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An alternate word for medical research is clinical research. Clinical research is done on human subjects and is typically done to assess a therapeutic drug's, a medical or surgical procedure's, or a device's effectiveness in treating or managing a patient. Additionally, clinical research can refer to any study that assesses the aetiology, symptoms, risk factors, and other aspects of a disease. Clinical trials, on the other hand, are research projects that evaluate a therapeutic medicine or device's potential for illness management, control, and prevention. The emphasis on clinical research becomes even more crucial in light of the rising rates of both communicable and non-communicable diseases, particularly in light of the impact that COVID-19 has had on public health globally. Understanding clinical research can help in the development of medications, equipment, and vaccines, which will enhance readiness for public health emergencies. Thus, we provide a thorough description of the essential components of clinical research in this study, which includes the phases, kinds, and designs of clinical trials as well as their operations, audit, and management, as well as ethical considerations.