Volume 11 | Issue 8

 Abstract

Abstract The Moviegoer, Walker Percy's first book, is about a boy named Binx Bolling who wants to escape from his everyday life. This article is about how Walker Percy uses films to show that Binx is an unreliable narrator and a hopeless searcher who is stuck because he doesn't realize how much his life is like the films he watches. Binx leaves the world and the people in it because he fears that life's everydayness will be too much for him. Binx's exile means that he doesn't know anything about the world anymore, but he doesn't know how his lack of information makes him sad. He is so sure of his ways to avoid things, like licensing, repetition, and rotation, that they keep him from seeing his absolute hopelessness and inability to do anything in the face of everydayness.

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Keywords- escape, unreliable, everydayness, exile, hopelessness

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A person's natural state is referred to as their Prakriti. Every person is thought to have a fixed Prakriti that is created by the situation of Tridosha at the time of the union of the sperm and ovum inside the uterus, according to Ayurveda, which categorizes people based on their Prakriti. The increasing incidence of lifestyle diseases has become a significant public health concern and continues to be the leading cause of death worldwide. Few Ayurvedic concepts can be used effectively in the prevention and treatment of lifestyle disorders. One such idea is Prakriti. The term "Prakriti" refers to the development of unique attributes brought on by the predominant presence of the three Doshas (Vata, Pitta, and Kapha, the functioning elements of the body). One of the earliest conceptions of preventive, personalised, or genetic medicine is known as Prakriti, which also impacts an individual's sensitivity to environmental factors, medications, and susceptibility to diseases. The Vikriti, which indicates a person's ill state, is the opposite of the Prakriti. Prakriti is crucial in defining Vikriti since without knowing what is normal, abnormality cannot be detected.

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Prakriti, Vikriti, Dashavidha Pariksha, Dosha, Genomic medicine, Pharmacogenomics

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Regional rural Banks plays an important role in the agriculture and rural development of Gujarat and Maharashtra. The RRBs have more reached by its network in rural areas of Gujarat and Maharashtra. Their level of financial stability is a key factor in the success of rural finance in Gujarat and Maharashtra. RRBs are a crucial source of finance for rural regions, and they are in charge of providing different sorts of agriculture credit in rural areas with the loans they require. The majority of regional rural banks are now dealing with issues including past due, recovery, non-performing assets, and other issues. There are two RRBs in Gujarat and Maharashtra. Therefore, it is necessary to comparative study of RRBs in Gujarat and Maharashtra. This paper attempts to analyze the comparison of non-performing asset of RRBs in Gujarat and Maharashtra as on 31st March 2022. The study is based on secondary data collected with the help of annual reports of NABARD, RBI and RRBs. In the current study, an analytical research design of Key Performance Indicators Analysis was used to measure variables such the number of districts and branches covered, deposits, loans, investments, recovery, and productivity. According to the report, Baroda Gujarat Gramin Bank (BGGB) has Gujarat's largest branch network and district coverage compared to Saurashtra Gramin Bank, and Baroda Gujarat Gramin Bank (BGGB) has a higher productivity. In Maharashtra the Maharashtra Gramin Bank (MGB) is the largest branch network and district coverage but the productivity of Vidharbha Konkan Gramin Bank VKGB is low in comparison of Maharashtra Gramin Bank (MGB).

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Baroda Gujarat Gramin Bank (BGGB), Saurashtra Gramin Bank (SGB), Vidharbha Konkan Gramin Bank (VKGB), Maharashtra Gramin Bank (MGB), Performance Indicators Analysis.

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Heart Failure is one of the most serious cardiovascular diseases across the world with a prevalence of close to 64 million patients across the globe. While diagnosis and prognosis of Heart Failure predominantly depends on LVEF, it has quite a few backdrops. A novel technology has emerged (patented by USPTO) wherein LVEF can be calculated from ECG graphs. This is sure to have a huge impact on healthcare at a global scale once the technology will be adapted into the modern-day ECG, Holter and Cardiac Monitoring machines.

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Heart Failure, LVEF, algorithm

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Social media is a collection of online platforms and tools that people use to share content, profiles, opinions, ideas, experiences, views and media, create event for online conversations and interactions between groups of people. In the current context, a young man cannot imagine his life without social networks. Pritam Gundcha and Huan Liu (2012) argue that the increasing use of social networks has gradually inspired users, especially the younger generation, which has shifted the power of information and influence from the media. to social media users. Foon Hew, (2011) studied the important role social media played during this period in bringing people together and making society and government listen to their voices in many cases in India. in recent times.

