Volume 11 | Issue 2 |

 Abstract

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Behaviour, contagion, death, epidemic, norm theory.

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Lactic acid bacteria (LAB) are a phylogenetically diverse group with the ability to convert soluble carbohydrates into lactic acid. Many LAB have a long history of safe use in fermented foods and are recognized as food-grade microorganisms. LAB are also natural inhabitants of the human intestinal tract and have beneficial effects on health. Considering these properties, LAB have potential applications as biotherapeutic vehicles to delivery cytokines, antigens and other medicinal molecules. In this review, we summarize the development of, and advances in, genome manipulation techniques for engineering LAB and the expected future development of such genetic tools. These methods are crucial for us to maximize the value of LAB. We also discuss applications of the genome-editing tools in enhancing probiotic characteristics and therapeutic functionalities of LAB.Together with novel approaches such as CRISPR-Cas, the established systems for engineering now allow significant improvements to LAB strains.use of GM-LAB as cell factories in closed systems that prevent their environmental release is the least problematic aspect, and this is also discussed.

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GENOME TOOLS FOR THE DEVELOPMENT OF RECOMBINANT LACTIC ACID BACTERIA AND THEIR SAFETY ASPECTS

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ABSTRACT Hair fall is the serious problem in our young generation to old. It can caused by variety of various disorder come in man and women. Author goining to study, some ingredient like,Collin, Piper nigrum,Murryakoenigii, Black sesame, Flax seeds. Some ingradent contain bioactive antioxidant properties which play essential role, keeping body healthy and free form disease. That provided overall effect on health, which protect and also prevent cell damage against neurodegenerative diseaseproviding beautiful hair and skin. [15].In this present study Author giving mixture of above said ingredient in regular diet for three men and three young ladies for one month. Result for their regular diet as well coming up with innovative ways of the technique or ingredient for hair growth.

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:Hair Fall, Reconstructed, Consuming,Ingredient.

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Stoicism is a philosophy that has its roots in ancient Greece and stresses the cultivation of self-control and fortitude in the face of difficulty. The stoic principles may be more applicable than ever in the fast-paced, often stressful world of today. This study explores the ways in which stoic principles may be applied to life and makes the argument that stoicism can assist people more effectively deal with the difficulties of living. The study discusses the key ideas of stoicism, such as the notion of accepting what cannot be altered, and looks at how these ideas might be used to foster a feeling of peace and satisfaction in life.

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Acceptance, forgiveness, nature, philosophy, peace of mind, stoicism

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Child Labour - A bird view.

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Child Labour - A bird view.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract Vitis Vinifera.L is one of the most consumed fruits in the world. In ancient Europe, the leaves and sap of the Vitis Vinifera.L plant have been used for centuries in traditional medicine. In addition to being a source of vitamins and fiber, the skin and seeds of Vitis Vinifera.L are very rich in polyphenols, especially proanthocyanidins. Vitis Vinifera.L seeds are easily available as they are the winemaker's product. This review article briefly describes the various pharmacological activities of Vitis Vinifera.L seed extract and various experimental studies have been conducted to support the extract's health-promoting properties. Through various studies, proanthocyanidin-rich Vitis Vinifera.L seed extract has been proven to be beneficial against many diseases. To other successful pharmaceutical formulations for better prospects in protective textile finishing applications as wound healing materials such as inflammation, cardiovascular disease, hypertension, diabetes, cancer, gastric ulcers, and microbial infections.

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Key Words: Vitis Vinifera.L, Functional ingredient, Textile, Finishing

