Volume 12 | Issue 8 |

 Abstract

Applications for contact tracking have been developed by researchers to automatically identify contacts who may be compromised by the index case. In order to stop the virus's spread, numerous researchers have taken advantage of the Internet of Things' artificial intelligence (AI) capabilities for early identification and surveillance of possible cases. In this investigation we are going to learn how IOT is involved in virus detection.

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IOT in virus detection

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Phyllodes tumors of the breast are known to be an uncommon and peculiar disease to treat because of the ambiguity of the diagnosis and the unpredictability of its evolution . We report here a case of a 54-year-old patient presenting with an ulcerating-bourgeoning lesion of the left breast . The diagnosis was confirmed by histological study. Surgical management was indicted.

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Phyllodes tumors , breast tumors

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Lenvatinib, a multi-targeted tyrosine kinase inhibitor, has shown promising anticancer activity against various malignancies. However, its clinical application is hindered by poor aqueous solubility, low bioavailability, and off-target toxicity. To address these limitations, liposomal drug delivery systems have emerged as an effective strategy to improve the pharmacokinetic and pharmacodynamic profiles of anticancer agents. In this study, we developed and characterized a novel liposomal formulation encapsulating Lenvatinib, aiming to enhance its therapeutic efficacy while minimizing adverse effects. The liposomes were prepared using a thin-film hydration method and optimized for particle size, encapsulation efficiency, and stability. Physicochemical characterization demonstrated uniform size distribution, high drug loading, and sustained release kinetics. In vitro studies revealed enhanced cellular uptake and cytotoxicity of Lenvatinib-loaded liposomes compared to free drug in various cancer cell lines. Furthermore, in vivo pharmacokinetic and biodistribution studies demonstrated prolonged circulation time and increased accumulation of Lenvatinib in tumor tissues following liposomal administration. Moreover, the liposomal formulation exhibited superior antitumor efficacy and reduced systemic toxicity in xenograft mouse models compared to the free drug. Overall, our findings suggest that the developed Lenvatinib-loaded liposomal formulation holds great promise as a targeted and efficacious anticancer therapy, warranting further preclinical and clinical investigations. This study highlights the potential of Lenvatinib-loaded liposomes as a promising approach for the targeted delivery of Lenvatinib, offering enhanced therapeutic efficacy and improved safety profile in the treatment of solid tumors.

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Lenvatinib, Liposomes. Anticancer, Drug delivery, Tyrosine kinase inhibitor, Formulation, Encapsulation, Nanomedicine, Targeted therapy.

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Cisplatin, carboplatin, and oxaliplatin are common platinum-based medicines used to treat cancer through chemotherapy. Platinum medicines' side effects, including low selectivity, significant systemic toxicity, and drug resistance, severely limit their clinical use. Recent breakthroughs in nanotechnology and chemical synthesis have led to significant progress in the treatment of cancer with Pt-based medicines. Several tactics, comparable to cisplatin's anti-cancer action, have been successful in altering current platinum medicines. Platinum nanoclusters, a type of nanodrug, have demonstrated promising clinical results in tumor-targeted therapy due to their new anti-cancer actions. This review analyzes the clinical development of first-line platinum chemotherapy medicines and their anti-cancer mechanisms. These treatments are frequently used in conjunction with other anticancer therapies. For example, colorectal cancer is frequently treated with the FOLFOX regimen. This regimen combines oxaliplatin with two other drugs: fluorouracil and folinic acid, Cisplatin was the first drug of this class to be identified. It has been used to treat cancer for over 40 years (Trusted Source). More recently, the Food and Drug Administration (FDA) approved oxaliplatin and carboplatin to treat a wide range of malignancies. Researchers are still investigating the potential benefits of newer platinum-based chemotherapy drugs including nedaplatin and lobaplatinTrusted Source. Researchers believe that future medications can reduce the side effects.

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platinum compounds, side effects , anticancer , chemotherapy

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The objective of the study is to evaluate patient's understanding and experiences of patient-centered counseling practices at various pharmacy outlets from their own perspectives. Method: Across-sectional study was undertaken in Anand and the surrounding area, Gujarat, India, involving the distribution of questionnaires to several hospital and community pharmacy stores further conducting a survey to assess whether patient counseling in both hospital and community pharmacies is being performed adequately or not. This survey aims to evaluate patient's guidance in hospital and community pharmacies. Data was collected from 200 patients in each setting and then it was analyzed by chi-square analysis. Result: The survey revealed that 53% of hospital and 45% of community patients lack awareness of medication precautions. Regarding advice on missing medication doses, hospitals guides approximately 67% of cases, while community pharmacies do so in around 54% of cases. Over-the-counter medication is discussed in 72% of hospital cases and 65% of community cases. Additionally, 44% of hospital and 57% of community patient's report not receiving any extra resources. Discussions about possible side effects are reported by 39% of hospital patients and 33% of community patients. The study found that the null hypothesis was accepted for warning, additional resources, over-the-counter medication, and side effects, indicating no significant effect. However, it was rejected for missed doses, suggesting a significant effect. Key aspects explored includes the frequency and depth of counseling interactions, patients' comfort levels with pharmacists, perceived impact on medication understanding and adherence ,and overall satisfaction with the counseling experience.

