Volume 11 | Issue 1

 Abstract

The third most prevalent cancer in the world is colorectal carcinoma. Adenomatous polyps, which occur in areas of epithelial cell hyperproliferation and crypt dysplasia, are precursor lesions to colorectal cancer. Chemotherapeutic medicines are used alone or in combination to treat the majority of CRC patients. However, up to 90% of patients with metastatic cancer encounter treatment failure, primarily due to medication resistance that has developed over time and can result in multidrug resistance (MDR). In this study, we looked into recent research on prospective herbal medicine CRC MDR reversal therapies (HMs). Panax Quinquefolius, Gymnaster Koraiensis, Zingiber Officinale, Punica Grantum, Vitis Vinifera, Camellia Sinensis, Zingiberaceae, etc. In recent years, emphasis has been drawn to the use of conventional therapies. The purpose of this study was to provide an overview of plants that have been shown to be useful in treating colon cancer, with a focus on their bioactive components and underlying mechanisms of action. The findings suggest that the best plants for preventing colon cancer are grape, soybean, green tea, and pomegranate. These medicinal herbs have a number of cancer-fighting strategies, including upregulating superoxide dismutase, lowering DNA oxidation, triggering apoptosis by stopping the cell cycle in the s phase, and downregulating PI3K and P-Akt expression.

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Colorectal Carcinoma / Colon Cancer, Epidemiology, Pathophysiology Herbal Approaches / Medicines.

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Diabetic Cardiomyopathy is a clinical condition of ventricular dysfunction that occurs in the absence of coronary atherosclerosis and hypertension in patients with diabetes mellitus. It is characterized by diastolic dysfunction, which is defined as a defect in left ventricular relaxation leading to increased pressures and subsequent impaired filling during diastole. And present to the pathogenesis of diabetic cardiomyopathy. Diabetic cardiomyopathy is accelerated by the variation in the adaptive and innate immune systems. Diabetic cardiomyopathy is characterized by interstitial fibrosis, mainly composed of collagen, and perivascular fibrosis. In the review, we will discuss various aspects, etiology, pathophysiology, and clinical manifestations of Diabetic Cardiomyopathy.

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Diabetic Cardiomyopathy, Diabetes Mellitus, Heart, Insulin, Clinical Condition

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It is an manuscript of review article .

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Advances in herbal Technology

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Here is a potential abstract for a paper on sign language recognition for deaf and mute individuals: "Sign language is a vital form of communication for deaf and mute individuals, but it has traditionally been difficult for them to access technology and services that rely on speech or text input. In this paper, we present a sign language recognition system that allows deaf and mute users to communicate with spoken language users and access a variety of services through a simple and intuitive gesture-based interface. Our system utilizes machine learning techniques to accurately interpret sign language inputs in real-time, and we demonstrate its effectiveness through a series of user studies. Our results show that the system is able to achieve high levels of accuracy and usability, and has the potential to greatly improve the daily lives of deaf and mute individuals by providing them with greater access to information and communication."

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SIGN & LANGUAGE

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The use of various fixed beds having higher surface area is effective in removing organic matters and nutrients from municipal wastewater. Due to the higher specific surface area, fibrous materials are often considered a better choice for increased microbial support and treatment efficiency. In the present study, efforts have been made to check the efficiency of two different fibrous materials, Agave sisalana fibres and Areca husk fibres having higher specific surface areas. They were used as packing media in two different bio-reactors for sewage treatment, under batch mode and similar experimental conditions. The reactors were continuously aerated for different contact times. The study reveals that these fibrous media could be acceptable for the efficient removal of organics and nutrients present in the sewage.

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Waste Management, Natural Fibres, Sewage treatment, wastewater

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Euphorbia Tirucalli also known as Pencil cactus and also milk bush plant . These plants are use worldwide natural source for medicinal purpose Euphorbia Tirucalli belonging to family Euphorbiaceae commonly known as Barki-thohar. Pencil cactus is grows freely in whole India. In Modern scientific medicine great advances but , Traditional Medicine is stillthe primary form of Treating diseases. According to World Health Organization about 80% of population stay in the developing countries rely almost exclusively on traditional medicine foe their primary healthcare needs. Human relied on nature or plants for basic needs such as clothing , food , shelter these all produces or manufacture from plants or plant parts. More compound extract from plants means drugs have been used for disease treatment. India approximately called as Botanical Garden of the world because India is the largest producer of Medicinal herbs. These herbs or medicinal involvement study in Ayurveda.

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Euphorbia Tirucalli , pencil cactus , Barki-thohar , Euphorbiaceae , Botanical Garden

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Spinning Industry, Export, Import, Production Utilization, Return on investments.

