Volume 10 | Issue 11 |

 Abstract

The search for new compounds with a given biological activity requires enormous effort in terms of manpower and cost. This effort arises from the large number of compounds that need to be synthesized and subsequently biologically evaluated. Virtual Screening (VS) has emerged in Drug discovery as a powerful Computational Approach to screen large no. Of small molecules for hits with desired properties. In the last years bioinformatics has experienced a great evolution due to the development of specialized software and to the increasing computer power. Through the computational approaches, speed up drug Discovery process & reduce the number of candidates to be tested experimentally, & to rationalize their choice. The codification of the structural information of molecules through molecular descriptors and the subsequent data analysis allow establishing QSAR models (Quantitative Structure-Activity Relationship) that can be applied to the design and the virtual screening of new drugs. The development of sophisticated Docking methodologies also allows a more accurate predict of the biological activity of molecules. Moreover, through this type of computational techniques and theoretical approaches, it is possible to develop explanatory hypothesis on the mechanism of action of drugs. This work provides a brief description of a series of studies implemented in the software MOE (Molecular Operating Environment) with particular attention to the medicinal chemistry aspects.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Virtual Screening, Drug Discovery, QSAR, Molecular Docking, Molecular Operating Environment (MOE).

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The quality of the molten metal, from which the products are cast directly affects the quality of the cast products. One of the most crucial factors in the control and forecasting of desired casting properties in the cast components is to properly treat the melt. Melt treatment have direct impact on casting quality. The amount of an alloying element present and how the melt is treated have a considerable impact on the mechanical properties and, consequently, the quality of castings. Therefore, one of the most crucial steps in producing a product of the appropriate quality is the melt treatment. Aluminum casting alloys are frequently used to make high quality components due to their higher strength-to-weight ratio, superior wear resistance, and lower coefficient of expansion. The degree of microstructure and melt treatment refinement determines the quality of end products. Phosphorus addition in the aluminum alloy melt is a effective method to refine grain size of silicon and to improve mechanical properties. In this research paper the factors influencing the melt refinement are investigated and it was found that phosphorous addition in the molten metal affects silicon grain size and mechanical properties like hardness. The optimum conditions are ascertain through experimental work.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Aluminum Silicon Alloy, Grain Refinement, Melt Treatment

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

As part of an automatic irrigation system, a soil moisture sensor is inserted into the plant's soil, and a water level sensor is mounted in the water container from which water will be pumped to the plants for irrigation. to assess the water level in tanks and manage the amount of water in the soil, an algorithm with threshold values for soil moisture sensors has been developed. An Arduino board with an ATMega328 microcontroller is needed for this project. An automated irrigation system uses a soil moisture sensor to determine the soil's moisture content, which controls whether the pumping motor is on or off.Better resource management and minimal power usage are features of the design. In this project, an 8051 family microcontroller is used. This programmable microcontroller accepts input signals that are then converted by soil moisture sensors into values of soil moisture. As soon as the microcontroller begins to receive the signals, it produces an output that causes a relay to open, activating the water pumping motor.The soil and water pump's moisture levels are shown on an LCD that is also connected to the microcontroller. To make sure there is enough water in the tank to efficiently irrigate crops, the tank's level is determined by the water level sensor.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Keywords: Microcontroller, water level sensor, Arduino UNO, soil moisture sensor.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Abstract: The strain on land has increased dramatically because of population growth, especially in developing nations. Jhum cultivation is a time-immemorial tradition that is still widely used in the hill districts of Manipur, where jhumians spend a lot of money on unreliable land usage. Due to population growth, the cycle of shifting that used to occur every 20 to 30 years in a specific location has been shortened to 2 to 5 years, which has worsened the environment, anthropogenic and geomorphologic problems. The aim and objective of the present study is to explore the causes, effects and affects of shifting cultivation in the study area. The major sources of data used in this research were primary data collected from four villages in the Manipur hill districts of Ukhrul, Chandel, Senapati, Tamenglong and Churachandpur. Secondary data are collected from several census publications compiled by the Directorate of Census Operations, Government of Manipur. Over the years, land in the hill tribal areas has changed, emphasising private property ownership more and more and thereby, the conventional slash-and-burn method of farming causes environmental disturbances and land degradation. Jhuming cultivation, though it is a primitive high rate of population growth, trash cycle is becoming shortened; the Jhum area and intensity are all increasing. It is destroying the forests and rich biodiversity and putting them in danger of being completely degraded due to the loss of top soil, fertility and vegetative cover, eventually turning them into a desolate wasteland.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Key word: Forest Fire, Deforestation, Erosion, Sustainable, Shifting Cycle

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Womanism, Epistolary, Feminism, Patriarchy

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

It's a Survey paper expressing the literature survey of voice assistants along with the proposed Voice Assistant architecture.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Voice assistant, Windows, Python

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

the impact of COVID pandemic in ophthalmic practice and services.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

COVID, pandemic,PPE

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The life style of well-being are define by consumption of electric load. Electricity play major setback both on economic as well as social well-being. Micro Hydro Power as cost effective and eco-friendly, is a magnolious tactic in deploying local natural sources for power such as from small scale rivers and streams. The turbine can run with or without the reservoir, usually fetch from run-off-river type. The flowing water strike directly into the turbine and then water flow down the stream without effecting the cycle of the system which in return gave minimal impact to the environment and maximum benefit to the surrounding where grid connectivity might not be recommendable due to its various cons. In many isolated remote area with few population grid connected has a major drawback on cost. So exploring more on locally available renewable resource will bring a wider prospect in terms of economical as well as maximum beneficial. In order to recapitulate the optimization hurdle of Micro Hydro Power plant a python programming has been done with a single objective function taken into account valuation of the plant as the fitness function (minimization problem).

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Renewable Energy, Optimization, economical

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Data mining, Credit card, machine learning, financial crisis, transaction history.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This region has been inhabited constantly by a group of nomadic tribals viz. Mahadeo Kolis, Dhangar, and Bhils for curing certain ethnobotanical ailments since ancient times. The present paper enumerates traditional ethnobotanical uses of 19 species belonging to 18 genera and 16 families by the natives of the study area i.e. Roti Ghat of Daund tahasil in district (M.S.) India. Out of these, seed in 3 plants, leaf in 6 plants, leaf and stem in 4 plants, root in 2 plants, stem in 2 plants, fruit in 1 plants and flower in 1 plant are used for ethnobotanical purposes by the local inhabitants

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Nomadic tribals, Roti Ghat, ethnobotanical.

  License

Creative Commons Attribution 4.0 and The Open Definition