Volume 10 | Issue 2 |

 Abstract

The High performances liquid chromatography (HPLC) is the type of column chromatography that is an essential analytical tool for drug product assessment. HPLC is the separating technique characterized by detection, separation, analysis and quantifies the drug. In the development and manufacturing of new pharmaceutical product the analytical method play an important role. The word validation means simply Validity or action of providing effectiveness. Validation is an analytical method that provides information about various parameters such as accuracy, precision, linearity, Limit if Detection, Limit of Quantification, specificity, robustness, range. As per ICH guidelines, the validation should be done. This article was prepared with the aim to review the method development and validation of HPLC.

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Chromatography, HPLC, Development method, Validation, impurity, Detector, Instrumentation

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DRT, DRAT, NPAs

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The M-type strontium hexagonal ferrite with molecular formula SrCexDyFe11-xO19 for x=0.00, 0.25, 0.50, 0.75 and 1were prepared by sol gel auto combustion method with citric acid as a chelating agent and metal to nitrates ration as an 1:3 with maintaining Ph 7. The powder was sintered at temperature 900o for 6 hours to get a stable product of strontium hexagonal ferrite. After sintering the powder grounded into fine powder and pressed in to pellets by using manual Hydraulic pellet press capacity 1-5 Ton. The dielectric properties studied using LCR meter with varying frequency at room temperature. It was observed that as the frequency increases dielectric constant decreases.

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Ferrite, sol gel method, Hexaferrite, Dielectric properties

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Abstract;- The Nairs were the original inhabitants of South India who engaged fulltime in agricultural pursuits . The Aryanisation brought about complete change in their social life. They raised them to the rank of Kshatriyas, for they performed the duties of the feudal soldiers, particularly the protection of the land and people. But the formation of the modern state of Travancore by Marthanda Varma. coming of Europeans, western military training, decline of traditional martial arts etc caused the decline of Nair militia system in Travancore.

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This study has been undertaken to investigate, back in November 2015, terrorism invasion causes a very huge impacts toward France tourism industry. From a popular choice of tourism destination into a low ranking where no one wants to come there to travel. To get into this topic, the main ideas is to mainly focus on the declining of tourism that cause by the terrorist attacks.

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Terrorist Invasion, Tourism Industry, Tourist, Government

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TO COMPARE THE EFFECTS OF CIRCUIT TRAINING PROGRAM AND STRETCHING IN SPASTIC DIPLEGIC CEREBRAL PALSY CHILDREN

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Turbidity is one of the major culprits which help microbes present in water and waste water to survive. Also drastically impact the water treatment efficiency mainly the process of disinfection. Coagulants such as Alum, PAC (Poly Aluminium Chloride), FeCl3 etc, are majorly used for the turbidity removal in water. Among this Alum is the most widely used coagulant in water treatment, because of its proven performance and cost effectiveness. Although alum has a proven track record, usage of same in drinking water system increases the concentration of Aluminium ion which does not falls under the WHO (World Health Organization) norms of drinking water standards. Hence this study would be an alternate approach for turbidity reduction in water by using natural coagulants. Different studies in ancient Tamil Literature show Strychnos potatorum Linn or Nirmali seed act as a best coagulating agent, which in turn helps in removal of turbidity in water. This study was done to evaluate the effectiveness of Strychnos potatorum Linn seed extract in removal of turbidity from the selected water samples. An existing water softener system of capacity 2 m3/hr from a Residential Apartment named M/s.Ozone Pavillion was selected with an existing scheme of Alum dosing system, Pressure sand filter, Activated Carbon filter and Softener. In this scheme the Alum dosing was replaced with Strychnos potatorum Linn seed extract dosing and the softener filter was bypassed. Two different water samples were selected (Bore Well Water and Surface Water) and jar test was performed with the Strychnos potatorum Linn extract to arrive the best suited dose for the turbidity reduction. Here the jar test performed with different concentration of Strychnos potatorum Linn extract starting from 20 mg/l to 60 mg/l and selected the concentration of 60 mg/l as the best suited dose for turbidity reduction. The selected concentration was used for a pilot plant study in the existing water treatment plant designed by M/s. Green Enviro Polestar. The study showed the turbidity removal efficiency of 40% to 60% and highly emphasizes the usage of Strychnos potatorum Linn seed extract as a natural coagulant in water treatment systems.

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Strychnos potatorum Linn, Water turbidity removal, Natural Coagulants, Drinking Water Treatment, Jar Test, Pilot Plant.

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BACKGROUND: Substance abuse is one of the major health and social problems all over the world. Globally Substance/drug abuse is growing problem and out of this it is more common among young children and adolescent,Substance dependency cause violence, trauma, pre mature death, unsafe sex, organ systems failure, peptic and gastric ulcers, cirrhosis of liver and poor nutritional status of the family. Families of substance dependent persons have often faulty, inappropriate communication leading to emotional isolation among the society and family members. AIM: This study is aimed to assess the impact of educational intervention on knowledge and coping abilities related to substance abuse among inmates in de-addiction centers of selected districts, Rajasthan. METHODS: Quantitative research approach and Pre experimental one group pre test post test research design was used to assess the impact of educational intervention among inmates of de-addiction centres. 300 inmates selected by non probability, convenience sampling technique. Data were collected by using socio demographic sheet, knowledge questionnaire and coping abilities scale. RESULTS: Pre-test mean score of substance users for knowledge and coping abilities was very low. A statistically significant increase in mean knowledge and coping abilities score from baseline to post-test (p=<0.001) was seen after intervention. CONCLUSION: Thus, findings conclude that educational intervention was highly effective in improving knowledge and coping abilities of substance users at post test.

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Impact of educational intervention on knowledge and coping abilities related to substance abuse among inmates of de-addiction centers of selected districts, Rajasthan

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NEED FOR STRONGER LAWS AGAINST HATE SPEECH ABSTRACT: Hate speech is a threat to values of democracy, social peace, and social stability. Hate speech must be confronted at all times as a matter of principle. Even if a situation worsens and the weak become victims, silence can show apathy to racism and intolerance. Combating hate speech is also critical for advancing the agenda by assisting in preventing armed conflict, atrocity crimes, and terrorism, the elimination of violence against women, other serious human rights violations, and the promotion of peaceful, inclusive, and just societies. "Hate discourse is interrelated to the opportunity of expression, person, group, and minority rights, as well as standards of nobility, uniformity, and individual security." Keywords: Democratic values, hate speech, peaceful

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Keywords: Democratic values, hate speech, peaceful

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Millions of tons of waste is produced in the world each year and most of it is not recyclable. Furthermore, recycling waste consumes energy and produces pollution. In addition , accumulation of waste in the suburbs and the disposal of waste are very dangerous for the environment. Using waste material in concrete production is an appropriate method for achieving two goals: eliminating waste and adding positive properties in concrete. Since the green concrete industry is expanding, it is necessary to evaluate concrete that contains waste from all aspects in order to determine its capability. This literature study consists of two parts i.e. the use of waste as a substitute for cement and as a substitute for aggregates. Leading waste material that has been used as substitutes is highlighted and the characteristics of the resulting concrete is evaluated. Ductility, strength, durability, etc. of concrete may be improved using waste materials.

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Concrete, recycling, durability, ductility, waste

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