Volume 12 | Issue 5 |

 Abstract

The aim of this research was to develop and evaluate a topical hydrogel containing Halobetasol. Various gelling agents, including HPMC, Sodium CMC, and Polaxomer, were utilized at different concentrations to formulate the gel. Parameters such as drug release, drug content, pH, physical appearance, and rheological properties like spreadability and extrudability were examined for the prepared hydrogel formulations. In vitro drug release from the gels was evaluated using Franz diffusion cells with cellophane membranes and phosphate buffer pH 6.8 as the receptor medium. Compatibility between drugs and excipients was investigated using FT-IR analysis, revealing no interaction. Results indicated that all gel compositions met the required criteria and exhibited acceptable physicochemical and rheological characteristics. Higher polymer concentrations were associated with reduced drug release, with Polaxomer displaying superior drug release compared to HPMC and Sodium CMC in all gel formulations. The most potent antifungal activity was observed in Formulation F4. Factorial design was employed based on trial batches, with subsequent validation indicatingsignificant model performance. The optimized batch, F12, underwent thorough analysis and was found to be stable during a 1-month stability study. Therefore, F12 was determined as the optimized batch.

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 Keywords

Halobetasol, HPMC, Sodium CMC, and Polaxomer, Hydrogel.

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Creative Commons Attribution 4.0 and The Open Definition

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This research study examines the domain of mutual funds, specifically examining equity funds provided by Franklin Templeton Investments. The research strives to examine fund performance, risk management strategies, portfolio composition, and investor behaviour within the context of the company's services. Through a full assessment of the research gap, hypothesis, aims, scope, research methods, limitations, data analysis, and conclusions, the study sheds light on essential aspects of mutual fund dynamics. In order to strengthen investor awareness and improve fund performance, it is recommended to emphasize the crucial importance of investor education and transparent communication within the mutual fund industry. The references include a range of studies on mutual funds, including performance evaluation, scheme comparisons, awareness levels, selection considerations, and investor attitudes.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Mutual funds, equity funds, Franklin Templeton Investments, fund performance, risk management, investor behaviour, investor education

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Creative Commons Attribution 4.0 and The Open Definition

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Increased perceived stress can lead to performance anxiety leading to diminished artistic expression, creative block and low confidence. Past research have highlighted that anxiety has negatively influenced the musicians' artistic expressions and creativity by infusing performance anxiety. The aim of this research was to study the effect of perceived stress on life satisfaction and happiness among musicians and non musicians. The objectives were to study the level differences, relationship and prediction between anxiety, life satisfaction and happiness among musicians and non musicians. A random sampling technique was used to collect a sample of 200 musicians and non musicians. Perceived stress scale (PSS)1983, Life satisfaction scale (LSS) 1971, Oxford happiness questionnaire 2002, were administered through a google form and offline mode. The data was analysed quantitatively for correlation, t-test and regression using Statistical Package for Social Sciences (SPSS). Overall, the study demonstrated the relationship between perceived stress, life satisfaction and happiness among musicians and non musicians. It emphasised the need to understand the impact of stress on musicians' life satisfaction and happiness, the necessity for promoting mental health awareness and measures that can be taken to reduce such stress on larger scale.

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 Keywords

perceived stress , life satisfaction , happiness , between musicians and non-musicians

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Creative Commons Attribution 4.0 and The Open Definition

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Women Entrepreneurship plays a prime role in industrial development. India has always been a land of entrepreneurs and also occupied a strategic position in the Indian economy. Today the village and MSME units account for about 45% of the total industrial production, 30% of the country exports and estimated to employ 96millions person in over 26 million units throughout the country. The government of India has defined women entrepreneurship based on women participation in equity and employed of a business enterprise. The researcher has taken this topic to identify the industrial profile, to identify the motivating factors of women entrepreneurs and contributing factors to the success and to analyze the relationship between industries related factors and success of entrepreneurs. The researcher has been selected 100 respondents from in and around Chennai City by convenience sampling method. The percentage analysis, weighted average rank analysis and chi-square statistical methods are used for the study.

