Published Paper Details:

Non-coding RNAs (ncRNAs) constitute a diverse family of RNA molecules that regulate various cellular processes, with implications spanning from basic molecular biology to clinical applications. This review explores the multifaceted roles of ncRNAs in gene regulation, focusing on their involvement in cancer biology and potential applications as diagnostic and therapeutic targets. NcRNAs encompass a wide array of molecules, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and others, each exerting regulatory effects on gene expression through various mechanisms. MiRNAs, for instance, regulate mRNA transcripts via sequence-specific interactions, while lncRNAs modulate gene expression at transcriptional and post-transcriptional levels. In cancer, dysregulated expression of ncRNAs contributes to tumorigenesis, metastasis, and drug resistance, highlighting their potential as biomarkers for diagnosis and prognosis. Liquid biopsies, utilizing circulating tumor-derived ncRNAs, offer less invasive alternatives to traditional tissue biopsies for cancer detection and monitoring. Additionally, advancements in RNA sequencing technologies enable comprehensive profiling of ncRNAs, aiding in the identification of cancer-specific signatures. Therapeutically, ncRNAs hold promise as targets for innovative treatments, such as RNA-based gene silencing therapies. Clinical trials investigating ncRNA-targeted therapies have shown encouraging results in diverse cancer types, although challenges remain in ensuring efficacy and safety. Overall, the burgeoning field of ncRNA research offers insights into the complex regulatory networks governing cancer biology and presents opportunities for the development of novel diagnostic tools and therapeutic interventions.