Volume 12 | Issue 1

 Abstract

Abstract: Around the world, the number of cases of diabetes has been rising rapidly in recent decades, and one of the most exciting fields of research is the search for small chemicals with strong anti-diabetic properties. Diabetes mellitus (DM) is a chronic metabolic condition characterized by an increase in blood glucose levels due to an imbalance in glucose homeostasis [1, 2]. Two relatively prevalent risk factors that contribute to both neurological diseases and cardiovascular disease are type 2 diabetes and hypertension [3]. With decades of history and potential for growth, heterocyclic chemistry has dominated the field and is essential to the synthesis of new medications. Among the heterocycles, triazoles and coumarins received the most attention due to their significant biological activity and natural occurrence. Coumarins are prepared via Pechmann condensation, catalytic annulation phenolic acetates with acrylates [4], ZnBr2 catalyzed reaction of salicylaldehyde with ynamides [5], Amberlyst-15 catalyzed reaction of 1,3-dihydroXybenzene and ethyl acetoacetate under micro- wave irradiation in a solvent free conditions [6] etc. Naturally occurring coumarins in the glycoside forms are useful in medicine [7], and coumarins shows antimicrobial [8], anti-HIV [9], radical scavenging [10], and anti-viral [11] properties.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

AMTCC, Fluorescence quenching, Diffusion Coefficient, Activation Energy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

??????? ??? ?? ?????? ?? ?????????? ???? ???? ????? ?? ???? ?? ???? ???? ??? ???? ?????? ??? ???????? ?????? ????? ???? ?????? ?? ??? ?? ?? ??? ???? ?? ?? ?????? ??????? ????? ?????? ?? ?????? ????? ???? ??? ?????? ?? ?

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

WOMEN EDUCATION

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This research paper attempts to explore the idea of tradition and modernity found in Dalit autobiography through the text of Y.B. Satyanarayana's 'My Father Baliah'. It delves deep into the strength of Dalits which helped them to resist the affixed order maintained by the mainstream. The element of modernity stands responsible for the growth of untouchables with the aid of education, job opportunities, gender equality and social inclusion in the society. With the advent of Britishers, modernity became focal point for development of excluded section of Indian society. The aim of the paper is to locate rising stature of the outcaste with the weapon of modernity over the obsolete tradition. It interrogates the way through which Dalits overcome the stringent regulations set by caste-dominated people. Gradually, the space of the desire is caricatured by the serious actions taken towards the upliftment of one particular section through railway jobs. By following the textual analysis, the objective is to reflect the potency of modernity behind the pinnacle of success.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Modernity, Dalit, Tradition, Conflict and Education

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Bioavailability can be enhanced , drug toxicity can be minimised, release of drug in a controlled manner can be achieved by preparing nanosponges. Nanosponges entrap both hydrophilic and lipophilic drug substances. Mirtazapine is an antidepressant drug. Mirtazapine entrapped nanosponges are prepared by Emulsion solvent diffusion method using Eudragit E-100 , PVA as polymers and dichloromethane as a solvent.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Mirtazapine, PVA, Depression ,hydrophobicity, entrapment.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

With the advancement of science and technology, the pharmaceutical industries have flourished drastically in recent years. However, the domain of pharmaceutical waste management is not in check and hence the improper disposal of pharmaceutical waste like dumping, burning, flushing, land filling has led to harmful impact in the environment like air and water pollution, change in aquatic ecosystem, destruction of flora and fauna, genetic changes, antimicrobial resistance, etc. The idea of reusing dispensed medicines is appealing to the general public provided its benefits are illustrated, its risks minimized, and the logistics resolved. For example, medicine reuse could help reduce medicinal waste, protect the environment and improve public health. A literature survey is undertaken to lay down the groundwork for implementing technologies on and around pharmaceutical packaging in order to meet stakeholders' previously expressed misgivings about medicine reuse ('stakeholder requirements'), and propose a novel ecosystem for, in effect, reusing returned medicines

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords: Reuse of medicines; reduce medicinal waste; intelligent pharmaceutical packaging; medicine re-dispensing; theory of planned behavior

