Volume 12 | Issue 7 |

 Abstract

BCS II lipid-lowering agent piroxicam. It is very little water-soluble and Phite buffer, pH 7.4, however it is not soluble in water solutions pH 4 along with lower. The current study aims to improve the the solvability and solubility of drugs that are inadequately soluble by developing a self-microemulsifies medication transport system that is SMEDDS. It was established whether Piroxicam was soluble in the separate microemulsion constituents, namely oil and surfactants. The ability of the surfactants to emulsify was tested. The solubility assessments and emulsification characteristics led to the selection of oil containing oleic acid and Tween 80 surfactants and PEG-8 Caprylic Capric Glyceride for more investigation. It was established how soluble proxicam was in various ratios of chosen oil to surfactants. For the formulation of SMEDDS, the oil:surfactant mixture with the highest solubility for piroxicam was utilized. A pseudoternary phase diagram was employed to assess the existence area of microemulsification. The development and screening of the formula was carried out according to the phase diagram results and the properties of the resulting microemulsions. The microemulsions were assessed for stability, in vitro dissolution, self-emulsification, phase separation, and emulsion droplet size. In contrast to the plain medication, which demonstrated a limited rate of dissolution, the SMEDDS formulation exhibited total release.

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 Keywords

Piroxicam,SMEDDS,Surfactant, Cosurfactant,Oil.

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 Abstract

This study is to differentiate between reference book and internet used by user for transmitting the user's knowledge. Main objective of the study is to find out the purpose and effectiveness of using the reference book and internet and also problem faced by them when using these study material.

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Reference book, internet, reference source

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Abstract: Sunscreen is a chemical compound that makes a difference to ensure UV beams. In spite of the fact that bright B light causes sunburn, bright A may be more destructive to the skin. The event of actinic keratosis, squamous cell carcinoma, and melanoma is diminished by schedule sunscreen utilize. Chemicals in sunscreen can be either natural or inorganic. Sunscreen utilize has expanded as a result of the rising frequency of skin cancer and the photo-damaging impacts of UV light. The plant's antioxidant, anti-inflammatory, clean, and antibacterial qualities, among others, are utilized to secure skin from different pathogens. Sunscreens ought to be totally able to secure the skin from sun harm and ought to be chemically inactive, non-irritating, +9on-toxic, photostable, and secure. The sun's UVA and UVB radiation cause skin cells to get harmed as a result of the skin creating receptive oxygen species. FORMULATION AND EVALUATION OF HERBAL SUNSCREEN CREAM FROM ETHANOLIC EXTRACT OF ANNONA SQUAMOSA LEAVES 1Shrikant Gosavi, 2 Jayesh Gotmare, 3Shraddha Tandale. 4Miss Pooja Wankhede 1Studant, 2Studant, 3Studant, 4Assistant professor , 1Pharmacognocy Navsahyadri institute of Pharmacy, Pune , India To viably avoid photo maturing and skin cancer, sunscreen ought to moreover contain antioxidant specialists.An home grown sunscreen cream is made utilizing plant extricates, such as Annona squamosa L. Vit E and the polyphenolic drug. can be utilized as an viable photoprotector (sunscreen) against the unfavorable impacts of UVA radiation. The show investigate work assesses photo absorptive properties and screening of sunscreen movement of distinctive extricates of takes off of Annona squamosa L. in the bright locale (200-400nm) and its comparison with a well-established standard sunscreen medicate, P-aminobenzoic corrosive (PABA). This plant contains phenols and flavonoids that have set up it has fabulous antioxidant activity.

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herbal Sunscreen, SPF(sun protection factor),skin burn.

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 Abstract

Cerebral venous thrombosis (CVT) is a rare but potentially life-threatening condition characterized by the formation of blood clots in the cerebral veins, leading to impaired blood flow and drainage from the brain. Polycythemia vera (PV), a myeloproliferative disorder characterized by the overproduction of red blood cells, is recognized as a predisposing factor for CVT. This comprehensive review explores the pathophysiology, clinical manifestations, diagnostic approach, and management strategies of CVT in the context of polycythemia vera. Through an in-depth analysis of case histories and clinical discussions, this article elucidates the complexities of managing CVT in individuals with polycythemia vera, highlighting the importance of early recognition, prompt intervention, and multidisciplinary collaboration in optimizing patient outcomes.

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CEREBRAL VENOUS THROMBOSIS,POLYCYTHEMIA VERA

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Around a century ago, a leader was emerging who would change the course of a country's struggle for independence. He scripted an incredible chapter in history that depicted people belonging to different classes, castes, languages and religions becoming united to win their freedom. He showed the way of humanity and the necessity of removing the cultural baggage that has divided people from each other and taught them to see each other only as humans. Gandhi started a war which used non-violence and love for the enemy as weapons. Gandhi wanted people to eliminate inner evil before taking on the external enemy. He wanted to remove untouchability which had colonised a section of society in India for centuries. People across the country were following his directions as if enchanted by him. His efforts resulted in a revolution and were recognised worldwide.

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Impact of Gandhi on Indian Writing in English: A Study of Rao's Kanthapura and Narayan's Waiting for the Mahatma

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The proliferation of indoor electronic gadgets has raised concerns regarding microbial contamination on their surfaces, posing potential health risks to users. This study investigates the efficacy of UV-C irradiation as a method for the removal of microorganisms from various indoor electronic devices. A systematic review of relevant literature is conducted to assess the current understanding of UV-C technology and its application in disinfection. Experimental protocols are designed to evaluate the effectiveness of UV-C irradiation on different types of electronic gadgets commonly found in indoor environments. Results indicate significant reductions in microbial load following UV-C treatment across various devices, highlighting its potential as a promising disinfection method. Furthermore, considerations for practical implementation, such as exposure time and dosage, are discussed to optimize efficacy while ensuring device integrity. Overall, this research contributes to the advancement of strategies for mitigating microbial contamination on indoor electronic gadgets, thereby enhancing public health and safety.

