation too. The government took many initiatives to uplift the socially disadvantaged people through implementing various schemes free educations, scholarships, free hostel, reservation policies to provide for the Dalit youth. Through these schemes, many youths have benefited from this category.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Social Mobility, Intergenerational Mobility, Education, Occupation, Dalit and Youth.

  License

Creative Commons Attribution 4.0 and The Open Definition