Volume 11 | Issue 7 |

 Abstract

Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs. Proteins and antigens intended for therapeutic purposes may be incorporated or adsorbed onto SLN, and further administered By parenteral routes or be alternative routes such as oral, nasal and pulmonary. The obstacles associated with conventional chemotherapy may be partially overcome by encapsulating them as SLN. The present review focuses on the utility of SLN in terms of their advantages, disadvantages, method of preparation, characterization and applications.

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Key Words: Solid lipid nanoparticles, drug delivery, drug incorporation.

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For 30 years SAS has been used in pharmaceutical research setting for data management, analyze, visualize and reporting. Traditionally, these roles were staffed by BASE SAS programmer and the statistician. At the same time, dramatic shift in the researches informatics eco-system have occurred with advance in standards, such as CDISC. ICH and convergence of clinical trials data management systems and modernization strategies, such as electronic data capture and report in the form of CRF. This paper provides a broad-based view of how SAS can be used across the research information spectrum. We are focusing on Server, Data Integration Studio and SAS Business Intelligence products. The SAS Drug Development solution merges the accessibility of the Internet with the Clinical Trials Workflow. Whether we focus is beating data into submission or making it sing and in reports, this paper will make the connections to the various solutions from SAS and where each solution is most valuable in the pharmaceutical setting. This paper is appreciated for people at all levels and across the spectrum of job skill, including the production of clinical study reports, clinical trials management and laboratory data analysis. It is specifically designed for the programmer, statistician, manager and system administrator and submit all the reports to regulatory authorities like FDA.

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 Keywords

Clinical SAS Drug Discovery ,Drug development, Preclinical trials,Clinical trials (Phase 1, Phase II, Phase III, Phase IV ) , Regulatory authorities involved in drug discovery, CDISC , CDMS, CDSCO, SAS

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The present research paper aims at analyzing Bapsi Sidhwa's Ice-Candy-Man and Amitav Ghosh's The Shadow Lines with reference to Decolonization. In the arena of Post-Colonial Studies, the article looks at Anti-Colonial theory as a counter-narrative. The paper illustrates how the selected texts interrogate the very notion of colonialism, develop consciousness among marginalized and subjugated individuals, and empower them to take radical actions in order to define their identities and resist colonial atrocities. Ice-Candy-Man, Bapsi Sidhwa's third and widely quoted novel is one of the most powerful narratives of recent time. The Shadow Line is a Sahitya Akademi Award-winning novel by Amitav Ghosh. It is a book that grabs the perspective of time and events, the lines that connect and divide individuals. The paper shall attempt to compare and evaluate the effects of colonialism and how those individuals tried to overcome imposed national identity interpellation through global cosmopolitan outreach.

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post-colonialism, decolonization, partition, communal riots, nationalism

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This research paper critically analyzes Margaret Atwood's dystopian novel, The Handmaid's Tale, from a feminist and political perspective. It focuses on the plight of women within the oppressive regime depicted in the narrative, examining the intricate web of power structures, gender roles, and reproductive control that dominate the totalitarian society of Gilead. The study also explores the subjugation and resilience of female characters within this context. Utilizing a feminist theoretical framework, the systemic oppression faced by women. It investigates themes of agency, resistance, and the role of language. The research highlights how Atwood's novel challenges patriarchal norms and exposes the role of language in subverting oppressive systems.

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Margaret Atwood, The Handmaid's Tale, Feminist Theory, Political Analysis, Women's Oppression, Gender Roles, Reproductive Control, Power Structures, Agency, Resistance, Language, Patriarchal Norms, Gilead, Dystopian Literature, Political Extremism, Feminist Discourse.

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Monoclonal antibodies (mAbs), which are defined as a single antibody (Ab) cloned from a single B cell, have been used as immune modulators for transplantation, autoimmune disorders, and cancer for decades. To protect itself from many invading diseases, the vertebrate immune system is continually changing. The vertebrate immune system responds to a foreign pathogen by producing complementary antibody (Ab) molecules that can bind to all molecular structures of the microbial pathogen (bacteria, viruses, fungi, nematodes, and other parasites) and keep up with an organism's diverse mutations. Antigen is any particle that enters the body and is identified by the vertebrate immune system as a foreign object. As a result, the immune system is attacked in two ways. First, B cells create a variety of antibodies that are specific for a novel antigen (epitope). Second, the antibody's paratope-encoding genes are rapidly altered in order to cope with and attach strongly to the antigen's epitope. As a result, antibodies were generated.

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Monoclonal Antibody, Hybridoma Technology, Applications, Types, Side effects.

