Published Paper Details:

The advancement of modern medicine has been pivotal in the fight against infectious diseases. However, due to the numerous side effects associated with conventional treatments, there has been a resurgence of interest in natural remedies, valued for their gentler impact on the body. Herbal medicines, rooted in centuries-old practices, have emerged as promising alternatives. Yet, their widespread adoption is impeded by challenges such as low bioavailability and solubility. Plant-based nanoparticles offer a potentially superior solution. Combining plant extracts with nanoparticles has shown to enhance bioavailability and solubility, thereby amplifying the effectiveness of herbal medicines. This review aims to highlight the pivotal role of nanotechnology as an innovative drug delivery system for herbal medicines, augmenting their therapeutic effects and bioavailability. It also explores the methodologies for formulating herbal nanoparticles and the rationale behind integrating herbs with nanoparticles. These insights are expected to steer future biomedical research and open up new avenues in this field. Recent advancements in nanotechnology have ushered in new opportunities for ongoing research, serving as a pivotal force in enhancing the therapeutic potential of phytomedicine and herbal remedies. Methodically crafted nanoparticles have significantly propelled the development of innovative herbal-nanomedicine (HNM). These nano formulations adeptly address challenges encountered by traditional herbal remedies. Extensive analysis of nanomaterial-herbal interactions has deepened our understanding of the HNM interface, facilitating the enhancement of phytochemicals and herbal remedies in terms of bioavailability, biocompatibility, pharmacokinetics, pharmacodynamics, and therapeutic index. A comprehensive HNM formulation seamlessly integrates all essential active ingredients into nano dosage forms, showcasing superior therapeutic indices compared to conventional phytochemicals and herbal remedies. This assessment underscores nanoscale herbal-nanomedicine as a promising avenue for therapy and drug delivery. The utilization of state-of-the-art techniques and current knowledge is imperative for HNM progression, potentially leading to the development of novel formulations and overcoming challenges in clinical pharmacokinetics and pharmacodynamics. The discussion emphasizes the therapeutic profile of HNM, encompassing critical pharmacokinetic and pharmacodynamic parameters such as absorption, distribution, metabolism, and excretion, crucial for the formulation of safe and effective herbal-nanomedicine products.