Volume 11 | Issue 7

 Abstract

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered By parenteral routes or be alternative routes such as oral, nasal and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of SLN in terms of their advantages, disadvantages, method of preparation, characterization and applications.

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Key Words: Solid lipid nanoparticles, drug delivery, drug incorporation.

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For 30 years SAS has been used in pharmaceutical research setting for data management, analyze, visualize and reporting. Traditionally, these roles were staffed by BASE SAS programmer and the statistician. At the same time, dramatic shift in the researches informatics eco-system have occurred with advance in standards, such as CDISC. ICH and convergence of clinical trials data management systems and modernization strategies, such as electronic data capture and report in the form of CRF. This paper provides a broad-based view of how SAS can be used across the research information spectrum. We are focusing on Server, Data Integration Studio and SAS Business Intelligence products. The SAS Drug Development solution merges the accessibility of the Internet with the Clinical Trials Workflow. Whether we focus is beating data into submission or making it sing and in reports, this paper will make the connections to the various solutions from SAS and where each solution is most valuable in the pharmaceutical setting. This paper is appreciated for people at all levels and across the spectrum of job skill, including the production of clinical study reports, clinical trials management and laboratory data analysis. It is specifically designed for the programmer, statistician, manager and system administrator and submit all the reports to regulatory authorities like FDA.

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Clinical SAS Drug Discovery ,Drug development, Preclinical trials,Clinical trials (Phase 1, Phase II, Phase III, Phase IV ) , Regulatory authorities involved in drug discovery, CDISC , CDMS, CDSCO, SAS

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The present research paper aims at analyzing Bapsi Sidhwa's Ice-Candy-Man and Amitav Ghosh's The Shadow Lines with reference to Decolonization. In the arena of Post-Colonial Studies, the article looks at Anti-Colonial theory as a counter-narrative. The paper illustrates how the selected texts interrogate the very notion of colonialism, develop consciousness among marginalized and subjugated individuals, and empower them to take radical actions in order to define their identities and resist colonial atrocities. Ice-Candy-Man, Bapsi Sidhwa's third and widely quoted novel is one of the most powerful narratives of recent time. The Shadow Line is a Sahitya Akademi Award-winning novel by Amitav Ghosh. It is a book that grabs the perspective of time and events, the lines that connect and divide individuals. The paper shall attempt to compare and evaluate the effects of colonialism and how those individuals tried to overcome imposed national identity interpellation through global cosmopolitan outreach.

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post-colonialism, decolonization, partition, communal riots, nationalism

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This research paper critically analyzes Margaret Atwood's dystopian novel, The Handmaid's Tale, from a feminist and political perspective. It focuses on the plight of women within the oppressive regime depicted in the narrative, examining the intricate web of power structures, gender roles, and reproductive control that dominate the totalitarian society of Gilead. The study also explores the subjugation and resilience of female characters within this context. Utilizing a feminist theoretical framework, the systemic oppression faced by women. It investigates themes of agency, resistance, and the role of language. The research highlights how Atwood's novel challenges patriarchal norms and exposes the role of language in subverting oppressive systems.

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Margaret Atwood, The Handmaid's Tale, Feminist Theory, Political Analysis, Women's Oppression, Gender Roles, Reproductive Control, Power Structures, Agency, Resistance, Language, Patriarchal Norms, Gilead, Dystopian Literature, Political Extremism, Feminist Discourse.

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Monoclonal antibodies (mAbs), which are defined as a single antibody (Ab) cloned from a single B cell, have been used as immune modulators for transplantation, autoimmune disorders, and cancer for decades. To protect itself from many invading diseases, the vertebrate immune system is continually changing. The vertebrate immune system responds to a foreign pathogen by producing complementary antibody (Ab) molecules that can bind to all molecular structures of the microbial pathogen (bacteria, viruses, fungi, nematodes, and other parasites) and keep up with an organism's diverse mutations. Antigen is any particle that enters the body and is identified by the vertebrate immune system as a foreign object. As a result, the immune system is attacked in two ways. First, B cells create a variety of antibodies that are specific for a novel antigen (epitope). Second, the antibody's paratope-encoding genes are rapidly altered in order to cope with and attach strongly to the antigen's epitope. As a result, antibodies were generated.

