Volume 12 | Issue 5

 Abstract

Mortality rate of ovarian cancer is highest among all gynaecological malignancies. Excision Repair Cross-Complementation Group1 (ERCC1) enzyme is an important component in Nucleotide Excision Repair (NER) pathway that reflects NER repair activity level. ERCC1 expression levels in human tumor tissues may have a role in clinical resistance to platinum compound. Various studies have examined the prognostic significance of ERCC1 gene in many malignancies. However, rare studies have elucidated its prognostic role in ovarian cancer. Therefore, this study aimed to explore the significance of ERCC1 expression in Epithelial Ovarian Cancer (EOC) patients. This study consists of 54 untreated EOC patients and 23 benign ovarian tumor. Quantitative real time RT-PCR was used to detect the messenger RNA (mRNA) expression levels of ERCC1 in ovarian cancer tissues and their relationships with clinicopathological parameters were analysed. The association of ERCC1 expression with disease free survival (DFS) and overall survival (OS), was investigated by Kaplan Meier survival analysis. Data was statistically analysed by SPSS software. ERCC1 mRNA expression was found to be significantly higher in EOC patients as compared to benign ovarian tumor (P=0.049) and the ROC curve also confirmed its differentiating efficacy between the benign epithelial ovarian diseases and EOC. ERCC1 mRNA expression was not significantly associated with any of the clinicopathological parameters of EOC patients with exception to inflammation and histological grade where, it showed a positive trend of significance with inflammation (P=0.068), indicating an increased ERCC1 mRNA expression with presence of inflammation. However, a trend of higher ERCC1 expression was observed in well differentiated tumors as compared to moderately differentiated tumors (p=0.076) and poorly differentiated tumors (p=0.084), respectively. Moreover, there was no statistically significant correlation of ERCC1 expression with DFS (P=0.390) or OS (P=0.139) of the studied patients. The results of the study reveal that, ERCC1 can be used as a marker for differentiating patients with benign ovarian disease and EOC. However, further investigation in a larger cohort with longer follow up period is required to determine the role of ERCC1 in prognosis and prediction of therapy in EOC patients.

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ERCC1, Epithelial ovarian cancer, ERCC1 mRNA expression

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The purpose of this investigation is thus classify types of rubbish produced by restaurants and hotels, their sources or originators, negative effects on human health and environment, besides current strategies for treating waste materials.

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Waste management, Sustainable development, food waste, Rural India waste generation

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Multilevel inverters have emerged as essential components in modern power electronics systems, offering significant advantages in voltage and waveform quality control for various applications. This paper explores the design, analysis, and implementation of a Multilevel Inverter to address the increasing demand for efficient and flexible power conversion solutions in industries like renewable energy integration, electric transportation, and grid-tied systems. Multilevel inverters are increasingly important in power electronics due to their ability to generate high-quality voltage waveforms with reduced harmonic content. Pulse Width Modulation (PWM) techniques play a pivotal role in controlling multilevel inverters. This paper focuses on the development and evaluation of simplified PWM algorithms tailored to multilevel inverter topologies. The designed PWM algorithms are simulated using MATLAB to assess their performance in terms of voltage quality, harmonic distortion, and switching losses. Comparative analyses with existing PWM techniques are conducted to highlight the advantages of the proposed simplified algorithms.

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Multilevel inverter, Pulse Width Modulation (PWM), Power electronics, Harmonic distortion, Voltage quality, Switching losses.

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The main application of bitumen is in the construction of airport, highway, and road pavements. Because bitumen is viscoelastic, temperature and the pace at which loads are applied have a significant impact on bitumen performance in pavements. The standards for bituminous binders in India are based on many empirical tests that little affect the bituminous binders' performance characteristics. This study aims to investigate the performance characteristics of bituminous binders, which are widely used in India, with respect to their rheological properties at both high and intermediate field temperatures. Variations in temperature, loading rate, and amount have all been examined in relation to the various factors that impact bituminous binders' behavior. It has been researched how the characteristics of bitumen, both unaltered and amended with crumb rubber, have changed in two regularly used grades (80-100 and 60-70). Additionally, research has been done on how age affects bituminous binders' rheological characteristics. It has been noted that the binders employed in this study meet the fatigue and rutting requirements outlined in the revised definition of Superior Performing Asphalt Pavement (super pave). The goal of the study is to comprehend how these characteristics affect bituminous materials' resistance, stability, and durability under various road conditions.

