Volume 11 | Issue 7 |

 Abstract

Abstract Cilnidipine is a medication which are used for the treatment of hypertension (The drug Which lowers the blood pressure). The Cilnidipine is a BCS Class-II drug.Cilnidipine is a medication which are used for the treatment of hypertension (The drug Which lowers the blood pressure). The Cilnidipine is a BCS Class-II drug.It is a novel dihydropyridine calcium antagonist and its calcium antagonistic activity last for a long time more than other drugs like Nifedipine and NicardipineThe objective of the study is to get knowledge about formulation and evaluation parameters of orodispersible tablets of Cilnidipine. The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine.

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 Keywords

Cilnidipine, Orodispersible,

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The high level leap of machines into additional adroit universes has lead examiners to cultivate complex systems that can investigate human diseases through computer based intelligence instruments and techniques. One of the key investigation locales in such way is the skin ailment disclosure through picture dealing with. Unmistakable evidence of skin contaminations from the high level pictures is extending a result of complex challenges of the area. Multiclass support vector machine system. For affirmation of the diseases from the skin pictures different notable surface and repeat region features like Dim Level Co-occasions Cross section (GLCM), have been used with Assistance Vector Machines (SVM) based classifiers. Most outrageous affirmation correctnesses of 96.25%. have been seen on test set. Probably this is the essential local automated innocuous system to recognize skin diseases in India.

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Index Terms - SVM,GLCM,Machine Learning,Image processing

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Abstract: - Humans have always tried to increase their cognitive capacities through a variety of methods, including the usage of stimulants. Healthy people use prescription drugs like methylphenidate and modafinil as well as commonly available stimulants like caffeine to improve their cognitive function. For the treatment of sleep disorders such as narcolepsy, obstructive sleep apnea syndrome, and shift work sleep disorder, doctors routinely prescribe modafinil, a non-amphetamine stimulant. Additionally, research has shown that Modafinil improves cognitive abilities. Thus, it is increasingly being used by healthy people to increase alertness or lessen feeling fatigued. Patients receiving modafinil for the treatment of cognitive impairment who have psychiatric illnesses have also reported experiencing similar effects. According to clinical studies, modafinil reduces the symptoms of attention-deficit hyperactivity disorder (ADHD), schizophrenia, and significant depression in patients. When evaluating patients, psychiatrists hardly ever ask about coffee consumption. This could fail to recognize caffeine-related issues and provide effective remedies. A lot of psychiatric diseases share symptoms with excessive coffee consumption. People with eating problems frequently abuse caffeine, which has been linked to the aggravation of sleep and anxiety issues. It blocks adenosine receptors, which could increase dopaminergic activity and make psychosis worse. Caffeine has been reported to exacerbate psychotic, hostile, and anxious symptoms in mental patients. Before administering hypnotics, a routine mental evaluation of the patient's coffee use should be conducted. It is probably better to gradually cut back on consumption or gradually switch to caffeine-free alternatives than to stop suddenly. In psychiatric wards, decaffeinated beverages should be available. Background: - Many different bioactive chemicals found in caffeine, which is extensively ingested in beverages including coffee, chocolate, and soft drinks, may have an impact on disease-related pathway activity. The Diagnostic and Statistical Manual of Mental Disorders (DSM-V) now includes revised guidelines for disorders associated with caffeine consumption. The diagnosis of caffeine withdrawal is now formally recognized, and criteria for caffeine use disorder have been put forth for further research. Similar to other substance use disorders, caffeine use disorder is supposed to be characterized by cognitive, behavioral, and physiological symptoms suggestive of caffeine use despite serious caffeine-related issues. However, given the prevalence of non-problematic caffeine use, some medical professionals may find it challenging to accept the potential that caffeine consumption might lead to the same pathological behavior as alcohol, cocaine, opiates, or other drugs of abuse. When evaluating patients, psychiatrists hardly ever ask about the consumption of caffeine. This could fail to recognize caffeine-related issues and provide effective remedies. A lot of psychiatric diseases share symptoms with excessive coffee consumption. People with eating problems frequently abuse caffeine, which has been linked to the aggravation of sleep and anxiety issues. Adenosine receptors are inhibited, which could increase dopaminergic activity and aggravate psychosis. Caffeine has been observed to exacerbate psychotic, hostile, and anxious symptoms in mental IPD patients. A routine psychiatric examination of caffeine consumption drinks (coffee, soft drinks, chocolates, etc.) should be conducted before prescription hypnotics. A gradual decrease in consumption or a gradual switch to caffeine-free alternatives is likely preferable to a sudden end. There should be decaffeinated beverages available in the Psychiatry ward. Objective: - The objective of this article is to give a thorough review and analysis of the research on human caffeine withdrawal to evaluate key aspects of the disease and empirically validate particular symptoms and indicators. To evaluate key aspects of health issues and the impact of cognitive behavior, this paper publication will present a thorough review and analysis of the literature on human consumption of caffeine withdrawal. Specific symptoms and signs will be validated through empirical research. Methods: - A literature search revealed found several survey research articles and some clinical investigations on the consumption of caffeine or addiction withdrawal which fulfilled the inclusion criteria. A relevant article was found by searching for terms like caffeine abuse, CNS stimulants, and alcoholism on relevant search engines such as Google Scholar, and PubMed, Research Gate. The methodology of each study was assessed to ascertain the validity of the effects. Results: - Compared to conventional psychostimulants like amphetamine, methylphenidate, or cocaine, modafinil is recognized to have fewer or no negative side effects. As an antipsychotic or anti-fatigue agent, it is usable. Modafinil's awakening process hasn't been fully uncovered, though. According to recent studies, modafinil usage and addiction are possible. Additionally, ongoing insomnia triggers stress reactions and impedes immunological performance. Therefore, a routine psychological assessment should include a caffeine intake examination. This is crucial for individuals who struggle with substance abuse, food disorders, sleep difficulties, and anxiety. The assessment of alcohol and drug usage can readily include assessment. It is fair to inquire about the usage of over-the-counter products containing caffeine in patients who abuse drugs or have eating disorders. Conclusion: - Anyone who needs to stay awake, work late, improve cognitive reactions, or lift their mood can utilize modafinil. Users, such as cancer patients or troops in a combat zone, may already be experiencing high levels of stress. Investigating the several functions of modafinil requires a psychoneuroimmunological approach. The caffeine-withdrawal syndrome has been adequately described, and there is enough research evidence to support its inclusion as a condition in the DSM and a change to the ICD's diagnostic criteria. It would seem that caffeine is not a "pure" cognitive enhancer. Caffeine's indirect effects on arousal, mood, and focus are a major factor in how well it might enhance cognition.

