Volume 9 | Issue 8

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Background and purpose: Adhesive capsulitis is a syndrome defined in its purest sense as idiopathic painful restriction of shoulder movement that results in global restriction of the glenohumeral joint.Loss of ROM, especially that of external rotation and pain in subjects with adhesive capsulitis results in severe functional impairments, especially overhead activities. Mobilizations are means of increasing joint mobility and decreasing pain by passively gliding the joint surfaces to stretch the capsule that has been shown to be effective by various researches throughout the globe. Muscle energy techniques are a newer technique that focuses on contractile elements to reduce pain, increase ROM and improve function. Methodology: 32 samples of adhesive capsulitis were selected by convenient sampling technique. Total study duration was of 2 months. Samples were randomly divided in to 2 groups. Conventional exercises were given in both the groups. In 1st group MET was given in addition to conventional exercise and in 2nd group Maitland mobilization was given. Total protocol was of 1 month,5 days a week ,twice a day. Two outcome measures were used.NPRS for Pain and Active External Rotation and abduction ROM (Using Universal Goniometer). Data analysis and Result: The data has been analysed using SPSS version 16. The significance level had been kept at 95%. The data has been screened for normality before applying any statistical tests. Changes in the outcome measures have been analysed within groups as well as between groups. NPRS in both the groups ROM in both the groups Conclusion: The present study found significant improvements in pain and ROM in both groups. Yet, greater improvement is found in MET group for pain and ROM as compared to Maitland group.

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Key-words: Adhesive capsulitis, MET, Maitland

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Targeting tumor-driven angiogenesis is a successful method for treating metastatic colorectal cancer (mCRC); however, the availability of multiple medicines, the incidence of resistance, and the paucity of data make selecting a second-line therapy difficult. Numerous prognostic and predictive biomarkers that have been verified The use of in this review is looked at. Second-line management with angiogenesis-targeted medicines Angiogenesis, or the formation of new blood vessels, has been targeted for the treatment of colorectal and other cancers through a variety of pathways and molecules. Angiogenesis is thought to be mediated by the binding of vascular endothelial growth fact Therapy for metastatic colorectal cancer (m CRC) has evolved significantly since the late 1990s, and now includes a combination of doublet or triplet chemotherapy and a targeted agent. Angiogenesis, or the formation of new blood vessels, can be targeted a crucial component of the overall treatment plan Since the first anti-angiogenesis drug was approved in 2004,multiple drugs or (VEGF)-A to VEGF receptor (VEGFR)-2. VEGF pathways in other animals VEGF-A, VEGF-B, and placental GR all play a role in angiogenesis.

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Angiogenesis, Vascular endothelial growth factor, Colorectal cancer

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When cancer starts in a woman's reproductive organs, it is called gynecologic cancer. The five main types of gynecologic cancer are cervical, ovarian, uterine, vaginal, and vulvar. (A sixth type of gynecologic cancer is the very rare fallopian tube cancer.) ?-Peltatin (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. ?-Peltatin is also expressed in endothelial cells and participates in the Estrogen Receptor ? (ER?) signaling to promote cell migration. In this study, we found overexpression of ?-Peltatin in human ovarian cancer. Given that we show that high expression of ?-Peltatin in ovarian cancer patients is associated with shorter recurrence- free survival, we investigated the relationship between ER? and ?-Peltatin at the molecular level. We found that the ?-Peltatin Nuclear Receptor box (NR box) drives a direct interaction with the C domain of ER?. Furthermore, ?-Peltatin participates in gene transcription activation of ER? target genes upon estrogen treatment. Besides, ?-Peltatin expression favors tumorigenicity (is the tendency for cultured cells to give rise to either benign or malignant growing tumors when infected to immunologically nonresponsive animals) and migration and is necessary for tumor growth in vivo in hen xenografted model of an ovarian cancer cell line. These findings suggest that ?-Peltatin is a new cofactor of ER? that functionally participates in the tumorigenic phenotype of ovarian cancer cells. In ER? ovarian cancer patients, ?-Peltatin overexpression is associated with poor survival and may be used as a predictive marker of ovarian cancer recurrence-free survival.