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Monoclonal Antibody, Hybridoma Technology, Applications, Types, Side effects.

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Kishkindha Kand is one of the seven kands in Valmiki's Ramayan. The Kand involves the meeting between Lord Rama and his disciple Hanuman. It also features the story of two vanar brothers Bali and Sugriva and how Rama killed Bali who enslaved Surgriva's wife. It was in Kishkindha Kand that Jambvant made Hanuman realise about his strength, powers and capabilities. We are here to narrate to you the story of Kishkindha Kand with the help of pictures. This part will tell you about the encounter with Hanuman and Surasa, the mother of Nagas.

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Kishkindha Kanda ,fourth chapter of Ramayana ,great epic of India

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Abstract Nowadays ovarian cysts are a common threat in reproductive women throughout the world. The present study was conducted to find out the physical and physiological problems may be faced by the women who have ovarian cyst. To carry out this study, total 30 adult female subjects (23-28years) having ovarian cysts were selected. Selected Physical and physiological variables were Body mass index (BMI), fat percentage, fat mass, lean body mass and problems related with menstruation cycle. The selected methods for the evaluation of physical and physiological variables were, BMI was measured by formula weight in kg and height in meter squire; and fat percentage, fat mass and lean body mass were calculated by using method YMCA skin fold Caliper. Physiological variables were determined by using questionnaire. The present study revealed that the value of Fat percentage (30.39%) of the patients having ovarian cysts was significantly high that may be considered in danger category. From the study, it was also observed that most of the female subjects faced irregular menstrual cycle, acne, abdominal pain, sleeping problem, anxiety, angriness etc. Most importantly, a challenging problem, infertility, was being observed among the patients. It can be concluded that the ovarian cysts may have a negative impact on physiology of menstrual cycle and create undesired effects on obesity, fertility and behavioral changes of the patients.

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Keywords: Ovarian cyst; Infertility; Menstrual cycle; Body composition

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This technical paper delves into the realm of network sniffing, a powerful technique used to capture and analyze network traffic. Through a comprehensive exploration of various network sniffing methods, tools, and protocols, this paper unveils the underlying concepts and implications of network sniffing. It discusses the potential applications of network sniffing in network monitoring, security analysis, and troubleshooting while addressing the ethical and legal aspects surrounding its usage. By shedding light on the intricacies of network sniffing, this paper aims to equip readers with a deeper understanding of this pervasive networking technique and its implications in today's digital landscape.

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Network sniffing, Network traffic analysis, Network monitoring, Security analysis, Network protocols, Network tools, Scapy, Digital landscape

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Due to rapid modernization, the number of building is increasing day by day. One of the main components of building is concrete since a huge amount of concrete is used in the construction of the building, the concrete should be eco-friendly, durable and its strength should be high. Concrete is a composite mixture of cement, coarse aggregate, fine aggregate, and water. But cement has many adverse effects on environment as well as on health. During the manufacture of cement, for 1kg of cement, it emits 900gm of Carbon dioxide (CO2). So, we found out many alternatives to cement, in that "Fly Ash" is an eco-friendly green material, which is produced by burning the coal in the electricity-producing Thermal Plant. Fly Ash in the concrete reduce the heat of hydration so the reduction of thermal crack is observed. The replacement of the cement by the Fly Ash improves the workability and pump ability of the concrete. The life of the concrete structure is estimated to be 40 years but in many research, it is found that if 35% of the cement are replaced by Fly Ash increases the life of cement structure by 120 years, but if the replacement is more in the concrete the compressive strength may decrease slightly. The cost of Fly Ash is more economical than cement. Direct disposal of Fly Ash causes environmental problem and health issues as it is a waste material. Hence considering all the research, the strength of the concrete increases using modified and activated Fly Ash in all research, the strength of the concrete increases using modified and activated Fly Ash in the correct amount.

