Volume 12 | Issue 6 |

 Abstract

The present study deals with the formulation and evaluation of rapid release oral film of Donepezil Hydrochloride which is a specific non-competitive reversible inhibitor of acetyl cholinesterase (AChE) used in the treatment of Alzhiemer's disease. The objective of preparing Donepezil HCl rapid release film was to dissolve or disintegrate the film in few seconds and release the drug in oral cavity for rapid therapeutic effect due to a well supplied vascular and lymphatic drainage. Donepezil HCl films were prepared by solvent casting technique using film forming polymer HPMC E-15, different types of disintegrants such as maize starch, pregelatinized starch and superdisintegrants such as sodium starch glycolate, croscarmellose sodium and crospovidone. Triacetin was incorporated as plasticizer to improve the flexibility of films, glycerin as emollient, mannitol as diluent to provide good mouth feel and aspartame as sweetener. The prepared films were evaluated for weight variation, thickness, surface pH, folding endurance, drug content, disintegration time and in vitro dissolution studies by Pharmaceutical standard methods. Formulation F5 is considered as the best formulation as it showed good tensile strength (39.52 N/cm2), percentage elongation (11.83%), maximum drug content (99.75%), rapid disintegration time (20 seconds) and maximum drug release (99.86%) at the end of 10 minutes. The study concludes that rapid release oral films of Donepezil Hydrochloride can be considered suitable for clinical use in the treatment of Alzhiemer's disease, where a quicker onset of action along with the convenience of administration with higher therapeutic efficacy and bioavailability was desirable.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Alzheimer's disease, Donepezil HCl, HPMC E-15, Rapid dissolving film, Solvent casting method.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

India's handicraft sector, particularly exemplified by Channa Patna Handicraft Industries in Karnataka, encapsulates a rich legacy of traditional skills and cultural expression. This labor-intensive, decentralized industry, employing over million artisans, serves as a pivotal source of employment, notably for marginalized groups and women, ranking second only to agriculture. However, artisans face multifaceted challenges amidst globalization and changing market dynamics. Handicrafts, ranging from handcrafted to machine-made, embody the artisan's specialized skills, infusing tradition with intricate designs and vibrant hues. Yet, artisans struggle with low literacy levels and dependence on intermediaries, hindering their access to market trends and consumer preferences. Commission brokers further complicate matters, obscuring genuine customer tastes. Addressing these problems, our study employs an exploratory research approach, leveraging both primary and secondary data sources. By analyzing online journals and articles, it identifies key opportunities and barriers in the marketing landscape. Recommendations are provided to empower artisans with appropriate marketing strategies, fostering economic growth and cultural preservation. In essence, this study underscores the imperative of empowering artisans and safeguarding India's cultural heritage. By equipping artisans with market insights and strategic tools, we can ensure the resilience of the handicraft industry while promoting social inclusion and economic development.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Handicraft, Channaptana, Artisans, Cultural heritage, Market dynamics, Empowerment, Economic development, Social inclusion.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The intricate nature of healthcare applications, handling sensitive patient data and influencing critical medical decisions, demands rigorous testing strategies. While manual testing remains vital, its limitations in efficiency and error susceptibility hinder comprehensive software evaluation. Test Automation Frameworks (TAFs) emerge as a powerful solution, streamlining the testing process for healthcare applications. We explore how TAFs enhance testing efficiency by automating repetitive tasks, allowing testers to focus on high-level and exploratory scenarios. This not only reduces testing costs but also leads to improved test accuracy and repeatability. TAFs enable running a broader spectrum of test cases, encompassing regression testing, edge cases, and integration testing, resulting in more comprehensive test coverage and reduced risks of undetected defects. This paper delves into the multifaceted advantages and practical uses of TAFs within the healthcare software domain. This paper further explores potential future directions for TAFs in the healthcare domain. Advancements in machine learning and artificial intelligence hold promise for enhanced test automation capabilities, enabling automated test generation and self-healing test scripts. Integrating TAFs with continuous integration/continuous delivery (CI/CD) pipelines streamlines the development process for healthcare applications. Embracing TAFs and staying at the forefront of technological advancements will allow developers and healthcare institutions to guarantee the quality and reliability of healthcare applications, ultimately contributing to improved patient care outcomes

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Software Testing, Test Automation Frameworks (TAFs), Page Object Model, Healthcare Quality Management.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The rapid development and implementation of humanoid robots has emerged as a key field of study in modern robotics, aimed at replicating human motion and behaviour to assist in various applications. This project focuses on the design and fabrication of a humanoid robot specifically tailored to assist in college admission processes. The primary objective is to create a robot that can interact with prospective students / parents / guardians, provide detailed information about courses, campus facilities, and admission procedures, and enhance the overall efficiency and experience of the admission process. The design phase emphasizes a flexible mechanical structure (Humanoid Robot) that mimics human movements, ensuring both functionality and an approachable appearance. This project aims to design a humanoid robot with additive manufacturing process for cost effectiveness. Various parts of the robot are designed in the Solid Work's Software and then the parts are printed with the help of a 3-D printer (material-PLA (Polylactic Acid)), and then they are assembled with addition to various components like servo motors etc. The fabrication process involved precision machining and assembly of parts, followed by the incorporation of sensors, actuators, and a robot control system. Humanoid robot is equipped with artificial intelligence (AI) algorithms and natural language processing (NLP) capabilities, enabling it to engage in meaningful conversations and process complex information efficiently. The successful implementation of this humanoid robot for college admissions not only illustrates a significant technological achievement but also sets a standard for further advancements in the field of educational robotics. The final prototype will be tested in a real-world college admission setting to evaluate its performance, usability, and impact on the admission process. Feedback from users will be gathered to refine the robot's functionalities and enhance its user interface. The project aims to demonstrate the potential of humanoid robots in transforming administrative processes and providing innovative solutions in educational environments.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Humanoid Robot, College Admission, Design and Fabrication, Artificial Intelligence, Natural Language Processing, Educational Robotics, Machine Learning, 3D Modelling, Mechanical Structure, Sensors and Actuators

