Volume 13 | Issue 6 |

 Abstract

Avipattikara Churna is one of the most effective Ayurvedic formulations to manage health problems due to an imbalance of Pitta dosha like acidity, indigestion and heartburn. These are either due to lack of physical activities, sedentary lifestyle or due to unhealthy eating habits. Avipattikara Churna helps reduce excessive heat generated due to an imbalance of Pitta dosha and provides a cooling effect inside the body.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Shunthi (Zingiber officinale) ,Maricha (Piper nigrum) ,Pippali (Piper longum) ,Haritaki (Terminalia chebula) ,Vibhitaka (Terminalia bellerica) ,Amalaki (Emblica officinalis) ,Musta (Cyperus rotundus) ,Salt (Vida Lavana) ,Vidanga (Embelia ribes)

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Creative Commons Attribution 4.0 and The Open Definition

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The August 2018 floods that destroyed Kerala were among the worst in the state's history in nearly a century. The 2018 Kerala flood had a severe impact, leading to widespread displacement, loss of life, and extensive damage to homes, infrastructure, and agricultural land. The disaster disrupted daily life across the state, overwhelmed public services, and caused long term economic and environmental consequences. This dissertation critically analyses the political role in managing this disaster in the post-disaster period, with a specific focus on the role of political leadership, institutional governance, and public participation in contributing to disaster response and recovery. Based on extensive reports of relief operations, intergovernmental relations, and engagement of diverse actors such as the state government, local self-governments, opposition parties, and civil society organizations, this research investigates the effectiveness and shortcomings of politically motivated disaster governance. The study highlights the critical leadership of Kerala's political leadership, especially the initiative of the Chief Minister and other major actors to mobilize resources, maintain open communication, and link decentralized governance structures for prompt response. It also assesses the relationship between the government and opposition, interaction with the civil society and volunteer networks, and the coordination with national agencies like the National Disaster Response Force (NDRF) and the central government. From this perspective, the research showcases the strengths and weaknesses of Kerala's political machinery in dealing with an unprecedented human crisis, providing insights into the wider implications of political agency for disaster resilience and recovery. The results underscore the significance of inclusive governance, inter-party collaboration, and decentralized administration in informing an effective post-disaster strategy.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Leadership, Governance, Kerala, Floods

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Humans and other biological entities are at a great risk from microplastics, which are ubiquitous in both marine and terrestrial ecosystems. Their capacity to transport and absorb harmful substances is demonstrated by recent research, which suggests that they may be the source of a number of health problems. By offering insights into the fundamental molecular processes and aiding in the development of abatement techniques, computational biology has emerged as a critical method for identifying important genes impacted by microplastic exposure. This work uses databases and bioinformatics methods, such as MalaCard, GeneCard, and OMIM to find and examine the genes that are affected by exposure to microplastics. Additionally, utilizing 12 distinct cytohubba characteristics, the protein-protein interaction networks were examined in order to identify the hub gene. "TNF" protein was identified as the key regulator of the network. A list of phytochemicals was also carefully selected after a thorough review of the literature in order to determine which ones would be useful in protecting against the exposure to microplastics. Using ADMETLab 3.0, the drug-like properties of these phytochemicals were tested. The structure of the key hub gene, that is, TNF was modeled using Swiss-Model. Molecular docking studies were done to explore the potential of phytochemicals against TNF. Molecular docking studies revealed the potential role of "Ellagic Acid" that has the highest binding energy of "-9.36" in the management of microplastics exposure in human. This study underscores the pervasive threat of microplastics to both human health and the environment, highlighting their ability to transport harmful substances. Computational biology has played a pivotal role in identifying key genes affected by microplastic exposure, with TNF emerging as a critical regulator. Through molecular modeling and docking studies, Ellagic Acid shows promising potential as a therapeutic agent against microplastic-induced health risks.

Licence: creative commons attribution 4.0

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Network biology, Computational biology, TNF, Mircoplastic, Molecular modeling, Exposure management, Gingerol, Binding energy.

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Creative Commons Attribution 4.0 and The Open Definition