Published Paper Details:

Traditional therapies, including the use of dietary components for wound healing and skin regeneration, are very common in Asian countries such as China and India. The increasing evidence of health-protective benefits of phytochemicals, components derived from plants is generating a lot of interest, warranting further scientific evaluation and mechanistic studies. Among different plants showing positive activity towards wound healing, Capparis spinosa-C. spinosa has many active constituents such as flavonoids such kaempferal and quercetin . Nature fruits of C. spinosahave glucose as 1-H Indole-3-acetonitrile etc, whereas C. zeylanica has reported to have fatty acids such as E-octodec-7enynoic acid isolated from chloroform extract of the roots . Extracts of C. decidua stems and flowers showed insecticidal and oviposition inhibitory activities against Bruchus chinensis. the photochemical from these plant extracts were found to possess significant wound healing promoting activity. In the present study, we have identified 12 potent active constituents viz., Capparispine, Glucocapparin, kaempferol, kaempferol-7-rhamnoside, Polyprenols, Proline betaine, Quercetin, Quercetin-3-rutinoside, Rhamnetin, Rutin, Saccharose, Sinigrin for wound healing promoting ability. These active constituents were subjected for docking study using a well established target GSK 3 Beta responsible for wound healing process in human. Our results, indicated that Capparispine, Glucocapparin, kaempferol, Polyprenols, Quercetin, Quercetin-3-rutinoside, Rhamnetin have a potent wound healing property among other compounds. In vivo/ in vitro studies to validate the present finding and to understand the exact mechanism and potential targets of these phytochemicals are under process