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?-Peltatin, Estrogen-receptor (ER), Ovarian cancer, In vitro, In vivo, Apoptosis, Genotoxic, Tumorigenicity, DNA, Cell Signaling.

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DETECTION OF TEMPERATURE AND CO CONTENT IN SERVER ROOM

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WSN TEMPERATURE DETECTION SENSORS

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E-learning Readiness, Item analysis, Reliability, Validity, Norms

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-life balance, job satisfaction, paramedical professionals, work load, performance

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A majority of youth in developing countries are in the low- income families where development constraints pose additional challenges to youth due to their limited access to resources, education and training, health care, employment and broader socio-economic development opportunities. The parents have few resources to invest in them and, as a consequence, their homes have the fewest cognitively stimulating materials, and their parents invest less in their education. The stress of living in poverty and struggling to meet daily needs can also impair parenting. The present study explores the elements of the intergenerational mobility among the lower-income families of scheduled caste communities predominant in Puducherry. A quantitative and qualitative approach is used to analyse the intergenerational mobility process. The educational status, occupational experience, family background, socioeconomic status, income variation, school, and college experience, and impact on caste and the government policy, political activities and geographical locations related to research are critically examined and consolidated in the study. They are still performing the traditional occupation and the occupation has even transformed to the next generation too. The government took many initiatives to uplift the socially disadvantaged people through implementing various schemes free educations, scholarships, free hostel, reservation policies to provide for the Dalit youth. Through these schemes, many youths have benefited from this category.

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Social Mobility, Intergenerational Mobility, Education, Occupation, Dalit and Youth.

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Online Assessment, Machine Learning, Convolution Neural Network, Artificial Intelligence

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Suggesting the best type of medicine for Health Care System is a system that uses a Logistic Regression algorithm to predict diseases based on information provided by the user and then suggests the best treatment for the diseases predicted. It also anticipates the patients or user's ailment based on the knowledge or symptoms entered into the system, and offer correct results based on that information. If the patient isn't in any danger, and the user simply wants to know what kind of ailment he or she is suffering from. The health industry now plays a major role in curing the diseases of patients, so by simply entering the symptoms and other relevant information, the user can gain a better understanding of the disease to which he or she is subjected, and thus the health industry can benefit from this technique by simply asking the user for their symptoms and entering them into the system, and in a matter of seconds, they can gain a better understanding of the disease to which they are subjected.

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Machine Learning, Logistic Regression, Health Care System

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Background: Breast cancer is the highest prevalence of malignancy for women in Indonesia and important national health problem. Several studies on gene expression have shown several subtypes of breast cancer, including the two most important subtypes, Estrogen Receptor (ER) positive (Luminal A and Luminal B) and ER negative (Triple negative and Her2 positive). Method: The research design is an associative test using a retrospective cohort observational analytical study design, associating the relationship between tumor subtypes with recurrence in locally advanced breast cancer patients after mastectomy and has received additional therapy according to standard procedures at Dr. Soetomo Surabaya This study used secondary data from the medical records of the Oncology Polyclinic, RSUD Dr. Soetomo Surabaya from 2014 to 2019. Results: The research subjects who have been selected according to inclusion criteria are 214 people, with the proportion in the population of luminal A and luminal B subtypes of 107 people each. Based on this study, the authors found that the subtype was positively correlated with recurrence in LABC patients who had undergone mastectomy with a significance value of p = 0.000 (p <0.05; 99% CI). Conclusion: According to this study, there is a relationship between the recurrence rate and the molecular subtype of breast cancer in locally advanced breast cancer (LABC) patients after mastectomy at Dr Soetomo Hospital.

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breast cancer, Luminal A, Luminal B, locally advance breast cancer (LABC), recurrence

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Bankruptcy, Creditor, Debt, Insolvency, Law.

