Volume 10 | Issue 6 |

 Abstract

Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. Lactobacillus acidophilus plays a most important role in the fermented products of the dairy industry and delivers the therapeutic characteristics of human health. As the greater quantity of antibiotics was used for the treatment of humans and farm animals as well and even for fish in aquaculture, that will result in the selection of pathogenic bacteria resistant to multiple drugs. Several research a great focus on the Identification of Lactic Acid Bacteria, that include conventional biochemical examinations like carbohydrate fermentation outlines using commercially accessible kits, physiological tests, and complex techniques by using molecular-based biology methods. More recently, Bio-log and API Kit have been applied to an enormous amount for Lactic Acid Bacteria Identification. The current study is carried out to isolate, identify, and evaluate the antagonistic activity of L. acidophilus. obtained from curd and milk samples as well. The antimicrobial action of this species was assessed with the agar well diffusion method against some pathogenic bacteria (Staphylococcus aureus, Escherichia coli, and Salmonella typhi). L. acidophilus. isolated and identified based on biochemical characterization as catalase-negative, motility negative, citrate negative indole negative, and fermentation of carbohydrates. In the present study, the total number of six isolates were detected as Lactobacillus sp. The isolated and identified L. acidophilus strains (n=6) were examined for their antagonistic activity against MDR strains of S. aureus, E. coli. and S. typhi.In the study, maximum inhibition was detected by LA1and LA4 against S.aureus (18mm) and S.typhi (18mm), respectively. The bare minimum inhibition was noticed in the case of LA3 against S. typhi i.e., 4.0mm. Other Lactobacillus isolates exhibited modest or nil antagonistic activity against tested pathogenic bacteria.

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 Keywords

Lactobacillus acidophilus, Curd, Antimicrobial Activity, Bacterial Pathogens (S. aureus, E. coli, and S. typhi).

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Creative Commons Attribution 4.0 and The Open Definition

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The aim of present article to understand, what is Inlay tablet and its advantages over the conventional tablet dosage form. The inlay tablet improves the pharmacokinetic and pharmacodynamics principles in the design of drug delivery system and also improve therapeutic efficacy. Inlay tablet reduces the frequency of dose administration and improve the patient compliance. Review focused on a novel approach of drug delivery system in preparation of inlay tablets.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Inlay tablets, Novel approach, Drug therapy Etc.

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Creative Commons Attribution 4.0 and The Open Definition

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Blind source separation (BSS) consists of the extraction of individual signals from their mixture using no prior knowledge about their nature. Here, we address the blind separation of audio sources by means of Principal component analysis (PCA) and Independent Component Analysis (ICA), which is a popular method for BSS using the assumption that the original sources are mutually independent. PCA and ICA algorithm working for mixed signals is studied and depicted in this paper.

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Creative Commons Attribution 4.0 and The Open Definition

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source separation, PCA, ICA

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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-

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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This dissertation addresses the importance of a business model from businesses in Kosovo, which is able to adapt innovations from the banking sector such as digital services, and through which become part of a global market where such developments occur step by step. very fast At the beginning of this paper will be given definitions related to the main concepts that are addressed such as business model, innovations in banking services - digitalization of services and the role and importance of linking a business model with banking services of the time. After the theoretical part, from which the main concepts of this paper are understood, the process of adaptation of innovations in banking services by businesses in Kosovo is presented, the difficulties that businesses have gone through to adapt these services as well as the banking sector to transmit them. to customers the latest services they offer. At the same time, the investments of the banking sector in the digitalization of services in countries with developed economies and the pace that the banking sector in Kosovo is following will be presented. And at the end of this paper are given recommendations that can be used by various companies in the country which still have reservations to adapt such a service technology in the bank and can understand that the use of digital banking services creates the opportunity for a easier business management, increasing money security, avoiding fraud and other benefits.

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Creative Commons Attribution 4.0 and The Open Definition

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Keywords: Business model, Service digitalization, Innovation, Adaptation

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Anupubbikath?, A?okan Edicts, dhamma, dhamma policy, Moral Guidelines, M.R.E., P.E.

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Creative Commons Attribution 4.0 and The Open Definition

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Drug discovery is a procedure that tries to find a therapeutically beneficial chemical for curing and treating disease. Identification of candidates, synthesis, characterisation, validation, optimization, screening, and tests for therapeutic efficacy are all part of this process. Once a molecule has been proven to be significant in these studies, it will begin the medication development process prior to clinical trials. To create a medicine that is safe, effective, and meets all regulatory standards, the new drug development process must go through numerous stages. One of the main points of our article is that the process is long, complicated, and expensive enough that multiple biological targets must be considered for any new treatment that is eventually approved for clinical use, and new research methods may be required to investigate each new target. It takes a long time and a lot of effort to turn a discovery into a commercial medicine. It takes roughly 12 to 15 years from discovery to licenced drug, and an expenditure of about $1 billion is required. A million molecules are screened on average, but only one is investigated in late-stage clinical trials and eventually made available to patients. This article gives a quick overview of how new drugs are discovered and developed.

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Drug discovery , Development , Validation, Optimization

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Creative Commons Attribution 4.0 and The Open Definition

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The present work has been studied on investigation of harvesting conditions of Geranium plantation. Geranium (Pelargonium graveolens L.) commonly known as rose-scented pelargonium, rose-scented geranium or rose geranium is one of the many fragrant species of Pelargonium, belonging to the family Geraniaceae. Geranium oil is one of the top 20 essential oils in the world, which has wide application in perfumery, cosmetics and flavor industry etc. It forms a part of many high-grade perfumes, antifungal, insect repellant and antibacterial activity; thus, it has extensive use in medicinal and agrochemical field. In literature, several authors were used different traditional extraction methods; such as soxhlet extraction, hydro distillation, solvent extraction and steam distillation etc. In this work, author has used the most promised technique as steam distillation for geranium oil extraction. The purpose of this work is to investigate the suitable conditions of geranium harvesting and method of suitability for extraction of geranium with higher yield in limited facilities and lower cost. Finally, author has conducted detailed analysis on soil for harvesting conditions of geranium plants and characterization of geranium oil by using GC-Analysis.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Geranium Leaves; Steam Distillation; Oil; Gas Chromatography

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition