Volume 8 | Issue 7 |

 Abstract

Skin is the constitutional and largest organ of the human body and also manageable organ of human body. The outermost layer of the skin stratum corneum (SC) causes a barrier for high molecular weight drug and hydrophilic drugs. Trans Dermal Drug Delivery system (TDDS) are the dosage form which are self-reliant ,distinct dosage form which reaches the system circulation when applied to the skin thus first pass metabolism. The objective of TDDS is to cross the stratum corneum (SC) for which various methods have been used to increase the penetration of the drugs into the skin this reaching the system circulation. Ethosomes are the most promising or pioneering novel drug delivery system. Ethosomes are the novel drug delivery system which contain high concentration of ethanol and water thus which improves the bioavailability and skin permeability. Ethosomes are the novel phospholipids carriers which enable the drugs to reach the blood circulation which are made up of phospholipids. This article focuses on advantages , disadvantages, preparation method, its dosage form such as gels, patches, and creams . Method of characterization parameters are highlighted such as vesicle size, zeta potential, size distribution etc. Ethosomes are innovative carriers for delivery of therapeutic agents

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 Keywords

transdermal, skin permeability, ethosomes

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Creative Commons Attribution 4.0 and The Open Definition

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Symmetric key algorithm also known as secret key, uses same key for encryption and decryption. In future we will have more powerful, faster and better technology, so there will be requirement of advanced cryptographic algorithm for information security. This paper discusses about some advanced cryptographic algorithm with their advantages and disadvantages.

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 Keywords

Symmetric key algorithm, AES, GOST, Kuznyechik, Magma, CAST, Serpent, SEED

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In an age where truth is found to be multifaceted and removed from personal reality, the concept of post truth gains importance This paper is an attempt to trace out a definition of post-truth, its specific characteristics in relation to the human world, and the influence of media, especially social media�how far it creates and distorts truth and the possibilities and prospects of this aspect in the post-truth world. It also discusses the erosion of trust that has taken part as the invasion of media and the ways to be devised to exercise a control over this condition.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

post truth, personal reality, media

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This Current trends in construction industry demands taller and lighter structures, which are also more flexible and having quite low damping value. This increases failure possibilities and also problems from serviceability point of view. Now-a-days several techniques are available to minimize the vibration of the structure, out of the several techniques available for vibration control ,concept of using TMD is a newer one. This study was made to study the effectiveness of using TMD for controlling vibration of structure. At first a numerical algorithm was developed to investigate the response of a shear building fitted with a TMD. Then another numerical algorithm was developed to investigate the response of a 2D frame model fitted with a TMD. A total of three loading conditions were applied at the base of the structure. First one was a sinusoidal loading, the second one was corresponding to compatible time history as per spectra of IS-1894 (Part -1):2002 for 5% damping at rocky soil with (PGA = 1g) and the third one was 1940 El Centro Earthquake record with (PGA = 0.313g). From the study it was found that, TMD can be effectively used for vibration control of structures. TMD was more effective when damping ratio of the structure is less. Gradually increasing the mass ratio of the TMD results in gradual decrement in the displacement response of the structure.

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 Keywords

Tuned mass damper, Vibration, Frame structure, Damping Ratio.

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Digitalisation has revolutionised the educational world right from designing the course structure, course content to the delivery and assessment of the learners. While the developing countries had long adapted to the digital environment in the field of higher education, the onslaught of the current pandemic has made it a necessity in the Indian scenario. This paper seeks to examine teachers� adaptability towards learning in a virtual environment in higher educational institutions in Guwahati. The research focuses on three vital aspects regarding the teachers� perspective namely, their attitude, personal innovation and style of teaching. The study concludes that the teachers present a positive picture for suitable adaptation to virtual learning environment in the higher educational institutions.

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 Keywords

Attitude, higher educational institutions, teachers, virtual learning environment.

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This article aims to describe the effectiveness of large scale social restrictions on the prevention of covid-19 transmission in Indonesia. Covid-19 is a very dangerous plague for the survival and progress of development in Indonesia. Therefore a large scale social Restriction policy is needed in order to prevent covid-19 transmission. The research method used is empirical law research. In this study using a case approach and legislation (statute approach). The analysis used is a qualitative analysis. The purpose of the LSSR policy is to prevent the widespread spreads of the Community Health Emergency disease that is happening among people in a certain area. The effectiveness of large scale social restrictions (LSSR) policies in Indonesia is still very weak due to several inhibiting factors, one of which is the level of public awareness.

