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ABSTRACT A Descriptive Research design was employed to evaluate the understanding of iron deficiency anemia among adolescent girls at a higher secondary school in Chandragiri, A.P. One hundred adolescent girls were chosen using the Non-Probability Purposive Sampling technique. Data collection was conducted through a structured questionnaire on iron deficiency anemia. The data was analyzed utilizing descriptive and inferential statistics. MAJOR FINDINGS OF THE STUDY Out of the 100 adolescent girls surveyed, 42 (42%) had inadequate knowledge of iron deficiency anemia, 35 (35%) possessed moderate knowledge, and 23 (23%) demonstrated adequate knowledge regarding iron deficiency anemia. There is a statistically significant association between socio-demographic variables and knowledge among adolescent girls, including age, father's education, father's occupation, and monthly income (significant at p<0.01). Additionally, there is a statistically significant association between socio-demographic variables and knowledge among adolescent girls, such as religion, education level, type of family, food pattern, source of knowledge, and birth order (significant at p<0.05). The results indicated that a significant number of adolescent girls had inadequate knowledge regarding iron deficiency anemia. In response to these findings, an information booklet was distributed to all adolescent girls to address and mitigate this condition, aiming to enhance their overall health status. This study contributes to equipping healthcare personnel with valuable insights to better educate adolescent girls about iron deficiency anemia. CONCLUSION: The study reveals that there is inadequate knowledge among adolescent girls regarding iron deficiency anemia. It is recommended that teachers and healthcare professionals collaborate to develop educational programs and offer guidance and health education on iron deficiency anemia, actively engaging adolescent girls. In response to these findings, information booklets were distributed to all adolescent girls to address this issue and enhance their health status. It emphasizes the importance of including iron-rich foods in the diet of adolescents,highlights several examples such as mustard leaves, powdered milk, grams, maize, and red meat, all of which have high iron content. Incorporating these items into the diet of adolescents can effectively address their iron requirements and contribute to overall health and well-being.