Volume 13 | Issue 9 |

 Abstract

The idea of 'the world as one family' and the 'Global Village' has become more of a reality with the advent of globalisation and technological advancement. Indeed, travelling within the country as well as international travel has become a routine experience. Globalisation has made nations increasingly interdependent, whether in the transfer of raw materials, food, technology, ideas, or other resources. However, disruption in ecosystems and supply-chains are often perceived as unhealthy for development, as they may cause imbalances in the country's economy. Globalisation not only impacts the economy but also brings socio-political, socio-economic, and socio-cultural changes in everyday life. For instance, cultural globalisation propelled by a country's soft power - such as Yoga in India - has had a tremendous influence on culture and livelihood worldwide. The present paper attempts to study the pros and cons of globalisation and the changing livelihood patterns that shaping the lives of the tribal people of Arunachal Pradesh, particularly the Phong Nocte of Soha village.

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Global Village, Phong Nocte, ecosystem, supply-chain, Soha.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

War has far-reaching effects that extend beyond immediate battlefield consequences. It significantly impacts national economies, social cohesion, public health, and political stability while reshaping international relations, trade, and security paradigms. This article explores the multifaceted effects of war on both national and international levels, drawing on historical and contemporary examples to highlight economic, social, political, and human. War has devastating and far-reaching effects on human life, affecting individuals, communities, and nations. This research explores the psychological, social, economic, and physical impacts of war on civilians and combatants alike. It draws from historical and contemporary conflicts to understand the multifaceted consequences of warfare as well as role of India and United State as well as United National Organization and World Health Organization in preventing war affairs.

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

National economies, social cohesion, public health, and political stability ,reshaping international relations, trade, and security paradigms, India , United State State, United Nation , World Health Organization.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The introduction of mRNA vaccines are a powerful alternative to standard practices accepted vaccines for many reasons including: potent, safe and efficacious induced immunity, rapid clinical development, and rapid and economical manufacture. These vaccines are no longer a curiosity; rather they are earning their place as the pandemic vaccine platform. Advances in delivering systems (i.e. LNP and other nanotechnology) for developing mRNA vacancies are exciting and important. This review is an examinable history of every aspect of the mRNA vaccine for infectious diseases. The article focus on mRNA structure, pharmacological use and function of immunity induction, lipid nanoparticles (LNP), from upstream, through downstream, and formulation of mRNA vaccines for manufacture. The article is specific to mRNA vaccines in clinical trials. The article looks at the future and potential of mRNA vaccines freeze-drying, eyewear delivery systems, and LNP characteristics which target antigen presenting cells and dendric cells.

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords:- mRNA structure; mRNA immunogenicity; mRNA vaccines clinical trials; lipid nanoparticles (LNPs); cationic lipids; ionizable lipids; PEGylated lipids; lyophilization of mRNA vaccines; adjuvants; antigen presentations

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

HPMC K4M, HPMC K15M, and HPMC K100M polymers are used in this study to make floating tablets of famotidine hydrochloride. Drug Delivery systems that are floating in the stomach have a lower bulk density than gastric fluids, therefore they stay buoyant in the stomach for a lengthy period of time without impacting gastric emptying rate. In the treatment of gastroesophageal reflex disease (GERD) and peptic ulcer (PUD). Famotidine is a histamine H2 receptor antagonist (GERD). Famotidine is an excellent option for a floating drug delivery system because of its short half-life, brief time in the stomach, and repeated doses. Melt granulation technique was used to make famotidine floating tablets using HPMC K4M, HPMC K15M, and HPMC K100M. In vitro buoyancy, drug polymer compatibility (IR Research), weight fluctuation, hardness, friability, thickness, drug content and invitro dissolution experiments were all performed on the floating tablets. Using in vitro buoyancy and dissolvability experiments, we were able to establish that the micromeritic characteristic were excellent. HPMC K100M-based formulation F4 has an excellent in vitro buoyancy lag time and floating time, and in vitro dissolution investigations demonstrate a 96.78 percent release for 12 hours. As a result of the findings of this research, it can be concluded that famotidine floating tablets provide the potential for longest- term drug delivery and a consequent reduction in dosage frequency

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

HPMC K4M, HPMC K15M, and HPMC K100M polymers, Famotidine Hydrochloride , Famotidine,

  License

Creative Commons Attribution 4.0 and The Open Definition