Volume 11 | Issue 6 |

 Abstract

Aphthous stomatitis, one of the most common ulcerative diseases, is primarily associated with the oral mucosa and is characterized by excruciatingly painful, recurring, single, or multiple ulcers in the upper throat and oral cavity. The condition is also known as canker sores, cold sores, recurrent aphthous stomatitis (RAS), and recurrent aphthous ulcers by both the general public and medical professionals (RAU). During the active disease phase, eating, drinking, and swallowing are all affected, lowering the quality of life. In most cases, analgesics, antibiotics, and topical steroid application are the only medications used to treat symptoms. These over-the-counter medications can have serious side effects on occasion. Herbal medicine is a safer and more effective alternative to pharmaceutical medications. The goal of this article is to examine the regularly use herbal remedies and determine how it is working to treat mouth ulcers.

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 Keywords

Mouth Ulcer, Herbal Treatment, Recurrent Aphthous Ulcer (RAU), Herpetiform Ulcer

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National highways and express ways play a crucial role in the development of states, but there is a pressing need for a road safety system to address this problem. Road traffic accidents have been identified as detrimental factors that hinder economic growth in developing countries due to their high associated costs, leading to social and economic concerns. Maharashtra, one of India's more advanced states, boasts a relatively dense road network and a higher concentration of motor vehicles compared to other states. The rapid growth of the population, coupled with increased economic development and motor vehicle usage, is a primary contributor to road accidents.

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Road safety, Accident Causes, Black Spot Identification, and Analysis

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Due to growing environmental awareness, as well as stricter regulations on managing industrial waste, the world is increasingly turning to researching properties of industrial wastes and finding solutions on using their valuable component parts so that those might be used as secondary raw material for other industrial applications. Lime sludge production is a by-product of paper making in the paper mill industries. To date, these by-products are being used in other industrial branches and in the field of civil constructions, such as in cement manufacturing along with clinker and in masonry work for civil works. Considering the specificity of physical and chemical properties of lime sludge and a series of possibilities for its use in concrete, this research work demonstrates the possibilities of using lime sludge as partial replacements of cement in concrete. This research work presents an investigation of different properties of materials used for mix design. Quality tests were conducted to check the suitability of material for mix design. Mix design was done according to IS guidelines and the result of it was 1:1.62:3.40. The objective of the study is to check the compressive strength of concrete by adding lime sludge as partial replacement of cement in various percentages. In this work 20% cement has been replaced by five proportions of lime sludge. The five proportions are (0% Lime sludge), (5% Lime sludge), (10% Lime sludge), (15 % Lime sludge) & (20% Lime sludge). It has been observed from the 3, 7 & 28 days tests of compressive strength of concrete that compressive strength decreases as the percentage of lime sludge increases in the mix when compared with controlled concrete. The compressive strength, analysis carried out in this work gives a deeper insight into the cementitious properties and pozzolanic behaviour of such by-products when used for construction purposes. The results show that the strength properties of concrete vary significantly when cement is partially replaced by lime sludge.

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Partial replacement of cement with lime sludge

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Glaucoma is one of the disorders that harms eye vision and gets worse over time. Internal ocular pressure increase is the cause of it. The development of optical coherence tomography (OCT) in retinal diagnostic imaging is the most important. Multiple methods are used to detect glaucoma, including macular edoema, blood vessels, the visual disc, and the optic nerve. The major objective of this essay is to explain to readers why it is unusual to find glaucoma in diabetic retinopathy and how various procedures are utilised to do so. It incorporates a number of technologies and different inputs. It also offers information on the open data sets that are used to develop and evaluate algorithms.

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OCT, macular edoema, diabetic retinopathy, glaucoma, and retinal diagnostic imaging

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Pharmacovigilance is defined by the World health organization as "the science and activities relating to the detection, assessment, understanding, assessment and prevention of adverse effects or any other drug related problems". Pharmacovigilance currently raises awareness in India about adverse drug reactions (ADR), and this review provides data on effectiveness in addressing existing issues. This essay's description of living in India, its difficulties, and its prospects for the future perfectly encapsulated the ideal and approach utilized in pharmacovigilance. In this article's goals are to make the argument for the importance of pharmacovigilance, to document its development and eventual recognition as a significant field of medical knowledge, and to discuss its effects on patient welfare and overall public health.

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 Keywords

Pharmacovigilance, Adverse drug reaction, Uppsala monitoring center, Drug safety, World Health Organization, Pharmacovigilance Program in India (PvPI)

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The procurement process plays a significant role and improvements can be made for increasing the productivity of the materials team thereby resulting in improvement in production. Being a public sector, following procurement guidelines viz: tendering, evaluation, conducting auctions amongst technically & commercially qualified bidders, and meeting the plant requirements on scheduled time is a challenging task for the company. The present study analyses the dimensions of the effectiveness of the input procurement system and also examines general information about the suppliers. The study stated that the identified five dimensions of the input procurement system have a positive opinions by the respondents. The results indicate that the dimensions transparency, adaptability, ease of, and grievance redressal are significantly associated while the timely payment is not significantly associated with the input procurement system.