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Cancer continues to be a global health challenge, necessitating the search for effective and accessible treatment options. In this context, traditional medicinal plants have garnered significant attention due to their potential therapeutic properties. As the environment play humongous role in the genetic makeover of an individual be it be flora or fauna. Within same species of plants a specific phytochemical can be present or absent which is different in different region of the world. In the same manner drugs originated from the people's native area where they are living will suit them better as compare to those originated from elsewhere. In future, medication will not be provided just randomly that single medicine for a particular disorder for whole population but personalized medications will be provided which will suit only that particular individual having that particular genome. The present abstract focuses on the pharmacological evaluation and anticancer potential of four prominent plant species native to Northern India: Hibiscus rosa sinensis, Withania somnifera, Mentha piperita, and Murraya koenigii. Hence these kind of study and collection of data is crucial in order to bring novel drugs into the market (drug discovery and development).The selected medicinal plants from Northern Indiaexhibit promising pharmacological profiles with notable anticancer properties. While further research, including clinical trials, is essential to validate their efficacy and safety in human subjects, these plants hold significant promise as potential sources of novel anticancer agents and supportive therapies. The exploration of traditional medicinal knowledge alongside modern scientific techniques presents a valuable avenue for advancing cancer treatment strategies.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Plant extraction, Phytochemicals, UV-VIS spectrophotometer, TLC, Phytochemical screening, Pharmacological activities, Antioxidant activity.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Single case study illustrated with Ayurveda therapeutic intervention of Male secondary infertility. 38 years old male patient was suffering with unable to have a child since 14-16 months associated with Lumbar pain (Kati Shool), Irregular & hard stools (Mala Vibandh) & General debility (Daurbalya) since 6 months. Case was diagnosed as Rasa Pradoshaj Klaibya resulting from injudicious use of food items, based on etiological sign and symptoms. Treatment is given accordingly, with Langhan, Pachan, Anuloman drugs orally in first stage and Balya, Bruhan & Vrishya drugs in second stage. Medicines used were Vaishwanar, Erand Bhrisht Haritaki, Shilapravang, all in tablet form & Dashmool Kwath in 2 different combinations. No any external management done for Kati Shool. After the treatment of 45 days, patient not only got relief in all of his complaints and also UPT of his wife came positive. His semen analysis report showed changes as Total motile sperm increased from 3% to 52%, Progressive motile sperm (million/ml) increased from 0.1 M/ml to 24.96 M/ml and Sperm vitality live sperm goes 71%, which earlier was 35% only.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Secondary Male infertility, Rasa Pradoshaj Klaibya, Shukra Kshay, Vrishya, Vata pacification Chikitsa

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Micro, small, and medium-sized enterprises (MSMEs) contribute significantly to the nation's economic development by creating jobs, offering entrepreneurial possibilities, providing technical support, and offering skill-based training. Small businesses do, in fact, help to reduce poverty. The MSME sector makes up about 29% of the GDP of the nation. With government assistance, women from both urban and rural areas are pursuing business development initiatives. The study aimed to assess the opinions of women entrepreneurs about entrepreneurship and detect trends in women's participation in funding schemes for micro-enterprise development. The program was first introduced in October 2000, and on September 29, 2005, it was amended with a 15% capital subsidy (compared to 12% before 2005) on institutional financing that they can use to introduce well-established and enhanced technology into approved subsectors and products, the revamped program seeks to facilitate micro and small enterprises' technology upgrades.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Micro, MSMEs, women entrepreneurs, program, capital subsidy, small enterprises, schemes

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Anomaly detection is a critical task with applications spanning various domains, including manufacturing, healthcare, and security and surveillance. This study introduces a comprehensive deep learning-based anomaly detection framework for video data using PyTorch. The architecture, built upon the "FNN" (Feedforward Neural Network) is "AnomalyDetectNet", employs multiple layers for feature extraction and classification, incorporating innovative techniques like Multiple Instance Learning (MIL) and the hyperbolic tangent (tanh) activation function to distinguish between regular and anomalous data effectively. Evaluation of benchmark datasets, particularly the UCF-Crime dataset, through metrics like the Area Under the Receiver Operating Characteristic Curve (AUC-ROC), demonstrates the model's proficiency in anomaly detection. Comparative analysis against a baseline approach reveals notable improvements, with our "AnomalyDetectNet" model achieving an accuracy of 84.84%, surpassing the baseline's 84.30%. This work contributes a potent tool for real-world applications in surveillance, security, and anomaly detection across diverse scenarios, advancing the field of anomaly detection research.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Feedforward neural network (FNN), Multiple instance learning (MIL), AnomalyDetectNet, hyperbolic tangent (tanh).

