Published Paper Details:

The purpose of the present research was to develop and evaluate pantoprazole enteric coated tablets utilizing Eudragit L100 as the enteric polymer. The medication was chosen based on a review of the literature, which showed that pantoprazole is unstable in the stomach's acidic environment. Eudragit L100 was chosen as the polymer of choice to coat the tablet. Preformulation characteristics for the medication, such as its melting point, IR, DSC, solubility, and partition coefficient, were assessed for identification and characterisation. The F5 batch of tablets was chosen for enteric coating based on the evaluation results of the core tablets. Enteric polymer Eudragit L100 was applied to the F5 batch at 6% and 8% with 1.5% PEG serving as a plasticizer. The drug content, weight fluctuation, hardness, and in vitro drug release of the coated F5 Batch containing 6% and 8% Eudragit L100 were assessed. It was discovered that the F5 batch coated with 8% polymer outperformed the F5 batch coated with 6% polymer. As a result, F5 (8%) was chosen as the best formulation.