Volume 11 | Issue 7 |

 Abstract

Tropical diseases affect the world's poorest countries. The area of the globe between Tropic of Cancer and Tropic of Capricorn is known as the tropical region. Due to geographical and climatic regions such as hot and humid climates and heavy rainfalls, conditions become favourable for vectors and carriers which cause these diseases. Another division of tropical diseases is Neglected tropical diseases (NTD's) because they lack research and development for their eradication. The WHO has recognized 17 diseases as NTD's caused by bacteria, parasites, protozoa, and viruses. Nanocarrier-based novel drug delivery systems (NDDS) or Nano medicine is an emerging field that works on nanosized particles for the treatment of chronic human diseases, diagnosis, and tissue regeneration. Due to limitations of conventional drug therapies like toxicity, unusual pharmacokinetic profiles, there is a need to reformulate available drugs. Importantly, NDDS can boost drug stability and water solubility, increase circulation time, promote drug uptake/entry into target cells or tissues, and decrease enzyme degradation, thus increasing drug safety and efficacy. This review article contains factors prevailing tropical diseases, current drug therapies and challenges associated with them, importance of nanobased therapeutics, types of nanotherapeutics used in treatment of NTD's. This review article also contains overview of different types of nanocarriers used in therapy and nanotechnology based case studies. It is a challenging task to develop new drugs for tropical diseases because a huge investment of time and money is required which is a much risky task.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Nanotherapeutics, tropical diseases, neglected tropical diseases, dengue malaria, noisome, dendrimer, liposome, novel drug delivery system

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The Indian Ocean has long been the hub of great power rivalry, and the Indian Ocean Region (IOR) remains hugely important for India in view of geo-strategically. Indian Ocean Rim Association (IORA) represents this region, and for strengthening relations with this organization, India needs to broaden its area of cooperation. Prime Minister Narendra Modi has been trying to unleash the potentiality of India's diplomacy towards Indian Ocean Region. Prime Minister Narendra Modi wants to strengthen the relations between India and IORA. Then, it is really necessary to understand to potentiality of IORA and its position on that matter. This article explains the role of India's foreign policy towards Indian Ocean Rim Association (IORA) in Modi's era, and how IORA works regarding this area, and also how India maintains its relations with countries in Indian Ocean through this sub-regional organization. This article discusses on that particular note.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

India's foreign policy, Prime Minister Narendra Modi, IORA, Cooperation.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

language is used more than written language in our daily life. English is spoken differently in countries where it is the first language. Hence, Received Pronunciation is chosen as a model in non English speaking countries. Pronunciation plays an important role in improving communication skills. The problem of teaching English is the non native context has become more complex because teaching pronunciation is often neglected in the language teaching. If the learner's general aim is to speak intelligibly in English, his/her attempt should be to acquire some skills in pronunciation. This study is intended to study mother tongue impact on students and how they can cope up with mother tongue and material provided to the students to improve pronunciation skills. It also intended to study techniques, methods and approaches taken to improve pronunciation skills among the students. The use of technology has become an important part of the learning process in and out of the classroom. It enables learners to adapt class room activities for improving pronunciation. It is also presents the importance of innovative trends and methods that are being used particularly in improving pronunciation. Key words: communication skills, methods, approaches, materials, mother tongue impact. ______

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

communication skills, methods, approaches, materials, mother tongue impact.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The Agriculture Produce Markets Regulation (Act) was enacted in the 1960s and 1970s. All major wholesalers are subject to these terms. Good and small businesses have been established and Marketing Committees (APMCs) have been created for all business lines to regulate the rules and regulations regarding the trade of these agricultural products. Thus, the agricultural products union emerged through market law. There are more than 6,600 retail stores across the country so far. The sample of the study consisted of 110 Nizamabad mandi farmers are selected by quota sampling method. One- way Anova and chi-square test were used in SPSS program to analyse the data. The study reveals that most of the farmers are not satisfied with grading, assaying facility, lack of net connectivity, difficulty in handling mobile application.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Agriculture, business, grading, assaying ,mobile application

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Understanding of end users' perceptions towards Information Technology Application in Tribal Region's Academic Library: An Analytical Study" refers to a research study conducted to explore how end users in academic libraries situated in tribal regions perceive the application of information technology (IT). The study aims to analyze the attitudes, opinions, and experiences of end users regarding the use of IT in these libraries. The research likely involved collecting data through surveys, interviews, or observation methods to gain insights into various aspects related to IT applications in tribal academic libraries. These aspects may include the usability of IT systems, access to digital resources, satisfaction with technology-based services, support for remote learning, or any other IT-related services offered by the library. By conducting an analytical study, researchers have employed statistical methods and qualitative analysis techniques to interpret the collected data. The findings of the study may help identify the strengths, weaknesses, challenges, and opportunities associated with IT applications in tribal academic libraries. This understanding can subsequently guide library administrators and policymakers in making informed decisions to improve IT infrastructure, services, and support systems in these libraries.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

User's Perception, Information Technology Applications, Library Promotion, Tribal Region's Academic Library

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This paper gives the idea to develop Aiming to address the growth and the integration of renewable sources and electronic loads, different types of dc-dc topologies with specific feature shave been proposed, going from medium frequency isolated Modular Multilevel Converter. This project presents the theoretical study and simulation validation of a PFC based AC DC using MMC converter applications. This topology is based on the modular multilevel converter (MMC) and employs the concepts of interleaving converters and integrated power stages. A single magnetic element operating at medium frequency is employed to perform galvanic isolation and coupling between the grid-side and load-side converters. The main characteristics of the structure are derived from the aforementioned characteristics, such as passive elements operating with an effective frequency higher than the switching frequency, minimized current ripples at high frequency, as well as reduced volume and weight.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Modular Multi-Level Converter, Switched Capacitor, Power Factor Correction Controller, Half Bridge

