Volume 11 | Issue 8 |

 Abstract

Urban environment alters biophysical mechanisms causes a change in surface to atmosphere temperature and forms storage heat flux (?QS) and releases as sensible heat flux which in turn forms Urban Heat Island (UHI) Intensity. So, the impact of UHI Intensity on human health and ecological evolution should be studied in a developing nation like India having a large young population and a diverse range of species. With this in mind, it is also necessary to examine the UHI Intensity mitigation processes. The current study examined the impact of UHI Intensity on human health and ecological evolution in Kanpur Metropolis, which is located on the banks of the Ganga but now/will, occupies/occupy the area of Kanpur Nagar District with the Yamuna River serving as the region's southern boundary due to urban sprawl. Urban Heat Island (UHI) Intensity Discomfort Index (DI) and Urban Thermal Field Variation Index (UTFVI) has been carried out for this region with projection WGS_1984_UTM_Zone_44N using Landsat 5, 7 & 8 data for the years 1991, 2001, 2011 & 2021 respectively. The best fit curve with a logarithmic trendline shows a positive correlation between UHI intensity and DI and UTFVI, which has been evaluated. The significant level (p) for DI and UTFVI was also evaluated, and the p value of <.005 was found to be satisfactory. This indicates that the severity of UHI intensity has a significant impact on human discomfort and ecological evolution. The study also offers insightful information about the policy-making processes involved in urban planning, such as how to create green and blue spaces and other human made infrastructures during urban spatial planning for UHI intensity mitigation.

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 Keywords

Ecological evolution, Discomfort, Green space, Blue space

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 Abstract

Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed. Despite the occurrence of vaginal ulcers, mucosal alterations, and toxic shock syndrome, large numbers of women continue to find vaginal tampons an acceptable and convenient method of menstrual protection. Government agencies and consumer groups are aware of the potential problems associated with tampon use and are actively concerned with surveillance and public education. Tampon manufactures have joined in this effort and continue to seek methods of improving their product and decreasing the risks associated with the use and abuse of vaginal tampons.

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 Keywords

History and background of Tampon, Ancient Tampon, and Herbal drug Tampon, Efficacy of Tampon in Female, Sala-e-Raham, Tampon in management of Myoma and Fibromyoma,

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Creative Commons Attribution 4.0 and The Open Definition

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The process of identifying and producing a novel drug is frequently viewed as time consuming and costly. As a result, computer-aided drug design technology is increasingly being used to increase the efficiency of drug discovery and development process. various CADD approaches are viewed as promising technique based on their demands; nevertheless, structure-based drug design and ligand-based drug design approaches are well-known as highly efficient and powerful drug discovery and development strategies. Both methods can be used as a molecular docking to do virtual screening for the purpose of discovering and optimizing leads. Computational tools have grown in popularity in pharmaceutical industry and academic sector in recent year as means of boosting efficiency and effectiveness of the drug discovery and development pipeline. In this piece, we will look at computational approaches, which offer a novel approach to finding new leads and assisting in drug discovery and development research.

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 Keywords

Computer aided drug design, structure based drug design, Ligand based drug design, Pharmacophore, virtual screening, Molecular docking, QSAR, Database.

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 Abstract

Ulcer is a common gastrointestinal disorder which is seen among many people in that bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs such as Paracetamol, Aspirin, Diclofenac, etc. Various herbal medicines have been used traditionally for the remedy of peptic ulcer disease (PUD), however scientific information with regards to their anti-peptic ulcer both in-vivo and in-vitro as well as clinical studies supporting their use is still inadequate. Preliminary phytochemical screening of these herbs has shown the presence of important secondary metabolites like flavonoids, alkaloids, terpenoids, tannins which are responsible for the anti-ulcer activity. The purpose of this study is to treat of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence using herbal medicinal plants.

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 Keywords

Helicobacter Pyroli, Peptic ulcer disease, Natural Pain Killer, Medicinal Plants, Abdominal Pain

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Academic performance depends on a complex interplay between intelligence and contextual variables, but health is a key factor in regulating a child's learning ability. The idea that healthy children learn better is empirically supported and widely accepted (Basch, 2010). Several studies have also confirmed that health benefits are associated with physical activity, including cardiovascular and muscle fitness, bone health, psychosocial outcomes, as well as cognitive and psychosocial outcomes. Brain Health (Strong et al., 2005; see Chapter 3). The relationships between physical activity and fitness, cognition and brain health, and academic performance are the subject of this chapter. Here in the present paper we shall discuss the importance of PE in student's overall performance and have an overview of the status of PE in the state of Gujarat-India.

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 Keywords

Physical Education, PE/PA, Physical activity and fittness

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An increasing number of comparative studies in public administration are required in today's era of globalisation to investigate the range of approaches taken by different nations while implementing new global models. Many of the key obstacles that have hampered the intellectual promise of previous waves of comparative administration remain to have an impact on the current state of the field. Presented at the PAR Symposium on Comparative Public Administration, this article offers a brief examination of the conceptual, epistemological, structural, and institutional obstacles to comparative administration and a few suggestions for overcoming them.

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comparative politics, policy studies, policy design, Public policy studies, Comparative Public Administration

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Creative Commons Attribution 4.0 and The Open Definition

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The present study is a review based study depicting the direct relationship between physical activities and academic performance of school students.

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PE, Physical activities, academic performance

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Background: This study set out to examine how COVID-19-affected and unaffected patients in 20 different wards around Malegaon were treated by their new team leaders, students, and technicians while they collected blood samples. Team leaders, students, and technicians all play crucial roles in helping participants with the blood-sampling process, which is used to measure IgG and IgM levels of immunity in Malegaon residents who have and have not been infected with COVID-19. Pre-analytical mistakes are unfortunately common throughout the blood sample collection process and may have negative effects like repeating the sampling process. Plus, some say that needle procedures are the most unpleasant. However, the team leaders, students, and technicians' personal experiences with mistakes made while collecting blood samples are unknown. Thus, the goal of this analysis is to the Learning Experience of Team Leaders, Students, and Technicians of Unani during Blood Samples Collection in Field Visits. A Descriptive Observational Study.

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 Keywords

Covid-19, Team leaders, students & technicians' experiences or perspectives, Thematical analysis, Focus group, Participants, Blood sampling procedure.

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A phototherapeutic approach is the modern drug designing and development for traditional medicinal plants. In that pure phytochemicals as drugs is time consuming and expensive. Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections. Liver is a most important organ of the body. It plays an important role to maintaining various physiological processes in the body. It is involved in several vital functions, such as metabolism, excretion and storage. It plays a central role in the detoxification and excretion of many exogenous and endogenous compounds. Hence, any injury or impairment of its function has grave implications for the health of the affected person. Many more drugs or therapies are available for the treatment of hepatic disorders, but still there is a need for the novel drug discovery which can target multiple disease pathways. In the 21st century has a great that paradigm shift towards therapeutic evaluation of herbal products. The use of herbal products has a great role in the treatment of liver diseases and has no side effects.

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Hepatotoxicity, Hepato protective herbs, Siddha medicine in liver morbidity.

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The objective of this study was to develop a reliable and accurate RP-HPLC method for the determination of Linezolid content in drug formulations. The method development involved the optimization of various parameters, including the mobile phase composition, column selection, and detection wavelength. The Linezolid drug and its formulation were subjected to RP-HPLC analysis using the developed method. For the validation of the RP-HPLC method, parameters such as linearity, precision, accuracy, specificity, robustness, and system suitability were evaluated. The linearity of the method was determined by analyzing Linezolid standard solutions at different concentrations. Precision was assessed by repeatability and intermediate precision studies. Accuracy was determined by recovery studies conducted at various spiked levels. The developed RP-HPLC method exhibited satisfactory results for all validation parameters. The linearity of the method was excellent over the specified concentration range. Specificity tests demonstrated that the method was selective for Linezolid, without interference from other components. The method showed robustness, as minor variations in the chromatographic conditions did not significantly affect the Linezolid peak. In conclusion, the developed RP-HPLC method proved to be reliable, accurate, and specific for the estimation of Linezolid drug and its formulation. The validation results indicated that the method is suitable for routine analysis of Linezolid samples, ensuring the quality control of Linezolid-based products and compliance with regulatory guidelines.

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 Keywords

Linezolid, bioavailability, Solubility, Qualitative analysis, RP-HPLC method.

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Creative Commons Attribution 4.0 and The Open Definition