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Caffeine, CNS Stimulant Drugs, Opioids, Alcohol-induced disorders, Alcohol-induced neurocognitive disorder

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ABSTRACT: In India, most of its population resides in rural areas and therefore the democracy should begin thereon in order to ensure good governance and a better functioning of democracy that we desire. To extend democracy to the rural India, the system of Panchayati Raj was established in India. The Panchayati Raj system is not a new concept and therefore is considered as one of the best ways of governance of the rural India. However, the system of Panchayati Raj, despite having derived their powers and existence from the Constitution of India, faces a lot of challenges in their day to day working because of various reasons and therefore this third tier of government has not been able to serve the purpose with which it was introduced in India.

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KEYWORDS: Panchayati Raj Institutions, Issues and Challenges.

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Management of a company's working capital entails controlling the balance between its current assets and current liabilities. The term "working capital" refers to money that a company uses to purchase immediate assets. Namely, goods in stock, accounts receivable, cash on hand, and loans and advances made to other parties. These current assets are crucial to the efficient running of the firm and effective utilisation of the fixed assets. Both liquidity and profitability may be affected by how effectively you manage your working capital. The cash available for daily operations is the engine that keeps a company running. Similar to how blood flow is vital to keeping a physical organism alive, a company's working capital is critical to keeping operations going smoothly. Without regular access to funds, it would be impossible to keep a firm afloat. It is often held that a company's profitability and liquidity levels are correlated negatively. To assist sustain future development, this study analyses the effect of steel authority of India ltd.'s working capital management practises over the fiscal years 2006 through 2016. Ratio analysis and a declaration of W.C. change are employed as research methods here

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Working Capital Management, Liquidity, Capital.

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The performance of convolutional neural networks (CNN) in the diagnosis of pneumonia and malaria, two serious illnesses, is examined in this article. The research compares the efficacy of various CNN architectures in identifying these diseases using a dataset of medical images that is openly accessible. With some architectures performing better than others, the findings show that CNNs can achieve high accuracy in the diagnosis of both malaria and pneumonia. According to the research, CNNs may prove to be an invaluable instrument for the rapid and accurate diagnosis of these diseases, which could lead to better patient outcomes and even lifesaving outcomes. Disease prediction system based on Convolutional Neural Network (CNN) (class of Deep Learning (DL) algorithm) with feature extraction and classification. Malaria spreads from the bites of mosquitoes and are transmitted to the people by the parasites. Pneumonia is an interstitial lung disease and affected to the childrens who were mostly less than two years old.

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Convolutional neural network (CNN), Malaria diagnosis, Pneumonia diagnosis, Computer-aided diagnosis (CAD), X-ray, Image segmentation, Performance evaluation, Clinical decision support

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The district of Dhemaji that lies in the north eastern part of Assam is a flood affected area. This study aims to understand the behaviour of the ground water in the vicinity of Dhemaji town in particular and in the district in general. Previous literature and data is scarce on it. An effort has been made to use the available technical data, primary data found in investigation and relevant literature reviews to infer about the behaviour of ground water in the study area. For the purpose of knowing the movement of ground water in the study area, hydrometeorology, soil characteristics, topographic slope, thickness and expansion of subsurface aquifers and hydrogeological characteristics of the area are also considered. The study reveals that ground water levels in the district are consistent over the years and long term trend of water level (rising or falling) over a period of 10 years is insignificant.

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aquifers, hydraulic gradient, ground water.

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Creative Commons Attribution 4.0 and The Open Definition

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In social accounting the focus tends to be on larger organisations such as multinational corporations (MNCs), and their visible, external accounts rather than informally produced accounts or accounts for internal use. The need for formality in making MNCs accountability is given by the spatial, financial and cultural distance of these organisations to those who are affecting and affected by itSocial Accounting has been one of the first major stepping stones in improvement in corporate social responsibility. For many organisations that undertake this process, it is the first time that attempts have been made to go beyond financial measurements.Social accounting supersedes the traditional audit audience, which is mainly composed of a company's shareholders and the financial community, by providing information to all of the organisation's stakeholders.

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Object, Needs and Present Situation

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Dr Bhimrao Ramji Ambedkar (1891-1956) was an Indian jurist, economist, politician and social reformer. He was a social revolutionary in many ways. Born into the 'Mahar' community, which was considered an 'untouchable' caste, as a child Dr Ambedkar had a first hand experience of the caste system in India and the discrimination meted out to the untouchables. Having gone through the dehumanizing experience of being ostracized by society by virtue of his 'caste', he made a firm resolve to radically alter the state of affairs. He criticized the caste system as unjust and the practice of untouchability as inhuman. He sought to awaken and organize the untouchables into a potent social and political force. He criticized the Hindu scriptures for their bias against the lower castes. He advocated the abolition of the caste system in his famous work The Annihilation of Caste. As the chief architect of the Indian Constitution, Dr Ambedkar also made sure that the practice of untouchability was banned. Dr Ambedkar has left an indelible mark on the Indian society. His untiring efforts for the upliftment of the untouchables shall be remembered for generations to come. It was largely due to his zeal that the untouchables have got legal and constitutional guarantees to live with dignity and equality.

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caste, untouchables, society, Constitution, equality

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Flyash (FA) a waste product of thermal power stations, generated problems of its disposal. Flyash has a variety of inorganic oxides and is available in finely powdered form and utilization as filler in plastics for enhancing the properties of product. In this work, fly ash treated with silane coupling agent is used as filler in Nylon-66/flyash prepared via melt blending. The comparison of the properties of composites filled with treated and untreated fly ash revealed that the composites with treated fly ash showed better reinforcing properties. Flyash treated with silane coupling agent gave better reinforcement than untreated flyash. The cracking of the particulate structure can be avoided due to adherence of flyash as particle which indicates the increase in strength of interfacial bonded. The properties of composites filled (10%FA) with treated and untreated are compared. These particulate reinforced thermoplastic composites are designed to improve the properties and to lower the overall cost of engineering plastics. In this study the effects of surface treatment with different percentage 1%, 2%, 3% on the mechanical, thermal and electrical properties of Nylon-66/flyash composites were reported.

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Nylon-66, Flyash, Coupling agent, Mechanical, SEM

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Creative Commons Attribution 4.0 and The Open Definition