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Bitumen, Rheological Properties, Performance characteristics, Binders

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Creative Commons Attribution 4.0 and The Open Definition

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The rapid advancement of nanotechnology is poised to revolutionize various aspects of food science and the food industry, fueled by substantial investments and expanding market shares. This paper provides a concise overview of the current applications of nanotechnology in food systems. While the integration of nanotechnology in food holds significant promise for enhancing food quality, safety, and nutritional value, it also introduces new challenges due to the unique physicochemical properties of nanomaterials. One major concern revolves around the safety implications associated with the use of nanotechnology in food-related processes. These concerns encompass the entire lifecycle of nanomaterials, including their manufacturing, processing, packaging, and eventual consumption. Addressing these safety concerns is crucial to ensure the responsible and sustainable implementation of nanotechnology in the food industry. Moreover, effective regulatory policies are necessary to establish standards, guidelines, and protocols to safeguard public health and the environment while fostering innovation and economic growth. Active packaging systems utilize nanomaterials to actively interact with the food environment, thereby extending shelf life, enhancing freshness, and preventing spoilage. Intelligent packaging systems, on the other hand, incorporate nanoscale sensors and indicators to monitor food quality and safety in real-time, providing valuable insights to consumers and stakeholders throughout the supply chain.

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Food science, Nanotechnology, Packaging, Safety assessment, Regulatory policies

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This research paper explores the role of Couple Connect Therapy (CCT) in addressing blaming and shaming dynamics within intimate relationships. Blaming and shaming behaviors have been identified as detrimental to relationship satisfaction and stability, yet effective interventions to address these dynamics are needed. Drawing upon theoretical frameworks from couples therapy and empirical research on relationship dynamics, this paper examines the origins, development, and specific techniques used in CCT to shift blaming and shaming patterns.

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Blaming Shaming Couple Therapy Couple Connect Therapy (CCT) Relationship Dynamics Communication Patterns Intervention Strategies Relationship Satisfaction Relationship Stability Empathy Understanding Attachment Theory Emotional Regulation

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The focus of this research work is on social and political impacts on the people of Jammu and Kashmir after the abrogation of article 370 and 35A of the Indian constitution and how for the peace has been restored by introducing political reforms and how far the developmental programmes are getting swiftness after August 5, 2019. The political truth actualized by the Modi led central government, by abrogating the ingredients like article 370 and 35A and the way government architected the state into two union territories-Jammu & Kashmir and Ladakh for bringing stability based on four components-modernity, rule of law, accountability and peace. With changing political scenario new social and political thoughts are emerging under the umbrella of liberal democracy and the people's positive political participation is showing huge improvement.

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Peace, accountability, reorganization act, referendum, Gujjar & Bakarwals, Pahari community, abrogation, decline, positive political participation.

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"To deprive a man of his natural liberty and to deny him the ordinary amenities of his life is worse than starving the body; it is starvation of the soul, the dweller in the body." -Mahatma Gandhi. Personal liberty is fundamental to each indivial, which is protected by Article 21 as an inherent and essential right. 'Anticipatory bail' is a very important element of this basic right even though it is not mentioned specifically in the 1973 Code of Criminal Procedure (CrPC), this clause was created with the intention to prevent unjustified incarceration and upholding the notion that 'someone is innocent until proven guilty', this allows a person to apply forbail even before they are placed under arrest. And because it is a provision that has in the past been absued by those who were accused of grave crimes, it can be said that anticipatory bail developed through many difficulties. The paper wants to explore the origins of anticipatory bail, contradictory verdicts by courts that led it to its current status, and the intended as well as adverse effects of the practice. It aims to give a thorough understanding of anticipatory bail's development and its effects on people's rights and the judicial system.