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SNS, Social media, Youth addiction of SM, Impact of SMS

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In the veterinary medicine Anthelmintics drugs are mostly used. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. Helminthiasis is also known as worm infection, is any macroparastic disease of humans and other animals in which a part of the body is infected with parasitic worms known as helminths. Anthelmintic agents are medicines that used for treatment and inhibition of parasitic infections caused by helminths; which involve both fl at worms, such as, flukes and tapeworms and round worms, such as, nematodes. Anthelmintics are categorized into groups depending on the basis of their identical chemical structure and mode of action. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites. The remarkable safety record involving more than several hundred million patient exposures over a 20 year period is also documented.

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Anthelmintic, Benzimidazoles, Avermectins, Vermicide

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The hydrogels represent three-dimensional networks comprising physically or chemically interconnected bonds of hydrophilic polymers. These insoluble hydrophilic structures possess the ability to absorb fluids from wounds and facilitate the diffusion of oxygen, thereby expediting the healing process. The primary objective of this current research is to create and assess a hydrogel containing Neomycin sulfate, intended for enhancing wound healing. Neomycin sulfate, an antibiotic employed in the treatment of bacterial skin infections, has proven efficacy in addressing infected lacerations, wounds, torn tissue, fatigue, and minor burns. The hydrogel formulation of neomycin sulfate, designed for topical application to promote wound healing, was developed using guar gum and Carbopol-940, followed by comprehensive evaluations. The judicious selection of appropriate polymers and their proportions is an essential prerequisite for devising and advancing a system for delivering drugs through the skin. The formulated hydrogel exhibited uniformity, strong stability, and improved rates of drug release compared to existing commercial formulations.

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The hydrogels represent three-dimensional networks comprising physically or chemically interconnected bonds of hydrophilic polymers. These insoluble hydrophilic structures possess the ability to absorb fluids from wounds and facilitate the diffusion of oxygen, thereby expediting the healing process. The primary objective of this current research is to create and assess a hydrogel containing Neomycin sulfate, intended for enhancing wound healing. Neomycin sulfate, an antibiotic employed in the tr

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DNA BASED ADVANCED ENCRYPTION STANDARD ALGORITHM USING VERILOG HDL

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DNA BASED ADVANCED ENCRYPTION STANDARD ALGORITHM USING VERILOG HDL

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Stress is sum of emotional and physical tension that is experienced by all in our modern society. Stress occurs when an individual fails to respond to any perceived or existing threats which can be physical or emotional. There are various sources of Indian education system, unpleasant emotions ,pressure from parents ,heavy academic workloads, negative relationship between teachers and students. The impact of academic stress on students are in the form o physical, psychological and academic performance. Various therapies are used for helping the students to deal with academic stress such as Cognitive behavioral therapy (CBT) or talk therapy, Solution- focused therapy, Problem-solving therapy, Life coaching, Meditation, relaxation and Yoga. Recently Bibliotherapy is gaining popularity as it is cost effective and easy to implement among students at any setting.

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Stress, Academic stress, students, Bibliotherapy

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Land Cover Indices gives information about the thermal behavior of land surfaces and when it coincide with sensible heat storage (?QS) then it forms urban heat island which in turn measure in its intensity. The current study analyzed the effects of land cover indices in the Kanpur Metropolis, which is located over the Indo Gangetic Plains but now a portion of the Kanpur Nagar District and has the Yamuna river as its southern boundary due to its urban sprawl. The land cover indices such as Modified Normalized Difference Water Index (MNDWI), Normalized Difference Barren index (NDBaI), Normalized Difference Built-up Index (NDBI), Difference Vegetation Index (NDVI) Soil Adjusted Vegetation Index (SAVI) affects Urban Heat Island (UHI) intensity. These land cover indices and Urban Heat Island (UHI) intensity has been calculated using data from Landsat 5, 7, and 8 for the years 1991, 2001, 2011, and 2021respectively for this region using projection WGS_1984_UTM_Zone_44N. A correlation between UHI Intensity and various land cover indices has also been evaluated, and it reveals that NDBI and NDBaI have a positive impact on UHI Intensity while MNDWI, NDVI, and SAVI have a negative impact. The UHI intensity is positively correlated with NDBaI and NDBI according to the best fit curve with a logarithmic trendline, but it is negatively correlated with MNDWI, NDVI, and SAVI. The significance level (p) for each land cover index was also evaluated, and in the majority of cases, a satisfactory p value of <.05 was discovered. The analysis demonstrates that while the land cover indices associated with vegetation density the Urban Heat Island Intensity has decreased in the region while indices associated with built-up such as NDBI, the UHI Intensity has increased. The study can offer insightful information about the policy-making process for urban spatial planning and strategies to mitigate UHI Intensity.

