Volume 12 | Issue 8 |

 Abstract

Research is focusing on the search for new types of natural chemotherapeutic agents derived from plants which are proving to be excellent sources of new compounds. This review aimed to highlight the information regarding physicochemical properties, Chemical Composition, Anticancer properties and their administrations of jackfruit. Artocarpus heterophyllus shows anticancer properties due to the presence of phytochemicals like lignans, saponins, flavonoids carotenoids, tannins, volatile acid steroids and also the properties such as anti-oxidant, anthelminthic, anti-inflammatory, anti-bacterial, anti-viral activities. The phytochemical constituent artocarpine have effect on cancer cells. Target specific agents that are capable of inducing selective apoptosis of cancer cells but are harmless to the normal cells are receiving considerable attention in the field of cancer prevention and therapy. The flavonoid compound artonine B have anti-cancerous effect on human cancer cells. Different studies are performed on this topic and reported. Also, further researches and studies are ongoing. OBJECTIVE: The objective of this article is to provide a detailed and systematic knowledge on the anti-cancer property of Artocarpus heterophyllus (jack fruit) and its medicinal values. METHODS: A vigorous, maximum sensitive and online search of the literature was performed in published articles in the last 20 years (JUNE 2000-JUNE 2020). The databases searched were MEDLINE (via PubMed) and Cochrane Library. CONCLUSION: Cancer is becoming a high profile disease in developed and developing worlds. In 2017 the WHO published that in 2015, 7.6 million people died from cancer related diseases with the majority of these people living in low-income countries. the demand for a cure and the prevention of cancer is extremely high. Experimental studies performed in the past suggest that, jackfruit possesses diverse medicinal uses including antioxidant, anti-inflammatory, antimicrobial, ant cariogenic, antineoplastic and hypoglycemic effects, inhibits melanin biosynthesis, possesses wound healing properties, and causes a transient decrease in the sexual performance. Target specific agents that are capable of inducing selective apoptosis of cancer cells, but are harmless to normal cells are receiving considerable attention in the fields of cancer prevention and therapy. Therefore, Artocarpus heterophyllus is a candidate for development as a Chemo preventive agent.

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 Keywords

Artocarpous Heterophyllus, Phytochemicals, jack Fruit

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Bosentan HCL, a widely used pharmaceutical compound, necessitates precise and reliable analytical methods for its estimation in bulk. This study focuses on the development and validation of an analytical method for the quantitative determination of Bosentan HCL in bulk samples. Various analytical techniques, including high-performance liquid chromatography (HPLC), UV-Visible spectrophotometry, and titrimetric methods, were explored for their suitability in Bosentan HCL analysis. The developed method involves the utilization of HPLC due to its high sensitivity, specificity, and reproducibility. Parameters such as mobile phase composition, column type, wavelength, flow rate, and injection volume were optimized to achieve robust separation and quantification of Bosentan HCL. Method validation was performed according to International Conference on Harmonization (ICH) guidelines, encompassing specificity, linearity, accuracy, precision, and robustness studies. The developed HPLC method exhibited excellent linearity over a wide concentration range, with good precision and accuracy. Specificity studies confirmed the absence of interference from potential impurities or excipients present in bulk samples. Validation results demonstrated the reliability and suitability of the developed method for Bosentan HCL estimation in bulk materials. This validated analytical method provides a valuable tool for quality control laboratories, pharmaceutical industries, and regulatory authorities involved in the assessment of Bosentan HCL raw materials and formulations. Moreover, it contributes to ensuring the safety, efficacy, and quality of pharmaceutical products containing Bosentan HCL. This abstract outlines the importance of developing an accurate and reliable method for the estimation of Bosentan HCL in bulk, the approach taken in the study, and the validation of the developed method according to regulatory standards.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

HPLC,UV,ICH

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Creative Commons Attribution 4.0 and The Open Definition

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This research investigates the interplay between corporate legal reforms, competition, and theevolving marketing landscape in India. Since the enactment of the Companies Act of 2013, the Indian corporate sector has undergone a significant transformation aimed at enhancingtransparency, accountability, and governance. The study examines the impact of these reforms on competitive dynamics within the market. Additionally, it delves into the imperative for legal reform in the contemporary marketing scenario characterized by digital disruption and ethical challenges. By analyzing the relationship between law and marketing, the research seeks to identify opportunities and constraints for fostering a fair, transparent, and sustainable marketplace. The study emphasizes the need for a proactive approach to legal reform that balances innovation with consumer protection and societal interests. Ultimately, it aims to contribute to the development of a regulatory framework that supports a competitive and ethical marketing ecosystem in India.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Corporate legal reforms, Competition, Marketing landscape, India, Transparency.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The stability of sheet pile structures is a critical consideration in geotechnical engineering, particularly when employed in cohesive soils. This study presents a comprehensive comparative analysis of sheet pile stability in cohesive soil under varying retaining wall lengths. The objective is to assess the influence of retaining wall length on the overall stability of sheet piles. The research methodology involves numerical simulations and analytical modelling using advanced geotechnical software and established engineering principles. A range of retaining wall lengths is considered to systematically evaluate their impact on the stability of sheet piles within cohesive soil profiles. Factors such as lateral earth pressure distribution, shear strength parameters, and deformation characteristics are incorporated into the analysis to provide a holistic understanding of the system behavior. This research is of practical significance for geotechnical engineers, designers, and practitioners involved in the planning and execution of projects requiring sheet pile structures in cohesive soil environments. The outcomes of this study can inform engineering practices, providing a basis for improved design guidelines and facilitating the development of more reliable and efficient solutions for retaining structures in similar geotechnical contexts.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Sheet Pile in clay, Retaining Height, PLAXIS 2D,

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Creative Commons Attribution 4.0 and The Open Definition