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Personal Liberty, Anticipatory Bail, Code of Criminal Procedure, Judiciary, Constitutional Rights, Police, Freedom, Accused, Human Rights, Criminal Justice System.

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BIT-Connect redefine the educational landscape by bridging the gap between academic learning and career readiness, fostering skill-based collaboration, and enabling data-driven student progress monitoring. Its innovative platform empowers students to articulate career aspirations, engage in targeted mentorship, and participate in real-time learning experiences. Leveraging advanced technical architecture and rich student skill data, BIT-Connect offers personalized tutor matching and holistic institutional insights, driving superior learning outcomes and institutional effectiveness. With a focus on scalability, performance, and adaptability, BIT-Connect emerge as a transformative force in education technology, poised to revolutionize the way students learn and institutions operate.

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Monolithic, PostgreSQL, Node.js, restful API, Collaboration.

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This comparative study investigates the awareness of intrapersonal skills among prospective teachers, highlighting the significance of these skills for effective teaching and leadership. Intrapersonal intelligence, essential for self-identification and understanding of personal needs and aspirations, fosters a positive internal dialogue, resilience, and appropriate emotional responses. According to Hogan and Warrenfelz's domain model, intrapersonal skills, including adaptability and self-management, are critical for problem-solving and success in changing environments. Adaptability encompasses coping with uncertainty, handling work stress, and interacting with diverse personalities and cultures. Self-management involves autonomous work, selfmonitoring, and continuous self-development. The study compares awareness levels across various demographics, including institution type (private vs. government), discipline (arts vs. science), and gender. Key findings indicate that prospective teachers from private institutions show a higher awareness of intrapersonal skills than government institutions. However, there is no significant difference in the awareness level of prospective teachers in the domains of discipline and gender. The study underscores the importance of fostering intrapersonal skills in teacher education programs to enhance future educators' selfregulation and adaptability, thereby improving their teaching efficacy and leadership potential.

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Intrapersonal skills, self-management, adaptability, resilience, strategic thinking, emotional balance.

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The study identifies the most important water quality parameter and location selection parameter, as well as the suitability index of two sites in Raipur, C.G.: Chandandih WTP and Nimora WTP.Now a days many water resources are polluted by anthropogenic sources including household and agricultural waste and industrial processes. Public concern over the environmental impact of wastewater pollution has increased. several conventional wastewater treatment techniques, i.e. Chem- ical coagulation, adsorption, activated sludge, have been applied to remove the pollution, however there are still some limitations, especially that of high operation costs.Waste water treatment can be defined as a process of removing organic and inorganic matter from the wastewater to make it suitable to be discharged back to the environment. Rainwater entering drains and industrial wastes also appear to fit under this category.

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Index Terms - WTP, Waste water, MCDM, rain water.

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The Goods and Services Tax (GST) implementation in India and a few other countries, such as Australia and the UK, is compared in this research with an emphasis on the pre-and post-COVID periods. Given its significance as a consumption tax mechanism on a worldwide scale, the effectiveness of the Goods and Services Tax (GST) must be thoroughly examined. Using data from five years of GST revenue collection and GDP growth rates, this study compares the performance of GST in India and the selected nations. Furthermore, this research expands its scope to include the pre-covid and post-covid eras, assessing the durability and adaptation of GST structures during the epidemic. Findings provide insights into the efficacy of GST implementation and make recommendations for policy upgrades, expanding the discussion on tax policy and economic resilience.

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Goods and service tax , Pre Covid , Post Covid , Policy upgrades , Tax policy and Economic resilience.

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This research paper delves into the multifaceted exploration of cultural expectations, gender roles, and family dynamics in Anita Desai's literary works, focusing primarily on her novels Clear Light of Day and Fasting, Feasting. Through a meticulous analysis of Desai's narrative techniques and character development, the study seeks to uncover the intricate layers of meaning embedded within these texts, shedding light on the complex interplay between individual aspirations and societal constraints. Drawing upon a range of critical perspectives, including feminist theory, postcolonial studies, and cultural criticism, the paper examines how Desai's portrayal of characters reflects and critiques the prevailing cultural norms and gender roles in Indian society. It explores the ways in which Desai's female protagonists navigate the expectations placed upon them by their families and communities, highlighting the challenges they face in asserting their own identities and desires within the confines of tradition.

