Volume 11 | Issue 3 |

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Key words: Thalassemia, bone marrow transplant, caregiving.

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Creative Commons Attribution 4.0 and The Open Definition

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Researchers worldwide, in the recent years have expanded our understanding of how, and the degree to which, the immune system interacts with the nervous system, and vice versa. The immune system is important for the protection of the body against injury and disease. In the past several decades, the association between stress and immune function has received considerable attention. By initiating changes in the hypothalamic-pituitary-adrenal axis and the immune system, chronic stress acts as a trigger for anxiety and depression. Both experimental and clinical evidence shows that a rise in the concentrations of proinflammatory cytokines and glucocorticoids, as occurs in chronically stressful situations and in depression, contribute to the behavioural changes associated with depression. Defects in serotonergic function are associated with hypercortisolemia and increased pro-inflammatory cytokines associated with depression. Glucocorticoids and proinflammatory cytokines promote the conversion of tryptophan to kynurenine. In addition to the resulting reduction in brain serotonin synthesis, this leads to the formation of neurotoxins such as the glutamate agonist quinolinic acid, which contributes to increased astrocyte, oligodendroglial, and neuronal apoptosis. The importance of the inflammatory hypothesis of depression is that it raises the possibility that psychotropic drugs with central anti-inflammatory activity will become a new generation of antidepressants. Chronic stress-induced neuroendocrine and immune system dysregulation is associated with psychological and physiological disorders, including depression. Several recent clinical and preclinical evidences suggest that neuroinflammation is a key factor interacting with three neurobiological correlates of major depressive disorder: brain serotonin Deficiency, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and alterations in the continued production of adult neurons generated in the dentate gyrus of the hippocampus. We are pleased to introduce a new overview series in this month's issue. Depression and their interaction as immune system dysfunction. An overview of how depression affects immune function is provided, and the literature evidence on various intrapersonal and interpersonal factors that may exacerbate or mitigate the health effects of depression is reviewed. Also, we have introduced new medications for depression and improvements in brain stimulation as a future treatment.

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Creative Commons Attribution 4.0 and The Open Definition

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Glucocorticoids, Pro-inflammatory cytokines Hypercortisolemia, Hypothalamic-pituitary-adrenal (HPA), Chronic stress-induced neuroendocrine.

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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na

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Initial Public Offerings, Mutual Funds, Gold, Silver, Returns.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract In today's competitive market, raising prices or implementing cost reducing measures that are only cosmetic may not be a viable alternative because they may result in a loss of market share or a decline in service quality, respectively. The capacity to precisely measure costs to ascertain genuine profit margins is essential for deciding whether or not to eliminate unprofitable goods, service lines, channels, or consumers. It's easy to track sales, but more difficult to estimate expenses. Poor strategic decision making and skewed product costs are the result of the use of outdated costing methods. The purpose of Activity-Based Costing (ABC) is to overcome these shortcomings of conventional cost accounting methods. This paper reports the results of a longitudinal research conducted at an ABC-compliant facility in India The research was conducted at the facilities of the component suppliers to major production companies The outcome shows that the current system is not standardised, and that there has been no systematic approach to determining the various rates.

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Key Words: ABC Costing, Decision making, Strategy, prices

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Fiction, History, Sundarbans, Tides and Diaspora

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Creative Commons Attribution 4.0 and The Open Definition

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Driven Engine, petroleum and gasoline

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The present study was undertaken to investigate diuretic effect of methanol extracts of the roots of Heteropogon contortous L., in normal rats. Method: methanol extract of Heteropogon contortous L. were administered to experimental rats orally at various doses (100mg/kg,200mg/kg,400mg/kg) p.o. Furosemide (10 mg/kg) was used as positive control in the study. The diuretic effect of the extracts was evaluated by measuring urine volume,diuretic index and Lipschitz value, sodium and potassium content, and chloride content.Saluretic index,Natriuretic index and Ion quotient were calculated. Result: Urine volume was significantly increased by the two doses of methanol extracts from root of Heteropogon contortous L., in comparison to control group. While the excretion of sodium was also increased by both extracts,The highest dose of extract significantly excreted sodium,chlorides in excess and had good saluretic,natriuretic activity which was comparable to that of standard drug. There was no potassium sparing effect found. There was no significant change in the pH of urine but they were mildly alkaline after administration of the Heteropogon contortous L., extracts. The diuretic effect of the extracts was comparable to that of the reference standard (Furosemide). Conclusion: We can conclude that methanol extracts of Heteropogon contortous L., produced diuretic effect. Present study provides a quantitative basis for explaining the diuretic use of Heteropogon contortous L., as a diuretic agent.

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Diuretic, urine volume, electrolytes, saluretic, natriuretic, diuretic index. etc

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Culture ,Alienation,Immigration,First Generation Second Generation

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Creative Commons Attribution 4.0 and The Open Definition

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Creative Commons Attribution 4.0 and The Open Definition

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Parkinson,tremors,pain

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Creative Commons Attribution 4.0 and The Open Definition