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Entrepreneurship, startup, innovation and students

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The role and importance of business and commerce education is growing by leaps and bounds. Post liberalization world there is growing demand for new business opportunities and competent people to handle business operations.The limitations of rural India as known to everyone is lack of education (Technical, Professional) Infrastructures, finance are an impediment to bring in new areas g of commerce in these areas. Without development of rural India, these cannot be development of India

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Opportunities, globalisation, rural.Challenges,Industries

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Awake, Women Entrepreneur, Social growth, Policy, Economic,

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Paytm, digital payments platform ,transfer cash, wallet via online banking, debit cards, and credit cards

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QSAR analysis on a set of indolylpyrimidine derivatives compounds for (PA) antibacterial activity was performed by using multiple regression procedure. The activity contributions of these compounds were determined from regression equation and the validation procedure to analyze the predictive ability of QSAR model was described. The best QSAR model with good correlation coefficient (r2=0.8360), Q-ratio= 0.341, F-ratio =30.593 and N = 22. The leave-one-out (LOO) cross validation method using Ridge regression analysis was used in the future to confirm this model.

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QSAR analysis, Inhibitory Activity, QSAR, LOO.

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Gold loan is one of the easiest and simplest ways to access credit, which requires no additional security or guarantee other than Gold itself. The recognition of gold loan as an asset with almost zero risk, its upwards movement of rates created ample of opportunities for gold loan lenders to come up with new age practices and strategies. Even though gold loan is a simplest form of credit, in a country like India people will easily invest on the Gold specially in southern part of the country and treat it as a treasure of pride and prosperity. At the same time, it is necessary to convince the customer to come forward for gold loans and to make them aware about the hidden benefits of it and it is one of the challenges as well as an opportunity to come up with new age techniques and products by the lenders to sustain in the market. The subject study is an attempt to analyze the present market scenario of gold loans in peer banks and Non-Banking Financial companies (NBFCs) based on the secondary data to know their stand in this dynamic market. This study employed different peer banks and NBFCs who are lending gold loans and the analysis of financial statements of the selected banks and NBFCs. The results of the study depicted that every gold loan lender is in a race to overtake the other via different new age approaches and practices in lending and promotion. Hence it can be concluded that only time has to decide who will be the front runner and which strategy will work better to make their gold loan glitter in the market

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Gold, Loans, Market, Non-Banking Financial Companies (NBFCs), Bank

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NODE MCU ,RFID,Navigation

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A wind turbine is a device that converts the wind energy into rotational energy by means of vanes called blades. Usually wind turbines are coupled with electrical generators and producing electrical energy directly. In the present work, an attempt has been made which deals with a wind turbine based compressed air storage system. The stored compressed air is used to drive the air turbine without any fluctuations. The alternator is coupled with the shaft of the turbine rotor. Part of the power developed by the rotor is converted into electrical energy using an alternator and the remaining power available in the rotor (mechanical energy) is used to run the compressor and produces compressed air and stored in the storage tank. The stored compressed air is used to drive the air turbine to generate electricity without any fluctuations.

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Compressed Air Storage, Wind Turbine, Renewable energy, Wind velocity

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?????? ???? ?????? ?? ?????? ??? ???? ?? ???? ?? 10 ???????? ?? ???? ?? ????? ????? ?? ??? ???? ?? ???? ????? ?? ????? ????? ?? ??? ???? ??l ??? ??????? ??? ?? ??? ??????? ?? ??????? ?????? ????? ????? ?????? ??l ?? ?????? ???? ???? ?? ???? 40% ????? ??????? ???? ?? ?????? ??? ?????? ??? ????? ?? ????? ?? l ?? ?????? ??? ????? ???? ?? ????? ??? ??? ???? ??? ?? ??? ???? ?? l ??? ?????? ??? ??????? ??? ????? ?????? ???? ??? 4000 ???? ?? ?????? ?? ???? ??? l ??? ?????? ??? ????? ???? ??? ??? ????? ?? l ????? ? ???? ???? ?? ????? ??? ?? ?????? ?? ? ????? ??? ??? ????? ?? ????? ?? ?????? ?? ??? ?? ? ?? ???? ?? ?? ???? ?? ???? ???? ??????? ??????? ???? ???????? ???? ??? l ?? ??? ??? ???? ?????? ?? ?????? ?? ???? ??? ?? ??????? ??? ???????? ??????? ?? ????? ??? ??, ?????? ????? ?? ???? ???? ?? ????? ?? ??? ??? ?????? ?? ???? ????? ?? ??????? ?????? ????? ?? ????? ???? ?? ?? ?? ??????? ??? ????? ????? ???? ?? ???? ???? ?????? ????? ?? ??? ?? ?? ??? ???? ?????? ?????? ???? ??????? ?? ?????? ?? ??? ???? ??????? ?? ??? ???? ?? ???? ??????? ?? ??????? ?? ???? ?? ???? ????? l ??? ?? ?? ?? ?????? ????? ??? ????? ???? ?????? ?? ???? ?????? ?? ????? ?????? ????? ??? ???? ????? ????? l ?????? ?? ?????? ?????? ???? ??????? ?? ????? ??? ?????? ?? ???? ???? ????? ???? ?? ???? ???????? ??????? ?? ???? ???? ?????? ?? ?????? ?????? ????? ?? ?????? ??? ????? ?? l ???? ????? ???? ?????? ????? ?? ??? ?????? ?? ???? ???? ?? ???? ?? ?????? ????? ?? ?? ??? ????? ????? ?? ??? ?? ??? ?? ???? ??? ?? ???? ?? ?? ????? ?? ?????? ?? ?????? ?? ???? ???? ?? ???? ????? ???? ??? ????? l ????? ?? ??? 10 ???????? ?? ???? ?? ????? ??????? ??????? ?? ??? ?? ??? ??? ?? ???? ???? ?????? ????? ?????? ?? ??????? ?????? ?????? ???? ?????? ??????? ?? 10 ?? ????? ??? ???????? ?? ????? ?? ????? ???? ?? l ??? ?? ????? ?? ???? ?? ???? ?? ??? ????? ??????? ??? ???? ??? ???? ??????? ??? ????? ???? ????? ?? ?? ???? ?? ??????? ??? ??????? ?????? ?? ????? ?? ?? ?? ??????? ??? ???? ?? ??? ???? ?? ???? ??? ?? ?? ????? ????? ????? ?? ???? ????? ?? ??? ????? ???? ???????? ?? ?? ?? ?? ????? ??? ????? ?? ??? ???? ?? ???????? ?? ??? ?? ????? ?? ?????? ?? ?? ?? ??? ????? ??? ???? ?? ?? ????? ??? ?????? ??? ????? ?? ?????? ???? ???? ?? ?? ??? ????? ??? ????l ?? ?????? ??? ?? ??? ?????? ?? ??? ???? ?? ???? ???? ???? ?????? ???????? ?? ????? ?? ?? ???? ?????? ?? ?? ???? ?????? ???? ?? ??? ???? ?? ???? ??? ?????? ?? ???????? ?????? ?? ???? ??? ??? ?? l ?? ???? ?????? ????? ?? ???????? ??? ???? ?????? ?? ??? ????? ?? ???????? ?????? ??? ???? ???? ?? ?????? ??? ???? ???? ?????? ?? ????? ???? ?? ?? ??? ????? ?? ???????? ?????? ??? ?? ??? ???????? ??? ???? ???? ?? ???? ?????? ????? ?? l