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Malaysia private universities are rapidly evolving environmental challenges and highly intensive competition within society, demand for skills and professional workers is on the rise. The education sector is very important for cultivating skilled labour to be educated through continuous improvements of future generations. Malaysia private universities provide academic success is one of the key oracles in the lives of learners, beginning with the secret to getting ahead among masters student. It is the product of a student's study atmosphere that indicates that the student develops well in his or her academic fields, once the expert in everything was a beginner. For any educational institution, schools, colleges and universities have little meaning without students are the most important commodity. Also, we study in this report in depends variables and depends variables of frameworks the country or environment's social and economic growth is directly related to the academic success of students. The student experience in academic and social environment among masters students in Malaysia private university. It was recommended that students be aided to develop effective social environment, so as to be successful in the education academic.in the end we summaries the article.

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Student experience, Student Academics, Social environment, Education system.

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HR, Hire, Virtual Interview

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In the current pandemic erra there has been a boom in the rize of people using social media platforms to be able to connect and interact with the world virtually, making the social media platforms a go to place for consuming day to day information about various topics related to an individual's preference.This information expands vast and diverse in its domain making most of it almost noisy data, irrelevant to an individual preference. Practical implementation approach to clustering in social media websites to group similar groups of tags that can be used to optimize the preference search and feeds of the users and optimize the content delivery of our platform using k-means clustering algorithm and existing popular technology stack known as MERN stack.

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MERN stack, k-means, clustering, Machine Learning, Data Mining.

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CSR, Covid-19, Indian Corporate Sector, Social Distancing, PM Cares Fund

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AIM AND OBJECTIVE: To evaluate the safety and efficacy of galcanezumab in chronic migraine. METHODS: An observational study of galcanezumab (LY2951742) in patients with chronic migraine. Eligible patients 18-65 years of age (n=60) with chronic migraine were given monthly injection of placebo, galcanezumab 120 mg or 240 mg. The mean change in monthly migraine headache days was the primary outcome. As safety outcomes, the percentages of patients who reported at least one adverse event, at least one significant adverse event, or who dropped out of the study where considered. RESULT: Both galcanezumab dose group demonstrated greater overall mean reduction in the number of monthly MHDs compared to placebo. There was a significant reduction in the proportion of remaining MHDs with nausea and vomiting for episodic and chronic migraine studies and with photophobia and phonophobia for episodic migraine studies.Galcanezumab was also found to be more effective in all important secondary outcomes. In terms of safety, the majority of adverse events were mild to moderate, with low dropout rates and significant adverse events. CONCLUSION: We conclude that both doses of galcanezumab is an efficacious and well tolerated preventive treatment for migraine and were superior to control group in reducing number of monthly MHDs.

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KEYWORDS: Galcanezumab, CGRP, Migraine, Monoclonal Antibodies, Preventive Measures.

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Pineapple is one of the largest produced fruits in the world with an annual production of 28.2 million tons, However, considerable of fruit production get spoiled and remain unutilized as post-harvest losses and pineapple is no exception. Pineapple (Ananas comosus) is one of the most popular and the choicest fruit in the world. Wine production from pineapple is a very good alternative to utilize the surplus and value addition. The literature available on pineapple wine production and characterization, the need of fruit wine and pineapple wine production and optimization of conditions has been reviewed briefly. To utilize the surplus for wine production has potential to contribute considerably to postharvest loss reduction and providing value added products.

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Pineapple, wine production, optimization of fermentation conditions

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The current mobile communication system has progressed greatly, requiring future control, performance measurement, and analysis. Filter-Bank-Multi-Carrier (FBMC) is a multicarrier modulation method frequently used in high-data-rate cellular and wireless systems. Throughout the preceding few decades, many researchers have inferred and examined the FBMC concept from diverse perspectives. This needs a flexible time-frequency resource allocation, which is difficult with Orthogonal Frequency Division Multiplexing (OFDM). As a result, OFDM modifications like windowing and filtering are required. The purpose of a current mobile-based research project is to increase bandwidth for all users, provide huge bandwidth, more efficient and managed connectivity, and give continuous and uninterrupted access. The proposed research provides a unified framework for FBMC, as well as a discussion and evaluation of the technology, as well as a comparison to OFDM-based systems. We show how to deal effectively with multiple antennas and channel estimate, two of the most common

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RACH, FBMC, OFDM, Stochastic

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foreign students ,academic-related

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