Published Paper Details:

Transdermal drug delivery was presented to overcome the difficulties of drug delivery especially oral route. Drug delivery through the skin a drug to achieve a systemic of drug is known as transdermal patches. Transdermal patches are widely used as cosmetic, topical, transdermal drug delivery system. Transdermal patch is medicated adhesive patch that is placed on the Skin to deliver a specific dose of medication through the skin and into the bloodstream. Topical administration of therapeutic agent's offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of drug. The basic components of transdermal patch consists of polymer matrixdrug reservoir, active ingredient (Drug), permeation enhancer, pressure sensitive adhesive, backing laminates, release liner, other excipients like plasticizer and solvent. There are many methods of preparation of transdermal patches like circular Teflon mould method, assymetric tpx membrane method, mercury substrate methods, IPM membrane methods, EVAC membrane method, free film method. Cellulose derivative, zein, gelatin, polyvinyl alcohol, polyvinyl chloride, polyethylene, polypropylene this are the polymers used in the preparation of transdermal patches. Also there are many evaluation parameter of transdermal patches like thickness, uniformity of weight, drug content determination, moisture content, moisture uptake, flatness, microscopic studies, adhesive studies, peel adhesion, tack properties, quick steel (peel tack method) test . This review article provides an overview of transdermal drug delivery system, its advantages over conventional dosage forms, drug delivery routes across human skin, permeation enhancer, and various preparation methods.