Volume 12 | Issue 12

 Abstract

As the business environment becomes increasingly competitive, organizations are compelled to maximize their capabilities. Ultimately, the success of these companies hinges on their human resources and effective business and marketing strategies, which are essential for gaining visibility in global markets. Consequently, network marketing has emerged as a widely adopted method to enhance the performance of both small and large logistics companies. Multi-level marketing is a strategy that encourages participants to promote a specific product within their social circles. The growing popularity of this approach can be attributed to the accessibility of modern social networks; however, it has existed in various forms long before the advent of the Internet, with the notorious pyramid scheme being a notable example of multi-level marketing that has been around for at least a century. The India Direct Selling Association (IDSA) has estimated that the network marketing industry will reach approximately Rs 9000 crores by the end of 2013. This paper aims to provide a deeper understanding of how network marketing serves as a marketing strategy and tool for the development of logistics companies in the new millennium. The objective is to explore the roots of localized practices within the context of rapidly evolving globalization, thereby facilitating a pathway toward broader global integration.

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 Keywords

Network Marketing, Logistic, Globalization, Customers, Mechanism.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract: Monkeypox (mpox) is a zoonotic disease belonging to the Orthopoxvirus genus, usually transmitted through physical contact, respiratory fluids, and contaminated objects. This disease has become a global focus of attention due to its increasing prevalence since 2022. It is difficult to completely eliminate. In the secondary stage, direct contact with the virus, respiratory diseases, and sometimes sexual intercourse through person-to-person transmission become the primary route. The main problems include poor protection, direct contact with infected people or equipment, and animal interactions such as hunting or feeding animals. Diagnosis is based on genetic, clinical, and immunologic factors, and treatment is limited to antiviral drugs such as Tecovirimat, cidofovir, and immunoglobulin.

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Mpox virus, Transmission Pattern, Risk Factor, Prevention, Symptoms

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 Abstract

Recent advancements in skin absorption mechanisms and transdermal drug delivery have significantly enhanced the effectiveness of therapeutic treatments. The integration of 3D printing technologies into this field has opened new possibilities for personalized, precise, and controlled drug administration. 3D printing allows for the fabrication of custom drug delivery systems, such as patches or microneedles, that can be tailored to individual patient needs. These systems can improve skin absorption by optimizing the design and delivery rate of active ingredients through the stratum corneum. Moreover, innovations in material science and the ability to print bioactive compounds directly onto skin-adhering substrates have accelerated the development of transdermal delivery devices that bypass the first-pass metabolism, ensuring higher bioavailability. This review explores the latest advancements in 3D printing for transdermal drug delivery, examining materials used, fabrication techniques, and their implications for enhanced skin absorption. Additionally, the challenges and future prospects of these technologies in clinical applications are discussed, highlighting the potential for 3D-printed systems to revolutionize the way drugs are delivered through the skin.

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 Keywords

Skin Absorption, 3D Printing, Personalized Medicine, Customizable patches.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Piper betel L. (locally known as Paan) is a widely distributed plant in the tropical and subtropical regions, its leaves being largely consumed as a mastication and mouth freshener. Piper Betel Linn. is an evergreen plant recognized for its diverse medicinal properties, including anti-inflammatory, antimicrobial, antifungal, antidiabetic, and anticancer activities. Historically, betel leaf extracts were commonly used in food preparation due to their flavour and aroma. The leaves contain various compounds such as alkaloids, flavonoids, tannins, and saponins, which contribute to these sensory qualities and health benefits.

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 Keywords

Betel leaf, Phytochemistry, pharmacological activity, Applications

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 Abstract

When five or more than five used on regular bases that is defined as polypharmacy, and the interactions/ adverse drug reaction occur by using these multiple medications is defined as drug-drug interactions. This study possess the risk of DDIs are rising because of multimorbidity and age related changes, which can cause organ toxicity, organ failure, and can be a reason for hospitalization. In this study we had found that in India, 25% of the total population are in older age in which 49% have no sign of polypharmacy but other 51% include 26% of men's and 24% of women's which shows high prevalence of polypharmacy. In this study we also go through the strategies to call out the risk associated with polypharmacy and various common drug-drug interaction (DDIs) with clinical implications and geriatric risks.

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Polypharmacy, Drug-drug interactions, Geriatric patients, Adverse drug reactions, Medications, Over the counter (OTC)

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

WeatherAlert is an automated system for delivering essential weather notifications via email, enabling users to stay updated with critical weather information in real-time. Leveraging the Open-Meteo API, WeatherAlert retrieves accurate, up-to-date weather data, including temperature and precipitation forecasts, to monitor potential hazards such as extreme heat and heavy rainfall. Upon detecting weather conditions that surpass defined thresholds--such as temperatures exceeding a safe limit or significant precipitation levels--the system promptly sends email alerts to users. These alerts aim to enhance users' awareness and preparedness by allowing them to take preventive actions as needed. Developed with Python for seamless data retrieval and email automation, WeatherAlert is designed to deliver notifications efficiently and reliably. The system's scheduled automation, managed through Task Scheduler, operates at regular intervals without requiring user input. It is especially suited for applications in both personal and professional contexts, including agriculture, construction, and event management. By enabling timely notifications for significant weather events, WeatherAlert contributes to improved readiness and reduced disruption due to adverse weather conditions.

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weather alert, python, api, weather monitoring, weather monitoring system, weather alert system, automatic, automatic weather alert system

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract;- AI is not just a concept; it's something that's actively shaping the way we stay. It helps us choose movies to look at, improves how doctors stumble on sicknesses or even performs a function in solving big problems like weather alternate. talk approximately the important function it plays, the chances it gives us to improve our lives, and the challenges we need to address as we hold to bring AI into greater components of the world around us. Artificial intelligence (AI), in its broadest sense, is intelligence exhibited by machines, particularly computer systems. It is a field of research in computer science that develops and studies methods and software that enable machines to perceive their environment and use learning and intelligence to take actions that maximize their chances of achieving defined goals. AI is anywhere. It powers voice assistants on our telephones, suggests films or indicates we would like on streaming systems, and facilitates in regions like healthcare, finance, and training. It's all about making existence easier and greater green whether that's supporting us find what we need quicker or making paintings tactics smoother.

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 Keywords

ARTIFICIAL INTELIGENCE, COMPUTER SYSTEMS, CYBER SECURITY, ROBOTS, LANGUAGES, LABOURS, SOFTWARE, NEW THOUGHTS

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This research critically analyses the impact of the International Coffee Organization (ICO) initiatives on women labor empowerment in coffee plantations. It examines how the ICO's programs and policies have influenced women's roles, access to resources, and participation in decision-making processes within the coffee sector. The study highlights both the successes and challenges of these initiatives, providing insights into the effectiveness of gender-focused interventions in promoting sustainable development and gender equality in the coffee industry. The International Coffee Organization (ICO) has implemented various initiatives aimed at promoting sustainable coffee production and improving the livelihoods of coffee farmers and laborers. There are still significant challenges to be addressed, including limited access to education and training, and persistent gender-based discrimination. The International Coffee Organization (ICO) plays a crucial role in promoting women's empowerment in coffee plantations worldwide.

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International Coffee Organization (ICO), Women Empowerment, Coffee Plantations, Gender Equality, Labor Rights

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract Political advertisements play a crucial role in shaping voter perceptions, preferences, and decisions in democratic elections. This study explores the impact of political advertisements on voter behavior, focusing on the interplay between emotional, rational, and psychological appeals across various media platforms, including print, television, and digital media. Drawing on theories such as agenda-setting and the elaboration likelihood model, this research investigates how the design and dissemination of political advertisements influence voters' attitudes and choices. The study employs a mixed-methods approach, combining surveys, interviews, and content analysis to assess the effectiveness of political advertisements in different demographic and socio-economic segments. Preliminary findings suggest that emotional appeals, such as fear and hope, have a more significant impact on voter behavior than rational arguments. Additionally, digital platforms are emerging as a dominant medium, particularly among younger voters, due to their targeted and interactive nature. This paper contributes to the understanding of voter psychology in the context of political marketing and offers strategic insights for political campaigners to design impactful advertisements. It also highlights the ethical considerations and challenges posed by manipulative advertising practices, emphasizing the need for regulatory oversight.

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Impact , Political Advertisement ,Voter Behaviour:

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Alopecia, a condition characterized by hair loss, affects millions of people worldwide and can have significant physical and emotional consequences. This paper explores various treatments for alopecia, focusing on both their effectiveness and the potential side effects associated with each. Current treatment options include topical solutions such as minoxidil, oral medications like finasteride, and corticosteroid injections, which aim to reduce hair loss or promote regrowth. While these treatments are widely used, they are not without risks, including scalp irritation, hormonal changes, and long-term dependency. The paper also discusses the side effects that can arise from these treatments. While traditional options like minoxidil may cause irritation or unwanted hair growth in other areas, newer treatments like Janus Kinase (JAK) inhibitors carry risks of immune suppression. Personalized treatment approaches are crucial, as different individuals respond differently to each therapy, and side effects can vary significantly. The research highlights the need for continued exploration of safer and more effective therapies for alopecia. Although advancements in medical science offer hope for better treatments, managing side effects remains a critical aspect of improving patient outcomes. This paper aims to provide a comprehensive overview of current and future treatments for alopecia, emphasizing the importance of balancing treatment effectiveness with the minimization of side effects. In addition to these established therapies, newer approaches like platelet-rich plasma (PRP) therapy, and stem cell treatments are gaining attention for their potential to offer more effective solutions. PRP involves using the patient's own blood to stimulate hair growth, while JAK inhibitors target autoimmune pathways responsible for certain types of alopecia. Stem cell therapies are being explored for their regenerative properties, with the potential to repair damaged hair follicles. However, these emerging treatments are still in development stages and require further clinical trials to fully understand their effectiveness and safety.

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 Keywords

Alopecia, Types of Alopecia, Hair loss Treatments, Hair Transplantation, minoxidil, finasteride, Platelet-Rich plasma, Immunotherapy, Stem cell therapy.

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Bankim Chandra Chatterjee's Anandmath (1882), a significant literary work of 19th-century Bengali literature, is often regarded as a crucial text in the intellectual and cultural development of modern India. The novel is set against the backdrop of the 1770s, during the time of the British colonial rule in India. It portrays the emergence of a nationalist movement and reflects the socio-political landscape of India under British oppression. This paper explores the politics of identity in Anandmath, focusing on the construction of Hindu identity and its role in the Indian struggle for independence. By examining themes such as religious identity, cultural nationalism, and the role of myth, the paper argues that Chatterjee's work played a pivotal role in shaping the political discourse around identity in the Indian independence movement.

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Hindu Nationalism, Cultural Identity, Indian Independence, Anandmath

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E-commerce is one of the top growing businesses in India and provides a great market potential for investments, foreign investors are funding e-commerce sector. The rise of mobile technology has led to a significant shift in consumer behaviour from eCommerce to M-Commerce. This shift has had a significant impact on businesses, as they must adapt their strategies to meet the changing needs and expectations of consumers. The study concludes that this article may help the stakeholders of the industry to see the opportunities and future trends available to them. This paper also makes them aware of threats in using this system so that an ecosystem can be developed that will be less risky and more beneficial to its users

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Key words: e-Commerce, m-commerce, smartphones, e-tailors, information, technology, digital, internet, strengths, weakness, opportunity, threats