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Kishkindha Kand is one of the seven kands in Valmiki's Ramayan. The Kand involves the meeting between Lord Rama and his disciple Hanuman. It also features the story of two vanar brothers Bali and Sugriva and how Rama killed Bali who enslaved Surgriva's wife. It was in Kishkindha Kand that Jambvant made Hanuman realise about his strength, powers and capabilities. We are here to narrate to you the story of Kishkindha Kand with the help of pictures. This part will tell you about the encounter with Hanuman and Surasa, the mother of Nagas.

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Kishkindha Kanda ,fourth chapter of Ramayana ,great epic of India

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Abstract Nowadays ovarian cysts are a common threat in reproductive women throughout the world. The present study was conducted to find out the physical and physiological problems may be faced by the women who have ovarian cyst. To carry out this study, total 30 adult female subjects (23-28years) having ovarian cysts were selected. Selected Physical and physiological variables were Body mass index (BMI), fat percentage, fat mass, lean body mass and problems related with menstruation cycle. The selected methods for the evaluation of physical and physiological variables were, BMI was measured by formula weight in kg and height in meter squire; and fat percentage, fat mass and lean body mass were calculated by using method YMCA skin fold Caliper. Physiological variables were determined by using questionnaire. The present study revealed that the value of Fat percentage (30.39%) of the patients having ovarian cysts was significantly high that may be considered in danger category. From the study, it was also observed that most of the female subjects faced irregular menstrual cycle, acne, abdominal pain, sleeping problem, anxiety, angriness etc. Most importantly, a challenging problem, infertility, was being observed among the patients. It can be concluded that the ovarian cysts may have a negative impact on physiology of menstrual cycle and create undesired effects on obesity, fertility and behavioral changes of the patients.

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Keywords: Ovarian cyst; Infertility; Menstrual cycle; Body composition

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This technical paper delves into the realm of network sniffing, a powerful technique used to capture and analyze network traffic. Through a comprehensive exploration of various network sniffing methods, tools, and protocols, this paper unveils the underlying concepts and implications of network sniffing. It discusses the potential applications of network sniffing in network monitoring, security analysis, and troubleshooting while addressing the ethical and legal aspects surrounding its usage. By shedding light on the intricacies of network sniffing, this paper aims to equip readers with a deeper understanding of this pervasive networking technique and its implications in today's digital landscape.

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Network sniffing, Network traffic analysis, Network monitoring, Security analysis, Network protocols, Network tools, Scapy, Digital landscape

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Due to rapid modernization, the number of building is increasing day by day. One of the main components of building is concrete since a huge amount of concrete is used in the construction of the building, the concrete should be eco-friendly, durable and its strength should be high. Concrete is a composite mixture of cement, coarse aggregate, fine aggregate, and water. But cement has many adverse effects on environment as well as on health. During the manufacture of cement, for 1kg of cement, it emits 900gm of Carbon dioxide (CO2). So, we found out many alternatives to cement, in that "Fly Ash" is an eco-friendly green material, which is produced by burning the coal in the electricity-producing Thermal Plant. Fly Ash in the concrete reduce the heat of hydration so the reduction of thermal crack is observed. The replacement of the cement by the Fly Ash improves the workability and pump ability of the concrete. The life of the concrete structure is estimated to be 40 years but in many research, it is found that if 35% of the cement are replaced by Fly Ash increases the life of cement structure by 120 years, but if the replacement is more in the concrete the compressive strength may decrease slightly. The cost of Fly Ash is more economical than cement. Direct disposal of Fly Ash causes environmental problem and health issues as it is a waste material. Hence considering all the research, the strength of the concrete increases using modified and activated Fly Ash in all research, the strength of the concrete increases using modified and activated Fly Ash in the correct amount.

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 Keywords

Eco-friendly, Durable, Modified, Activated, Workability

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There has historically been a nearly global propensity to enhance the capacity demand of the structure in order to counterbalance such events, which occur after every significant earthquake. Only in the last ten years have innovative approaches to solving this issue successfully been created. The emphasis is now placed on serviceability and safety under various earthquake magnitudes in the current international practice of performance-based engineering design. Additionally, it is becoming increasingly clear that in addition to methods for increasing ductility, the toolkit of a structural engineer should also contain devices that dissipate and share energy as well as those that can regulate a system's response. In order to prevent "dislodgement" or "unseating" of the superstructure in the event of strong ground shaking, new methods and systems have been developed. The focus of this work is on how these concepts might be applied to bridge designs that are reasonably earthquake resistant. One of the structural processes that significantly affects bridge design is wind load. The wind load is dynamic by nature. This indicates that it has a time- and space-dependent magnitude. As a result, analysing and modelling such a load and its respective effects on a building may be rather difficult and require a deep understanding of both structural analysis and mathematics.

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Wind load analysis, Bridge design, Seismic retrofitting, Seismic vulnerability assessment, Seismic isolation systems

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