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Keywords: Anita Desai, Clear Light of Day, Fasting, Feasting, cultural expectations, gender roles, family dynamics, Indian society

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This research paper delves into the multifaceted landscape of business disputes, examining their origins, manifestations, and the array of resolution methods available. Business disputes, inherent to commercial interactions, encompass diverse issues ranging from contractual breaches to intellectual property conflicts, often posing significant challenges to organizational stability and growth. Understanding the dynamics of these disputes is crucial for businesses to mitigate risks and maintain sustainable operations. The paper begins by delineating the various types and causes of business disputes, emphasizing the role of miscommunication, divergent interests, and changing market conditions in their emergence. Through empirical analysis and case studies, it illustrates the pervasive nature of these disputes across industries and organizational scales, highlighting their detrimental impacts on profitability, reputation, and stakeholder relationships. Subsequently, the paper explores the spectrum of resolution methods available to address business disputes, categorizing them into traditional and alternative approaches. Traditional methods, such as litigation and arbitration, offer formalized procedures governed by legal frameworks, while alternative methods, including negotiation, mediation, and collaborative problem-solving, emphasize flexibility, confidentiality, and party autonomy. Drawing on comparative analyses and theoretical frameworks, the paper elucidates the strengths, limitations, and suitability of each method in different dispute contexts. Furthermore, the research scrutinizes the factors influencing the choice of resolution methods by businesses, including legal considerations, cost-benefit analyses, and strategic objectives. It elucidates the evolving landscape of dispute resolution, characterized by increasing preference for alternative methods driven by efficiency imperatives, stakeholder expectations, and changing regulatory environments. In conclusion, the paper underscores the imperative for businesses to adopt proactive strategies for managing and resolving disputes, emphasizing the value of early intervention, tailored approaches, and interdisciplinary collaboration. By leveraging a nuanced understanding of dispute dynamics and selecting appropriate resolution methods, businesses can mitigate risks, enhance organizational resilience, and foster sustainable growth in an increasingly complex and interconnected business environment.

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Spectrum ,emphasizes flexibility, confidentiality, leveraging, stakeholder

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Here the project introduces an AI-driven framework to combat predatory publishing, a major threat to scientific literature's credibility. Traditional manual methods are inefficient, prompting the development of an automated system using machine learning. The framework, trained on a dataset of predatory and legitimate journals, evaluated seven models, with the CNN model emerging as the most effective. While CNN offers high accuracy, it demands substantial computational resources. To address this, the project optimized the Random Forest algorithm, maintaining the CNN's accuracy but with reduced computational intensity. This innovative approach streamlines the detection of predatory practices, bolstering the trustworthiness of scholarly publishing.

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Predatory,Publishing,CNN

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An online voting system integrating facial recognition enhances voting security and accuracy. It verifies voters' identities, restricting participation to eligible individuals, and eliminates the need for physical polling stations, enhancing accessibility and reducing costs. The system features authentication of voter identities, secure vote storage, and fraud prevention. Object detection employs Haar feature-based cascade classifiers and Local Binary Pattern (LBP). The server cross-references data with the database, granting voting permission upon matching and notifying in case of discrepancies. In Conclusion, this system has the potential to revolutionize elections by increasing efficiency, security, and accessibility.

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Face Recognition, Haar Cascade, LBPH, User Authentication.