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Adaptability, Effectiveness, Grievance, Procurement, System, Transparency

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This study investigates how Basalt Fiber Reinforced Self-Compacting Concrete (BFRSCC) performs in exterior beam-column joints subjected to positive quasi-static loading. The research focuses on understanding the behavior of basalt fibers when combined with M30 grade Self-Compacting Rubberized Concrete (SCRC) and 12mm chopped Basalt fiber. The aim is to provide valuable insights for the design and construction industry on the use of BFRSCC in reinforced concrete structures, following the principles of strong column weak beam theory for ensuring structural integrity. Experimental findings consistently show that the initial crack occurs near the bottom of the beam close to the joint and progresses upward during loading cycles, resulting in flexural cracks and beam hinging at the joint interface. Shear failure is identified as the primary mechanism leading to failure. By incorporating smaller proportions of crumb rubber and basalt fiber, the ductility of the specimens is improved in terms of displacement and stiffness. Crumb rubber inclusion enhances crack load and ultimate deflection, while basalt fiber reinforcement enhances crack load, ultimate load, and ultimate deflection. However, careful selection of the fiber content is crucial to balance the load-carrying capacity and stiffness. Challenges in meeting flowability requirements limit the exploration of higher fiber percentages, calling for further research. The study evaluates ductility and reveals significant enhancements with crumb rubber and basalt fiber. The findings contribute to construction practices and provide guidance for engineers, researchers, and practitioners involved in the construction of resilient and durable moment-resisting frame structures. Future research can explore alternative mix designs and examine the behavior of BFRSCC under different loading conditions to expand its practical applications.

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Basalt Fiber Reinforced Self-Compacting Concrete; Beam-Column Joints; Positive Quasi-Static Loading; Ductility; Crumb Rubber; Structural performance

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 Abstract

The mucus layer that covers the mucosal epithelial surface interacts with mucoadhesive drug delivery systems, and mucin molecules lengthen the dosage form's stay at the absorption site. The situation in which two materials, at least one of which is biological in nature, are kept together for extended periods of time by interfacial forces is known as bioadhesion. Since mucosal layer lines many parts of the body, such as the gastrointestinal tract, urogenital tract, vaginal tract, eye, ear, and nose, it represents prospective sites for the attachment of any bioadhesive systems. The mucoadhesive bilayer tablets include two different therapeutic molecules that each exhibit a unique set of effects at their respective locations.

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mechanism of permeation, bioadhassion, polymer, bilayer tablet, NDDS, Novel Drug.

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The sunlight consists of harmful radiations which affects the skin. The Ultraviolet radiations are of 3 types Ultraviolet A, Ultraviolet B and Ultraviolet C. This article gives a detailed review on different types of Ultraviolet radiation. To protect our skin from Ultraviolet radiation sunscreen formulations are used which either absorbs scatters or reflects the radiation. The harmful effects on skin like photo aging, skin cancer, DNA damage are explained. The present review explains the various types of sunscreen formulations and the agents used for the purpose of sun screening. The agents are of two type's physical and chemical sun screening agents. The physical agents which block the sun light and the chemical agents which absorb the sunlight are listed and explained. To know the efficacy of the formulation sun protection factor calculation is done. The equation used to calculate the Sun Protection Factor value is explained in detail. The ultraviolet spectroscopic method is employed to calculate the Sun Protection Factor. The proposed method is found to be easy and rapid for the calculation of Sun Protection Factor values in the in vitro studies. The herbal formulation is more advantageous than the chemical formulation because of its fewer side effects. Few herbal sun screen agents are listed and explained its activity.

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 Keywords

UV radiations, Sunscreen agents, Sun Protection Factor, Herbal sunscreens

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Abstract-- Nowadays, cosmetics are becoming more high demand in daily life and it was used frequently by many of people per year. Mankind uses various products to enhance beauty and elegance to look young and charming. Cosmetics thus play a vital role in human life. Now days, herbal cosmetic are widely used because of the belief that they have fewer side effects and better safety. Hair is one of the primary parts of the body which acts as a protective appendage. The main objective of the present work is to develop an herbal hair serum for general purpose (daily use) using various herbs with this evaluate the characteristics of cosmetic serum and to identify the best formulation of cosmetic serum. Three formulations of cosmetic serum (H1, H2 and H3) with different concentration of excipients have been developed. They were evaluated for its physical appearance, pH, homogeneity test, viscosity, spreadability test and stability test. All the parameters were found to be good and within the standards. Current research has revealed that herbal formulations are effective in enhancing hair consistency. In the mammalian system, the hair follicle is known to be the most significant organ that determines appearance, gender distinction, give violent temperature protection, and plays a part in tone- defense. The youngish generation have begun to suffer from extreme hair loss problems due to numerous life- related changes similar as fatigue, anxiety, input of junk foods, use of diiferent hairstyling/ coloring styles, etc. The loss of hair isn't temporary in utmost cases, but it results in alopia. numerous people suffering from hair loss are in hunt of multiple treatments due to extreme anxiety and pressure, from tradition to traditional and remedial mending to the use of minoxidil and finasteride. To ameliorate hair growth and to help hair loss, hair root activation is needed. Herbal dress are still generally used by average citizens because of smaller side goods and lesser protection and safety profile. The present study was intended to use different sauces to formulate herbal hair serum for general purposes (hair operation).

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 Keywords

: Citrus Sinensis, flaxseed, Nigella sativa, Zingiber officinale, castor oil painting, Trigonella ,Cosmetic, hair, herbs, formulation, effective, etc.

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