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Eco-friendly, Durable, Modified, Activated, Workability

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There has historically been a nearly global propensity to enhance the capacity demand of the structure in order to counterbalance such events, which occur after every significant earthquake. Only in the last ten years have innovative approaches to solving this issue successfully been created. The emphasis is now placed on serviceability and safety under various earthquake magnitudes in the current international practice of performance-based engineering design. Additionally, it is becoming increasingly clear that in addition to methods for increasing ductility, the toolkit of a structural engineer should also contain devices that dissipate and share energy as well as those that can regulate a system's response. In order to prevent "dislodgement" or "unseating" of the superstructure in the event of strong ground shaking, new methods and systems have been developed. The focus of this work is on how these concepts might be applied to bridge designs that are reasonably earthquake resistant. One of the structural processes that significantly affects bridge design is wind load. The wind load is dynamic by nature. This indicates that it has a time- and space-dependent magnitude. As a result, analysing and modelling such a load and its respective effects on a building may be rather difficult and require a deep understanding of both structural analysis and mathematics.

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Wind load analysis, Bridge design, Seismic retrofitting, Seismic vulnerability assessment, Seismic isolation systems

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A few unique substituted azetidinones were synthesized and evaluated for their potential as prospective new therapeutic molecules for the treatment of depression. All of the produced compounds were evaluated for the clarity of their structures. These chemicals' antidepressant trials revealed that they exhibited strong antidepressant effect. Three stages of SN2 type substitution were used in the synthesis of the compounds. The stretching vibration peaks caused by C-N, C=O, and C=N were seen in the IR spectra of all the compounds at 1400-1000 cm-1, 1765-1645 cm-1, and 1690-1520 cm-1 (middle), respectively. The spectra also showed vibrations from the aromatic compounds C=C and C-H, C-H alkane, C-Cl (4e), CO (4d), C-H (methoxy), C-C (cycobutyl), and C=O. (cycobutyl). The test chemical 4d considerably enhanced the swimming frequency in FST. TST-like action was seen, and compounds 4a, 4b, 4c, and 4e did not perform as anticipated.

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Antidepressant, forced swim test, synthesis, azetidinone, tail suspension test

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Two types of metal wire use here for theory. Normally we look fan,light inside and outside metal wire different.

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Jana Theory

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One of the main difficulties standing up to this present reality is the ascent in street mishaps. Inappropriate and scatterbrained driving is the main source of street mishaps. This study's principal objective is to foster a non-meddlesome framework that can recognize human exhaustion and give an early admonition. Drivers who don't stop much of the time while driving significant distances are in danger of becoming tired, which they some of the time don't understand until it is past the point of no return. The driver's sluggishness or absence of focus is respected to be an essential consider such episodes. Driver lethargy checking exploration could help with the decrease of mishaps. As per master research, about a fourth of serious thruway mishaps can be credited to sluggish drivers who need to rest, and that implies that lethargic drivers cause more car crashes than drink-driving. The innovation will utilize a camera to follow and screen drivers' eyes, and by building a Milestones calculation, we will actually want to identify drowsiness side effects in drivers sufficiently early to keep away from mishaps. Thus, this examination will help with recognizing a driver's sluggishness ahead of time and giving admonition yield as cautions ,along this really genuine we have executed an IoT-empowered liquor recognition ,pulse (BPM) and Spo2 observing framework which closes down the vehicle's motor, sets off a caution during driver id sleepy and liquor consumed circumstances. This framework shares the live area utilizing GPS innovation . Anyhow in thinking of concept and academic studies implementing the system with available resources and building a POC with PC and ESP32 controller with addition sensor and actuators ,This combination of modules will identify tiredness or fatigue and can be used to automatically stop the vehicle .

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Index Terms - IoT,GPS,technology,ESP32,Spo2,BPM.

