Published Paper Details:

Controlled and targeted delivery of active pharmaceutical ingredients (APIs) has emerged as a promising therapeutic strategy. However, challenges such as low water solubility of most APIs and the need for efficient drug delivery systems persist. Traditional organic solvents used in drug formulation pose health and environmental concerns. Ionic liquids (ILs) have garnered attention as potential alternatives due to their unique properties. This review paper explores the diverse applications of ILs in drug delivery, ranging from solubilizing APIs and enhancing their bioavailability to serving as novel components in biopolymer-based delivery systems.We discuss the potential of ILs as solvents and co-solvents for low water-soluble APIs, showcasing significant improvements in solubility and stability. Furthermore, ILs enable the conversion of solid APIs into liquid forms (API-ILs), addressing challenges related to polymorphism and bioavailability. Their role as effective permeation enhancers and microemulsion components for drug delivery is also highlighted, along with their ability to dissolve biopolymers like cellulose and chitosan. ILs open avenues for customized drug delivery systems, allowing for controlled release profiles and responsive behaviors based on environmental stimuli.Through an in-depth analysis of recent research and advancements, this paper underscores the vast potential of ILs in revolutionizing drug delivery systems, offering safer, more efficient, and sustainable alternatives to traditional approaches.