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Creative Commons Attribution 4.0 and The Open Definition

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The Panchamahabhuta theory in Ayurveda, which comprises Ether, Air, Fire, Water, and Earth, is foundational for understanding human anatomy, physiology, and clinical practice. This research examines the correlations of these elements within the human body by comparing classical Ayurvedic texts like the Charaka Samhita and Sushruta Samhita with modern anatomical and physiological sciences. The study aims to bridge traditional and contemporary medical paradigms, emphasizing Ayurveda's holistic approach that integrates body, mind, and spirit. Each element is linked to specific bodily structures and functions: Ether to cavities and consciousness, Air to movement and neural activity, Fire to metabolism and vision, Water to fluids and cohesion, and Earth to structural integrity and stability. This chapter explores these manifestations from the cellular to the systemic level, noting, for instance, the association of bones with the Earth element and digestive enzymes with Fire. It also highlights the clinical relevance of the Panchamahabhuta theory, using case studies to show how imbalances in these elements cause health issues and how Ayurvedic treatments can restore balance. By integrating Ayurvedic concepts with modern medical understanding, the study enhances Ayurvedic practice and provides valuable insights for contemporary medicine, promoting a more holistic and effective healthcare approach.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Panchamahabhuta, Five Elements, Panchmahabhut Theory, Panchmahabhut chikitsa

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Creative Commons Attribution 4.0 and The Open Definition

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In today's world, ensuring the safety of women is paramount. To address this concern, we present a novel women safety device equipped with advanced technologies. The device integrates an ESP32 microcontroller, NEO-6M GPS module, I2C LCD display, push buttons, relay for pepper spray activation, and a DC motor for anesthesia control. These components work together to provide comprehensive safety features. In conclusion, our women safety device represents a significant advancement in personal security technology. By combining cutting-edge features with user-friendly design, it empowers women to navigate the world with confidence and peace of mind.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Injection,Pepper spray,GPS,Google Firebase

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

UTTRAKHAND KE MHILAO KI STHITI : DASHA AUR DISHA (POLICE BALO KE VISHESH SHANDARBH ME )

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Creative Commons Attribution 4.0 and The Open Definition

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UTTRAKHAND KE MHILAO KI STHITI : DASHA AUR DISHA (POLICE BALO KE VISHESH SHANDARBH ME )

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The focus of the project is OCR. The acronym for this is "Optical Character Recognition." An input device called OCR is used to read printed text. Character by character, OCR optically reads the text, transforms it into a machine-readable code, stores it in the system memory, and then creates a document out of it. Optical character recognition (OCR) technology was employed to convert printed text into editable text. OCR is a very useful and common method in many applications. Techniques for segmenting and preparing text can affect the accuracy of OCR. Text retrieval from the image may occasionally be difficult due to its complex backdrop, style, size, and orientation variations. This technology can identify text contained within a digital picture. Text recognition in scanned documents and images is a widely used feature. OCR can be used to turn an image or a physical paper document into a text-rich, readable electronic version.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Flutter Framework, Dart, Flutter, Android.

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Creative Commons Attribution 4.0 and The Open Definition

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One of the most significant dental conditions that adds to the worldwide burden of chronic illness is periodontal disease. This study aimed at finding the awareness and motivation surrounding periodontal health among an educated demographic class not affiliated with the medical profession. Through an online survey, responses from individuals outside the medical field, aged between 20 and 60, were collected to gauge their understanding of periodontal health. Initial findings suggested a nuanced panorama of awareness among this cohort. A questionnaire set of 20 was created on Google forms and forwarded with link on social media. 500 people of various professions including teachers, engineers, data scientist, pilot etc. were included in survey and result were collected in the digital pie diagram. It was a 6 month survey during June to December 2023.The result were in percentage which revealed that the respondents' knowledge of the value of dental care, particularly periodontal health care, is only minimal.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

- Survey, Periodontal health, Awareness, Motivation, Oral health perspectives, Preventive measures.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

In the sector of community control and safety, maintaining an accurate and stable community surroundings gives massive challenges that often exceed conventional tracking strategies. This look at examines the effectiveness of net scanners, with a particular cognizance on their capacity to enhance safety, optimize performance, and make certain compliance. The studies method consists of deploying advanced network scanning gear to find out gadgets, analyze open ports, and determine network vulnerabilities. These tools file targeted records about community settings and device interactions, enabling you to become aware of potential protection dangers and activity. By analyzing dynamic characteristics along with network traffic, tool conduct, and protocol utilization, the scanner can locate subtle anomalies that traditional strategies may also pass over. Extensive information sets, inclusive of actual network configurations and hobby logs, are cautiously amassed, pre-processed, and used to assess the tools. Benchmark analyses are in comparison to standard manual strategies, conventional community control software, and other automatic scanners to evaluate the effectiveness of the network scanner. In conclusion, the combination of advanced community scanners is a promising manner to improve community safety, overall performance control, and compliance. This research contributes to ongoing efforts to broaden the extra sturdy and adaptive network management answers had to keep a steady and efficient virtual infrastructure in modern day complicated network environments.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Web Scanning, Anomalous conduct and worm.

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Creative Commons Attribution 4.0 and The Open Definition