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Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catalytic reactions, which spans various methodologies, each contributing to the broader landscape of the enantioselective synthesis of chiral molecules. Transition metals play a central role as catalysts for a wide range of transformations with chiral ligands such as phosphines, N-heterocyclic carbenes (NHCs), etc., facilitating the formation of chiral C-C and C-X bonds, enabling precise control over stereochemistry. Enantioselective photocatalytic reactions leverage the power of light as a driving force for the synthesis of chiral molecules. Asymmetric electrocatalysis has emerged as a sustainable approach, being both atom-efficient and environmentally friendly, while offering a versatile toolkit for enantioselective reductions and oxidations. Biocatalysis relies on nature's most efficient catalysts, i.e., enzymes, to provide exquisite selectivity, as well as a high tolerance for diverse functional groups under mild conditions. Thus, enzymatic optical resolution, kinetic resolution and dynamic kinetic resolution have revolutionized the production of enantiopure compounds. Enantioselective organocatalysis uses metal-free organocatalysts, consisting of modular chiral phosphorus, sulfur and nitrogen components, facilitating remarkably efficient and diverse enantioselective transformations. Additionally, unlocking traditionally unreactive C-H bonds through selective functionalization has expanded the arsenal of catalytic asymmetric synthesis, enabling the efficient and atom-economical construction of enantiopure chiral molecules. Incorporating flow chemistry into asymmetric catalysis has been transformative, as continuous flow systems provide precise control over reaction conditions, enhancing the efficiency and facilitating optimization. Researchers are increasingly adopting hybrid approaches that combine multiple strategies synergistically to tackle complex synthetic challenges. This convergence holds great promise, propelling the field of asymmetric catalysis forward and facilitating the efficient construction of complex molecules in enantiopure form. As these methodologies evolve and complement one another, they push the boundaries of what can be accomplished in catalytic asymmetric synthesis, leading to the discovery of novel, highly selective transformations which may lead to groundbreaking applications across various industries

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asymmetric catalytic synthesis, asymmetric organocatalysis, asymmetric photocatalysis, asymmetric electrocatalysis, biocatalysis, C-H activation, flow chemistry

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This research paper examines the complex interplay between Herman Melville's sharp critique of anthropocentric ideologies and his palatable advocacy for post-humanist perspectives in Moby Dick. Anthropocentrism is chiefly a worldview that places humans at the center of existence, asserting human dominance and hubris over nature and other non-human entities. Per contra, posthumanism reinforces the interconnectivity and equity of all living beings, which dismisses human exceptionalism. Rather than leaving his work any simpler, Melville has significantly blended these aspects, making Moby-Dick a more rigorous fiction that confronts the anthropocentric mindset of his time--an era that witnessed the rise of modernity--while still remaining relevant to contemporary human-nature conundrum. Through an eco-critical analysis of the novel's plot and its dynamic characters, this paper will reinterpret Moby Dick as an early post-humanist manifesto, urging for a strong re-evaluation of humanity's place in this vast world.

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Anthropocentrism, posthumanism, interconnectivity, eco-criticism, nature, modernity

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The demand for robust live-streaming platforms has surged with advancements in communication and multimedia technologies. This paper introduces Spectra, a comprehensive live-streaming solution, leveraging cutting-edge technologies such as RTMP(Real-Time Messaging Protocol) and WHIP(WebRTC HTTP Ingestion Protocol) protocols for seamless video ingestion, WebSockets for real-time interactivity, and a dynamic, feature-rich interface designed with Next.js and WebRTC. Key functionalities include real-time chat, user authentication with Clerk, streamer dashboards, community engagement tools, and recommendations powered by server-side rendering (SSR). The application integrates PostgreSQL for reliable data storage and Prisma ORM(Object-Relational Mapping) for optimized database queries. Deployment flexibility ensures scalability and performance. By combining state-of-the-art technologies, Spectra delivers a user-friendly platform that caters to broadcasters and audiences alike.

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Live streaming, RTMP, WHIP, WebRTC, WebSockets, Next.js, React.js Clerk authentication, PostgreSQL, Prisma, Server-Side Rendering (SSR).