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Nearly everywhere in the world has seen negative economic growth as a result of the COVID-19 epidemic that has been present since December 2019 (in China) and March 2020 (in Indonesia). This also applies to Indonesia. In order to stop the covid-19 virus from spreading, the community's economic movement was restricted (PSBB), which resulted in this negative economic growth. PSBB has an impact on lowering household consumption. Consumption is one of the key drivers of overall spending and significantly contributes to economic expansion. There are both objective and subjective elements that affect household consumption. Using a literature review, it was determined what degree of consumption households would experience during a pandemic. The analyses' findings back the Keynesian theory, which holds that disposable income will have a substantial impact on household consumption during the COVID-19 epidemic

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Pandemic, Economic Growth, Household Consumption, Disposable Income, and Keynesian Theory

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Procrastination as a widespread phenomenon that experiencing negative results due to unnecessarily avoiding task. It is a serious issue in the educational environment which involves voluntarily delaying the unpleasant task for another time, where learner experiences short term benefits and long-term costs. This paper includes thirty-five studies of the researchers from India and abroad, with the intent to ascertain the relationship among academic procrastination, self-efficacy and locus of control. In first phase the focus was established on the relationship between academic procrastination and self-efficacy and in second phase focus was on the relationship between academic procrastination and locus of control. From detailed analysis of reviews, earlier studies depicted mixed and contradictory results on the relationship among these variables. some studies found significant relationship among the variables and some did not. To address some limitations, future research should expand the understanding of relationship among these variables. This paper would provide a direction to the future researcher in order to understand the nature and predictors of academic procrastination.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Academic Procrastination, Self-efficacy, Locus of control

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Scrub typhus is a bacterial infection caused by the Orientia tsutsugamushi bacteria. The illness can cause anything from a fever to serious multi-organ malfunction. Clinical symptoms and antibody serological testing, which have low sensitivity and specificity, are used to make the diagnosis. Multiple organ dysfunction syndrome (MODS) and hemophagocytic lymphohistiocytosis (HLH) are only infrequently linked to scrub typhus. In this study, we describe a 62 year old female who had a prolonged fever without eschar. Following the negative results of normal tests, she was identified as having scrub typhus. After receiving dexamethasone, enhanced life support, and anti-rickettsial medication, the patient, who had progressed to HLH and MODS, made a successful Furthermore, we provide a brief review of the literature on scrub typhus and its complicationsrecovery. Furthermore, we provide a brief review of the literature on scrub typhus and its complications. Introduction Thebacteria Orientia tsutsugamushi causes the natural foci illness scrub typhus. The illness can cause anything from a minor fever to many system dysfunctions. The most pathognomonic symptom is an eschar. Despite their poor sensitivity and specificity, clinical symptoms and serological tests (such as the Weil-Felix test) are employed to diagnose scrub typhus. Alternative testing include enzyme-linked immunosorbent assays (ELISA), polymerase chain reactions (PCR), serum immunoglobulinM (IgM) and immunoglobulinG (IgG) antibodies. mNGS, or metagenomic next generation sequencing, is a cutting-edge approach for locating unique pathogenic diseases. Scrub typhus cases have only seldom been confirmed by mNGS up to this point. Scrub typhus cases have been recorded more frequently in recent years. Multiple organ dysfunction syndrome (MODS) and haemophagocytic lymphohistiocytosis (HLH) linked with scrub typhus have only been described in a small number of investigations. In the rare and fatal hyperinflammatory disease known as HLH, T lymphocytes and macrophages are overactive, while natural killer (NK) cells and cytotoxic T lymphocytes are depleted. This leads to various organ dysfunction caused by cytokine-mediated multiple histiocytic phagocytosis of blood cells. Genetic mutations are the root cause of primary HLH. Immunodeficiency, autoimmune disorders, infections, and malignancies are the primary causes of secondary HLH. In this case report, scrub typhus without eschar was determined by immunoglobulins . The patient developed HLH and MODS but showed clinical improvement. We also analysed the clinical characteristics, diagnostic approaches, therapeutic approaches, and clinical results of scrub typhus and associated HLH.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Orientia tsutsugamushi, hemophagocytic lymphohistiocytosis disease, scrub typhus

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The term premenstrual syndrome has been used for many years to describe disturbances of mood or physical symptoms occurring regularly 7-10 days before menses and remitting during menses. The Diagnostic and Statistical Manual of Mental Disorders (DSM III- R) Included PMS among the ,,proposed Diagnostic Categories Needing Further Study" under the Name of Late Luteal Phase Dysphoric Disorder (LLPDD) and established among its diagnostic Criteria the need for daily prospective symptoms self-ratings during at least two cycles for Confirmation. In this paper, we discuss anxiety level of the adolescent girls about premenstrual syndrome. The main study was conducted at government girl's Higher Secondary school Thiruvandarkoil, Puducherry. The period of data collection was 1 week, and the data were collected from the 60 adolescent's girls by using questionnaires and anxiety scale. Convenience sampling technique was used. The findings shows that Majority of the adolescent girls 50(83.3%) had Moderate level of anxiety towards on Premenstrual Syndrome and 14(23.3%) had low level of Anxiety towards on Premenstrual Syndrome and the mean and standard deviation the level of Anxiety towards on Premenstrual Syndrome among adolescent girls is (10.75+2.096) Re The study shows that Majority of the adolescent girls have moderate level of Anxiety..

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

premenstrual syndrome, adolescent girls, anxiety

  License

Creative Commons Attribution 4.0 and The Open Definition