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This research proposes a comprehensive three-phase grid integration system incorporating solar energy through a bidirectional buck-boost converter topology. The photovoltaic (PV) array output undergoes a boosting process via the bidirectional DC-DC converter, with control facilitated by the Maximum Power Point Tracking (MPPT) technique for optimal power extraction. The grid and PV array operate in parallel, ensuring a continuous power supply to electric vehicle (EV) batteries. The study advocates for utilizing EV batteries as energy storage units in microgrids, employing Grid-To-Vehicle (G2V) and Vehicle-To-Grid (V2G) strategies to manage energy surplus and deficit. The paper underscores the importance of establishing infrastructure and control mechanisms for effective implementation. The research delineates the architecture of EV battery charging within a V2G-G2V system on a microgrid, demonstrating power transfer through simulation. Test results reveal that EV batteries actively regulate microgrid power dynamics using G2V-V2G operating modes. The proposed controller exhibits enhanced dynamic performance in terms of DC bus voltage stability, and the charging station design mitigates harmonic distortion in grid-injected current.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Optimal charging scheduling, vehicle to grid, grid to the vehicle, bidirectional dc-dc converter, MPPT technique, Solar plugin hybrid electric vehicle, Batteries, Charge controller, HEV, Bi-directional DC convertor), DC Grids, Digital charging test bed, Plug-in electric vehicle, Photo voltaic cell control, Smart grid, Magnetic resonance, Power system of vehicle, Fuel cell vehicle, Internal combustion engine vehicle.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The purpose of this study is to investigate the impact of diverse top management teams (TMTs) on corporate performance and innovation in Indian enterprises. Using regression analysis on data from 10 publicly traded Indian firms, The study reveals a discernible link between a diverse TMT--spanning nationality, educational backgrounds, age, and boardroom experience--and amplified firm performance alongside heightened innovation within Indian enterprises. Notably, while the study focuses on data from India, its ramifications are global. The found association between TMT diversity and improved firm performance highlights the findings' potential relevance beyond the Indian corporate scene. The implications are relevant not only for businesses but also for policymakers and stakeholders seeking strategic guidance in fostering diverse leadership for improved outcomes on a broader scale.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Innovation, performance, India, diversity, top management teams

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Education plays the most significant role in nation building. India has its unique education system based on its diversified socio-cultural conditions. Education provides the strongest pillar to any nation's progress. To excel in each domain like social, economic, technological dimensions India needed a major change in its education system as per the need of 21st century which could ensure holistic development of its citizen and promote national development. For that a well-planned set of ideas and strategies in form of a policy was much needed. A well-defined, structured, time-appropriate, and futuristic education policy can cater to development in school education, higher education, and vocational education which will lead to national development by boosting economic and social progress. Indian Government implemented a new education policy for the next decade of the 21st century named the National Education Policy (NEP-2020). NEP-2020 started with the innovative and futuristic vision to provide quality inclusive and equitable education from pre-school to higher education with an expectation of holistic development, and a multidisciplinary, technology and research-oriented approach.This paper initially depicts an overview of NEP 2020, the paradigm shift of the Indian school system, identifying how it is affecting current school system in India. Finally, some recommendations are made to implement the NEP 2020 effectively irrespective of various constraints.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

National Education Policy, Indian School Education system and Impact of NEP 2020

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

?????????? ?????? ???? ???????? ?????????????. ???? ??????? ?? ?????????? ???????? ???????? ???????? ????????????. ??????? ???? ???????? ??????????? ???? ?????????? ??? ???????. ???????, ?????? ??????? ???????? ??????????? ???????; ?? ?????. ?????? ?????????????, ???? ?????????????? ????????????????? ?????????? ???????????? ??????? ???????, ?????????? ?????????? ???????? ??????? ???? ????????????? ???? ??????????? ???????? ??????????????. ????, ????, ????? ???? ?????????? ?????????????? ??????????? ?????????????? ????????? ???????? ??????? ??????????? ??????????????. ????? ????????? ???????? ????????? ?????? ??????????? ???????????? ????? ??????? ???????? ?????????????????. ??????????? ?????????? ??????? ??????????? ?????? ????????? ????????? ???????? ????, ?????? ?????? ???? ?????????????????? ??? ????????????? ????????????? ?????????????. ??????????? ??????????? ???????????? ??????, ??????????, ??????????, ????????? ??????? ????????? ??????????? ?????????? ??????????? ??????????? ???????? ????????? ?????? ?????????????? ??????? ????? ???????????????. ?????? ?????????? ???????????? ??????? ????????? ???? ??????????? ????????? ???????????? ???????????? ??????? ?????????????????. ???? ??????????? ??????? ?????????????? ???????????? ???? ?????????????? ???????? ???????? ????????? ????????? ??????????????.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

???????????, ????????????, ???????? ???????????, ????????? ???????