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The floating drug delivery system or hydrodynamically balanced systems are among the several approaches that have been made developed in order to increase the gastric transit time of drug. The microspheres are characteristically free flowing powders consisting of natural or synthetic polymers and ideally having a particle size less than 200?m. Microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for the controlled release of drug.1 Microspheres are one of the multiarticulate delivery system and are prepared to obtain controlled the drug release from the dosage form to improve bioavailability, reduces the adverse action and prolong the action of drug, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. It is needed to formulate in long-acting dosage form, reaching to effective biological site rapidly.2,3 Famotidine is H2 receptor antagonist which is used for ulcers thus by formulating it in the form of floating microspheres it will not only show targeted action but also shows sustainability and reduced dosing interval. Thus, by formulating it as a floating microsphere the targeted action can be achieved. Famotidine is formulated as floating microspheres by Solvent evaporation method is the preparation technique that is widely preferred for the preparation of controlled release microspheres. To prepare emulsion by adding the dispersed phase consisting of drug, polymer and appropriate dispersion agent in organic solvent to dispersion medium which is immiscible with the dispersed phase and Mini matrix forms are obtained by removing the solvent used at the dispersed phase from the droplets which are formed in the emulsion5, 6.The obtained microspheres of famotidine were subjected to various analytical techniques like Particle size analysis, SEM analysis, invitro dissolution studies and stability studies.

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Famotidine, Floating microspheres, Solvent evaporation technique, Stability Studies

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Creative Commons Attribution 4.0 and The Open Definition

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Empowerment of women is said to be a day dream unless there is proper opportunity for their education. A society can achieve holistic development only when education is equally accessible to both men and women. Higher Education helps the women not only in gaining knowledge but also enables her to earn a living. Money is a necessity in maintaining life and education helps in preserving life. An educated woman plays an important role in a family, dealing with both health care and financial support to the family. As primary caregivers, educated mothers said to have significant impact on children development, nurturing educated families that contribute to societal progress. The paper highlights how women's participation in academia not only enhances their personal growth but also encourages collective upliftment within communities. This study explores the critical role of women in higher education within Barak Valley region of Assam, their presence in academia which tend to reveal the link they have particularly in improving livelihood and social transformation in general.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Women academia, higher education, Society, Barak Valley, Assam

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Creative Commons Attribution 4.0 and The Open Definition

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This days more trained in herbalism and herbal cosmetic it well liked by people world wide. Hair is a simple structure light in weight and delicate part of body it easily go to damage condition. Nowdays, people put back use of herbal cosmetics rather than the chemical treatment. Herb gives better result to make damage and dandruff free hair. Thus, create a herbal antidandruff hair mask it's a good for hair and hair problems. Totally chemical free formulation gift with extreme outcome use of herbal antidandruff hair mask gives assistance to darken and strengthen hair also obstruct the frizzy and damage hair. It also eliminate debris and dandruff this mask prevent many hair problem such as itching, chronic scalp infection, premature greying, increase scalp health as well as recent damage of the hair. Applications of herbal hair mask raise the hair healthy, glossy, hydrate, bouncy, and nourish. Herbal antidandruff hair mass is very affordable to people who look for more natural and lighter hair care product rather than the chemical spa. In composition of the mask many ancient Ayurvedic herbs used which provide the various favourable advantages to hair.

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Antidandruff, healthy hair, herbal, glossy, hydrate, advantages, hair problems, dandruff.

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Creative Commons Attribution 4.0 and The Open Definition

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This paper presents a deep learning approach to detect and classify brain tumors using Convolutional Neural Networks (CNN). The study leverages brain MRI scans, a non-invasive imaging technique, to detect abnormalities in the brain, which may indicate the presence of a tumor. A CNN-based model is proposed to automatically classify brain images into categories such as glioma, meningioma, and no tumor. Experimental results demonstrate that the proposed CNN model achieves a high classification accuracy, outperforming traditional methods. This approach significantly reduces the need for manual analysis, providing faster and more reliable results for early diagnosis.

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Creative Commons Attribution 4.0 and The Open Definition

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Tumor,bizarre cells, Magnetic Resonance Image

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This paper demonstrates building a feature-packed content generator using the MERN stack, highlighting its interactivity, scalability, and potential for future enhancements like user login and third-party tools.

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Creative Commons Attribution 4.0 and The Open Definition

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MongoDB, Express, React, and Node.js, Node.js, Express, Tailwind css/ Tanstack query, Optional authentication, rich text editor, responsive design

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Creative Commons Attribution 4.0 and The Open Definition