Volume 8 | Issue 6

 Abstract

The Bilayered tablets containing Dasatinib SR and Dasatinib IR were successfully prepared by direct compression and wet granulation method respectively. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index The physiochemical evaluation results for the dry blend of all trials pass the official limits in angle of repose, compressibility index. The prepared blend for IR relaese were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 2.58�0.66, average hardness of 4.6�0.57, average weight of 183�1.14 mg, friability of 0.34 and 100.24�1.25%. The prepared dry mixer for sustained release were also upheld the physiochemical properties of tablets such as thickness, weight variation, friability. The optimized formulation contains the average thickness of 3.80�0.80, average hardness of 7.6�0.40, average weight of 178�0.54, friability of 0.36. In the F3 trial, the optimized formulation was F3 trial which releases the dasatinib in sustained manner in 1st hour it releases 28 % but the remaning drug release was sustained up to 12 hours and dasatinib immediate release with in an 20min since the tablet disintegrated within 2 minutes 12 seconds.

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 Keywords

Dasatinib, compressibility index, sustained release.

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The article aims to predict a level of stress by assessing the individual's activities. This is done through the use of a sensor that is mounted on a glove. The motion sensor selected for this project was chosen as compared to a physiological signal, due to its low cost and the fact that it is least affected by environmental factors. The main cause of accidents nowadays is the increased level of stress on the crew members. The physiological signal measurements using the sensors are mandatory for measuring the stresses of the crew member. This paper presents the concept of predicting the stress level of the crew members based on heart beat rate and body temperature. This is achieved through the use of temperature sensor, IR sensor and heartbeat sensor, which is placed in the gloves worn by the crew members. The GSM module transmits the total readings to the mobile unit. The crew members 'self-reports are used as the basis for estimating the crew members' stress levels. Infrared sensor is used for accident prevention. If there is an irregular condition in the pilot's heartbeat the flight is switched to automatic mode. Then the person's current status is sent out using GSM. The readings of the sensors used above revealed that exact values could be obtained. This shows the need to include the temperature sensor, IR sensor, pulse sensor for tracking the stress level of the crew members.

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 Keywords

Temperature sensor, IR sensor, Heartbeat sensor, stress monitoring, wearable system.

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This study aimed to analyze the prevalence of role conflict among the nursing professionals of multispecialty medical college hospitals of Dakshina Kannada district in Karnataka state. There is a need to highlight the problem of nurses who play an important role in providing healthcare to the community. Thus a sample of 500 respondents selected through simple random method showed that majority of nurses had moderate level of role conflict (72.2%). An integrated coherent framework of specific strategies are needed to reduce their job stress and role conflict.

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Nursing professionals, Role conflict

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Since the development of urbanization in the world. The construction has increased rapidly. The increase in demand of construction leads to the production of Co2 in the environment. About 7% of the environmental pollution is due to cement manufacturing industries. Thus to lower the amount of objective to do this in concrete is as the dumping of rice husk has been a problem where it leads to problem in land cover and its nature of light weight made this to produce the polluted particles into environment. Also, the husk ash contains silicon which is a major constrain that material strong and fineness equal to cement. Here in, we had a problem as rice husk don�t have the properties of the binding when mixed with water. So, as a concern there placement is limited to 5%, 10% and 15%. Thus mixed concrete is allowed to curing after passing its fresh stage tests. After curing the major mechanical property, compression, tensile and flexure test, where as these are the major test that defines the quality of the concrete. The final aim of the project is produce a concrete that is environmentally free and structurally strengthen concrete.

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 Keywords

Light weight concrete, Rice husk ash Concrete, Compression, Environmental free Concrete.

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 Abstract

The role of ion channels in the development of different cancer has become a novel area of research. There are so many ion channels which are responsible for cancer like phenotype. Among all chloride ion channel is considered to be one of the most active channels along with potassium in case of tumor genesis. High rates of proliferation, active migration, and invasiveness are all hallmarks of cancer which are caused due to channelopathy. It is known that all this action requires action of chloride channel activity as well as the action of ANOCTAMIN genes, which controls the expression of chloride channels in cancer. As the chloride channels involvement is very essential for cancer cell, and as it is known that the abnormal activity of chloride channels can promote the cancer so they can be used as possible aims to cure cancer. Here in this reviewthe chloride channels how they can acts as biomarkers of cancer and specifically which channels are responsible for cancer and ways of linking it for developing anti-tumor drugs will be discussed.

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CLIC, CLCA, Oncochannelopathy, Tumorigenesis, Anoctamins.

