Volume 11 | Issue 10 |

 Abstract

Pharmaceutical drug discovery is an expensive and time consuming process.The development of a drug from an initial idea to its entry into the market is a very complex process which can take around 5-10 yrs. and cost is very high upto billion. It is an development process involves use of variety of computational techniques ,such as structure activity relationship ,quantitative structure activity relationship ,molecular mechanics ,quantam mechanics,molecular dynamics and drug protein docking. The idea for a new development can come from a variety of sources which include the current necessities of the market, new emerging diseases , academic and clinical research , commercial sector. The pharmaceutical industry is under pressure in developing cost effectiveness drug molecule from the previous knowledge and established Quantitative Structure Activity Relationships.The structure based design is one of reliable and promising techniques used in drug designing. In drug design , the main aim is to find out the three dimensional structure of pharmacologically significant receptor ligand complexes. The aim of this review is to give an overview on the rational drug design approaches with a case study on drug discovery for influenza A virus , HER2 Receptor , targeting dopamine D3 receptor , purpose , and applications of QSAR. This article highlight the benefits and promises of developing tools for drug discovery.

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 Keywords

CADD , Pharmacophore , Docking , QSAR , ADMET

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Creative Commons Attribution 4.0 and The Open Definition

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The study reflects to examine how technology affected the Millennial age cohorts in India (1980-2000) combined their personal and professional lives. The study was conducted to investigate how online technology affects the merger of work and life. The study used a causal model. A causal model was adopted to construct the research work. Web technology, virtual communication, had been considered as the predictor towards the behavioral response of work life fusion. Virtual contact over the internet was once thought to be a behavioural indicator of the merging of work and life. The objective of the study focused on the influence of technology towards work life fusion of generation cohorts of Millennials in India (1982-2000). The study carried out with the objective of exploring the influence of web technology on work life fusion. A causal model was adopted to construct the research work. Web technology, virtual communication, had been considered as the predictor towards the behavioral response of work life fusion. Study was conducted in two parts, one on the Millennial in rural regions and the other on the Millennial in metropolitan areas. Both respondents from the study's urban and rural populations provided information for the researchers. A structured questionnaire was employed as the survey method, and a 5-point Likert scale was used to collect the replies. Cronbach's alpha value was used to gauge the consistency of each variable. The internal consistencies were confirmed by the dependability of all the variables. The potential association between the variables was evaluated using correlation and regression analysis. Students' sample t test and other statistical methods like correlation and regression analysis were employed. It was clearly demonstrated as the investigation moved towards its conclusions that the impact of web technology, virtual communication on work life fusion. Study also confirmed the gender differences impact on work life fusion.

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 Keywords

Fusion, work and life, web technology, millennials

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Organic food comprises those agriculture food products that are not treated with chemical fertilizers, pesticides, herbicides and other synthetic chemical substances during its production, processing and storage. In addition, organic food products are not containing genetically modified materials, with the purpose of reaching a sustainable system of agriculture. The organic food products awareness towards the public is keep on increasing, because of the health consciousness and the environment consciousness. The main objective of the study is to know the knowledge and awareness of consumers on organic food products in Bangalore City. The research is focused on consumer awareness and satisfaction towards organic food products.

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Awareness & Perception, Organic food, Consumer Perception.

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The system is used for car theft detection and remote engine locking which is basically used for detecting car location and locking the engine from any location. The Android phone acts as the controller from which we can control our system through the Blynk app. And we can also track location through GPS module. The engine will be off from the Blynk app through the relay.

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Vehicle security system, Theft detection Remote engine locking ,Anti-theft technology ,Vehicle tracking ,Immobilizer system ,GPS tracking.

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Donkey milk is the milk from the domesticated donkey. It has been used since antiquity for cosmetic purposes as well as infant nutrition.Donkey milk has been used by humans for alimentary and cosmetic purposes since Egyptian antiquity. Doctors recommended it to treat several afflictions, due to its healing and cosmetic virtues. Donkey milk (DM) has gained scientific attention in recent years.Because it has compelling nutrients and functional elements.(Mansueto et al. 2013 There are much similarites in chemical compositions of human milk and donkey milk.Donkey's milk is used as an alternative for infants with multiple food allergies and intolerances.Recently, fermented beverages based on donkey milk were proposed as important sources of probiotics and antioxidants with several health benefits. Donkey milk contains high levels of lactose and minimal amounts of casein and fat. One of the main particularities of Donkey milk is its high lysozyme's content. Lysozyme shows antibacterial activity against numerous Gram-positive bacteria; including lactic acid bacteria (LAB). Recently, overuse of antibiotics has led to the emergence and spread of high bacterial resistance, making difficult to treat infections involving tremendous research efforts by the medical and scientific community(Chiavari et al. 2005).In fact, living organisms have developed an immense molecular diversity, containing ubiquitous low molecular weight secondary metabolites isolated from plants, insects, marine organisms, and other microorganisms, including lactic acid bacteria (LAB).

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Donkey milk; 16S rRNA Sequencing; lactic acid bacteria.