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Religiosity and devotion perform a crucial part in many human 's life and can have a number of consequences on their mental health. Religious and spiritual activities, such as prayer and attendance at religious services, have indeed been shown in studies to help people manage with stress and anxiety, resulting in improved mental health. Furthermore, religious and spiritual views can provide people a feeling of mission, meaning, and confidence, which can lead to greater psychological health. However, religious views and practises can be stressful for some people, especially if they cause emotions of regret or shame. Ultimately, the connection among religion and spirituality and mental health is multifaceted and differs widely depending on one's background and beliefs. More work is required to better comprehend the connection among religiosity and devotion and mental health, in addition to find appropriate treatments for people who struggle with this issue. Religion and spirituality have indeed been proven to perform a part in the therapy and control of a various of mental health issues, such as depression, bipolar disorder, and addictions, in addition to stress and anxiety. Some people with depression, for example, find some comfort and consolation in their religiosity or devotional beliefs, which can assist to reduce depression symptoms. Moreover, several research studies have shown that religiosity and devotional practises, such as mindfulness meditating and praying, can enhance brain function, resulting in increased mood and reduced symptoms of despair and anxiety. It is crucial to emphasise, however, that religiosity and devotion can have an adverse effect on mental health in some people. Religious views that emphasise guilt and shame, for example, it might leads to feelings of worthlessness and low self-esteem, which can contribute to the development of melancholy and anxiety. Likewise, religious and spiritual activities utilized for dominance or manipulation can be detrimental to mental health.

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Religion, Spirituality, Mental health

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Imidazopyridine derivatives are a proton pump inhibitor that reduces gastric acid secretion and has been successfully used to heal and relieve symptoms of gastric or duodenal ulcers and gastro-esophageal reflux. It has been synthesized by an oxidation of sulfide produced from a substitution reaction between 2-mercaptobenzimidazole and pyridine derivatives. The transformation of sulfide into sulfinyl has been generally carried out with peroxyacid such as mCPBA. The method for optical resolution includes fractional recrystallisation. The fractional recrystallisation method includes a method in which a salt is formed between a racemate and an optically active compound [eg. (+)-Mandellic acid, (-)-Mandellic acid] and salt is separated by fractional recrystallisation etc. and if desired subjected to neutralization process to give a free optical isomer. The chiral column method includes a method in which a racemate or a salt is applied to a column for optical isomer separation. In High performance liquid chromatography for example optical isomer are separated by adding the racemate to a chiral column (such as Daicel series) and eluting in water a buffer (for example, a phosphate), an organic solvent (for example, hexane, ethanol, methanol, isopropanol, acetonitrile, triethylamine or mixture thereof) or mixture of the foregoing.

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Imidazopyridine, Recrystallisation, Chromatography, Racemate, Proton-pump inhibitor

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This study had made to reinforce the problematic black cotton soil and to avoid the settlement of the foundation, by installing Micro-Piles (M-P) individually and in group. In the group piles, the three pile group and four piles group is adopted in this study. The three pile group is installed in triangular pattern, whereas the four pile groups installed in square pattern at different length and different spacing, also the group efficiency is determined for both patterns and is compared with each other. The model tests were performed with the use of mild steel model test tank of dimension 350mm in length, 350mm in width, 350mm in depth and the model footing of the size 140mm x 140mm of 6mm thick. The analysis was carried out for individual and group piles of respective pattern which are installed in the black cotton soil with different lengths i.e. 30%, 50% and 70% of length and spacing of 2D, 3D and 4D respectively, where D=dia of micro-pile. The vertical load is applied to experimental setup and the ultimate bearing resistance is recorded with respect to 30mm settlement. It is examined that, the ultimate loads bearing resistance of the M-P in Black Cotton Soil rises with increase in length and spacing between the piles. Due to upraise in the load holding capacity, inversely the foundation settlement also decreases, it also observed that the load taken by the piles increases with increase in their numbers. The maximum load of 14.6 KN and 18.8KN is observed in three and four numbers of piles and 7.8 and 13.5KN is the least loads observed in three and square group piles respectively. When it comes to the Group efficiency (GE), it is found that the GE decrease with increase in the length, but the GE elevates with increase in distance between the piles, the GE observed in different patterns of triangular and square pattern of group piles. It is observed that the GE has a peak value of 79.24% in Square pattern at 30% of length and spacing of 4D, minimum value of GE is found to be 42.59% in triangular pattern at 70% length i.e. 245mm length at spacing of 2D.

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Black cotton Soil, Micro Piles, CPVC Pipes, Ultimate Bearing Capacity, Efficiency, Space Length.

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The folksingers are the people from the marginalized society.The prima materia of folk song is its materialistic attitude towards life. The prime aim of this song is not only to please the audience but also to delineate the picture of injustice, inequality and inequity in the society and state as well. To increase the awareness of building an exploitation-free society is the purpose of composing the folk songs.

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Folk song, exploitation, protest, revolt.

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Creative Commons Attribution 4.0 and The Open Definition