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 Keywords

Employed, Entrepreneurship, MSME and Strategic Position.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

In present days of increasing software development environment sometimes it turns into challenging to mold the Product Lifecycle Management software as per requirement of clients. Most of the time user requires some simplified applications for its business solution and simplified process for their organization. To solve this problem client side customization is necessary means customize the client User Interface by using the Rich Architecture Customization and also used different Application Program Interface and Java language. Product Lifecycle Management is mainly concern about the data and through the Product Lifecycle Management we can integrate the data, people, processes and business systems. My aim is to import Legacy Data i.e. raw data present in form of physical files with different extensions to be imported in Teamcenter with same name of file to be given for Item Name, Revision Name and Dataset and I have also exported Workflow Inprocess Objects with Item ID, Item Name and Process Stage List i.e. Status from Teamcenter into MS Excel format. For this work I have used Teamcenter 12.0 along with Eclipse Photon tool, for client side customization. Data Exportation and Importation is an important activity in real-time implementation of Product Lifecycle Management which can be achieved through default functionality of PLM Teamcenter in xml format only. So, to export and import data according to client requirement in any format we have to use customization in PLM Teamcenter using API's provided by Siemens for client customization. By using the Eclipse plug-in project, I have made Swing Custom User Interface from that I can select file path in my computer where report is to be generated and by clicking export button data is exported in MS Excel format from Teamcenter.

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Creative Commons Attribution 4.0 and The Open Definition

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Product Lifecycle Management, Rich Application Client Customization, Teamcenter 12, Eclipse Based Plug in Project, User Interface.

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Creative Commons Attribution 4.0 and The Open Definition

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This project introduces a cutting-edge fusion of technology to revolutionize the fashion shopping experience. By seamlessly integrating computer vision and augmented reality, it aims to redefine how customers explore, try on, and buy clothing. With precise measurements and virtual fittings, it addresses the issue of poor fit, reducing return rates and enhancing satisfaction. Additionally, it offers personalized dress recommendations, deepening the connection between customers and the platform. Overall, this initiative promises to usher in a new era of dynamic and immersive retail interactions while meeting the evolving expectations of modern consumers.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Evolution, Innovation, Digitalization, Customer Satisfaction

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Creative Commons Attribution 4.0 and The Open Definition

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Introduction:- Terminalia arjuna has been reported to exhibit beneficial effects in ventricular hypertrophy, a serious consequence of hemodynamically stressful conditions like hypertension and valve disease, indicating its potential therapeutic role in mitigating this condition. Method:- This study aimed to identify potential compounds responsible for Terminalia arjuna's activity against cardiac hypertrophy and elucidate their mechanisms through network pharmacology and molecular docking. Databases including PubChem, KEGG, TTD, and PDB were mined to extract compound structures, probable targets, and relevant 3D structures. Molecular docking analysis was then conducted to assess interactions between active compounds and target proteins associated with cardiac hypertrophy. Result:- Network pharmacology unveiled the potential interaction of two compounds from TA, Luteolin and Apigenin, with MAP Kinase, a key enzyme implicated in pathological hypertrophic gene expression. Docking analysis further validated their capability to interact with MAPK. Conclusion:- TA might be having efficacy in cardiac hypertrophy via inhibition of MAPK through Luteolin and Apigenin.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Network pharmacology, molecular docking, Terminalia arjuna, Cardiac hypertrophy, 3D structures, PubChem, KEGG, TTD

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Creative Commons Attribution 4.0 and The Open Definition

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This project presents an innovative method for precise bird species population estimation using sound recognition technology. Unlike traditional Convolutional Neural Networks (CNNs) which face challenges with time-frequency tasks like bird sound identification, our approach introduces a lightweight model with frequency dynamic convolution. This enhances feature extraction across various frequency bands. Model integrates Coordinate Attention and a feature fusion module, surpassing existing Lightweight CNNs in top1 and top5 accuracy with a 160-bird sound dataset. To boost the model's accuracy further, we applied a Hybrid Random Forest ensemble model. This method extracts features from the lightweight model and retrains them, achieving enhanced accuracy without using additional ensemble models.

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Creative Commons Attribution 4.0 and The Open Definition

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Bird Species,

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Periodontal therapy is indicated in cases where there is a destruction of the periodontal ligament, the root cementum and the alveolar bone primarily caused by the bacteria found in the dental plaque. An ideal periodontal therapy aims to reduce pocket probing depth and gain in clinical attachment level. Conventional periodontal therapy results in attaining the above entities and reduces the inflammation but often results in gingival recession and the integrity of the papilla is usually not preserved. Hence, papilla preservation flaps were introduced, as it minimizes the post operative recession and preserves the integrity of the papilla. In this case report, conventional papilla preservation technique was done.

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 Keywords

Papilla preservation flap, Modified papilla preservation technique, Simplified papilla preservation technique, Minimally invasive surgical techniques.

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Creative Commons Attribution 4.0 and The Open Definition