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Hospital pharmacy, Community pharmacy, Patient satisfaction, Medication error, Patient counseling.

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ISSUES OF SOCIAL OUTCAST & EXCLUSION IN VICTORIAN ERA WITH SPECIAL REFERENCE TO THE CHARACTER OF PIP IN GREAT EXPECTATIONS BY CHARLES DICKENS - A STUDY

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Victorian Era, Exclusion, Social Outcast, Great Expectations, Charles Dickens

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This paper critically examines the philosophical and ethical dimensions of Indian art practices about environmental degradation. By analyzing Mughal miniature paintings, Pattachitra scrolls, and the works of Raja Ravi Varma, it explores how these artistic forms address themes of environmental management, exploitation, and the visualization of ecological consequences. This study situates historical and artistic responses within contemporary environmental discourse, arguing for their continued relevance and impact on modern environmental issues.

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ethical considerations, environmental degradation, environmental justice, human-nature relationship, industrialisation, interconnectedness, sustainability, traditional art forms.

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Vehicle identification and classification are crucial for applications such as traffic management, security, and automated systems. This study presents a novel approach to vehicle identification and classification using advanced image processing techniques and machine learning algorithms. Specifically, the method employs Convolutional Neural Networks (CNNs) for feature extraction and classification, leveraging deep learning to analyze and differentiate vehicles based on make, model, and other distinguishing characteristics. To enhance the robustness of the system, algorithms such as Histogram of Oriented Gradients (HOG) for feature extraction and Support Vector Machines (SVM) for classification are integrated. These techniques address challenges posed by varying vehicle shapes, sizes, and environmental conditions, improving the accuracy and reliability of the identification system. The proposed method is evaluated against traditional approaches, demonstrating superior performance in terms of precision, robustness, and processing efficiency. This approach not only advances vehicle recognition technology but also supports improved traffic management and security applications, contributing to more effective and efficient transportation systems.

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Vehicle Identification, Vehicle Classification, Image Processing, Convolutional Neural Networks (CNNs), Histogram of Oriented Gradients (HOG), Support Vector Machines (SVM), Feature Extraction, Deep Learning, Traffic Management, Security Systems, Machine Learning Algorithms, Automated Systems.

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Mythology is not mere tales read and told as bed time stories for pleasure, they contain aspects of human truth and conduct. Each mythological story and the characters in it shed light upon various human values, morale and conduct. The mythological charcters, victories, follies, decisions, and every single aspect of mythology that binds mythology into a whole symbolises the ethics, human conduct, life lessons and moral values to all the generations to come. There are umpteen versions of the Ramayana and the Mahabharata today. Majority of the narratives that are written are male-centered, but not to forget in recent times there are works of mythology focussing on women narratives. Broadly speaking Indian Mythology is in itself patriarchal in nature. What about the women characters then, do they exist? Aren't the women in Mythology important? What role do they play? The answer to all of these questions is Yes, women do exist and play a pivotal role in mythology. But women in mythology are seldom main stream characters and are mostly side-lined. Women in Indian mythology are mostly showcased as an epitome of beauty, devotion, kindness, chastity, sacrifice and so on. There are quite a few narratives of mythology from women's perspective but we barely come across or pay attention to such narratives, may be because we are so indulged and focussed on defending the central male characters that have been told to us since time immemorial and this is where we have neglected the female characters of the epic.

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Mythology, Women, Re-defining, Warrior, Re-telling

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The National Food Security Act, 2013 is being implemented in all the States/UTs, on an all-India basis. Out of maximum coverage of 81.35 crore, around 80.04 crore persons are covered under NFSA at present for receiving highly subsidized foodgrains. Coverage under the Act is under two categories - households covered under Antyodaya Anna Yojana (AAY) and Priority households (PHH). The monthly entitlement of foodgrains is 5 kg per person for eligible households under 'priority' category and 35 kg per family for AAY households. Beneficiaries under the Act are entitled for subsidized foodgrains at `3/2/1 per kg for rice/wheat/coarse grains for an initial period of three years from the date of commencement of the Act (July 5, 2013). Thereafter, prices were to be fixed by the Central Government from time to time, but not exceeding MSP. Government decided from time to time to continue the above-mentioned subsidized prices under NFSA. Central Government has now decided to provide foodgrains free of cost to the 81.35 crore NFSA beneficiaries i.e. AAY Families and PHH persons for one year from 01.01.2023 to 31.12.2023. The decision is taken to strengthen the provisions of NFSA in terms of accessibility, affordability and availability of entitled foodgrains for the poor and ensure effective and uniform implementation of National Food Security Act 2013 (ONE NATION-ONE PRICE-ONE RATION). The additional cost of making foodgrains free of cost to the NFSA beneficiaries will be borne by Government of India. Notification to this effect was published in the Gazette of India on 30.12.2022.

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Agriculture, Food Security, Environment, Nutrition Security

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Creative Commons Attribution 4.0 and The Open Definition