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Adhatoda vasica (L.) Nees, botanically known as Justicia adhatoda L., is a member of the Acanthaceae family and is regarded as the world's most significant plant. It is found throughout India and the world and is also referred to as Vasaka, Vasica, Adosa, or Malbur nut. It is a widely used herb in the Unani and Ayurvedic medical systems. For more than 2,000 years, this herb has been part of India's traditional medical system. The plant is extremely valuable medicinally and is used to treat a wide range of illnesses, most commonly respiratory conditions such as chronic bronchitis, asthma, TB, and common cold symptoms. The plant is used to make medications in all of its components. The primary chemical component of this plant, which has several therapeutic uses and is incorporated into several Ayurvedic formulas, is vasicine. Additionally, it has a number of pharmacological qualities that have been recorded, including antispasmodic, sedative, expectorant, antitussive, oxytocic, antibacterial, anti-diabetic, wound healing, abortifacient, antiasthma, and anti-pyorrhea effects.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Adhatoda vasica nees, Evalution, Pharmacological Activity, Formulation.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Every individual is unique, having different potential, and it is the responsibility of education to promote, protect, and preserve an individual's unique potential and identity. Unhealthy competition and unnecessary emphasis on scores in exams are killing students' creativity and are giving birth to a banking system of education that has undetectable brain damage. This banking system of education produces such young minds that they cannot think freely; they think in a trained way, having zero creativity. One of the principles on which NEP (2020) is based is creativity and critical thinking, and it aims to produce engaged, productive, and contributing citizens. So, this paper raises four research questions: First, why is the present system of Indian school education a banking system of education? Second, how is the banking system of education affecting creativity? Third, how is creativity related to undetectable brain damage, fourth, what are the necessary steps we immediately need to take to promote creativity and prevent undetectable brain damage? The researcher has gone through various resources to answer all these questions. These questions on education are need of an hour, as schools prepare the next generation.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Key words- Undetectable, Brain-damage, Creativity, Education-system, Productive

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Capital structure is important part of the financial decision-making. It is a conjunction of equity and debt capital. The Pecuniary decision makers of company want to earn maximum return and enhance the wealth firm. So, the financial manager decides an optimum capital structure to achieve the objective of maximum return and wealth. This research work study the pattern and trend of capital structure of NSE listed companies of Indian steel industry. Out of all NSE listed steel companies, the five leading steel companies selected as sample based on Market Capitalization. The financial accounts are the source of the secondary data provided in the sampled company's annual reports covering the ten-year period from 2013-14 to 2022-23. The statistical tools used to analyze the available data are frequency, average, and trend using MS-Excel. The findings reveal that the highest average equity capital was found of the SAIL (Rs. 4130.53 crores) and lowest of the APL Appollo company (Rs. 29.69 crores). Whereas, the highest average debt was found of the JSW steel (Rs. 32972.12 crores) during the study period. The study concludes that which steel company used an appropriate mixture of debt and equity funds in your capital structure that earn a high rate of return.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Capital Structure, Equity, Debt, Pattern, Trend etc.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Bone mineral density (BMD) loss causes osteoporosis, a disease that affects the bones of adults but is most prevalent in postmenopausal women. While X-rays and dual energy X-ray absorptiometry (DEXA) images can both measure bone mineral density (BMD), the focus of this article is on a survey of the use of DEXA images for the diagnosis of osteoporosis in women past menopause. In this study, we take a look at the many methods used to diagnose osteoporosis. Limitations of deep learning for osteoporosis diagnosis in postmenopausal women, including the requirement for big datasets, interpretability of the models, and potential biases in the data, are also highlighted, along with the many approaches applied in BMD. Each set of results is followed by a discussion of their limitations which leads as a suggestion for future study.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Dexa Scan Images, Image Processing, Image Segmentation, ANN