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The Excellence is the normal and regularly expected term utilized in each workplace. Employee Excellence is reliably settled through remarkable accomplishment and commitment to the associations. Employee Excellence is exhibited through the positive and obvious effect of accomplishments. These accomplishments fundamentally surpass the presentation assumptions related with obligations at the banks, represent the vision, mission, objectives and upsides of the banks and effectively improve the standing of the scheduled commercial banks (SCBs). The financial area is the main area in the present day economy. The financial area goes about as one of the significant mainstays of the monetary area. It assumes a significant part in the working of an economy. The performance of the Scheduled Commercial Banks completely relies upon the viability of the bank workers. The worker's greatness has a significant influence in the exhibition of the people and the banks. This exploration study focusses on the immensity of the bank representatives. Execution Appraisal is one of the huge elements of authoritative capacity which is likewise the focal point of this review. Execution examination is an assessment of representative's performance in the banks and clears the path for upgrading the greatness of the bank workers. This analysis tends to the Employee Excellence and execution evaluation in Scheduled Commercial Banks to dissect the greatness of bank representatives according to different points of view. The analysis would empower the SCBs banks to comprehend the greatness level of their staff and to zero in on required regions for ceaseless improvement

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Employee, Excellence, Performance appraisal and banks.

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Creative Commons Attribution 4.0 and The Open Definition

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Church buildings in India are an important pedigree of social identity and continue to have a consort presence in public life. Concurrently religious practices have evolved, and it has become ostensible that church buildings represent a religious heritage and, equally importantly, a historical heritage. church buildings play an indispensable role in the urban and social structure of the town and surrounding landscape. These church buildings are provenance of great pride not only for the fellowships but also for the wider local community. The church building in India possesses rich culture, and built heritage, and includes many magnificent churches, monuments, and temples. Most of these churches are world-famous and constructed way back in the 17th century and are the best examples of Manueline and Gothic architecture. These churches have very intricate detailing and ornamentation reflecting the past and playing an important role in shaping the community to know about the ancient culture, way of life, architecture, level of development, building techniques, and use of material, art, and other aspects of the society of a particular period. The rich heritage structures are on the verge of deterioration and alarms for effective management.

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Creative Commons Attribution 4.0 and The Open Definition

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Fresh purslane leaves, lyophilization chapathi, lyophilized purslane powder, nutritional composition, functional components, storage stability.

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Presently in the 21st century, women empowerment is the most important topic of discussion in the half of the world's population. From the beginning, women have been deprived of social, economic, educational and political development. This shows the backward position of women in the society. Initially, the society and the rulers did not do any important work for the education of women. If we look at the Vedic period, there was definitely no restriction on women, there women were given equal preference as men at almost every level. But by the time of medieval period, women had to face many bad practices like sati system, child marriage, devadasi system, slave system, purdah system and female slaughter. In the last decades of the 19th century, many great social reformers like Raja Ram Mohan Roy, Swami Dayanand Saraswati, Swami Vivekananda, Mahatma Jyotiba Phule, not only raised their voice against these evil practices prevalent in front of women, but also contributed in ending many evil practices. Various social and religious reform movements came into existence after India's independence and raised many questions for the rights of marginalized women in terms of their social, economic, religious, political and educational development. After independence, legal protection was provided to the rights of women through the Indian Constitution. Many movements and laws have been made for women empowerment by the central government and the state governments at their own level as well. If we see from the legal point of view, there is no deficiency in the legal provisions of the nation for women empowerment, if the need is to implement those legal provisions properly and adopt the quick justice process. It should also be noted here that it is meaningless to talk about women's rights and women's empowerment only through legal provisions. For this, we have to positively change the mindset of the students and people from the school and college level itself. The first beginning of respect for these mothers of the world who emit energy in the society should be from their home. Governments have to keep in mind that the protection of women's rights should not be done by merely making laws. Strong machinery will also have to be upgraded for their comprehensive protection, promotion and implementation. This research paper of mine is also based on women empowerment through various legal provisions.

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Keywords: Legal Provision, Women Education, Women Empowerment, Sati Pratha, Devadasi Pratha, Dowry Pratha.

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Water is an important natural resource that acts as the backbone for every living thing to survive. India accounts for 4 percent of fresh water, according to the Water Resources Information System, but this varies with the distribution of water. However, changing trends in drinking water quality and access have already been studied. The project's primary goal is to examine the trends in drinking water quality over a 25-year period in each block of the study region. The second objective is to study the underground water level in the study area so that we can get information about the rise or fall of the ground water level in the last twenty-five years. The study's third goal is to identify the source of drinking water and the distance travelled by households to obtain it. Eastern Hisar district is facing the problem of water logging, so the quality of drinking water is low in this area. There are many other factors contributing to the low quality of drinking water, such as excessive use of fertilisers in agriculture, lack of awareness, urbanisation, mismanagement of water, digging toilets (cutcha), borewells, etc. The purpose of the research was to evaluate the local drinking water's quality, accessibility to homes, and changes in ground water levels. It is helpful to make people aware of modern technology for water conservation, policies by the government to improve water facilities, and self-treatment of drinking water at home.

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 Keywords

Resource; Water-logging; Underground; Self-treatment; Eastern Hissar.

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Creative Commons Attribution 4.0 and The Open Definition