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ABSTRACT Background: Asthma is a broad term used to refer a disorder of the respiratory system that leads to episodic difficulty in breathing.It leads to airway hyper responsiveness, obstruction, hyper production of mucus and remodeling of airway walls. Bronchial asthma is a recurrent but reversible obstruction of the airways. Asthma is a major cause of disability and health resource utilization, and reduces quality of life. This is partly caused by asthma exacerbations, which have a huge impact on patients and their families. Over the last 25 years,the increase in asthma prevalence is due to the changes in our environmental or lifestyle modification. Aim: To assess the prescribing pattern and medication adherence in asthmatic patients and evaluate their quality of life. Objectives: o To assess the prescribing pattern in asthmatic patients . o To investigate the medication adherence in asthmatic patients . o To evaluate the quality of life of selected population . Materials and Methods: The prospective observational study was carried out in 10 patients with asthma in Cosmopolitan Hospital, Trivandrum. The study was conducted after getting informed consent from the patient. Proforma was used for collecting the demographic details of the patient and patient counselling was given to them using PILs.The prescription pattern, medication adherence and quality of life of subjects was assessed. The details of the drugs prescribed were noted down. Medication adherencewas assessed using AAMQ [Adherence to Asthma Medication Questionnaire] and quality of life was assessed using AQLQ [ Asthma Quality of life questionnaire with standardized Activities]questionnaires both before and after counselling(follow up done after 2 weeks) and essential details were documented . Result: During the study 10 asthma patients were included for the study who satisfied the inclusion criteria.The prescription was analyzed and found that the mostly prescribed drugs were Leukotriene Antagonists, Corticosteroids, Methyl Xanthines and Beta-Agonists.The mostly given therapy is anti- asthmatic drug combinations rather than monotherapy. Out of 24 drugs prescribed 15 were prescribed with oral dosage form and rest via inhalational route. In the study we have seen a significant improvement in medication adherence and quality of life in patients after receiving proper counselling. Conclusion: It was concluded that the mostly prescribed anti-asthmatic drug is leukotriene antagonists and the patients diagnosed with asthma mostly received oral therapy than by inhalation. There is significant improvement in medication adherence and QOL after proper counselling given to the subjects.