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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
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Paper Title
FORMULATION AND EVALUATION OF SOLUBILITY MODULATED ATORVASTATIN CALCIUM AS COLON SPECIFIC DRUG DELIVERY
Authors
PALEPU SWATHI
Keywords
Atorvastatin Calcium , ?-Cyclo dextrin, HMG CoA, Colon Specific.
Abstract
Hyperlipidemia or hyperlipoprotienemia or dyslipidemia is the presence of elevated or abnormal levels of lipids or lipoproteins in the blood.Lipid and lipoprotein abnormalities are regarded as a highly modifiable risk factor for cardiovascular diseases due to influence of cholesterol.
Statins are the most commonly prescribed lipid-lowering agents because they are effective ,well tolerated and easy to administer. Atorvastatin is a selective competitive inhibitor of HMG CoA reductase.Its absolute bio availability is 14%.Atorvastatin is slightly soluble in water,BCS Class II drug. Based on Atorvastatin calcium characteristics the bioavailability is improved by complexation technique with ?-Cyclo dextrin a solubilizing agent by solvent evaporation method.
After these the coating is done with methacrylic acid copolymers for the targeting action to avoid first pass metabolism and convertion of Atorvastatin calcium into its respective lactone. This project theme is to lowering the cholesterol level by using statins drug of Atorvastatin calcium and it is unstable in gastric pH, so it is targeted to colonic pH which is stable and less side effects.
IJCRT's Publication Details
Unique Identification Number - IJPUB1801263
Paper ID - 181581
Page Number(s) - 1668 - 1677
Pubished in - Volume 6 | Issue 1 | March 2018
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
PALEPU SWATHI, "FORMULATION AND EVALUATION OF SOLUBILITY MODULATED ATORVASTATIN CALCIUM AS COLON SPECIFIC DRUG DELIVERY", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.6, Issue 1, pp.1668 - 1677, March 2018, Available at :http://www.ijcrt.org/papers/IJPUB1801263.pdf
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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