Volume 11 | Issue 6 |

 Abstract

Orodispersible drug delivery systems are used to improve how much of a drug is absorbed by the body and to make it easier for patients to take their medication. Orodispersible tablets, a new type of medicine, quickly break down in the mouth (within 1-3 minutes) when taken orally, without needing to be chewed or swallowed with water. Compared to regular tablets and capsules, orodispersible tablets (ODT) have gained attention over the past three decades because they offer better patient compliance, increased solubility, and stability. Orodispersible tablets have the special characteristic of rapidly disintegrating within seconds when placed on the tongue, as they mainly consist of medicinal substances in solid form. This innovative ODT technology improves the overall treatment experience for patients, especially those with difficulties swallowing, such as children, older adults, and individuals with psychiatric conditions. This advancement in technology has motivated the academic and industry sectors to develop new ways to formulate and evaluate orally disintegrating medications that will be beneficial for future drug candidates.

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 Keywords

Orodispersible, Tablet, Domperidone ,Orodispersible drug delivery system.

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 Abstract

Oral hygiene is essential to a person's overall health. To develop an oral care cosmeceutical as tooth whitening formulation, propane extract of whole peel (WBP) and inner peel of banana (BPI) Musa paradisiaca L. were prepared and evaluated for their phytoconstituents. The extracts (WBP) and (BPI) were then used to prepare teeth whitening formulations T2 and T3. The formulations were evaluated with respect to their physico-chemical parameters, stability studies and in-vitro cosmeceutical use as tooth whitening agents in comparison with the commercial standard formulation T4. Statistical results are expressed as : Mean + S.E.M (n 10), the values "P<0.05 is significant as compared to placebo, **P<0.01 is very significant as compared to placebo, ***P<0.001 is highly significant as compared to placebo.The demand for herbal based product such as toothpaste is high these days. Consumers believed by using herbal based toothpaste are safe, effective and less toxicity because less and only safe chemical used as compared to the synthetically produced toothpaste. Therefore, this study was aimed to formulate and evaluate new polyherbal toothpaste which containing herbal extracts that available in Malaysia to treat periodontal problem. The polyherbal toothpaste was formulated using three herbal extracts namely banana peel (Musa acuminate), guava leaves (Psidium guajava) and orange peel (Citrus arranticum) and tested against Staphylococcus aureus. Bacillus cereus. Escherichia coli and Pseudomonas aeruginosa with different concentrations varying from 100 mg/mL. 250 mg/mL and 500 mg/mL. The significant inhibition has seen against Staphylococcus aureus (12-18 mm) followed by Bacillus cereus (11-15 mm) and there is no inhibition for both Escherichia coli and Pseudomonas aeruginosa. The formulated toothpaste was also evaluated with the standard physiochemical parameters along with the antimicrobial activity. The formulated toothpaste showed potent inhibition against gram positive bacteria but not against gram negative bacteria. Thereby. it opens a window for future study to enhance the ability of the toothpaste and to prove the efficacy and safety of the formulated toothpaste.

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 Keywords

Polyherbal toothpaste, antibacterial activity, Musa acuminate, Psidium guajava Citrus arranticum

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Mathadi workers are Head loaders carrying a load of material on their heads or back to stack at the appropriate place. They are regularly engaged with a specific operation such as loading, unloading, stacking, carrying, weighing, measuring, or other work. Mathadi workers develop chronic low back aches because of these cumulative forces passing on the spine with excessive job demands. The fear-avoidance model (FAM) of musculoskeletal pain describes a potential process for the development of chronic pain syndromes. Hence it was necessary to find out the kinesiophobia in Mathadi workers. 40 Mathadi workers with chronic nonspecific low back pain were evaluated for kinesiophobia using the Tampa scale of kinesiophobia TSK-11. This study showed an average score of 22 points on the scale of kinesiophobia, which is considered a very low level for patients with chronic low back pain. Also, the correlation of kinesiophobia score with age, work experience, and pain intensity showed a very weak correlation which was statistically insignificant. These results are different from the previous studies as behavioural responses observed in Mathadi workers show that these workers choose to face pain, believing that the presence of pain does not justify the limitation of their functional activities.

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 Keywords

Mathadi worker, kinesiophobia, chronic back pain

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The goal of this study was to create a famotidine floating medication delivery system. The floating microspheres can be created to boost famotidine's absorption and bioavailability by keeping the system in the stomach for a prolonged period of time. Floating microspheres carrying famotidine were produced using a variety of polymers, including ethyl cellulose and hydroxy propyl methyl cellulose, using the solvent diffusion-evaporation method. The microspheres featured smooth surfaces, free-flowing behaviour, and good packing. Ethyl cellulose microspheres, with a yield of up to 73.320.14%, contained the most medication. Scanning electron microscopy confirmed their hollow structures with diameters of 331.6 nm. Extended drug release was seen in the created microspheres, and 73.250.23 percent buoyancy was found. The generated batches were examined for % entrapment efficiency, flow characteristics, and yield investigations. The formulations underwent stability testing, and information on in-vitro release and release kinetics was fed into a number of dissolving models. The oral bioavailability, effectiveness, and patient compliance of famotidine floating microspheres were found to be improved by this good and practical strategy for sustained drug release over an extended period of time.

