Volume 9 | Issue 8 |

 Abstract

Museums are the custodians of cultural and natural heritage. These are informal centres of education. In the beginning the museum focuses on the collection of objects but now a days museum focus on their collection and their detail also. Without knowledge museum value is meaningless.Museum organises different educational programmes for all age group. In this paper the author summarises different educational role of museum.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Museum, Education, Programmes, Disabled Person, Cultural heritage

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

AIM: The goal of this study is to learn more about the clinical features and efficacy of Lenvatinib, an orally active inhibitor of several receptor tyrosine kinases, in patients with hepatocellular carcinoma. METHOD: 92 individuals with hepatocellular cancer were enrolled in a multicentre, randomised, non-inferiority trial. Lenvatinib (12mg orally once daily) was given to patients in a 1:1 ratio. RESULTS: The majority of patients (67.8%) were men. Child-Pugh A was found in 44.6% of the population, whereas Child-Pugh B was found in 39.1 %. In 9 % of cases, dose decreases were noted. PFS and OS medians were not reached. The benchmark PFS and OS at 6 and 12 months were 85.1 and 64.9 %, respectively, and 91.8 and 72.6 %, respectively. CONCLUSION: Lenvatinib therapy was shown to be effective and safe.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Lenvatinib, Hepatocellular carcinoma, Tyrosine kinase, Liver cancer, Multikinase inhibitor

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Creative Commons Attribution 4.0 and The Open Definition

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Key words: Effectiveness, application of breast milk, prevention of sore nipple, postnatal mothers, hind milk.

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Creative Commons Attribution 4.0 and The Open Definition

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The consumption of junk food increases the risk of obesity, cardio-vascular disease, worsens appetite and digestion. The main objective of this project was to estimate the possibility of using watermelon rind, a fruit waste for production of functional foods. Studies show that Rind and seeds are rich source of dietary fiber and bioactive compounds and it could be used in various nutraceuticals. In this project the watermelon rind was ground into fine paste and utilized in chips. The chips were formulated with watermelon rind and composite flour (masoor dal, moong dal, channa dal, soybean dal), salt and pepper. The valorization of watermelon rind fortified with composite flour as a simple baked snack product has a major advantage of being an easy and light food. It is also a protein enriching snack. The final product was tested to have high dietary fiber and low fat content with nil trans-fat. It also had appreciable amount of protein.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

composite flour, dietary chips, sensory analysis, shelf life, watermelon rind.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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Creative Commons Attribution 4.0 and The Open Definition

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finance software, business models, artificial intelligence, finance information system, finance decision.

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Creative Commons Attribution 4.0 and The Open Definition

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The quantity and complexity of network attacks is increasing. The majority of Internet users depend on firewalls to enforce their security policies. To protect an institutional network from malicious attacks from the public Internet, various network devices such as firewalls are used. Firewall which is commonly used for network security. Firewall technologies which are commonly used to prevent unauthorized access from internet. Firewall software is a must-have for anyone who wants to protect themselves from hacking, viruses, and other security purpose. Various types of firewall technologies are used to create a secure network. Many studies has been conducted on firewall technologies. This project proposes a technique that detects the action of the user in proxy network and to perform account suspension by detecting the user using clustering technique. The algorithm we used here is K-Means. K-Means algorithm is used for clustering.

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Creative Commons Attribution 4.0 and The Open Definition

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K-Means, Firewall, Policy, Proxy network, network address translation

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Modern adaptive springs are designed in such a way that they vary their parameters with respect to applied load as well as adapt the assembly to perform well and give maximum life. In most of the cases the springs are attached with the damper mechanism. Some other springs are also attached with leaf springs to absorb shocks. The main objective of adaptive spring is to support damper mechanism to kill or absorb shock. The adaptive nature itself makes it user friendly. In this paper the development of adaptive spring is to be done with the help of CAD tool like CATIA V5R19 which is further imported into CAE Tool like ANSYS to perform various types of analysis. Structural Analysis and shape optimization analysis will give the stress and deformation values along with the scope for modifying the shape. By redesigning the spring, same analysis is to be repeated to check the results. Accordingly the conclusion will be drawn.

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 Keywords

Spring, Adaptive spring in CAD, CAE Tool, Shape Optimisation, Structural Analysis.

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Creative Commons Attribution 4.0 and The Open Definition

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The top objective of any pharmaceutical industry is to produce products of necessary characteristic and quality reliably, in a cost-effective manner. Development of a method is essential for discovery, development, and evaluation of medicines in the pharmaceutical formulation. The main aim of this review article was to check the development and validation of the procedure employed for the medication from the starting of the formulation to the complete commercial batch of product. At the point when an analytical technique is applied to produce outcomes for the quality of medicine associated samples, it is necessary that the outcomes are reliable. In the pharma industry, validation policy is documented for how to perform validation, types of validation and validation policy are complied with the necessities of good manufacturing practice (GMP) regulations. Validation is very important for the effective running of the pharmaceutical firms. At every stage from raw material to the finished, stability, everywhere validation was performed. The method was developed properly, and validation parameters are explained in terms of accuracy, specificity, precision, limit of detection (LOD), limit of quantitation (LOQ), ruggedness, robustness, and system suitability testing with the example of certain drugs. All validation parameters are used in the routine and stability analysis.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Validation, Method development, Limit of quantitation, Limit of detection, Linearity, Robustness, Ruggedness.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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Creative Commons Attribution 4.0 and The Open Definition

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Dravet Syndrome (DS), Infants, Stiripentol, Ketogenic diet

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Creative Commons Attribution 4.0 and The Open Definition

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The paper presents development of a device which could help the oral therapy of drug delivery to patients. The paper focuses on development of a patient friendly drug delivery device, which could automatically deliver the drug into the patient body without his notice. The proposed deice will definitely help the elderly people who very often forget taking their pills on time. In this work, we present the design, simulation and analysis of silicon-based microneedles with piezoelectrically actuated micro?uidic device for transdermal drug delivery (TDD). In the work presented in the paper depicts the use of array of cantilever beams, containing a microfluidic chamber and array of needles for drug storage and delivery. Silicon microneedles are used to pears the superficial skin layer followed by the delivery of the drug. Microneedles deliver the drug into the epidermis without disruption of nerve endings, due to which the patient does not feel any pain during drug delivery using transdermal system. Microneedles are fabricated using MEMS technology employing silicon, metals, polymers. The development of microneedle arrays is an approach which allows drug delivery through skin by improving safety, efficiency, bioavailability. The device developed in this work can deliver drug as per patient requirement.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

MEMS, Microneedles, TDD, PMMA, Polymers

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Creative Commons Attribution 4.0 and The Open Definition