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Seat belts or safety belts are important for automobile vehicles. The webbing plays an important role in the properties of the seat belts. The structure and type of fabric improves the performance of the seat belts. The various seat belts, the seat belts with energy storing properties, seat belts with load sensitive properties, seat belts with printed face and back and woven seat belts are available. In this review, the production of the above seat belts are described.

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Seat belt, webbing, non woven, woven, braiding, safety, performance, production.

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This article discusses the way at validating a Measurement for the ramifications of armed conflict that impact in the different aspects of the basic needs for human life in society. the sample included (443) students and academics in three universities in Yemen, Malaysia, and Gaza Palestine. The students and academics sample chosen are from Arab the belong to countries where armed-conflict is quite dominant in during this period, The researchers followed several steps in order to validate the Measurement. These steps included (1) formulating the Measurement elements, (2) verifying the validity of the apparent consistency of the questionnaire by presenting it to the arbitrators from professors specializing in the fields of management, education and statistics and (3) using exploratory factor analysis (EFA) ) by the Statistical Package for Social Sciences (SPSS) to examine the validity Internal consistency, and analysis of correlation coefficients between variables on the Measurement, and relying on the Kaiser criterion for generating and extracting factors that exceed or equal its latent roots 1. Factor Confirmation Analysis (CFA) using the AMOS program for underlying factors that constitute a set the Measurement of this study, where the tables of standard regression weights and multiple square correlations revealed each for each item that each factor is one-dimensional. By the modelling of the structural equation (SEM) has been verified Convergence validity, differentiation validity, and compound reliability for concepts stability. The results of the study denoted that the Measurement in its final form contained (43) items distributed over six factors, according to accurate statistical treatment, and it was excluding (7) items that did not meet the standard conditions in the two programs.

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 Keywords

A Measurement of Ramifications, Armed conflicts, Basic Needs Fields, Humans Life

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 Abstract

Guava is a significant food crop also as restorative plant observed tropical and subtropical areas. Psidium guajava linn. is an individual from Myrtaceae family, which contains 133 genera and excess of 3,800 plant species. Guava is wealthy maximum of phenols, triterpenes, flavonoids, oils, saponins, lectins, vitamin-c and fiber. The leaf of guava is reach source of flavonoids specifically quercetin, kamiferol luteol. The guava is helpful to increase bowel movement is ascribed due to favonoids and fibres. The flavonoids have pharmacological activity like antibacterial, antioxidant, hepatoprotective. In isolation of quercetin separate form from leaves of Psidium guajava l. by using methanol and fallowed the different chemical and analytical test like Lead acetic acid derivation test, Sodium Hydroxide test and Shinoda test , thin layer chromatography mobile phase was Ethyl acetate: Formic acid: GAA: Water, and different procedures UV, IR, NMR, HPLC and HPTLC of Quercetin was studied .

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Guava is a significant food crop also as restorative plant observed tropical and subtropical areas. Psidium guajava linn. is an individual from Myrtaceae family, which contains 133 genera and excess of 3,800 plant species. Guava is wealthy maximum of phenols, triterpenes, flavonoids, oils, saponins, lectins, vitamin-c and fiber. The leaf of guava is reach source of flavonoids specifically quercetin, kamiferol luteol. The guava is helpful to increase bowel movement is ascribed due to favonoids a

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Tourism is a short time movement of people from one place to another place which have travelling for fun. People who travel for fun are called tourists. Tourism is now a day considered as an important industry which has vast scope for the generation of income and employment. It is one of the world�s fastest growing industries. A major source of foreign exchange earner of a nation. The state of Bihar specially mithilanchal is best known for its unique Madhubani Art ( Mithila Painitng ) . A Phullahar the village contains the temple of goddess Girija, Ahilya Asthan (Darbhanga), Maa Janki (Sita) Janam sthali Punaura Dham (Sitamarhi), Halewhwar Asthan (Sitamarhi) , Shyama Mai Temple ( Darbhanga) and many more. Although the whole north region of Bihar has tremendous potential, the tourism industry in the area is still miles to go to exploit the proper potentialities. The state as well as the entire northern region of India has subjected to century long neglect, even after 71 years of the country�s independence. The present paper has been an attempt to highlights the main prospects and problems of tourism in mithilanchal, Bihar

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Tourism, Famous tourist place, Development.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Paperless Operation has become a very big matter of fact and demand of the society in this fast growing world around us. With increasing population and proportionally increasing services day by day it is ethically very hard to accommodate every single transaction with a piece of paper because that costs a number of trees to the environment. As this rapid cutting of trees have adverse effect on environment and the ecological balance. To solve such problem we need paperless technologies. Digi-Sign is a digital signature system that facilitates creation of digital signatures for documents online, and also facilitates users to communicate online with the help of AES methodology. It also allows status tracking of the document and empowers the owner to maintain the same. Digi-Sign has built in features which allows feasibility of operation with digital signatures and also allows faster creation of signature keys alongside provide instant verification of document online. It binds every single signatory and addressee together into a same network for faster communication that has never been possible before. Digi-Sign do not encrypt the entire document, it creates signatures using basic information of any document. It hosts a public database to index the all the documents created by various owner in one place. That helps easy accessibility for validation of information about any document.