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The Indian judiciary plays a pivotal role in resolving business disputes, shaping the contours of commercial law, and fostering a conducive environment for economic growth. This paper offers a critical analysis of the multifaceted involvement of the Indian judiciary in adjudicating business disputes, exploring its efficacy, challenges, and impact on the business landscape. Drawing from an interdisciplinary approach, the research examines the historical evolution of commercial jurisprudence in India and evaluates the judiciary's response to the complexities arising from globalization, technological advancements, and changing business paradigms. It delves into landmark judgments, judicial trends, and legal frameworks to assess the judiciary's adaptability and effectiveness in addressing diverse business disputes ranging from contractual breaches to corporate governance issues. Furthermore, the paper scrutinizes the procedural mechanisms, judicial activism, and institutional frameworks governing commercial litigation in India. It probes into the efficiency of dispute resolution mechanisms such as arbitration, mediation, and specialized commercial courts in alleviating the burden on the judiciary and expediting the resolution of business disputes. Moreover, the research critically analyzes the challenges confronting the Indian judiciary in adjudicating business disputes, including judicial backlog, procedural delays, lack of specialized expertise, and the interface between law and business dynamics. It explores the implications of judicial decisions on investor confidence, contractual sanctity, and the overall ease of doing business in India. Additionally, the paper examines the role of alternative dispute resolution mechanisms in supplementing the adjudicatory functions of the judiciary and fostering a culture of consensual dispute resolution in the business realm. It underscores the importance of judicial reforms, capacity-building initiatives, and technological interventions to enhance the efficacy and accessibility of commercial justice delivery. In conclusion, the research underscores the indispensable role of the Indian judiciary in fostering a conducive business environment by providing timely, impartial, and effective resolution of disputes. It advocates for a nuanced understanding of the challenges and opportunities inherent in the judiciary's involvement in business disputes, with a view towards promoting transparency, efficiency, and investor confidence in India's commercial jurisprudence.

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Judiciary, fostering, contractual sancity ,procedure mechanism, business

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The dentistry field, with its complicated architecture and specialized tissues, poses unique problems that can benefit substantially from the accuracy and personalization provided by 3D bioprinting. The mouth is not only a functional element for mastication and speaking; it also has an important role in aesthetics and general health. It is critical to ensure that the repair or replacement of dental components satisfies both functional and cosmetic standards.The potential of 3D printing to generate extremely precise and individualized dental prostheses in a shorter period has fueled its growth in prosthodontics. Dental prostheses are currently made from a variety of materials, including resin-based materials, metal alloys, and ceramics, utilizing 3D printing technology. Prosthodontics can benefit greatly from the use of 3D printing materials because to their increased precision and customisation, increased time and cost efficiency, and better aesthetic results.This article presents an overview of the impact of some of 3D printing materials in surgical procedures prior to prosthetic rehabilitation.

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Preprosthetic Surgery, Bioprinting, Scaffolds

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The project introduces a health monitoring system that uses Arduino technology and leverages the Internet of Things (IoT). This system aims to measure key health parameters like heart rate, blood oxygen level, and body temperature. IoT enables smart devices to connect to the internet seamlessly. In health monitoring, IoT encourages the development of systems using sensors worn either inside or outside the body. These sensors collect physical and logical data, as well as patient movements, offering comprehensive insights into health conditions. The system integrates sensors such as LM35 and Pulse Oximeter & Heart Rate Sensor, connected to an Arduino UNO board and ESP8266 for wireless data transmission to Thing Speak. This setup allows continuous monitoring and recording of health parameters, promoting proactive health management. Additionally, the system employs a 7-segment display to indicate the number of drug tablets and the type of vitamin in a tablet-bottling assembly line. Logic expressions, circuitry, and VHDL code are used to display the tablet count (0 - 9) and the corresponding vitamin type (Vitamin A, B, C, D, E) via a BBC micro bit microcontroller. This feature provides visual cues for the production stage/phase, with potential applications in various industrial settings. Overall, the proposed health monitoring system offers a promising solution for personalized and real-time health monitoring, promoting proactive healthcare management while enhancing industrial monitoring capabilities.

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Keywords: IOT, Health Monitoring, Heart Rate, Body Temperature, ARDUINO, Thing Speak

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As is clear from the name itself, revolutionaries are a group of people who are full of national love and patriotism, who are ready to sacrifice their body, mind and wealth for the country without worrying about their lives. Those who are capable of overcoming the obstacles coming in their way without any fear, whose strength and unity are their weapons, for whom nothing else matters more than country and freedom. It is true to call such brave men revolutionaries. that would be very appropriate.

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Patriotism, Sacrifice, Struggle, National unity, Self-confidence, Socialism etc.

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Creative Commons Attribution 4.0 and The Open Definition