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Landsat, land use indices, urban heat island intensity.

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Urban environment alters biophysical mechanisms causes a change in surface to atmosphere temperature and forms storage heat flux (?QS) and releases as sensible heat flux which in turn forms Urban Heat Island (UHI) Intensity. So, the impact of UHI Intensity on human health and ecological evolution should be studied in a developing nation like India having a large young population and a diverse range of species. With this in mind, it is also necessary to examine the UHI Intensity mitigation processes. The current study examined the impact of UHI Intensity on human health and ecological evolution in Kanpur Metropolis, which is located on the banks of the Ganga but now/will, occupies/occupy the area of Kanpur Nagar District with the Yamuna River serving as the region's southern boundary due to urban sprawl. Urban Heat Island (UHI) Intensity Discomfort Index (DI) and Urban Thermal Field Variation Index (UTFVI) has been carried out for this region with projection WGS_1984_UTM_Zone_44N using Landsat 5, 7 & 8 data for the years 1991, 2001, 2011 & 2021 respectively. The best fit curve with a logarithmic trendline shows a positive correlation between UHI intensity and DI and UTFVI, which has been evaluated. The significant level (p) for DI and UTFVI was also evaluated, and the p value of <.005 was found to be satisfactory. This indicates that the severity of UHI intensity has a significant impact on human discomfort and ecological evolution. The study also offers insightful information about the policy-making processes involved in urban planning, such as how to create green and blue spaces and other human made infrastructures during urban spatial planning for UHI intensity mitigation.

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Ecological evolution, Discomfort, Green space, Blue space

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Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed. Despite the occurrence of vaginal ulcers, mucosal alterations, and toxic shock syndrome, large numbers of women continue to find vaginal tampons an acceptable and convenient method of menstrual protection. Government agencies and consumer groups are aware of the potential problems associated with tampon use and are actively concerned with surveillance and public education. Tampon manufactures have joined in this effort and continue to seek methods of improving their product and decreasing the risks associated with the use and abuse of vaginal tampons.

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History and background of Tampon, Ancient Tampon, and Herbal drug Tampon, Efficacy of Tampon in Female, Sala-e-Raham, Tampon in management of Myoma and Fibromyoma,

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The process of identifying and producing a novel drug is frequently viewed as time consuming and costly. As a result, computer-aided drug design technology is increasingly being used to increase the efficiency of drug discovery and development process. various CADD approaches are viewed as promising technique based on their demands; nevertheless, structure-based drug design and ligand-based drug design approaches are well-known as highly efficient and powerful drug discovery and development strategies. Both methods can be used as a molecular docking to do virtual screening for the purpose of discovering and optimizing leads. Computational tools have grown in popularity in pharmaceutical industry and academic sector in recent year as means of boosting efficiency and effectiveness of the drug discovery and development pipeline. In this piece, we will look at computational approaches, which offer a novel approach to finding new leads and assisting in drug discovery and development research.

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Computer aided drug design, structure based drug design, Ligand based drug design, Pharmacophore, virtual screening, Molecular docking, QSAR, Database.

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Ulcer is a common gastrointestinal disorder which is seen among many people in that bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs such as Paracetamol, Aspirin, Diclofenac, etc. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. Preliminary phytochemical screening of these herbs has shown the presence of important secondary metabolites like flavonoids, alkaloids, terpenoids, tannins which are responsible for the anti-ulcer activity. The purpose of this study is to treat of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence using herbal medicinal plants.