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

?????? ??????? ??? ?????? ?? ????? ??? ?? ???????, ??, ???, ???, ?? ???? ??? ?? ???????? ????? ???? ??? ?????? ?? ??? ??? ?? ?????? ??,?? ??? ?? ?? ???????? ?? ????? ?? ??? ?? ?? ????????? ????? ?????? ?? ??? ???? ????, ?? ??? ?? ?????? ?? ?????????? ?????? ?? ??????? ?? ??? ?? ??? ?????? ?? ??????? ?????? ?? ?????? ???? | ????? ???? ?? ???????? ???? ?? ????????? ?? ?? ??? ????? ?? ???? ??? ??? ?? ?????? ?? ?????? ?? ??? ????? ???????? ??? ?????? ?? ?????????? ??????? ?????? ?? ????? ??? ???? ?? ?? ???? ?? ?????? ??,????? ???? ?? ????? ?? ???? ??? ???? ???????? ?? ??????? ???? ?? ???? ????? ???? ?? ???? ???? ???? ?? ??? ???? ?? ???? ?? ?? ???? ???? ?? ???? ???? ??? ???? ??? ????????, ????? ,??????? ,??????? ,??????? ,?????? ?????, ???????? ?? ????????? ?? ????? ???? ????? ???? ??| ?????? ?? ??? ?????? ?? ?? ?????????? ??????? ?? ??? ??? ????? ??|

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

??? ???? ??? ,??????????, ???????? ,???????

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Transdermal drug delivery system was first introduced more than 20 years ago. Transdermal drug delivery system is a type of convenient drug delivery system where drug goes to the systemic circulation through the protective barrier i.e. skin is the main target of topical and transdermal preparations. Major aim of transdermal drug delivery system is to cross the stratum corneum. Ethosomes are the ethanolic phospholipid vesicles which are used mainly for transdermal delivery of drugs. Ethosomes have gained importance in the area of research, because of their intensified skin permeation, better delivery of drug and increased drug entrapment efficiency. Ethosomes are brand-new lipid vesicular carriers with a reasonably high ethanol content that are used as a transdermal drug delivery system to test the effectiveness of a targeted medication at the site of action. Ethosomes are soft, malleable vesicles composed mainly of phospholipids, ethanol (relatively high concentration) and water. Several approaches have been developed to weaken this skin barrier. One of the approaches for increasing the skin penetration of drugs and many cosmetic chemicals is the use of vesicular systems such as ethosomes. Ethanol is known as an efficient permeation enhancer and has been added in the vesicular systems to prepare elastic nanovesicles. Ethosomal dispersions are added to gels, patches, and creams for ease of use and stability. The ethosomes efficacy in dermal/transdermal administration is evaluated via clinical studies as well as a wide range of in vivo models. The present review focuses mainly on the various aspects of ethosomes including their mechanism of penetration, preparation, composition, characterization, advantages, applications and marketed product of ethosomes.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Transdermal ,Ethosomes , Ethanol, Skin, Penetration, Vesiclar

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Talinum portulacifolium, often known as Fame Flower or Jewels of Opar, has piqued the curiosity of botanical and pharmacological researchers. This review paper attempts to provide a detailed analysis of Talinum portulacifolium's phytochemistry and pharmacological potential. The review begins by delving into the phytochemical composition of various plant sections, such as leaves, roots, and the entire plant. The discovery and characterisation of bioactive chemicals such as alkaloids, flavonoids, saponins, and triterpenoids that contribute to the therapeutic characteristics of the plant are prioritized. Talinum portulacifolium's pharmacological actions are then thoroughly investigated. Studies on its antioxidant and anti-inflammatory activities are discussed, offering light on possible applications in oxidative stress and inflammation-related disorders. The article also delves into the plant's traditional applications in many cultures and places, providing insights into its past therapeutic roles. Recent research on Talinum portulacifolium's possible hypolipidemic activity is highlighted, along with its implications for cardiovascular health..

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Talinum portulacifolium, Fame Flower, Jewels of Opar, phytochemistry, pharmacological potential, leaves, roots, entire plant, alkaloids, flavonoids, saponins, triterpenoids, therapeutic characteristics, antioxidant, anti-inflammatory, oxidative stress, inflammation-related disorders, traditional applications, cultures, past therapeutic roles, hypolipidemic activity, cardiovascular health

  License

Creative Commons Attribution 4.0 and The Open Definition