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AES, Encryption, Digi-Sign(digital signature), centralized Database.

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The motivation for this thesis is the desire to overcome the problem associated with reliability and yield of these staggeringly small devices called MicroElecro Mechanical System (MEMS).The field of Microelectromechanical system involves the interaction of the physical environment with electrical signals through the use of micro batch fabricated devices. MEMS are an emerging technology which finds applications in diverse fields such as automotive medicine aeronautics communication and defense. The device dimensions range well into the micrometer regime and are soon approaching the length scales studied by nanotribologist though the MEMS technology has made a substantial impact over the past decade at the device or component level, it has yet to realize a wide range commercial success. Stiction, adhesion, friction and wear seem to be main deterrents to their lifetime, and hence full commercialization of these devices. These problems can be attributed to the high surface to volume ratio, substantial solid surface nano contacts, close proximity of microstructure and a myriad other device complications. Several researchers have come up with solutions to avoid release -related stiction, but in use stiction and friction still persist, proving detrimental to the life span of these microstructures. Though a variety of engineering solutions have been employed to solve them . In this study ,an attempt is made to remove stiction by sublimating the resin via low melting point liquid t-butyl alcohol. An experimental setup is developed such that the microstructure would be rinsed by t-butyl alcohol directly by sublimation, to maintain the temperature peltier chips are used as they are pretty small and available and create freezing temperature.

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MicroElecro Mechanical System (MEMS), nanotribologist , Stiction, t-butyl alcohol

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Since the turn of the mid-twentieth century, mankind has witnessed prodigious health improvements. But its effects keep varying from country to country. Considering our country, India continues to face high mortality. Children are highly prone to ill health`, with infections and parasitic diseases. Even adults are now experiencing substantial premature mortality. If we dwell deep, the condition of poorer groups has worsened considerably as compared to the richer ones. Recent mortality analysis emphasizes the significance of the communicable disease, which epitomizes approximately 90 per cent of avoidable death cases for all age/sex groups. But now research has the tools to address the great burden of communicable diseases, like malaria, TB, and HIV/AIDS, as well as other vaccine-preventable diseases. Despite this, the majority of common mass lacks effective access to prevention and treatment. This paper is trying to attempt reviewing the gravity of problems and challenges in communicable disease in India.

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mortality, communicable disease, prevention, Malaria, TB, HIV/AIDS

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The advent of smartphones, coupled with mobile computing technology, provides construction engineers with unprecedented opportunities to improve the existing processes of on-site construction management. Capitalizing on smartphone technology, this study aimed to develop an effective on-site management system. The system was focused on three important functions of on-site management: site monitoring, task management, and real-time information sharing. For system development, various component technologies, such as wireless communication, augmented reality, and client-server database was utilized to efficiently manage, transfer, and visualize project information on a mobile computing platform. The applicability of the mobile system was verified on a real building construction site. This study contributed to the body of knowledge by illustrating how mobile computing technology embodied in smartphones can be used to streamline on-site construction management. The proposed system is expected to assist construction engineers in achieving a high level of productivity and efficiency.

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- Mobile Application, Information Management, construction site, mobile computing.

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 Abstract

India is regarded as a secular federal republic that is governed in a democratic parliamentary system. The Constitution of India is regarded as Suprema Lex of the land. Which does not only confine to the statutes made by legislature or judiciary but also deeply rooted in the culture, tradition, norms, values of the Indian society it's self. And hence the Indian criminal justice system is largely influenced by REFORMATIVE THEORIES. Solitary confinement is something less of reformation and more of a punishment. Solitary confinement is an isolation of a prisoner from other co-prisoners where a prisoner experiences complete segregation from society. In solitary confinement, the prisoner experiences stressful conditions which may lead to potentially harmful health effects that may be physical and mental. The Constitution always strives to protect the rights of individuals even behind the bars. The supreme courts in few of the leading cases highlighted solitary confinement as against Article 19 and 21. As article 21 speaks more of life and less of liberty and complete solitude is Against the natural principle of human life as well as against freedom by contrast It may also result in the arbitration of the authority upon the prisoner which would absolutely break the rule of law as well. This paper deals with the constitutional validity of solitary confinement and its effects in the life Of prisoner and put forward other reformatory majors. Promoting public awareness is the point of utmost importance of this paper.

