Volume 1 | Issue 3 |

 Abstract

Abstract Neisseria meningitidis is an obligate, gram-negative, human commensal that is spread from person to person by droplet infection. This bacteria colonises the nasopharyngeal mucosa of human and in due course resulted in bacteremia and finally fatal sepsis. Most of the metabolic enzymes that are involved in various biochemical cycles are found to have many secondary functions such as adhesions, regulators of transcription etc. GAPDH is a glycolytic enzyme which is mainly located in the cytoplasm. In addition to its primary metabolic function, it is observed that GAPDH is present on the surface of several microbial pathogens and invasion of host tissues. Since no structural models are available for GAPDH of N. meningitidis, the present study was performed to explore its structural characteristics. It was recorded that the selected protein GAPDH of N.meningitidis was cytoplasmic, stable and with secondary structural elements such as helix and coils, Ramachandran plot showed that it has 92% of aminoacids in the favourable region. The modeled 3D structure of the query protein was refined and validated for its structural features with Q mean, PROCHECK, ERRAT, and PROTSAV servers. The scores given by all these servers were consistent with the fact that the 3D model predicted had good overall quality. Protein function prediction analysis (PFP) showed that the query protein C6S993 has enzymatic role in glycolysis. Binding site analysis revealed that the protein GAPDH of N.meningitidis has binding sites for NAD. The structural model computed in the present study could be used for a comprehensive understanding of the structural characteristics and moonlighting role of GAPDH of N.meningitidis. Details regarding whether the primary and secondary functions are independent or related need further investigation. This study will pave the way for further systematic analysis towards the identification of targets and potential biomarkers to design specific targets

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 Keywords

Index terms: Neisseria meningitidis, GAPDH, moonlighting protein.

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Skin problems are a basic in general clinical issue related with colossal number of individuals. With the speedy improvement of degrees of progress and the use of different information mining procedures of late, the movement of dermatological discerning arrangement has become logically smart and careful. Along these lines, movement of PC based insight systems, which can actually seclude dermatology infirmity gathering, is essential. The inspiration driving this work is to evaluate the introduction of PC put together insight systems with respect to skin problems check using Naive Bayes and Logistic Regression assessments. The exhibition of the appraisals is evaluated through after execution appraisals: exactness, accuracy and audit. The best result among two computations for as a rule rate was achieved by Logistic Regression model with a speed of 98.56%. This approach could improve and work with the procedure of portray the sort of skin torment in six outstanding classes. We show that the Logistic Regression performs best among others to the extent that precision.

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An Exploratory Focus on Dermatology infection utilizing Data Mining Strategies

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Teachers must be prepared with a variety of information and abilities in order to create and sustain successful teaching environments that allow them to improve students' comprehension and learning. One component of teachers' professional knowledge is knowledge of students, which is defined as teachers' knowledge of what mathematical concepts are difficult for students to grasp, which concepts students typically have misconceptions about, possible sources of students' errors, and how to eliminate those difficulties and misconceptions. The study's goal was to look at the nature of preservice mathematics instructors' understanding of pupils. Six preservice teachers took part in the research, and data was gathered via observations, interviews, and written documentation. The results demonstrated that preservice instructors struggled to identify the root of their students' misunderstandings and mistakes, as well as to devise effective approaches to eradicate such misconceptions. They often failed to recognise what conceptual understanding the students lacked, and they tended to address students' failures by instructing them on how to carry out the method or apply the rule appropriately to answer the given issue. As a result, preservice teachers should be given opportunities to 1) take content-specific courses in which they can discuss fundamental high school mathematics concepts in depth in order to gain a solid understanding of how mathematical concepts are related and why mathematical rules and procedures work, and 2) analyse an act of teaching by watching videos of classrooms or discussing student work and classroom cases in order to determine how to address students' errors and shortcomings.

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knowledge, pedagogical content, mathematics, teacher.

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EXPLORING THE ROLE OF GENDER IN THE WORKPLACE: A SOCIOLOGICAL PERSPECTIVE

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A STUDY ON PRIVATISATION OF PUBLIC SECTOR ENTERPRISES IN INDIA - AN ECONOMIC ANALYSIS

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Abstract: This explains in very general terms how a biologist goes about using computer programs for sequence analysis. The fundamental building blocks of life are proteins. In addition, much of the structure of a cell is made up of proteins. Proteins are variable length linear, mixed polymers of 20 different amino acids. Other terms used more or less inter changeably for amino acid polymers are peptides and polypeptides. These topologically linear polymers fold upon themselves to generate a shape characteristic of each different protein, and this shape along with the different chemical properties of the 20 amino acids determine the function of the protein.

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Bio-computing, Drug Design, Genomics, Bioinformatics

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 Abstract

Kanakadaasara Saamajika Ashayagalu

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ABandaya Kadambarigalalli Mahila Sumvedane

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 Abstract

Asprushyate Mattu Samajada Honegaarike

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A STUDY ON PRIVATISATION OF PUBLIC SECTOR ENTERPRISES IN INDIA - AN ECONOMIC ANALYSIS

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THE ROLE OF INFORMATION AND COMMUNICATION TECHNOLOGY IN HIGHER EDUCATION TO FACE GLOBAL COMPETITION

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A STUDY ON PRIVATISATION OF PUBLIC SECTOR ENTERPRISES IN INDIA - AN ECONOMIC ANALYSIS

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Abstract African humanism is a philosophical enquiry in the significance of African sense of respect for the human person. The traditional values of hospitality, primacy of person, respect for life, sense of the sacred, family hood, brotherhood, solidarity and other characteristic features of the communalistic life of an African person are brought into cognizance. Which applies the descriptive analytic and phenomenological methods of enquiry and spreading forth the scope of our coverage to include not only black negroes within the confines of the geographical configuration of Africa but also diasporas and those of any race and color within the continent, practical examples are sourced in order to illumine our subject matter salient questions are raised with respect to the essence of the centrality of the human person, his/her dignity right and the need for fair-play and sense of responsibility on the part of the citizenry and general leadership.

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African sensibility, Humanism,

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

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prises as a mother ensures her kids against the en

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