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 Keywords

Famotidine, Hydroxypropyl Methyl Cellulose, Solvent Diffusion Evaporation Method, Ethyl cellulose microspheres.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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 Keywords

medication adherence, patient care, medication, factors

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Vitiligo, a common depigmenting skin complaint, has an estimated frequence of0.5- 2 of the population worldwide. Vitiligo is frequently dismissed as a ornamental problem, although its goods can be psychologically ruinous, frequently with a considerable burden on diurnal life. About 80 of vitiligo threat is attributable to inheritable factors; and the rest( 20) is attributable to the terrain. Indeed though vitiligo is constantly dismissed as an esthetic issue, it can have serious internal consequences and significantly intrude with diurnal life. There are multitudinous pharmaceutical procedures available on the request that aim to stop the development of and induce epidermal repigmentation. Variable situations of skin saturation have been observed with similar curatives, either alone or in combination, and their ascendance was safe and effective. There are many vitiligo treatments available, and none of them can reliably beget repigmentation in every existent. Personalized operation is needed depending on terrain, physical appearance, and the presence of illness conditioning. The antedating study aims to give sapience into the implicit prospects of vitiligo drug while also recapitulating the current body of knowledge on the condition.

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 Keywords

Ointment, Pathogenesis, treatment options, vitiligo, autoimmunity, skin color, hypopigmentation, vitiligo, pigmentation, Haritaki, Neem, Almond oil, Spredability.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

DAKSHIN ESHIYA ME CHIN KI BELT AND ROD INSITIVE RANNITI

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DAKSHIN ESHIYA ME CHIN KI BELT AND ROD INSITIVE RANNITI

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This study has been undertaken to investigate the impact of extroversion on learned helplessness among young-adults (18 - 26 years). A non-probability sampling technique was used to collect a sample of 202 young-adults. The Learned Helplessness Scale by Frances Ward (1988) and The Introversion - Extroversion Scale by Greg A. Grove (2001) were administered through a google form and offline mode. The data was analysed quantitatively using correlation and regression using Statistical Package for Social Sciences (SPSS). Findings suggest that there is a significant difference in the thinking introversion with a mean score of females being higher than males. A significant difference was observed in the emotional introversion of males and females with the scores of males being higher than females. The association of learned helplessness with thinking extroversion was significant and positive. Stepwise linear regression suggested that thinking extroversion explains 6.9% of positive variance in learned helplessness. Thinking extroverts may be more prone to stress and arousal-seeking behaviour, which can lead them to engage in risky or impulsive behaviours that could exacerbate the effects of learned helplessness.

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 Keywords

Introversion, Extroversion, Learned Helplessness, Personality

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Kumbakonam temple that give varies benefits, there are many cities with temples in Tamil Nadu, Kanchipuram and Kumbakonam are important among them. The number of temples in both these cities is huge. Among them Kumbakonam has the most temples for curing doshas. There are various temples here to get rid of navagraha dosha and marriage ban. There are temples in Kumbakonam which offer benefits from child birth to satabhishekam. Kumbakonam in the 3rd century established. The Pallava kings ruled the region from the 4th century to the 9th century controlled. Then came the Chola dynasty. It built many notable temples. Famous among them is the Prahadeeswarar temple in Thanjavur. After the fall of the Chola Empire in the middle of the 12th century. The Pandya dynasty ruled their rule lasted until. The 14th century when Kumbakonam became the capital of the Vijayanagara dynasty. Krishna Devaraya II, the king of Vijayanagara visited this place from 1524. Madurai and Thanjavur Nayaks raided Kumbakonam from 1535 to 1673. The Chola period is known as the Golden Age of Kumbakonam.

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Heritage, Culture, Tourism

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The project proposes a novel method of data communication using Li-Fi technology. The proposed system utilizes the Android mobile phone's flashlight to transmit data in Morse code, which is then received by an Arduino Uno board using an LDR sensor. The received data is then displayed on an LCD screen, and also sent as an SMS notification using a GSM module. The proposed system offers an alternative to traditional communication methods that rely on radio waves, such as Wi-Fi and Bluetooth. The system is cost-effective, secure, and offers a high-speed data transmission rate. The Arduino Uno board uses an LDR sensor to receive the modulated light signal and decode the Morse code. The received data is then displayed on an LCD screen, which can be used to display messages or other relevant information. Additionally, the system can also send an SMS notification using a GSM module, which can be useful for sending alerts or notifications to the user.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Li-Fi, Wi- Fi, VLC (Visible light communication), LED (Light emitting diode), Arduino uno, GSM Module

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Creative Commons Attribution 4.0 and The Open Definition