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Solitary Confinement, The Constitution Of India, Reformative theory

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Abstract: Non-utilization of maternal and child health care services at the right time and right place exposed to physical and mental health related problems among the pregnant women, mothers and child and even lead to death. Hence, timely utilization of maternal and child health care services is extremely important for the health of a mother and child as because they are very much vulnerable to health complications especially during the time of pregnancy and child birth. Education exposes women to new ideas, to new information, and to new heights and maternal education is very important as it plays significant role in family welfare and in determination of child�s and mother�s own health. Many international and national researches have persistently advocated that availability of health personnel and location of facility (distance of the facility from home) as the main barriers to utilisation of health care services. However, in a study conducted in the state of Arunachal Pradesh it was found that besides availability of health personnel and location of the facility; factors like maternal educational level, perception of women, occupation of the mother, transportation and communication bottlenecks etc., also acts as a strong barriers in utilisation of maternal and child health care services in the state of Arunachal. In this paper an attempt has been made to analyze the barriers to utilization of maternal and child health care services in Arunachal Pradesh based on empirical evidences from field survey.

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Arunachal Pradesh, barriers, health care services utilization, maternal health, child health, maternal education, vulnerable

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Creative Commons Attribution 4.0 and The Open Definition

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This study demonstrates that tasks are an essential part of teaching English language. The paper also serves as an eye-opener to many issues on how a task-based and skill-based syllabus ensures a communicative or interactive approach of teaching. Through task-based teaching, it is explored that all the aspects of language like prose, poetry, grammar and vocabulary can be taught in an interesting manner. The paper tries to analyse that the various language learning skills like listening, speaking, reading and writing which are also enhanced effectively through the task-based method of teaching.

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Tasks, Grammar, Language, Poetry, Prose, Skills, Vocabulary.

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Ear and nose foreign bodies are routine problems affecting mainly children but adults are not an exception. A prospective study involving 50 patients is undertaken concentrating on presentation of patients with various types of ear or nasal foreign bodies. Usually nasal foreign bodies does not cause serious complications but rarely intracranial complications may occur. Similarly mastoiditis may occur rarely in sequel to impacted ear foreign body .As an E.N.T. surgeon we should always have high suspicion considering presence of foreign bodies even in the absence of appropriate clinical signs and symptoms suggestive of a foreign body in ear or nose.

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Foreign bodies � Ear and nose � Fungal invasion � Vascular thrombosis � Mastoiditis

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The study sought to examine how the research methods and their respective findings of prior studies on perceived factors influencing examination malpractices from 2012 to 2019. Initially, we access 15 studies electronically for review purpose but nine were opted for the meta-analysis. They include seven quantitative method studies and two mixed method studies. The study revealed that, there is prevalence of examination malpractices particularly in some parts of Asian and African continents but cautions should be adhere to by researchers and elites in their attempts to generalize this finding. Moreover, study revealed key players, forms/methods, causes and effects or factors that influence examination malpractices, measures to check the malpractices as well as the association between examination malpractices and learners� academic work and corruption and suggested that a generalization could be made in connection to them. Based on the identified findings, we recommended that examination bodies, schools, colleges etc should adhere to the measures and solutions put forward by various researchers that are presented in this study and also address the causes identified to foster the act of combating examination malpractices. Lastly, we propose to future researchers to boost their skills and knowledge on research methods in order to halt the existence of the shortfalls identified in this meta-analysis.

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meta-analysis, examination malpractices, academic achievement, education system, learning objectives

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Our Research Objectives are: - 1) To understand the various aspects of male dominance 2) To correlate male dominance and patriarchy to Indian cinema 3) To understand the prevalence of male dominance behind the camera 4) To observe the changes male dominance and patriarchal society has undergone over the decades

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Cinema, Male Dominance, Patriarchy, Misogynist, Society

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Malnutrition, defined as underweight, is a serious public-health problem that has been linked to a substantial increase in the risk of mortality and morbidity. Severe acute malnutrition affects nearly 20 million preschool-age children mostly from the African Region and South-East Asia Region. Severe anaemia is a leading cause of paediatric morbidity, hospitalization, and mortality and also a very important co morbidity in children with severe acute malnutrition. Severe Acute Malnutrition (SAM) with anaemia has 2.62 times higher mortality as compared to SAM with no anaemia. So this study was meant to evaluate this co-morbidity further.

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 Keywords

Anaemia, Malnutrition, Microcytic hypochromic

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Creative Commons Attribution 4.0 and The Open Definition