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Indoor Electronic Gadgets, Microbial Contamination, Microorganisms, Microbial Load, UV-C treatment

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The animation industry is a vibrant and quickly expanding sector that comprises a wide variety of animated content. These forms of animated content include movies, television shows, web series, video games, TV commercials, and more. Animating anything is giving the impression that something is moving by stringing together a number of still photographs or using computer-generated graphics. A startup is a newly formed business with the goal of producing and commercializing novel products, services or technologies. Startups are known for their significant expansion potential, scalability, and disruptive nature. As they operate in dynamic and competitive scenarios, startups are subject to uncertainty and risk. They necessitate an adaptable and flexible strategy, as well as the capacity to iterate and adjust plans in response to market input. Animation start-ups operate in a dynamic and competitive industry, which need rigorous financial planning in order to develop a business model that can be sustained over time. This article takes a look at the crucial parts of financial planning for animation companies who are working towards establishing a profitable business model in a field that is fraught with intense competition. This article examines opportunities, challenges faced by the industry in India and the critical aspects of financial planning that animation firms must consider if they wish to create a sustainable brand in a sector that is notoriously competitive. The development of new technologies, the proliferation of digital platforms, and a rising level of interest on the part of consumers have all contributed to the quick expansion and rising demand witnessed in the animation sector. The creation of an animation studio or production company, on the other hand, presents a variety of financial risks and challenges, all of which require substantial forethought and planning. However, opening an animation studio or production firm comes with a wide variety of financial obstacles and dangers that need to be carefully considered and planned before being tackled. This study investigates the essential components of financial planning, including budgeting, revenue streams, cost management, funding options, and risk mitigation strategies, providing valuable insights to aspiring entrepreneurs and industry professionals.

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Financial planning, Animation, Startups, Business model, Competitive market, Budgeting, Revenue streams, Cost management, Funding options, Risk management.

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Teen suicide is a serious public health issue that affects people, families, and communities all around the world. This research paper tries to look into the various elements that contribute to teen suicide. The study investigates the impact of social, psychological, and environmental factors on teen suicide rates. This study conducts a comprehensive literature analysis to find numerous relevant features related with an increased risk of teen suicide. These include mental health issues including despair and anxiety, as well as social factors such as bullying, family conflict, and peer pressure. Environmental problems such as access to lethal means and media coverage of suicide are also addressed. This study investigates why some youths worry about and attempt suicide. It demonstrates how vital it is to find out early If a teenager is feeling this way, please help them. Schools and communities should offer mental health services. It is also critical to educate teenagers healthy problem-solving skills and resilience. The paper helps us understand why youth suicide occurs. It demonstrates that we must take more action to put an end to it. Understanding these factors allows us to develop better approaches to prevent suicide and help young people feel better.

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Data mining, risk factors , reasons, prevention, intervention, and youth suicide

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Demographic trends are the result of interaction of fertility, mortality and migration in a society. Fertility is a crucial aspect in the study of population for various reasons. The most important reason being that fertility is directly responsible for the biological replacement and maintenance of human society. Fertility is a positive force through which the population expands while mortality is a counteractive force in the sense it causes attrition in the size of population. Migration both the inward and outward movements are considered. The decadal census of 2011 is expected to give the all India population a count of 120 crores as against 102 crores of 2001 census. The world's biggest ever population counting process in the history of mankind has just begun in the country. Andhra Pradesh has a starting figure of 985 females per 1000 males in the year 1901 while at the national level, the sex ratio was 972. This difference was maintained all through the century.

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Fertility , Child Sex ratio, Sex ratio, Demographic, Population, Growth rates, Trends

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This study examines the effectiveness of e-Governance initiatives implemented by the New Delhi Municipal Council (NDMC) in enhancing citizen participation. With rapid urbanization and the digital transformation of public services, e-Governance has emerged as a vital tool for improving government-citizen interactions. The research adopts a mixed-method approach, combining quantitative surveys with qualitative interviews to gather comprehensive insights from a diverse range of stakeholders, including citizens, government officials, and experts in information technology. The findings indicate that the NDMC's e-Governance initiatives have significantly improved transparency, efficiency, and accessibility of municipal services, leading to increased citizen engagement. Digital platforms have enabled citizens to report issues, access information, and participate in decision-making processes more easily than before. However, the study also identifies several challenges, such as digital literacy, privacy concerns, and the digital divide, that could hinder the full potential of these initiatives. The implications of this research underscore the importance of continuous improvement and adaptation of e-Governance strategies to meet the evolving needs of citizens. Recommendations include enhancing digital literacy programs, implementing robust data protection measures, and developing inclusive strategies to ensure equitable access to e-Governance services. By addressing these challenges, the NDMC can further strengthen citizen participation and foster a more responsive and accountable urban governance framework. This abstract summarizes the essence of the study, providing a clear overview of its objectives, methodology, key findings, and implications, without diving into the specifics of the data or the detailed recommendations.

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e-Governance, Citizen Participation, New Delhi Municipal Council (NDMC), Digital Transformation, Urban Governance.

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