Volume 9 | Issue 4 |

 Abstract

Introduction: Premature ejaculation is one of the most commonly encountered sexual dysfunction in men. Around 30 % of men in the world suffer from premature ejaculation. One of the most frequently given pharmacological treatments are SSRI and PDE5 inhibitor. Several studies attempted to combine the two, however the results are different from each other. Therefore, this systematic review and meta-analysis aimed to evaluate the difference of efficacy and safety between on-demand PDE5 inhibitor with the combination of PDE5 inhibitor and SSRI. Materials and methods: This study is a systematic review and meta-analysis evaluating Randomized controlled trials analyzing the combination between the PDE5 inhibitor and its combination with SSRI. The results are measured in Intravaginal ejaculation latency time (IELT) and adverse effects. The search and screening process adheres to The Preffered Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Cochrane Risk of Bias (RoB) tool is used to analyze the bias in the studies. Results: A total of 3 RCTs, with a total of 190 patients diagnosed with premature ejaculation were analyzed in this study. The results of the analysis were statistically significant (mean difference = 1.30; 95% CI = 1.07-1.54); p <0.00001), indicating that the combined on-demand PDE5 inhibitor and SSRI increased the mean IELT 1.3 minutes compared to the on-demand PDE5 inhibitor alone. Analysis of the side effects of nausea (OR = 5.16; 95% CI = 1.58-16.78; p = 0.006) and yawning (OR = 10.98; 95% CI = 1.32-91.02; p = 0.03) showed significant results. Conclusion: The combination of on-demand PDE5 inhibitor and SSRI showed promising results in PE management compared to on-demand PDE5 inhibitor monotherapy based on the IELT with few minimal side effects, such as nausea and yawning.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

PDE5 inhibitor, SSRI, on-demand, IELT, premature ejaculation

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Vicharchika is stated as a Kshudra-Kushtha & Sadhya Kushtha by all acharya, but Kushtha is one among Ashta Mahagada. So, it is difficult to cure. Vicharchika can be seen at any age but frequently in young age due to exposure to occupational, environmental factors and mental stress. Now a day junk food, irregularity in food taking, suppression of natural urges, uses of cosmetics and other chemicals, polluted environment, stressful life and Emotional disturbances definitely play a major role in manifestation of Vicharchika.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Vicharchika, Kustha, Kshudra Roga

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The main problem in India with respect to floods is inundation, drainage congestion due to urbanization and bank erosion. The problem depends on the river system, topography of the place and flow phenomenon. Flooding occurs when an extreme volume of water is carried by rivers, creeks and many other geographical features into areas where the water cannot be drained adequately. Floods cause extremely large numbers of fatalities in every country, but due to India's extremely high population density and often under-enforced development standards, a large amount of damages and many deaths which could be otherwise avoided. India witnesses flood due to excessive rain which then results in overflow of rivers, lakes and dams, which adds to cause large amounts of damage to people's lives and property. Hence this novel approach is used to monitor and alert floods using Arduino in affecting prone areas.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Arduino Uno; GSM modem; SMS notification; Solar Panel; Battery; ULN2003 IC

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

ABSTRACT: According to Ayurveda, Sandhigata Vata is described in all Samhitas. Acharya Charak described the disease separately named Sandhigat Anilal. The trouble of Sandhis by Prakupita Vata is main phenomena in Samprapti of Sandhigatavata. Sandhigatavata is the most common form of joint disorder amongst elderly and obese person. It is major cause of morbidity and disability. The attacks of this disease is insidious causing loss of function as well as deformity of the joints especially weight bearing joints like knee joint.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Sandhigata Vata, Vata Vyadhi

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Angle closure in a myopic patient is rare. Here is presented a report of one 37- years old female patient who presented with cloudiness of vision in both eyes (OU) since 2 months, associated with occasional ocular pain and heaviness around temporal region for 1 year. There was no history of ocular trauma. On presentation, her best corrected visual acuity was 6/9[ -4.50/-1.25x120] in Right eye and 6/9[-5.25DS] in Left Eye. Slit Lamp examination demonstrated a shallow anterior chamber [Van Herick Grade I] in both eyes. Moreover both the eyes exhibited shorter axial length with increased Lens vault and thickness. The intraocular pressures (IOP) recorded were 14mm Hg for right eye and 16 mm Hg for Left eye respectively. Gonioscopy revealed completely closed angles for both the eyes. However she was successfully treated with Peripheral Laser Iridotomy in both eyes to completely open her angles. This case demonstrates the uncommon presentation of narrow angles in a moderately myopic patient. The age and refractive error of this patient should immediately raise the possibility of an atypical cause of angle narrowing. In this case, the examination findings point to Microspherophakia with increased Lens vault as a cause of angle narrowing.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Microspherophakia, Glaucoma, Lenticular myopia, Lens Vault

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

HR practices is an essential for any organization. This study will be helpful to know the perception and satisfaction level of employees about HR practices and policies in the organization and also this would be a chance for them to give suggestions for the improvement in them. It is to be noted that all the existing HR practices of the organization are not studied and analyzed wherein special preference is given to Recruitment & Selection, Induction, Training & Development and Performance appraisal. This project was undertaken with the purpose to study the employees perception towards HR practices at Mahindra and Mahindra (president motors) Cars Pvt. Ltd in Navsari. In this project report satisfaction/dissatisfaction and to know the effectiveness of employees perception towards HR practices has been measured using standard statistical tool. The data collection method is a structured questionnaire with the sample size of 50 employees at Mahindra and Mahindra Pvt Ltd in Navsari. The purpose of this study is to get the comprehensive knowledge and insight into various aspects of employees towards HR practices which is one of the necessary practices to evaluate people working in the company.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

HR practices, employees, training and development

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Madatyaya, Chikitsa, Pathya, Apathya, Alcohol

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Behavioural Finance, Public relations, Media, visibility, exposure, investment decision, investor bias

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Formal Education, Sarva Shiksha Abhiyan, 6-14 years and Community Development.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

History of Dalits is not seriously discussed at least in the context of Karnataka. most of the articles appeared on Dalits are either connected or related to more ideological debates since last three decades in Karnataka. this article, however intends to discuss some of the aspects of Dalits in the history of medieval Karnataka, especially issues related to caste hierarchy, habitation, slavery and occupation.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

In the history of Karnataka most of communities are not being seriously discussed. owing to the limitation in writing of history, Dalits have not become a part of Karnataka. in this contest present article examine the Dalits in the history of medieval Karnataka.

  License

Creative Commons Attribution 4.0 and The Open Definition