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 Keywords

Effectiveness, Policy, Large scale Social Restrictions, Prevention, Transmission, Covid-19

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Creative Commons Attribution 4.0 and The Open Definition

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The outbreak of COVID-19(Severe Acute Respiratory Syndrome Coronavirus- 2) caused threatening viral pneumonia by the end of year 2019. It affects the respiratory tract mainly by binding to the ACE-2 receptors and TMPRSS2, SARS-CoV-2 belongs to the genus Beta-coronavirus, caused the global epicentre in Wuhan, China, and then transformed into a pandemic affecting millions across the world. In India, The World Health Organization and The Central Government of India are ensuring detection and Administrative management of cases suffering from SARS-CoV-2. Recommended guidelines are released by the Central Government of India, Department of Health Research (DHR) and The Indian Council of Medical Research (ICMR). These organisations are able to control and measure the infection of SARS-CoV-2 in accordance to the guidelines of WHO and The Centre for Disease Control and Prevention (CDC) health care professionals and research scientists are trying to identify, isolate, collect specimen and identify the different courses of transmission in humans, manage affected cases of covid-19 by using these recommended guidelines. The detailed genomic sequence(Compare of SARS-CoV-2, SARS-CoV, and MERS-CoV), have many similarities and differences in their genomic structures based on its phylogenetic relationships and is useful for developing diagnostic kits, efficient anti corona virus drugs and also in development of vaccinations. The National Institutes of Health (NIH) providing funding opportunities on COVID-19 clinical trials. In this review article we are trying to focus all these points mainly in Indian perspective and our centre�s experiences that may help prevent the further spread of the pandemic.

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 Keywords

Covid-19, lockdown, Indian Situation, recommended guidelines, SARS-CoV-2, SARS-CoV, and MERS-CoV

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Creative Commons Attribution 4.0 and The Open Definition

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Online reviews play a vital role in today�s business and commerce. In the world of e-commerce, reviews are the best signs of success and failure. Business that has good reviews get a lot of free exposure on websites and pages that have good reviews show up at top of the search results. Fake Reviews are everywhere online. Online fake reviews are the reviews which are written by someone who has not actually used the product or the services. Because of the cut-throat competitions, sellers are now willing to resort unfair means of making their product shine out .This work introduces some supervised machine learning techniques to detect fake online reviews and also be able to block the malicious users who post such reviews.

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Fake Review Prediction, Machine Learning, Na�ve Bayes Classifier, Natural Language Processing (NLP)

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Creative Commons Attribution 4.0 and The Open Definition

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Technology and Language Progression Abstract English language is always adapting, but these changes have come about more hastily as technology has developed in recent years. Rapidly growing influence of technology has altered the way in which we live and think. The cultural, social, and economic life of man has drastically changed. The transform was not limited to the technical things but also the very production and reception of literature. As human beings we develop our own ways to express new things, as well as adapting to different forms of communications. As the digital era has changed the way we communicate, it has also affected the way we use language. We delve deeper in to the ways digital devices have been changing our lives to see how this has affected the English language. In recent years, more and more of our communications are carried out via mobile devices, internet, and social media. These communication channels have introduced some new challenges to users, which have brought about changes in the use of language.

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English, language, technology,change

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract Norms could be a scale that allows conversion from raw score to a score capable of comparison and interpretations. Norms are representative of some larger population. Skill related fitness has six components namely power, speed, agility, balance, coordination and reaction time. All these components are playing important role during sports activities. Power is the ability to employ a maximum force in as short a time as possible as in accelerating, jumping and throwing implements. Power is the ability to pass the body parts promptly while applying the maximum force of the muscles. Power is a composite of both speed and muscular strength. There are so many tests to measure power of an individual. But the researcher took Standing Broad Jump test to measuring leg explosive power of the school students. Objective of the present study were- 1. to construct norms in standing broad jump test of boys students, 2. to construct norms in standing broad jump test of girls students. 3. to measure leg explosive power of school students. Highly positive correlations were found during testing Validity and Reliability of the test item. Total 800 girls and 1000 boys� samples were collected from various schools in West Bengal ages between 9-14 years. After collection of data a percentile norms were prepared for boys and girls students. Percentile norms were prepared according to age group and sex wise.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Norms, Explosive Power, Percentile scale, Standing Broad Jump

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Creative Commons Attribution 4.0 and The Open Definition