Published Paper Details:

An effervescent floating tablet formulation of Acebutolol hydrochloride was developed to enhance bioavailability by improving stomach retention. Using a direct compression method, various synthetic and natural polymers were evaluated. Effervescent agents, sodium bicarbonate and citric acid, were incorporated with polymers to lower the dosage form's density below that of gastric fluid, thereby extending gastric residence time. FTIR analysis was employed for drug identification, followed by the creation of floating tablets to assess polymer effects on swelling and buoyancy. Drug-excipient compatibility studies and FTIR comparisons with pure drug indicated no interactions in the optimal formulation. Stability tests confirmed unchanged post-compression parameters. The most effective combination of sodium bicarbonate, citric acid, and karaya gum (FA7) resulted in a floating lag time of 1 second, total floating time of 590 minutes, and 98.91% release after 600 minutes. Release kinetics analysis revealed adherence to a zero-order non-fickian diffusion-controlled system. The study found no drug-excipient interactions and demonstrated that Acebutolol hydrochloride floating tablets with karaya gum (FA7) mitigate plasma concentration fluctuations associated with frequent dosing of conventional immediate-release forms by prolonging gastric residence time