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INTERNATIONAL JOURNAL OF CREATIVE RESEARCH THOUGHTS - IJCRT (IJCRT.ORG)
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ISSN Approved Journal No: 2320-2882 | Impact factor: 7.97 | ESTD Year: 2013
Call For Paper - Volume 12 | Issue 7 | Month- July 2024
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Paper Title
SIGNIFICNCE ANALYSIS OF TARGET PROFILE IN TUBERCULOSIS USING GENE INTERACTIONS AND INSILICO DOCKING APPROACH TO FIND POTENTIAL LIGANDS
Authors
Dr.Manjunath, Shambhu M.G Apeksha, Chandana N, Lakshmi S, Mounika S
Keywords
Mycobacterium tuberculosis, Rifapentine
Abstract
Tuberculosis is a common and deadly infectious disease caused by Mycobacteria. WHO estimates that one third of global population is infected with Mycobacterium tuberculosis. Tuberculosis is a Multidrug resistant since their are a lot of mutations occur in genes .Our study focused on uncharacterized mutated tuberculosis target identification by using Systems Biology Approach, which is used to find the better drug targets. From the advance search by using UniProt we observed seven receptors are the significant targets 2CCA,1P44, 3VZ1,3IFZ, 1KOR,2EYQ .Tuberculosis target candidates are screened and validated by docking studies using Auto dock Software .Analysis has revealed that among 14 ligands it has been observed that Josamycine and Rifapentine showed a better interaction score (-10.3 kcal/mol and -12.7 kcal/mol) and could be potential ligands. These potential ligands have also shown better ADMET properties in Insilico studies by using ADMET SAR software.
IJCRT's Publication Details
Unique Identification Number - IJCRTOXFO025
Paper ID - 190032
Page Number(s) - 400-410
Pubished in - Volume 6 | Issue 2 | APRIL 2018
DOI (Digital Object Identifier) -
Publisher Name - IJCRT | www.ijcrt.org | ISSN : 2320-2882
E-ISSN Number - 2320-2882
Cite this article
Dr.Manjunath, Shambhu M.G Apeksha, Chandana N, Lakshmi S, Mounika S, "SIGNIFICNCE ANALYSIS OF TARGET PROFILE IN TUBERCULOSIS USING GENE INTERACTIONS AND INSILICO DOCKING APPROACH TO FIND POTENTIAL LIGANDS ", International Journal of Creative Research Thoughts (IJCRT), ISSN:2320-2882, Volume.6, Issue 2, pp.400-410, APRIL 2018, Available at :http://www.ijcrt.org/papers/IJCRTOXFO025.pdf
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Volume 12 | Issue 7
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ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
ISSN and 7.97 Impact Factor Details
ISSN: 2320-2882 Impact Factor: 7.97 and ISSN APPROVED Journal Starting Year (ESTD) : 2013
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