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Mouth dissolving tablet or dispersible tablets is a widely acceptable dosage forms which dissolves rapidly in the saliva without water. It enhanced efficacy and bioavailability thus reducing the dose and dosing frequency to minimize the side effects. The purpose of this research was to develop mouth dissolving tablets of Clemastine. Clemastine is also known as Meclastin, is a first-generation antihistaminic drug. It can be used in allergic symptoms including sneezing, runny nose and red, itchy, tearing eyes. In the present study attempt has been made to formulate Clemastine mouth dissolving tablet by direct compression method and optimize mouth dissolving Clemastine tablets containing superdisintegrants viz crosspovidone, Crosscarmellose and Indion 414 in the different ratios (1:1, 1:2 & 1:3) along with directly compressible mannitol (Pearlitol SD200) to enhance mouth feel and to compare the optimized formulation of each superdisintegrant. Compatibility study were done in FT-IR shows that there is no significant interactions occur between clemastine and excipients. The blend of excipients developed were evaluated (pre formulation) was examined for angle of repose, bulk density, tapped density, % compressibility and hausner's ratio. The angle of repose of the developed excipients blend was found to be < 27o, Carr's index in the range of 11-15% and Hausner's ratio in the range of 1.12-1.15. Mouth dissolving tablets of Clemastine fumarate were prepared using the above co-processed superdisintegrants and evaluated. The systematic formulation approach helped in understanding the effect of formulation processing variables. The prepared batches of tablets were evaluated for various parameters like various taste, thickness, hardness, friability, drug content uniformity, wetting time, In vitro disintegration time, and In-vitro dissolution time. All the parameters were found to be within limits. Based on in vitro disintegration time (approximately 30 s), promising formulation F8 was tested for in vitro drug release pattern in pH 6.8 Phosphate buffer and short-term stability (at 400C/75% RH for 3 months).The developed formulation of Clemastine batch F8 (9 % Indion 414) showed good palatability and dispersed within 30 seconds as compared to crosscarmellose sodium and crosspovidone. Based on the in vitro drug release characteristics from clemastine mouth dissolving tablet it was concluded that the Indion 414 has a great potential in the formulation of Mouth dissolving tablets of Clemastine.

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Mouth Dissolving Tablets; Clemastine; Indion 414; Crosscarmellose sodium; Crosspovidone; Superdisintegrants.

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From the earliest years of Patiala becoming a state, the Maharajas of Patiala made an effort to maintain friendly ties with the East India Company. Because of these relationships, the state's calm was preserved, and the rulers were highly educated and westernised. As a result they were able to provide able patronage to works of social, economic and modern improvement and development. The arts and culture at Patiala that was founded and flourished under the patronage of these monarchs included singing, painting, architecture, and photography. The cultural pulse of Patiala is still present in the monuments, art and cultural nuances of the state which make it distinctive and special, forming the melodic symphony of the past. This research paper aims to examine the cultural significance of the Royal city of Patiala. The impact of Patiala on the development of Punjabi culture has been enormous, and the various types of craft evolution, diversification, tradition, and local customs, as well as their connections to lifestyle, dress, jewellery, diet, and accessories that reflect royalty, class, pride, and cultural wealth, are now a part of Punjabi culture.

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Keywords: Patiala, Maharajas, Culture, Art, Punjab

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Chieftainship institution is the oldest form of tribal administration that still works among the Nocte tribes of Arunachal Pradesh. Though in many tribal areas of Northeast India Chieftainship has declined due to the introduction of democratic institution, it still functions among the Noctes society with a slight change. The respective district administration gives due respect and importance to the chiefs and their assistance were sought whenever required. The chief help the administration in maintaining law and order and assist the district administration in solving various problems related to local matters and other administration matters. In spite of the significant role played by the chieftaincy institution among the Nocte villages, the institution has come under attack as many question its relevance in modern political dispensation. This article explores the prospect and challenges of Nocte Chieftaincy institutions in the contemporary democratic set up.