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Helicobacter Pyroli, Peptic ulcer disease, Natural Pain Killer, Medicinal Plants, Abdominal Pain

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Academic performance depends on a complex interplay between intelligence and contextual variables, but health is a key factor in regulating a child's learning ability. The idea that healthy children learn better is empirically supported and widely accepted (Basch, 2010). Several studies have also confirmed that health benefits are associated with physical activity, including cardiovascular and muscle fitness, bone health, psychosocial outcomes, as well as cognitive and psychosocial outcomes. Brain Health (Strong et al., 2005; see Chapter 3). The relationships between physical activity and fitness, cognition and brain health, and academic performance are the subject of this chapter. Here in the present paper we shall discuss the importance of PE in student's overall performance and have an overview of the status of PE in the state of Gujarat-India.

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Physical Education, PE/PA, Physical activity and fittness

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An increasing number of comparative studies in public administration are required in today's era of globalisation to investigate the range of approaches taken by different nations while implementing new global models. Many of the key obstacles that have hampered the intellectual promise of previous waves of comparative administration remain to have an impact on the current state of the field. Presented at the PAR Symposium on Comparative Public Administration, this article offers a brief examination of the conceptual, epistemological, structural, and institutional obstacles to comparative administration and a few suggestions for overcoming them.

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comparative politics, policy studies, policy design, Public policy studies, Comparative Public Administration

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The present study is a review based study depicting the direct relationship between physical activities and academic performance of school students.

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PE, Physical activities, academic performance

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Background: This study set out to examine how COVID-19-affected and unaffected patients in 20 different wards around Malegaon were treated by their new team leaders, students, and technicians while they collected blood samples. Team leaders, students, and technicians all play crucial roles in helping participants with the blood-sampling process, which is used to measure IgG and IgM levels of immunity in Malegaon residents who have and have not been infected with COVID-19. Pre-analytical mistakes are unfortunately common throughout the blood sample collection process and may have negative effects like repeating the sampling process. Plus, some say that needle procedures are the most unpleasant. However, the team leaders, students, and technicians' personal experiences with mistakes made while collecting blood samples are unknown. Thus, the goal of this analysis is to the Learning Experience of Team Leaders, Students, and Technicians of Unani during Blood Samples Collection in Field Visits. A Descriptive Observational Study.

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Covid-19, Team leaders, students & technicians' experiences or perspectives, Thematical analysis, Focus group, Participants, Blood sampling procedure.

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A phototherapeutic approach is the modern drug designing and development for traditional medicinal plants. In that pure phytochemicals as drugs is time consuming and expensive. Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections. Liver is a most important organ of the body. It plays an important role to maintaining various physiological processes in the body. It is involved in several vital functions, such as metabolism, excretion and storage. It plays a central role in the detoxification and excretion of many exogenous and endogenous compounds. Hence, any injury or impairment of its function has grave implications for the health of the affected person. Many more drugs or therapies are available for the treatment of hepatic disorders, but still there is a need for the novel drug discovery which can target multiple disease pathways. In the 21st century has a great that paradigm shift towards therapeutic evaluation of herbal products. The use of herbal products has a great role in the treatment of liver diseases and has no side effects.

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Hepatotoxicity, Hepato protective herbs, Siddha medicine in liver morbidity.

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The objective of this study was to develop a reliable and accurate RP-HPLC method for the determination of Linezolid content in drug formulations. The method development involved the optimization of various parameters, including the mobile phase composition, column selection, and detection wavelength. The Linezolid drug and its formulation were subjected to RP-HPLC analysis using the developed method. For the validation of the RP-HPLC method, parameters such as linearity, precision, accuracy, specificity, robustness, and system suitability were evaluated. The linearity of the method was determined by analyzing Linezolid standard solutions at different concentrations. Precision was assessed by repeatability and intermediate precision studies. Accuracy was determined by recovery studies conducted at various spiked levels. The developed RP-HPLC method exhibited satisfactory results for all validation parameters. The linearity of the method was excellent over the specified concentration range. Specificity tests demonstrated that the method was selective for Linezolid, without interference from other components. The method showed robustness, as minor variations in the chromatographic conditions did not significantly affect the Linezolid peak. In conclusion, the developed RP-HPLC method proved to be reliable, accurate, and specific for the estimation of Linezolid drug and its formulation. The validation results indicated that the method is suitable for routine analysis of Linezolid samples, ensuring the quality control of Linezolid-based products and compliance with regulatory guidelines.

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Linezolid, bioavailability, Solubility, Qualitative analysis, RP-HPLC method.

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