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?????? ???????? ?????? ??? ???? ???? ?????????, ?????? ????? ??? ????? ?????? ?? ??????, ??????? ?? ?????? ????? ???? ??? ???? ???? ?????????, ?? ?? ????? ?? ?????? ?? ?? ????? ?? ?????????? l

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Vividness, Survey, Observation, Influence, Adaptation.

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Abstract The Harry Potter and the Goblet of Fire part of the Harry Potter series has blurred the line between the fantasy and reality. The author J K Rowling has used the power of fantasy to give wings to the imagination of her readers. This is the fourth part in the Harry Potter fantasy series. Literature has advanced over a period of few decades and everything done now has changed its course. Advances have brought the blessing of doing things differently and more efficiently. Fiction in literature has also evolved and now uses the fantasy framework to move on the path of scalability. Fantasy is the new term used for fiction in literature and has become very popular lately. Earlier the fiction in literature writing used to be very tedious and involved a lot of repetitive work which used to take days and was not even accurate. Now the times have changed and the world of fiction has brought a different perspective to the books. In this part of the Harry Potter series, Harry Potter has reached to the fourth year in Hogwarts. The school of witchcraft has been phenomenal so far for the Harry Potter and his friends Ron Weasely and Hermoine.

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Fantasy, Fiction, Reality, Witchcraft, Imagination

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Background: Life is a precious gift by god and it should be handled with care. Nursing professions is one of the main professions responsible for the care, to care the life of people by providing preventive, curative, promotive, restorative and rehabilitative care. Children are major consumers of health care. They are not only large in number but also vulnerable to various health problems and considered as special risk group. Children always need that special care to live and succeed. 2 Of the distraction methods used during Preschool age, audio-visual distraction is the more effective it is a easy, labor saving and easy to provide therapy that relieves pain and distress in children during painful procedures as similarly as and efficiently as common psychological interventions.2 Objectives: To assess the effectiveness of audio visual distraction on pain among children undergoing venipuncture in pediatric ward of selected hospitals. Methodology: a quasi experimental post test only control group design was adopted for the study. It was conducted over 60 pediatric (pre schooler age) patients and was selected by using Non probability purposive sampling technique and quota sampling techniques. Audio visual distraction therapy provided to pre schooler child before 5 minutes and during procedure and after the procedures for 5 minutes. Result: The study reveals that, In Experimental group (Group I) the mean score is 3.70 and standard deviation is 2.15 whereas, in Control group (Group II) the mean score is 7.83 and standard deviation is 1.48. The tabulated value for n=60 degree of freedom is 2.00. The calculated chi square value is 31.29. The calculated x2 value is higher than tabulated value at 5% level of significance which is statistically acceptable level of significance. Hence the research hypothesis H1 is accepted and null hypothesis H0 is rejected. Thus, it is statistically interpreted that there is a significant difference between mean pain score of patients who receive Audio visual distraction. , it shows that Audio visual distraction is more effective for reducing intensity of pain among preschoolers receiving venipuncture. Conclusion: The significantly association was found on pain score with age (in years), none of the other demographic variables were associated with pain score.

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Effectiveness, Selected Hospitals, Venipuncture, audio visual distraction, pain, children.

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