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Chieftainship, Tribal, Nocte, Prospects, Challenges, Democratic, Village councils & Chief

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With a view to determine the extent of adoption of recommended soybean production technology, the present study was conducted in Shajapur district of Madhya Pradesh with a sample of 120 farmers. The finding reflected that more than one-half (57.5 per cent) of the soybean growers had high adoption level about soybean production technology

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Adoption, Respondents, Soybean, Technology and Farmers

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The concern of the women across the globe, despite the women being oppressed for ages; they have come out to voice their agonies that have long been suppressed. The woman who wants to ascertain that she wants to have a private space, wherein she can talk to herself though not to others, whether a woman is in or out, she doesn't have freedom to proclaim that she is intellectually free to speak her mind. However, is that as simple as for a woman to achieve a private space? What are the challenges a woman has to encounter? "The Office" is a short story in which a reader explores the challenges of a woman who aspires for a private space. In this story, Alice Munro presents a young wife who has zeal to fulfil her passion encountering the stereotype norms of gender indoctrination in the society.

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Private space, Intellectually free, Indoctrination, Stereotype norms, Empowerment

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In the context of the higher education provision and arrangements of Bangladesh, Colleges under 'National University of Bangladesh (NUB)' are applying traditional teaching and learning techniques for long. We are bound to deliver our lectures in large-sized classes. In large classrooms, however, students' attention and concentration are difficult to retain. For proper delivery of lessons, limited class time is another serious impediment. Since we have to deal with the students who are heterogeneous in terms of their abilities, differentiated nourishment is required to make learning effective. Most of the time, all these shortcomings hinder students from understanding their class lessons properly. It is, therefore, high time that we redesign our teaching techniques for the purpose of ensuring proper and quality education. A technology-supported pedagogy - flipped mode of classroom integrates online and offline altogether. "By this mode, traditional lectures and instructions are sent out of class and free class time is used for practice, problem-solving and interactive learning in groups" (Selwyn, 2007, as cited in Rossing et al., 2012). Students get the vital opportunity to progress in their learning journey at their own paces which makes them confident and thereby they can put forth their learning responsibility by themselves (Beaumont, 2018; Moffett & Mill, 2014). For this purpose, in this essay, at first our current teaching practices have been reviewed and afterwards the failures of it in achieving teaching and learning objectives along with challenges ahead have been identified. It has been attempted to identify the prospects of flipped approach using Google Classroom in eradicating the problems of prevailing traditional approach of pedagogy. The possible impact of flipped pedagogy using Google Classroom is not only a quantitative improvement like raising the pass rate of the students, but rather it facilitates qualitative achievement in learning. Revising the national education policy is required for the proper implementation of the procedure. We can benefit from flipped classroom approach using Google Classroom even with the prevailing grading system and education policy if we are able to acquire the competency of applying this technique in our education structure.

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Flipped Classroom, Google Classroom, Technology-supported Pedagogy, Active Learning, Student-centered Learning, Education Policy,

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Coarctation of the aorta is a birth defect in which a part of the aorta, the tube that carries oxygen-rich blood to the body, is narrower than usual. An estimated incidence of approximately 3 cases per 10000 births has been recorded. Coarctation of the aorta may occur as an isolated defect or in association with various other lesions, most commonly bicuspid aortic valve and ventricular septal defect (VSD). The most common symptoms are Chest pain, head ache, difficulty in breathing, high blood pressure etc.. The cause of coarctation of the aorta is unclear. Coarctation of the aorta is more common in males than in females. Having certain genetic conditions, such as Turner syndrome, also raises the risk of coarctation of the aorta. Complications includes haemorrhage , coronary artery disease , stroke. This condition can be diagnosed by ECG , CT scan .A 17 years old patient admitted in cardiology department in DDHRC with chief complaints of shortness of breath ,k/c/o-CHD. On examination patient was found to be conscious, coherent . ECG showed sinus rhythm , CT aortogram showed coarctation of aorta with bicuspid Av.Intially patient was treated intravenous antibiotic ,anticoagulants ,antiplatelets ,statins and other supplements

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valve and ventricular septal defect, congenital heart defect

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